LOCUS       NM_173080                751 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens small proline rich protein 4 (SPRR4), mRNA.
ACCESSION   NM_173080
VERSION     NM_173080.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 751)
  AUTHORS   Kainu,K., Kivinen,K., Zucchelli,M., Suomela,S., Kere,J., Inerot,A.,
            Baker,B.S., Powles,A.V., Fry,L., Samuelsson,L. and
            Saarialho-Kere,U.
  TITLE     Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus
            on 1q shows heterogeneity between Finnish, Swedish and Irish
            families
  JOURNAL   Exp Dermatol 18 (2), 109-115 (2009)
   PUBMED   18643845
  REMARK    GeneRIF: Association of psoriasis to PGLYRP and SPRR genes at
            PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and
            Irish families.
REFERENCE   2  (bases 1 to 751)
  AUTHORS   Cabral,A., Sayin,A., de Winter,S., Fischer,D.F., Pavel,S. and
            Backendorf,C.
  TITLE     SPRR4, a novel cornified envelope precursor: UV-dependent epidermal
            expression and selective incorporation into fragile envelopes
  JOURNAL   J Cell Sci 114 (Pt 21), 3837-3843 (2001)
   PUBMED   11719550
REFERENCE   3  (bases 1 to 751)
  AUTHORS   Cabral,A., Voskamp,P., Cleton-Jansen,A.M., South,A., Nizetic,D. and
            Backendorf,C.
  TITLE     Structural organization and regulation of the small proline-rich
            family of cornified envelope precursors suggest a role in adaptive
            barrier function
  JOURNAL   J Biol Chem 276 (22), 19231-19237 (2001)
   PUBMED   11279051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356867.23, BC112170.1, W77994.1 and AI125483.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173080.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112170.1, AA339786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328051.3/ ENSP00000332163.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL356867.23        46971-46975
            6-294               BC112170.1         1-289
            295-404             W77994.1           223-332
            405-751             AI125483.1         8-354               c
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..751
                     /gene="SPRR4"
                     /note="small proline rich protein 4"
                     /db_xref="GeneID:163778"
                     /db_xref="HGNC:HGNC:23173"
                     /db_xref="MIM:616363"
     exon            1..47
                     /gene="SPRR4"
                     /inference="alignment:Splign:2.1.0"
     exon            48..751
                     /gene="SPRR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..307
                     /gene="SPRR4"
                     /codon_start=1
                     /product="small proline-rich protein 4"
                     /protein_id="NP_775103.1"
                     /db_xref="CCDS:CCDS1031.1"
                     /db_xref="GeneID:163778"
                     /db_xref="HGNC:HGNC:23173"
                     /db_xref="MIM:616363"
                     /translation="MSSQQQQRQQQQCPPQRAQQQQVKQPCQPPPVKCQETCAPKTKD
                     PCAPQVKKQCPPKGTIIPAQQKCPSAQQASKSKQK"
     regulatory      726..731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR4"
                     /note="hexamer: AATAAA"
     polyA_site      751
                     /gene="SPRR4"
                     /note="major polyA site"
ORIGIN      
        1 ggacaagggc tcagcctcct ctcctggggt ccagcttgtc gcctctggct cacctgttcc
       61 tagagcaatg tcttcccagc agcagcagcg gcagcagcag cagtgcccac cccagagggc
      121 ccagcagcag caagtgaagc agccttgtca gccaccccct gttaaatgtc aagagacatg
      181 tgcacccaaa accaaggatc catgtgctcc ccaggtcaag aagcaatgcc caccgaaagg
      241 caccatcatt ccagcccagc agaagtgtcc ctcagcccag caagcctcca agagcaaaca
      301 gaagtaagga tggactggat attaccatca tccaccatcc tggctaccag atggaacctt
      361 ctcttcttcc ttctcctctt ccctccagct cttgagccta ccctcctctc acatctcctc
      421 ctgcccaaga tgtaaggaag cattgtaagg atttcttccc atcgtaccct tccccacaca
      481 taccaccttg gcttcttcta tatcccaccc cgatgctctc ccaggtgggt gtgagagaga
      541 cctcattctc tgcaggctcc agcgtggcca cagctaaggc ccatccattt cccaaagtga
      601 ggaaagtgtc tgggcttctt ctggggttcc accctgacaa gtagggtcac agaggctggt
      661 gcacagtttc tgcctcattc ctctccatga tgccccctgc tctgggcttc tctcctgttt
      721 tccccaataa atatgtgcct catgtaataa a
//
