LOCUS       NM_001097589             900 bp    mRNA    linear   PRI 13-NOV-2024
DEFINITION  Homo sapiens small proline rich protein 3 (SPRR3), transcript
            variant 2, mRNA.
ACCESSION   NM_001097589
VERSION     NM_001097589.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 900)
  AUTHORS   Liao,S., Zhao,W., Yin,S., Xu,J., Yang,L., Yang,Y., Yan,H., Ou,T.
            and Zeng,X.
  TITLE     Predictive role and molecular biological function of proline-rich
            small repeat protein SPRR3 in the diagnosis of lung adenocarcinoma
  JOURNAL   Int J Biol Macromol 278 (Pt 1), 134674 (2024)
   PUBMED   39134193
  REMARK    GeneRIF: Predictive role and molecular biological function of
            proline-rich small repeat protein SPRR3 in the diagnosis of lung
            adenocarcinoma.
REFERENCE   2  (bases 1 to 900)
  AUTHORS   Xie,Y., Li,H., Zhong,B., Zhu,X., Ye,R., Xie,B. and Zhang,J.
  TITLE     SPRR3 Contributes to Aggressiveness of Pancreatic Cancer Cells via
            NF-kappaB Signaling Pathway
  JOURNAL   Biomed Res Int 2023, 7518744 (2023)
   PUBMED   36685674
  REMARK    GeneRIF: SPRR3 Contributes to Aggressiveness of Pancreatic Cancer
            Cells via NF-kappaB Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 900)
  AUTHORS   Zhu,G., Cai,H., Ye,L., Mo,Y., Zhu,M., Zeng,Y., Song,X., Yang,C.,
            Gao,X., Wang,J. and Jin,M.
  TITLE     Small Proline-Rich Protein 3 Regulates IL-33/ILC2 Axis to Promote
            Allergic Airway Inflammation
  JOURNAL   Front Immunol 12, 758829 (2022)
   PUBMED   35126350
  REMARK    GeneRIF: Small Proline-Rich Protein 3 Regulates IL-33/ILC2 Axis to
            Promote Allergic Airway Inflammation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 900)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 900)
  AUTHORS   Bae,J.E., Choi,H., Shin,D.W., Na,H.W., Park,N.Y., Kim,J.B.,
            Jo,D.S., Cho,M.J., Lyu,J.H., Chang,J.H., Lee,E.H., Lee,T.R.,
            Kim,H.J. and Cho,D.H.
  TITLE     Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing
            SPRR3 expression via c-Jun activation in RPE cells and skin
            keratinocytes
  JOURNAL   Sci Rep 9 (1), 3994 (2019)
   PUBMED   30850686
  REMARK    GeneRIF: Fine particulate matter (PM2.5) inhibits ciliogenesis by
            increasing SPRR3 expression via c-Jun activation in RPE cells and
            skin keratinocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 900)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     Direct evidence that involucrin is a major early isopeptide
            cross-linked component of the keratinocyte cornified cell envelope
  JOURNAL   J Biol Chem 272 (3), 2021-2030 (1997)
   PUBMED   8999895
REFERENCE   7  (bases 1 to 900)
  AUTHORS   Abraham,J.M., Wang,S., Suzuki,H., Jiang,H.Y., Rosenblum-Vos,L.S.,
            Yin,J. and Meltzer,S.J.
  TITLE     Esophagin cDNA cloning and characterization: a tissue-specific
            member of the small proline-rich protein family that is not
            expressed in esophageal tumors
  JOURNAL   Cell Growth Differ 7 (7), 855-860 (1996)
   PUBMED   8809402
REFERENCE   8  (bases 1 to 900)
  AUTHORS   Greco,M.A., Lorand,L., Lane,W.S., Baden,H.P., Parameswaran,K.N. and
            Kvedar,J.C.
  TITLE     The pancornulins: a group of small proline rich-related cornified
            envelope precursors with bifunctional capabilities in isopeptide
            bond formation
  JOURNAL   J Invest Dermatol 104 (2), 204-210 (1995)
   PUBMED   7829876
REFERENCE   9  (bases 1 to 900)
  AUTHORS   Robinson,P.A., Marley,J.J., High,A.S. and Hume,W.J.
  TITLE     Differential expression of protease inhibitor and small
            proline-rich protein genes between normal human oral tissue and
            odontogenic keratocysts
  JOURNAL   Arch Oral Biol 39 (3), 251-259 (1994)
   PUBMED   8018055
REFERENCE   10 (bases 1 to 900)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA763011.1, AL356867.23 and BM955458.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001097589.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. Both variants 1 and 2 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017802.1, AY118269.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295367.5/ ENSP00000295367.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-579               DA763011.1         1-579
            580-874             AL356867.23        79859-80153
            875-900             BM955458.1         156-181
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..900
                     /gene="SPRR3"
                     /note="small proline rich protein 3"
                     /db_xref="GeneID:6707"
                     /db_xref="HGNC:HGNC:11268"
                     /db_xref="MIM:182271"
     exon            1..45
                     /gene="SPRR3"
                     /inference="alignment:Splign:2.1.0"
     exon            46..900
                     /gene="SPRR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..574
                     /gene="SPRR3"
                     /note="esophagin; cornifin beta; 22 kDa pancornulin"
                     /codon_start=1
                     /product="small proline-rich protein 3"
                     /protein_id="NP_001091058.1"
                     /db_xref="CCDS:CCDS1033.1"
                     /db_xref="GeneID:6707"
                     /db_xref="HGNC:HGNC:11268"
                     /db_xref="MIM:182271"
                     /translation="MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSK
                     VPQPGNTKIPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVP
                     EPGYTKVPEPGSIKVPDQGFIKFPEPGAIKVPEQGYTKVPVPGYTKLPEPCPSTVTPG
                     PAQQKTKQK"
     regulatory      880..885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR3"
                     /note="hexamer: ATTAAA"
     polyA_site      900
                     /gene="SPRR3"
                     /note="major polyA site"
ORIGIN      
        1 accagatccc agaggctgaa cacctcgacc ttctctgcac agcaggtcca gcatcctttg
       61 aagcatgagt tcttaccagc agaagcagac ctttacccca ccacctcagc ttcaacagca
      121 gcaggtgaaa caacccagcc agcctccacc tcaggaaata tttgttccca caaccaagga
      181 gccatgccac tcaaaggttc cacaacctgg aaacacaaag attccagagc caggctgtac
      241 caaggtccct gagccaggct gtaccaaggt ccctgagcca ggctgtacca aggtccctga
      301 gccaggttgt accaaggtcc ctgagccagg ctgtaccaag gtccctgagc caggttgtac
      361 caaggtccct gagccaggct acaccaaggt ccctgaacca ggcagcatca aggtccctga
      421 ccaaggcttc atcaagtttc ctgagccagg tgccatcaaa gttcctgagc aaggatacac
      481 caaagttcct gtgccaggct acacaaagct accagagcca tgtccttcaa cggtcactcc
      541 aggcccagct cagcagaaga ccaagcagaa gtaatttggt gcacagacaa gcccttgaga
      601 agccaaccac cagatgctgg acaccctctt cccatctgtt tctgtgtctt aattgtctgt
      661 agaccttgta atcagcacat tgtcacccca agccatagtc tctctcttat ttgtatccta
      721 aaaatacgta ctataaagct tttgttcaca cacactctga agaatcctgt aagcccctga
      781 attaagcaga aagtcttcat ggcttttctg gtcttcggct gctcagggtt catctgaaga
      841 ttcgaatgaa aagaaatgca tgtttcctgc tcttccctca ttaaattgct tttaattcca
//
