LOCUS       NM_005842               2286 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sprouty RTK signaling antagonist 2 (SPRY2), transcript
            variant 1, mRNA.
ACCESSION   NM_005842
VERSION     NM_005842.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2286)
  AUTHORS   Hong,Y., Li,Z., Su,Y., Pu,H. and Zhang,X.
  TITLE     The ceRNA Mechanism of lncRNA MEG3/miR-21-5p/SPRY2 in Cell
            Proliferation and Apoptosis in Bladder Cancer
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (1), 55-68 (2024)
   PUBMED   37824392
  REMARK    GeneRIF: The ceRNA Mechanism of lncRNA MEG3/miR-21-5p/SPRY2 in Cell
            Proliferation and Apoptosis in Bladder Cancer.
REFERENCE   2  (bases 1 to 2286)
  AUTHORS   Acikgoz,Y., Yildirim,F.U., Esen,S.A., Ucar,G., Ergun,Y., Bal,O.,
            Dogan,M. and Uncu,D.
  TITLE     The Prognostic and Functional Impact of Sprouty 2 Expression in
            Non-small Cell Lung Cancer
  JOURNAL   Am J Clin Oncol 46 (12), 543-550 (2023)
   PUBMED   37700432
  REMARK    GeneRIF: The Prognostic and Functional Impact of Sprouty 2
            Expression in Non-small Cell Lung Cancer.
REFERENCE   3  (bases 1 to 2286)
  AUTHORS   Dai,H., Xu,W., Wang,L., Li,X., Sheng,X., Zhu,L., Li,Y., Dong,X.,
            Zhou,W., Han,C., Mao,Y. and Yao,L.
  TITLE     Loss of SPRY2 contributes to cancer-associated fibroblasts
            activation and promotes breast cancer development
  JOURNAL   Breast Cancer Res 25 (1), 90 (2023)
   PUBMED   37507768
  REMARK    GeneRIF: Loss of SPRY2 contributes to cancer-associated fibroblasts
            activation and promotes breast cancer development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2286)
  AUTHORS   Jiang,W., Zhao,W., Ye,F., Huang,S., Wu,Y., Chen,H., Zhou,R. and
            Fu,G.
  TITLE     SNHG12 regulates biological behaviors of ox-LDL-induced HA-VSMCs
            through upregulation of SPRY2 and NUB1
  JOURNAL   Atherosclerosis 340, 1-11 (2022)
   PUBMED   34847450
  REMARK    GeneRIF: SNHG12 regulates biological behaviors of ox-LDL-induced
            HA-VSMCs through upregulation of SPRY2 and NUB1.
REFERENCE   5  (bases 1 to 2286)
  AUTHORS   Stuckel,A.J., Zeng,S., Lyu,Z., Zhang,W., Zhang,X., Dougherty,U.,
            Mustafi,R., Zhang,Q., Joshi,T., Bissonnette,M., Choudhury,S.R. and
            Khare,S.
  TITLE     Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal
            Cancers
  JOURNAL   Cells 10 (10), 2632 (2021)
   PUBMED   34685612
  REMARK    GeneRIF: Epigenetic DNA Modifications Upregulate SPRY2 in Human
            Colorectal Cancers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2286)
  AUTHORS   Yusoff,P., Lao,D.H., Ong,S.H., Wong,E.S., Lim,J., Lo,T.L.,
            Leong,H.F., Fong,C.W. and Guy,G.R.
  TITLE     Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the
            activation of Raf
  JOURNAL   J Biol Chem 277 (5), 3195-3201 (2002)
   PUBMED   11698404
REFERENCE   7  (bases 1 to 2286)
  AUTHORS   Wong,E.S., Lim,J., Low,B.C., Chen,Q. and Guy,G.R.
  TITLE     Evidence for direct interaction between Sprouty and Cbl
  JOURNAL   J Biol Chem 276 (8), 5866-5875 (2001)
   PUBMED   11053437
REFERENCE   8  (bases 1 to 2286)
  AUTHORS   Lim,J., Wong,E.S., Ong,S.H., Yusoff,P., Low,B.C. and Guy,G.R.
  TITLE     Sprouty proteins are targeted to membrane ruffles upon growth
            factor receptor tyrosine kinase activation. Identification of a
            novel translocation domain
  JOURNAL   J Biol Chem 275 (42), 32837-32845 (2000)
   PUBMED   10887178
REFERENCE   9  (bases 1 to 2286)
  AUTHORS   Glienke,J., Fenten,G., Seemann,M., Sturz,A. and Thierauch,K.H.
  TITLE     Human SPRY2 inhibits FGF2 signalling by a secreted factor
  JOURNAL   Mech Dev 96 (1), 91-99 (2000)
   PUBMED   10940627
REFERENCE   10 (bases 1 to 2286)
  AUTHORS   Hacohen,N., Kramer,S., Sutherland,D., Hiromi,Y. and Krasnow,M.A.
  TITLE     sprouty encodes a novel antagonist of FGF signaling that patterns
            apical branching of the Drosophila airways
  JOURNAL   Cell 92 (2), 253-263 (1998)
   PUBMED   9458049
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354668.13, CX866409.1 and
            BC015745.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005842.3.
            
            Summary: This gene encodes a protein belonging to the sprouty
            family. The encoded protein contains a carboxyl-terminal
            cysteine-rich domain essential for the inhibitory activity on
            receptor tyrosine kinase signaling proteins and is required for
            growth factor stimulated translocation of the protein to membrane
            ruffles. In primary dermal endothelial cells this gene is
            transiently upregulated in response to fibroblast growth factor
            two. This protein is indirectly involved in the non-cell autonomous
            inhibitory effect on fibroblast growth factor two signaling. The
            protein interacts with Cas-Br-M (murine) ectropic retroviral
            transforming sequence, and can function as a bimodal regulator of
            epidermal growth factor receptor/mitogen-activated protein kinase
            signaling. This protein may play a role in alveoli branching during
            lung development as shown by a similar mouse protein. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Transcript variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF039843.1, SRR1660809.155142.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377104.4/ ENSP00000366308.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL354668.13        172548-172558
            12-450              CX866409.1         1-439
            451-2286            BC015745.1         1-1836
FEATURES             Location/Qualifiers
     source          1..2286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q31.1"
     gene            1..2286
                     /gene="SPRY2"
                     /gene_synonym="hSPRY2; IGAN3"
                     /note="sprouty RTK signaling antagonist 2"
                     /db_xref="GeneID:10253"
                     /db_xref="HGNC:HGNC:11270"
                     /db_xref="MIM:602466"
     exon            1..505
                     /gene="SPRY2"
                     /gene_synonym="hSPRY2; IGAN3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..2286
                     /gene="SPRY2"
                     /gene_synonym="hSPRY2; IGAN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             557..1504
                     /gene="SPRY2"
                     /gene_synonym="hSPRY2; IGAN3"
                     /codon_start=1
                     /product="protein sprouty homolog 2"
                     /protein_id="NP_005833.1"
                     /db_xref="CCDS:CCDS9463.1"
                     /db_xref="GeneID:10253"
                     /db_xref="HGNC:HGNC:11270"
                     /db_xref="MIM:602466"
                     /translation="MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLD
                     QIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSS
                     ARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKP
                     GELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTC
                     VCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCL
                     KLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRY2"
                     /gene_synonym="hSPRY2; IGAN3"
                     /note="hexamer: AATATA"
     polyA_site      2286
                     /gene="SPRY2"
                     /gene_synonym="hSPRY2; IGAN3"
                     /note="major polyA site"
ORIGIN      
        1 agtctgcacc gccgagagct gcgcgccgca gcgctagcgg aggagagggg ccggcggagc
       61 gcgcagcgcc caggcccccg cgcccgcccg gcccggcccg gcccgcgccc ccgcgccgcc
      121 tccgctacga cgcggccccg gccgcaccac ttggcgatct ggctttaggt tctccgtaag
      181 gccgttttct tttcccattc gctcatctgc caggaaaagg gacttgccgt tggcgcttcg
      241 gcctcttgtt cattgagaaa aaagaggaaa tactccgcgt gcgcttgtag aaggggagtc
      301 gtctccagct ccgaaccccg gagtgttcat cagcggggaa tctggctccg aattctcttt
      361 ttttctcccg ccgattgctc ggaagttggt ctaaagcaga ggttggaaag aaaggaaaaa
      421 agtttgcatc gagactggat ttatttgcac atcgcagaaa gaagagaatc caagggagag
      481 gggttggtgc aaagccgcga tcacggagtt cagatgtgtt ctaagcctgc tggagtgacc
      541 acacttccaa gacctgatgg aggccagagc tcagagtggc aacgggtcgc agcccttgct
      601 gcagacgccc cgtgacggtg gcagacagcg tggggagccc gaccccagag acgccctcac
      661 ccagcaggta catgtcttgt ctctggatca gatcagagcc atccgaaaca ccaatgagta
      721 cacagagggg cctactgtcg tcccaagacc tgggctcaag cctgctcctc gcccctccac
      781 tcagcacaaa cacgagagac tccacggtct gcctgagcac cgccagcctc ctaggctcca
      841 gcactcgcag gtccattctt ctgcacgagc ccctctgtcc agatccataa gcacggtcag
      901 ctcagggtcg cggagcagta cgaggacaag taccagcagc agctcctctg aacagagact
      961 gctaggatca tccttctcct ccgggcctgt tgctgatggc ataatccggg tgcaacccaa
     1021 atctgagctc aagccaggtg agcttaagcc actgagcaag gaagatttgg gcctgcacgc
     1081 ctacaggtgt gaggactgtg gcaagtgcaa atgtaaggag tgcacctacc caaggcctct
     1141 gccatcagac tggatctgcg acaagcagtg cctttgctcg gcccagaacg tgattgacta
     1201 tgggacttgt gtatgctgtg tgaaaggtct cttctatcac tgttctaatg atgatgagga
     1261 caactgtgct gacaacccat gttcttgcag ccagtctcac tgttgtacac gatggtcagc
     1321 catgggtgtc atgtccctct ttttgccttg tttatggtgt taccttccag ccaagggttg
     1381 ccttaaattg tgccaggggt gttatgaccg ggttaacagg cctggttgcc gctgtaaaaa
     1441 ctcaaacaca gtttgctgca aagttcccac tgtcccccct aggaactttg aaaaaccaac
     1501 atagcatcat taatcaggaa tattacagta atgaggattt tttctttctt tttttaatac
     1561 acatatgcaa ccaactaaac agttataatc ttggcactgt taatagaaag gtgggatagt
     1621 ctttgctgtt tgcggtgaaa tgctttttgt ccatgtgccg ttttaactga tatgcttgtt
     1681 agaactcagc taatggagct caaagtatga gatacagaac ttggtgaccc atgtattgca
     1741 taagctaaag caacacagac actcctaggc aaagtttttg tttgtgaata gtacttgcaa
     1801 aacttgtaaa ttagcagatg acttttttcc attgttttct ccagagagaa tgtgctatat
     1861 ttttgtatat acaataatat ttgcaactgt gaaaaacaag ttgtgccata ctacatggca
     1921 cagacacaaa atattatact aatatgttgt acattcggaa gaatgtgaat caatcagtat
     1981 gtttttagat tgtattttgc cttacagaaa gcctttattg taagactctg atttcccttt
     2041 ggacttcatg tatattgtac agttacagta aaattcaacc tttattttct aattttttca
     2101 acatattgtt tagtgtaaag aatatttatt tgaagtttta ttattttata aaaaagaata
     2161 tttattttaa gaggcatctt acaaattttg ccccttttat gaggatgtga tagttgctgc
     2221 aaatgagggg ttacagatgc atatgtccaa tataaaatag aaaatatatt aacgtttgaa
     2281 attaaa
//
