LOCUS       NM_001014291             589 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens small proline rich protein 2G (SPRR2G), mRNA.
ACCESSION   NM_001014291
VERSION     NM_001014291.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 589)
  AUTHORS   Micci,F., Panagopoulos,I., Haugom,L., Dahlback,H.S.,
            Pretorius,M.E., Davidson,B., Abeler,V.M., Trope,C.G.,
            Danielsen,H.E. and Heim,S.
  TITLE     Genomic aberration patterns and expression profiles of squamous
            cell carcinomas of the vulva
  JOURNAL   Genes Chromosomes Cancer 52 (6), 551-563 (2013)
   PUBMED   23404381
  REMARK    GeneRIF: High SPRR2G expression is associated with squamous cell
            carcinomas of the vulva.
REFERENCE   2  (bases 1 to 589)
  AUTHORS   Kainu,K., Kivinen,K., Zucchelli,M., Suomela,S., Kere,J., Inerot,A.,
            Baker,B.S., Powles,A.V., Fry,L., Samuelsson,L. and
            Saarialho-Kere,U.
  TITLE     Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus
            on 1q shows heterogeneity between Finnish, Swedish and Irish
            families
  JOURNAL   Exp Dermatol 18 (2), 109-115 (2009)
   PUBMED   18643845
  REMARK    GeneRIF: Association of psoriasis to PGLYRP and SPRR genes at
            PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and
            Irish families.
REFERENCE   3  (bases 1 to 589)
  AUTHORS   Hong,S.H., Nah,H.Y., Lee,J.Y., Lee,Y.J., Lee,J.W., Gye,M.C.,
            Kim,C.H., Kang,B.M. and Kim,M.K.
  TITLE     Estrogen regulates the expression of the small proline-rich 2 gene
            family in the mouse uterus
  JOURNAL   Mol Cells 17 (3), 477-484 (2004)
   PUBMED   15232223
REFERENCE   4  (bases 1 to 589)
  AUTHORS   Cabral,A., Voskamp,P., Cleton-Jansen,A.M., South,A., Nizetic,D. and
            Backendorf,C.
  TITLE     Structural organization and regulation of the small proline-rich
            family of cornified envelope precursors suggest a role in adaptive
            barrier function
  JOURNAL   J Biol Chem 276 (22), 19231-19237 (2001)
   PUBMED   11279051
REFERENCE   5  (bases 1 to 589)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   6  (bases 1 to 589)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC133041.1 and AL157405.10.
            
            On Nov 22, 2018 this sequence version replaced NM_001014291.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130455.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368748.5/ ENSP00000357737.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-388               BC133041.1         62-449
            389-589             AL157405.10        31043-31243         c
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..589
                     /gene="SPRR2G"
                     /note="small proline rich protein 2G"
                     /db_xref="GeneID:6706"
                     /db_xref="HGNC:HGNC:11267"
                     /db_xref="MIM:617590"
     exon            1..39
                     /gene="SPRR2G"
                     /inference="alignment:Splign:2.1.0"
     exon            40..589
                     /gene="SPRR2G"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..282
                     /gene="SPRR2G"
                     /note="SPR-2G"
                     /codon_start=1
                     /product="small proline-rich protein 2G"
                     /protein_id="NP_001014313.1"
                     /db_xref="CCDS:CCDS30868.1"
                     /db_xref="GeneID:6706"
                     /db_xref="HGNC:HGNC:11267"
                     /db_xref="MIM:617590"
                     /translation="MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPYLPPPCPPE
                     HCPPPPCQDKCPPVQPYPPCQQKYPPKSK"
     regulatory      560..565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR2G"
                     /note="hexamer: AATAAA"
     polyA_site      589
                     /gene="SPRR2G"
                     /note="major polyA site"
ORIGIN      
        1 atcttcttgc cattcagttg tagatctttg aagactctga ttctctgaga ctgaggagag
       61 atgtcttacc agcagcagca gtgcaagcag ccctgccagc cacctcctgt gtgccccacg
      121 ccaaagtgcc cagagccatg tccacccccg aagtgccctg agccttacct gcctcctcct
      181 tgtccacctg agcattgccc acctccacca tgccaggata aatgccctcc tgtgcaacca
      241 tacccaccct gccagcagaa gtatccaccc aagagcaagt aacatcacta gaattcatca
      301 ggaccatgaa acaacaagat ccagtggctc ttcttactcc caggactcca tcatcttccc
      361 ttcagctgta gtgggaggct gcatcttccc taacctctgt ctggcttgag cgttgacaga
      421 gaaaaggctt agttctgaaa accgatatgt tgttggaaga tgagcagcca gatcactgcc
      481 taatctcgct ttgctgtctg tgatgtagat ggtggttcct atcctgagag caagtgtgtt
      541 tattcttttg cttctcccca ataaagcaca tgtttcatgg tcaagccca
//
