LOCUS       NM_001304990            8931 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens sprouty RTK signaling antagonist 3 (SPRY3), transcript
            variant 2, mRNA.
ACCESSION   NM_001304990 XM_005274642
VERSION     NM_001304990.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8931)
  AUTHORS   Kamptner,A.Z.M., Mayer,C.E. and Sutterluty,H.
  TITLE     Sprouty3, but Not Sprouty1, Expression Is Beneficial for the
            Malignant Potential of Osteosarcoma Cells
  JOURNAL   Int J Mol Sci 22 (21), 11944 (2021)
   PUBMED   34769378
  REMARK    GeneRIF: Sprouty3, but Not Sprouty1, Expression Is Beneficial for
            the Malignant Potential of Osteosarcoma Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8931)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 8931)
  AUTHORS   Celik-Selvi,B.E., Stutz,A., Mayer,C.E., Salhi,J., Siegwart,G. and
            Sutterluty,H.
  TITLE     Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit
            FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and
            Migration of Glioblastoma-Derived Cells
  JOURNAL   Cells 8 (8), 808 (2019)
   PUBMED   31374860
  REMARK    GeneRIF: The authors presented the data that Spry3 potentiates the
            tumorigenic potential of glioblastoma cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8931)
  AUTHORS   Li,C., Li,J., Xue,K., Zhang,J., Wang,C., Zhang,Q., Chen,X., Gao,C.,
            Yu,X. and Sun,L.
  TITLE     MicroRNA-143-3p promotes human cardiac fibrosis via targeting
            sprouty3 after myocardial infarction
  JOURNAL   J Mol Cell Cardiol 129, 281-292 (2019)
   PUBMED   30878395
REFERENCE   5  (bases 1 to 8931)
  AUTHORS   Stockum,A., Snijders,A.P. and Maertens,G.N.
  TITLE     USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle
            formation
  JOURNAL   PLoS One 13 (1), e0190513 (2018)
   PUBMED   29293652
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8931)
  AUTHORS   Anteby,E.Y., Natanson-Yaron,S., Greenfield,C., Goldman-Wohl,D.,
            Haimov-Kochman,R., Holzer,H. and Yagel,S.
  TITLE     Human placental Hofbauer cells express sprouty proteins: a possible
            modulating mechanism of villous branching
  JOURNAL   Placenta 26 (6), 476-483 (2005)
   PUBMED   15950061
  REMARK    GeneRIF: Spry 1, 2 and 3 expression was observed in placental
            tissue from all three trimesters
REFERENCE   7  (bases 1 to 8931)
  AUTHORS   Lim,J., Yusoff,P., Wong,E.S., Chandramouli,S., Lao,D.H., Fong,C.W.
            and Guy,G.R.
  TITLE     The cysteine-rich sprouty translocation domain targets
            mitogen-activated protein kinase inhibitory proteins to
            phosphatidylinositol 4,5-bisphosphate in plasma membranes
  JOURNAL   Mol Cell Biol 22 (22), 7953-7966 (2002)
   PUBMED   12391162
REFERENCE   8  (bases 1 to 8931)
  AUTHORS   Lim,J., Wong,E.S., Ong,S.H., Yusoff,P., Low,B.C. and Guy,G.R.
  TITLE     Sprouty proteins are targeted to membrane ruffles upon growth
            factor receptor tyrosine kinase activation. Identification of a
            novel translocation domain
  JOURNAL   J Biol Chem 275 (42), 32837-32845 (2000)
   PUBMED   10887178
REFERENCE   9  (bases 1 to 8931)
  AUTHORS   Ciccodicola,A., D'Esposito,M., Esposito,T., Gianfrancesco,F.,
            Migliaccio,C., Miano,M.G., Matarazzo,M.R., Vacca,M., Franze,A.,
            Cuccurese,M., Cocchia,M., Curci,A., Terracciano,A., Torino,A.,
            Cocchia,S., Mercadante,G., Pannone,E., Archidiacono,N., Rocchi,M.,
            Schlessinger,D. and D'Urso,M.
  TITLE     Differentially regulated and evolved genes in the fully sequenced
            Xq/Yq pseudoautosomal region
  JOURNAL   Hum Mol Genet 9 (3), 395-401 (2000)
   PUBMED   10655549
REFERENCE   10 (bases 1 to 8931)
  AUTHORS   Hacohen,N., Kramer,S., Sutherland,D., Hiromi,Y. and Krasnow,M.A.
  TITLE     sprouty encodes a novel antagonist of FGF signaling that patterns
            apical branching of the Drosophila airways
  JOURNAL   Cell 92 (2), 253-263 (1998)
   PUBMED   9458049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX323057.3, AJ271735.1, KC877980.1, KC877984.1, KF495814.1,
            KC877988.1 and KC877989.1.
            
            On Oct 8, 2020 this sequence version replaced NM_001304990.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. This variant is only expected to be expressed from
            the X chromosome. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3706732.1, DA102958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695325.1/ ENSP00000511806.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BX323057.3         15101-15162
            63-237              AJ271735.1         135725-135899
            238-2573            AJ271735.1         141529-143864
            2574-3148           KC877980.1         1-575               c
            3149-3502           AJ271735.1         144440-144793
            3503-4073           KC877984.1         1-571
            4074-5070           AJ271735.1         145365-146361
            5071-6342           KF495814.1         1-1272
            6343-7069           AJ271735.1         147634-148360
            7070-7244           KC877988.1         1-175
            7245-8680           AJ271735.1         148536-149971
            8681-8931           KC877989.1         270-520             c
FEATURES             Location/Qualifiers
     source          1..8931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="Xq28 and Yq12"
     gene            1..8931
                     /gene="SPRY3"
                     /gene_synonym="spry-3"
                     /note="sprouty RTK signaling antagonist 3"
                     /db_xref="GeneID:10251"
                     /db_xref="HGNC:HGNC:11271"
                     /db_xref="MIM:300531"
     exon            1..62
                     /gene="SPRY3"
                     /gene_synonym="spry-3"
                     /inference="alignment:Splign:2.1.0"
     exon            63..237
                     /gene="SPRY3"
                     /gene_synonym="spry-3"
                     /inference="alignment:Splign:2.1.0"
     exon            238..8931
                     /gene="SPRY3"
                     /gene_synonym="spry-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1210
                     /gene="SPRY3"
                     /gene_synonym="spry-3"
                     /note="antagonist of FGF signaling; sprouty homolog 3;
                     sprouty3"
                     /codon_start=1
                     /product="protein sprouty homolog 3"
                     /protein_id="NP_001291919.1"
                     /db_xref="CCDS:CCDS14769.4"
                     /db_xref="GeneID:10251"
                     /db_xref="HGNC:HGNC:11271"
                     /db_xref="MIM:300531"
                     /translation="MDAAVTDDFQQILPIEQLRSTHASNDYVERPPAPCKQALSSPSL
                     IVQTHKSDWSLATMPTSLPRSLSQCHQLQPLPQHLSQSSIASSMSHSTTASDQRLLAS
                     ITPSPSGQSIIRTQPGAGVHPKADGALKGEAEQSAGHPSEHLFICEECGRCKCVPCTA
                     ARPLPSCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPSSC
                     FVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKISSG
                     SAPFPKAQEKSV"
     regulatory      8906..8911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRY3"
                     /gene_synonym="spry-3"
                     /note="hexamer: AATAAA"
     polyA_site      8931
                     /gene="SPRY3"
                     /gene_synonym="spry-3"
                     /note="major polyA site"
ORIGIN      
        1 acagatcgtg acgacaaccc tgcggcaagg caggagtggc cttcctctcc gccagggtta
       61 agaacaagac agaactatct ctgtttctgg ctccactgcc tgccagtgaa ggagttttca
      121 ttcagacttt ccgaagagag gtggagaaac ctaaagactg aggagaagag atcctttgag
      181 ccagatgggg cattagttct tctgcttttc tcagcatgga taaaccattt cctcaaggat
      241 tttctcatgt gccctgaaat ccatgtaact acaagggctc ctctttatca ccataagtgc
      301 caccctgact taaaaccact cagagctaaa aaatcaaggc aaaatggatg ctgcggtgac
      361 agatgatttt caacaaattc tgcctattga acagctgcgc tctactcatg ctagcaatga
      421 ctacgtggaa cggcctccag ccccctgtaa acaggccctc tccagccctt cccttattgt
      481 gcaaacccac aagtctgatt ggtctctggc taccatgcct acttctctcc cccgcagtct
      541 cagccagtgc catcaactgc agcccttgcc tcagcatctg agccaatcta gcattgccag
      601 ctcaatgtcc catagcacca ctgcctctga tcaaaggctc ttggccagca ttacaccctc
      661 accttcaggc caatccatca tccgaaccca acctggagca ggggtccacc caaaggctga
      721 tggtgctctg aagggagaag ctgagcaatc tgcagggcac cctagtgagc acctcttcat
      781 ctgtgaggaa tgtgggcgct gcaagtgcgt cccctgcaca gcagctcgcc ctctcccctc
      841 ctgctggctg tgcaaccagc gctgcctttg ctctgctgag agcctcctcg attatggcac
      901 ttgtctctgc tgtgtcaagg gcctcttcta ccactgctcc actgatgatg aagacaactg
      961 tgctgatgag ccctgctctt gtgggcctag ttcttgcttt gtccgctggg cagccatgag
     1021 cctcatctcc ctcttcctac cctgcctgtg ctgctacctg cctacccgtg gatgcctcca
     1081 tctgtgccaa cagggctatg atagcctccg gcgaccaggc tgccgctgca agaggcacac
     1141 caacactgtg tgcagaaaga tctcttctgg tagtgcaccc ttccccaagg cccaggaaaa
     1201 gtctgtatga ccttccaaca aggtggatcc agagcttttc tccttcgagt ccccaacagc
     1261 aaagcatagg cctcatcttt ggagaggggg aggagtgata aactagccaa agttagggcc
     1321 tctcttttgt tcctgcagtg tcaggggaat gaccaagtac atcctggtgc aggatgcctt
     1381 gttctttctc acagtatcta tcccactcct cttcagtctt tacaccctgc cagctcagcc
     1441 tttatggttg tcatggcaaa ttcaggtgat atatgggtat gaggtttgaa cactgaggac
     1501 tgacagggcc agcaacgtgg aggtttaggg gctccccaat gtaatacctc tcgatgcagg
     1561 ctctgatcgt cactctgttt tctgctgtgc ctttggaagc tttcttctaa gatggttttc
     1621 acaggtacat gtggaacagc gttcaacctt ccagggaata cgaccccttc tccctgttac
     1681 tgcccttctc ttctttattc ctctctcctc tttcattatt ctgttctgta ttcctttccc
     1741 cttcattctc accctgtctg cttttacttt ttctctttct tcctcccttt ctccttctcc
     1801 cctccttctt tttcagactg atcctttctc tgcctgtatt tctatctcat ttgatctata
     1861 tttgtctctc tctacctgtc cctttttctc taacatgtcc aaaagtgctg tttttccata
     1921 gatgtttcct tagatgccaa actttgctat gctatactat ttactaattt ttattaaggg
     1981 aaatggatta ctgtaatgaa ctgatcacta gcaatagtgt gtatcccgat gtgtgtgtgt
     2041 gctcacaacc actctcacct gttcgtgagc gcatgaggcg aagttatctt atatttccag
     2101 gtttaactag ttggagtttt tctccctttc tcaataatca acttatagtg ctgacagatt
     2161 ccactagcat gctgagtagg atagtaaatc aggatgctca taactttgta tgtctgaccc
     2221 aagtgccaaa ggcagacgtg ctttatagct aaatgaacaa agcaaaggat acagaggtat
     2281 gttctctctt agaagctaac ttccctgaga ctgcatggct caggcgttaa taatggacat
     2341 aaaaagtcat aaaacgttag agctggaagg aatcttaact attaatctag ttcaatgccc
     2401 ttattttaca gatgggaaaa ctgaggcctg gaggtaggaa gggacttgcc cccaaggccg
     2461 cacactgagt taacagcaga attgagactg gaatataggc cttctgactc ctagttcagt
     2521 attcttaccc ctgtaccaca ttgagtcatg ggactttttc ctagggctct attaacagtg
     2581 acagaaagcc attcccattc aattactttt caggaaccat gcctagttag tgtggtggtc
     2641 tttctccagt gcatggtggg tagctaatta actatcaggt gttgaggctg cccccagtgg
     2701 acatcacctt tggctctgtc accttgtaga agctcaagtg tggaaaagaa aagcttaaag
     2761 aagccctaac caagctgtat cttcgccatt gcatctactc tttgctgcac acactgtgct
     2821 tgctcctggc tttgtctgca atggcagctg cctgagaact taaatttcag caacagtgaa
     2881 aaactgagat gaaagatgta taatgtagag aactgacttc tctcttaaaa agtacagaga
     2941 gcctgtgctg tgaaccccct tcaatgggaa aaagctgcag tggtgatggc aggctcctaa
     3001 agactgctgc taaaagacac aagaattata cagtttccct ctataagtga atccaaaatt
     3061 cactgacgaa ttcagagatt gagggcactt gcttgaaatc aaggtgctcc aacttagttt
     3121 aagacctcca gactctaact ttatagatca tctcttctag agtgtgcatg gatgtgtgtt
     3181 gcagggtgga gaagtgggga gaagtgtata gtagtacacg gggggaagag gggacctcca
     3241 tgtccctttg ttggatacat attacagaaa tatgtgccac tcactttttg ttggttctga
     3301 atcttcctga agtgtactga catttgggct gcacagagcc ccacaccttc acttacacct
     3361 cctcttctag aattgctttg ctctattttt gtatatataa atatgttatg atgattatta
     3421 ataatgttaa tgatattgct gcaaatggtg ccatatataa ggttaggctt cttggaacat
     3481 ttataaaccc aaaccaatac ctgtaacctc ttatgttgct ttcagatcct tcaattttaa
     3541 gtaacttttt aatcttacaa gtctgcttga ttgtacttta cacttatcta ccctgaaaag
     3601 ctctgcccag ttctctgggt caagctggat ggtgatgagt agcaacacac acttctctgc
     3661 ttctgcctga aatgtgctta gagctcagtt atctaaggat tctctgacac tagtgcattg
     3721 ttcctggagc taaattattc tatggatgtt tgcttattag tttcaggccc caaaataaca
     3781 cgagcccctc ctccttgata gctccttgat atcccaatct tgcagtccta actcaggcaa
     3841 attgtgcact gccagagggg ccctgggttc tgccatatac ccagaggagc ctttctcagt
     3901 gtgtttctaa atggccttac acttggtaga agaaattgaa gggttactca aatacagttg
     3961 caatctgcaa tctgctgttg agtcagggct ttcacttgtg tccaagttgg cctgatatgg
     4021 actgcatctg ctttacgtat agatgggtcc tgttgggata tgcgcatgga cgtgtgagtg
     4081 agtgtgcgta tgtatccctt ctgtgattat atatattcac acatctctat atattttaat
     4141 gtattgcaca tgtatattta aaatatatac gaaagaactc taaatcctgc agggaggctc
     4201 tgttttcatt atttttctac tttgtgtcat gtcctgtata aacaggaata tttagagggt
     4261 gtttcctgct tagcattttt ttgcagttaa atcatctgtt agcccctaac tctactgcct
     4321 tccacatatt ggttccttga tacatttcat atgatatcag ccaagagttt tcctgtggtt
     4381 ccagcccatc ttccctaatc acaatagcaa taataaatat agtgaatact tacatagtgc
     4441 ttactatatg ctaagcacta tttttagcat gttatttata ttagctcatt cattcctcac
     4501 aattctacaa cataggtatc attccaacct ctattttaca gatgagaaaa ctgaagcaca
     4561 gagaagttaa gtgacttgcc aaaaggtaac aattgtaaat ggtagagcta agatttgaac
     4621 ccagggtgtc tgactcccag gtccatgctc cagagtcaga tatagaaggc tggagcacag
     4681 tgtaaaccat tctggagtaa caagcctcaa atggtgaata attctttccc taactctggt
     4741 ccacctgcaa cctaggagtt aaaataagta tcttgctatg ttaagagtaa agcaatagtt
     4801 acaggcatca tatattagct gtcttgctcc caaaatggtg acattacaaa cttttccact
     4861 attccctttg aaaacatgct tgcagccagt taccatttct tagcttatga tgtagagcta
     4921 ttaagggagt attttcactt gtgccaaaga gggtaagcgt ttattagcct tatctttatt
     4981 ggccagggaa aactaattca attttttttt gaacaaagta taactgagac tatttttgga
     5041 gcttaagatt tgttagagct gttaacattc aaccttattg attatattga gagcgctctt
     5101 ctgattcaaa tgtaagcaaa ccactgatga ccactggtcc gtataacaca ttttaccaac
     5161 agctccttca cactgaatcc tttaacttgg ccaaaggacc cttaaagaac atctagtcca
     5221 atgtcaacat tttatagctg gagaaaggga tgcacagaga gggaaaataa cctgtccaaa
     5281 gtcacacagt tctgaaaatt gagtggaatt atgactttat accagagttc ctaatttcca
     5341 ggtatcttag cctcagtttc ttaaaaaata gagtttgaag caaaagctat gtacgatcca
     5401 gggtagtatg agtaaggaaa gggttaatga gggagggaag aaagaagaac aaataaaaag
     5461 catgtcactg agttggccac agtctgttcc ttggcaagct aatttcgcaa ttttttgtga
     5521 cagaccatat aaaactacta catctccata cagcccacgt ggtggaggaa aggaggtgaa
     5581 ttcatctgct agctctcatc tcattagtca aattcttccc catgtgatat ttacccttct
     5641 acatttttgg gtagtgcgtg atgggcactt aaatatgtac cttggcattt catgcttcag
     5701 caataatggg aaggattgtg gctccactat aaacagtaag gcaagtatat gaatataggg
     5761 agattaaatt taaagtgcta cactagggtg gtgcttttac cttatgtctt taatcacatt
     5821 ccttcgaagt aagttagaga taacctacca cctttaaagt aaataaagct ttattgtggc
     5881 tcttagaact gtactatgtt tgccttcctg aacctattta ttctctagct tgctttaaag
     5941 ggcttctttt ttatatggaa attaattccc tgttcaatta aaggagtaac aaactctcaa
     6001 aatatctttc ttcttaatat aaaaaggaat ttcatattat tgaactcctc aaaaagcatg
     6061 tgtaagtcaa aatatgtatg tgaaggcaca tatgttcttt taggttccat gagcataata
     6121 gcaggaaaac tggttaagtc aataaatgct ggggaaaaaa tggctaaaca aggtattctg
     6181 taacatgaaa ataaagcaat gagttggttg gctggctttt taaaaaatat ttcagccact
     6241 aattatgaca cagacacatt ataagaatta tgctaccttt tattcacata tacaatagtt
     6301 ccctgtgtcc tatagatcat tgtcacataa agcaaaagca ttagtgcccc atttggacct
     6361 ttggccgaag gtttgataag attttgtagg actgaaattc ttggtccctt tatcctagtt
     6421 taggcccata tccttatttt cactctcaaa gataagatca tgacactacc agtgttgctg
     6481 ctgttaaagg ccaggatgga caagataagg aaaggcattt tgggaatgac actgactaat
     6541 gttaggaatc ttgctgtcat tacaatccaa gttatatatg tttgctccca tatgtatttg
     6601 ttggccaatc tcctgaaaaa gaagaaggta attctaaccc acacattgtc attcccaaac
     6661 taacctggca atccttttga ccataccagg taatagtcat ccctctgatg gtaaaagaca
     6721 gagatgtcaa ggctctggaa gctcccaggt ccttgaagaa ctaactaaac tgctgaacac
     6781 agaagtggta atgtaggcaa gccacaggta tgttctcttg taacaagatg gggttgacca
     6841 tatgtgaacc ctgaagagtc attttgaacc tgtgtcctaa ggcctagagt actttaatcc
     6901 tcatcttcaa agtcttacca ctctgataac aaaaagaaac actacaaaga aactgcaagg
     6961 aaagggacag tcattttttt taatatctac caattattta gttattcata tatgcatttc
     7021 tttatataga aaagtattta tatgaagttt ccaaaagact ctgatattca gctttatagt
     7081 cttggataga aaatcatgtg tccttggatg gggattcaca caccaaggct taacagaatt
     7141 agtttgggga atactcattt ttactctaga gattagttgg cttaaacaac tttactcgtg
     7201 aatttttttc ttaatggagg tgaagacctc ccaaagagga gaaggcccca ggcctttctt
     7261 aatatataaa ccatattgaa agaaagaaag aaaaaagtaa tgggaagtaa tagtaaatgt
     7321 ggatccagaa agaaaaacaa aggttaagaa aatgatgtat gtgaaagaaa aaaagctcta
     7381 taatcagtgt gtttctctca cctaaaacac catttactaa ctacttggtt cagttgtacc
     7441 ctttaactct attttgtcct tgacttatat caacactctt cttttccaaa ctcctatagc
     7501 tctccatctg gaatgattct atggggtggg gggtcggggg aggagaaagg gagacagcag
     7561 aagaaagaaa gagagagaaa gatagagaga gagagagaga tgggtggaga cttggcctct
     7621 ctcctagagg ttcaaagtta gaatatgcca ctaacactat ctgcctttca aactcccttc
     7681 taggacatgc tccatagtac ttagatctta tatcaaatga caaggtttct ctccttcaga
     7741 gagaaatacc agactggatt tgtggtttcc ctggattggt tttttctgag tcaaagtggt
     7801 gttgtagaaa tcacagtacc ctgagaccaa ttaagtcaga atctttggag gtgttgagga
     7861 atggattttt aaagttccca gatgattata atatgcaaac agatttgaga aaattgaatc
     7921 actttattcc ataaatgcag atagtgaggc taagagaggg aaagtgactt actcataacc
     7981 acaccgtgag ttagtgacca agtcaggata agaatccagg tctgctgact cctaggccag
     8041 aattcttgtc tttatactac actgcttcta tctctaccct attccccctc tgagcctttg
     8101 cttttctcat ctgtaaaatg acgataataa agcctagaga gtgtatgaga atcattaaag
     8161 cagaagcatt tttcttaatg tacaaggttc tatacaaatg caagggaatt aatgtataac
     8221 atatatgtgg ggctaagtct ctaaaacaac ataataaaag ttgtttttat tttagtcaat
     8281 cttttaggta ttgtgtctac ctgatagcat gtaacaagat tgaacacttg tgtaggtcgt
     8341 atgtgccttt aatctgaggt tggcctcagt gacaatcaaa attagcagtt gaggaaaaag
     8401 gtcatacatt tttctcttgc ccttgctgga atagggatca agaggaatat aaaagcagtg
     8461 ggatatctgg atttcttata ctcagtcaac cacaacatgg ccttagtact gaactagccc
     8521 agggtttcaa tggaactcgt agatctcatt cccaaggctg gtcctggttg aagggagaag
     8581 gtcaaaaaag gacgtgtctt ctgaaaggca ttacccatgg aaagccaagg gggagggttg
     8641 cccactagga ggagcttctt ttgtagaagc cagaatggag gaaaggggct ttctgacttg
     8701 gagcatctga ggaaatagat tatttgagga tctagtactc ccagaataat ctgtaaccac
     8761 aagaaacaca tttcttgaac tccagcgccc cagaacagga tatccatatc caatcccatc
     8821 gtatccatcc tggatgttat gaatttccag agagggccac ttctaccccc ctaggagtca
     8881 tacatctggc tacttatttg ttaaaaataa aattctgtac catttataaa a
//
