LOCUS       NM_001395435             762 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens small proline rich protein 5 (SPRR5), mRNA.
ACCESSION   NM_001395435
VERSION     NM_001395435.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 762)
  AUTHORS   Ziegler,C., Graf,J., Faderl,S., Schedlbauer,J., Strieder,N.,
            Forstl,B., Spang,R., Bruckmann,A., Merkl,R., Hombach,S. and
            Kretz,M.
  TITLE     The long non-coding RNA LINC00941 and SPRR5 are novel regulators of
            human epidermal homeostasis
  JOURNAL   EMBO Rep 20 (2) (2019)
   PUBMED   30622217
  REMARK    GeneRIF: LINC00941 represses SPRR5, a previously uncharacterized
            molecule, which functions as an essential positive regulator of
            keratinocyte differentiation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356867.23.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636302.2/ ENSP00000489807.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL356867.23        23529-23571
            44-762              AL356867.23        24860-25578
FEATURES             Location/Qualifiers
     source          1..762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..762
                     /gene="SPRR5"
                     /note="small proline rich protein 5"
                     /db_xref="GeneID:110806278"
                     /db_xref="HGNC:HGNC:53428"
     exon            1..43
                     /gene="SPRR5"
                     /inference="alignment:Splign:2.1.0"
     exon            44..762
                     /gene="SPRR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..388
                     /gene="SPRR5"
                     /codon_start=1
                     /product="putative small proline-rich protein 5"
                     /protein_id="NP_001382364.1"
                     /db_xref="CCDS:CCDS91056.1"
                     /db_xref="GeneID:110806278"
                     /db_xref="HGNC:HGNC:53428"
                     /translation="MSQQKQKQCAPPQQCCPPPQQRCPPPQQCCPPPQQCCPPPQQCC
                     PPPQQCCPPPQQCCPPPQQCCPPPQQYCPPPQQTKQPCQPPPKCQEPCAPKCPPPQQC
                     QTSKQK"
     regulatory      740..745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR5"
                     /note="hexamer: ATTAAA"
     polyA_site      762
                     /gene="SPRR5"
                     /note="major polyA site"
ORIGIN      
        1 aaacccctcc acacctatct gctccagtcg ctggtgaacc ttgttgcaag tccagcccag
       61 aatgtctcag cagaagcaga agcagtgtgc tcccccgcag cagtgctgcc ccccacccca
      121 gcagcgctgc cccccacccc agcagtgctg ccccccgcct caacagtgct gccccccacc
      181 ccagcagtgc tgcccgccgc ctcaacaatg ctgcccccct ccccagcagt gctgtccccc
      241 accccagcag tgctgccctc cacctcagca gtactgcccc ccaccccaac agaccaagca
      301 gccttgccag cccccaccca agtgccagga gccctgtgcc cccaagtgcc caccccctca
      361 gcagtgccag acgtccaagc agaagtaagc cctgggcatg tgatcagagg cgaaccccca
      421 ggaaaaacag agcatgaagt tccttctggg ccagcatctt acactccaca ggccaagcaa
      481 agccctgctc accagtgctt ctggatgcag ccacacttca cacttgcagg agaggcagca
      541 ccaggctggc agctggcggc ttcctcgagc tctactcttc ttaattagca gctgcagttt
      601 ccatctcaga caaggatctg gttctaaact atctaatcat ctttcctgac atgcatctac
      661 attgccctgc tggaaacatg agcggcatgc acaggcatct tctcctacca cgcttcccct
      721 cagctcctgt tttcaaacaa ttaaaacaga attcctctgg ca
//
