LOCUS       NM_001258038            2603 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens sprouty RTK signaling antagonist 1 (SPRY1), transcript
            variant 1, mRNA.
ACCESSION   NM_001258038
VERSION     NM_001258038.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2603)
  AUTHORS   Qiu,B., Yang,E., Zheng,Y. and Zhang,H.
  TITLE     Association between SPRY1 and TET3 in skin photoaging and natural
            aging mechanisms
  JOURNAL   J Cosmet Dermatol 23 (4), 1396-1403 (2024)
   PUBMED   38054565
  REMARK    GeneRIF: Association between SPRY1 and TET3 in skin photoaging and
            natural aging mechanisms.
REFERENCE   2  (bases 1 to 2603)
  AUTHORS   Shi,T., Li,X., Zheng,J., Duan,Z., Ooi,Y.Y., Gao,Y., Wang,Q.,
            Yang,J., Wang,L. and Yao,L.
  TITLE     Increased SPRY1 expression activates NF-kappaB signaling and
            promotes pancreatic cancer progression by recruiting neutrophils
            and macrophages through CXCL12-CXCR4 axis
  JOURNAL   Cell Oncol (Dordr) 46 (4), 969-985 (2023)
   PUBMED   37014552
  REMARK    GeneRIF: Increased SPRY1 expression activates NF-kappaB signaling
            and promotes pancreatic cancer progression by recruiting
            neutrophils and macrophages through CXCL12-CXCR4 axis.
REFERENCE   3  (bases 1 to 2603)
  AUTHORS   Yang,X., Yang,C., Friesel,R.E. and Liaw,L.
  TITLE     Sprouty1 has a protective role in atherogenesis and modifies the
            migratory and inflammatory phenotype of vascular smooth muscle
            cells
  JOURNAL   Atherosclerosis 373, 17-28 (2023)
   PUBMED   37121163
  REMARK    GeneRIF: Sprouty1 has a protective role in atherogenesis and
            modifies the migratory and inflammatory phenotype of vascular
            smooth muscle cells.
REFERENCE   4  (bases 1 to 2603)
  AUTHORS   Wang,J., Wang,Z., Huang,M., Zhang,Y. and Xu,L.
  TITLE     Circ_0099630 Participates in SPRY1-Mediated Repression in
            Periodontitis
  JOURNAL   Int Dent J 73 (1), 136-143 (2023)
   PUBMED   35933226
  REMARK    GeneRIF: Circ_0099630 Participates in SPRY1-Mediated Repression in
            Periodontitis.
REFERENCE   5  (bases 1 to 2603)
  AUTHORS   Zhou,Y., Wang,P., Chen,X.Y., Yan,B.X., Landeck,L., Wang,Z.Y.,
            Xu,F., Zheng,M. and Man,X.Y.
  TITLE     Sprouty1 exerts a preventive effect on the initiation of psoriasis
            by inhibiting innate immune antimicrobial peptide cathelicidin and
            immunocytes
  JOURNAL   Cell Prolif 55 (10), e13290 (2022)
   PUBMED   35716036
  REMARK    GeneRIF: Sprouty1 exerts a preventive effect on the initiation of
            psoriasis by inhibiting innate immune antimicrobial peptide
            cathelicidin and immunocytes.
REFERENCE   6  (bases 1 to 2603)
  AUTHORS   Hall,A.B., Jura,N., DaSilva,J., Jang,Y.J., Gong,D. and Bar-Sagi,D.
  TITLE     hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by
            c-Cbl
  JOURNAL   Curr Biol 13 (4), 308-314 (2003)
   PUBMED   12593796
REFERENCE   7  (bases 1 to 2603)
  AUTHORS   Hanafusa,H., Torii,S., Yasunaga,T. and Nishida,E.
  TITLE     Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK
            signalling pathway
  JOURNAL   Nat Cell Biol 4 (11), 850-858 (2002)
   PUBMED   12402043
REFERENCE   8  (bases 1 to 2603)
  AUTHORS   Egan,J.E., Hall,A.B., Yatsula,B.A. and Bar-Sagi,D.
  TITLE     The bimodal regulation of epidermal growth factor signaling by
            human Sprouty proteins
  JOURNAL   Proc Natl Acad Sci U S A 99 (9), 6041-6046 (2002)
   PUBMED   11983899
  REMARK    GeneRIF: The bimodal regulation of epidermal growth factor
            signaling by human Sprouty proteins
REFERENCE   9  (bases 1 to 2603)
  AUTHORS   Lim,J., Wong,E.S., Ong,S.H., Yusoff,P., Low,B.C. and Guy,G.R.
  TITLE     Sprouty proteins are targeted to membrane ruffles upon growth
            factor receptor tyrosine kinase activation. Identification of a
            novel translocation domain
  JOURNAL   J Biol Chem 275 (42), 32837-32845 (2000)
   PUBMED   10887178
REFERENCE   10 (bases 1 to 2603)
  AUTHORS   Hacohen,N., Kramer,S., Sutherland,D., Hiromi,Y. and Krasnow,M.A.
  TITLE     sprouty encodes a novel antagonist of FGF signaling that patterns
            apical branching of the Drosophila airways
  JOURNAL   Cell 92 (2), 253-263 (1998)
   PUBMED   9458049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL602431.1, DA765300.1, AY590694.1 and CA447611.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001258038.1.
            
            Transcript Variant: This variant (1) represents the longest
            variant. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL602431.1, DA765300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651917.1/ ENSP00000498292.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL602431.1         2-30
            30-578              DA765300.1         1-549
            579-2599            AY590694.1         131-2151
            2600-2603           CA447611.1         24-27               c
FEATURES             Location/Qualifiers
     source          1..2603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.1"
     gene            1..2603
                     /gene="SPRY1"
                     /gene_synonym="hSPRY1"
                     /note="sprouty RTK signaling antagonist 1"
                     /db_xref="GeneID:10252"
                     /db_xref="HGNC:HGNC:11269"
                     /db_xref="MIM:602465"
     exon            1..138
                     /gene="SPRY1"
                     /gene_synonym="hSPRY1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..384
                     /gene="SPRY1"
                     /gene_synonym="hSPRY1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..2603
                     /gene="SPRY1"
                     /gene_synonym="hSPRY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..1399
                     /gene="SPRY1"
                     /gene_synonym="hSPRY1"
                     /note="sprouty, Drosophila, homolog of, 1 (antagonist of
                     FGF signaling); spry-1; sprouty homolog 1, antagonist of
                     FGF signaling"
                     /codon_start=1
                     /product="protein sprouty homolog 1"
                     /protein_id="NP_001244967.1"
                     /db_xref="CCDS:CCDS3731.1"
                     /db_xref="GeneID:10252"
                     /db_xref="HGNC:HGNC:11269"
                     /db_xref="MIM:602465"
                     /translation="MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQI
                     KAIRGSNEYTEGPSVVKRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVL
                     PSNARGPILSRSTSTGSAASSGSNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPKQ
                     LIVDDLKGSLKEDLTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEY
                     GTCMCLVKGIFYHCSNDDEGDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPA
                     KGCLKLCRRCYDWIHRPGCRCKNSNTVYCKLESCPSRGQGKPS"
     regulatory      2585..2590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRY1"
                     /gene_synonym="hSPRY1"
                     /note="hexamer: AATATA"
     polyA_site      2603
                     /gene="SPRY1"
                     /gene_synonym="hSPRY1"
                     /note="major polyA site"
ORIGIN      
        1 gtagccggag tgagaccgct ctgcaaacca ctgcgtgctt tgcagagtga ttatcagcac
       61 agttccctgc cctggataag gaacagctac agtcgctgtt aaatgtgcct gaaaagcaat
      121 ttgcaatctt tgcattaggc atttcggccg tggaacccca ggctcggagg actgggtgtg
      181 agcgctgccc gggagaggct gacctgccgg gaccggagtg cccggggacg ctgtgccccc
      241 acttgcccaa cgtgcggaat cggctaagcg cgtcggcctg cgcggggcac aagggacgac
      301 gcccgccttt ctctctccga gaaggatccc caaacctcac tctcttcact cctccccgct
      361 aaaaaaaaaa aaaaaaagaa aagggatttc agatgcatgc caggtttcca ctgattgcca
      421 gaactcgaga tcactacaca tggatcccca aaatcaacat ggcagtggca gttcgttagt
      481 tgtgatccag cagccttctt tggatagccg tcagagatta gactatgaga gagagattca
      541 gcctactgct attttgtcct tagaccagat caaggccata agaggcagca atgaatacac
      601 agaagggcct tcggtggtga aaagacctgc tcctcggaca gcaccaagac aagaaaagca
      661 tgaaaggact catgaaatca taccaattaa tgtgaataat aactacgagc acagacacac
      721 aagccacctg ggacatgcag tactcccaag taatgccagg ggccccattt tgagcagatc
      781 aaccagcact ggaagtgcag ccagctctgg gagcaacagc agtgcctctt ctgaacaggg
      841 actgttagga aggtcaccac caaccagacc agtccctggt cataggtctg aaagggcaat
      901 ccggacccag cccaagcaac tgattgtgga tgacttgaag ggttccttga aagaggacct
      961 gacacagcac aagttcattt gtgaacagtg tgggaagtgc aagtgtggag aatgcactgc
     1021 tcccaggacc ctaccatcct gtttggcctg taaccggcag tgcctttgct ctgctgagag
     1081 catggtggaa tatggaacct gcatgtgctt agtcaagggc atcttctacc actgctccaa
     1141 tgacgacgaa ggggattcct attcagataa tccttgctcc tgttcacaat cacactgctg
     1201 ctctagatac ctgtgtatgg gagccatgtc tttattttta ccttgcttac tctgttatcc
     1261 tcctgctaaa ggatgcctga agctgtgcag gaggtgttat gactggatcc atcgcccagg
     1321 gtgcagatgt aagaactcca acactgtcta ttgtaagctg gagagctgcc cctcccgggg
     1381 tcagggtaaa ccatcatgat ttttggaggt gggttgtacc tcctgaactt ttagctttca
     1441 agttgtggct gttttttgtt tttgtttttg tttttgtttt ctttagaatt tttccctgtt
     1501 tcccaccttc tcttcccctg ttgccaaggt ctaactcatg gatttttctc tttcctcatg
     1561 gatgatcttc agcaagagtg gactgggaag ctgcacctgg ctcccacttt caacaagagc
     1621 ctctgccatc cacttgaggg tattgagagc cagtgggctt ttgtgtagcc tttttgttct
     1681 gcaagcaact ttctaaagtt gtgtacatga acatacaccc acatccagac tacagtgatt
     1741 tagagttgtt ttgattgggt accgtgggag cagggaaatt ggttttttaa aaagcaactg
     1801 tttaattgct taaataagct atgtattaaa tctgtctcca gttagggcta tcttcctagc
     1861 ataggcccct taagtagcat gggggatata ttttttgcta taacgtaaaa attttccttt
     1921 aaccactgcc ctctccttct ttctccttca aggttctttc cccctcagtt ttgttgttgt
     1981 cttactctgg agatgccaag tgtatttttt ctttctatgt aattttagat tcgccttaca
     2041 atgtaaatct tcacattgga gataatattg gttggacctt gcccatcttc actctagcct
     2101 tcgtatttgt gaaggactca gccaccttcc ttcttcaccc catgcttctc accaaatttt
     2161 tgttgtcatt gagggcactt ggataactca agttgatatt tatagctgat caatctatat
     2221 gtgtcacaga actatgctgc ctaaagtgat cttggctcct taatggtcct tttggcccct
     2281 tggatagtta acagctgagt aattctaatc tcttctgtgt tttccttgcc ttaaccacaa
     2341 attgtggtgc tttttgtata ttttatgtat aaatcacaaa gttgaattct gactattttt
     2401 aagacaaaag tctgttaaac ttttttattg taaagaatat ttattatgcg aatctctatt
     2461 attttatggt atttattgca aaagactgtt gaaatgtact catgtttgaa tataacaaaa
     2521 tatcaatact taacggaaaa taaggtgaca cgaagaaagt acatatgtta actataatgc
     2581 agaaaatata ttaattaatg aaa
//
