LOCUS       NM_001014450             675 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens small proline rich protein 2F (SPRR2F), transcript
            variant 1, mRNA.
ACCESSION   NM_001014450
VERSION     NM_001014450.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 675)
  AUTHORS   Wang,Y., Anderson,E.P. and Tatakis,D.N.
  TITLE     Whole transcriptome analysis of smoker palatal mucosa identifies
            multiple downregulated innate immunity genes
  JOURNAL   J Periodontol 91 (6), 756-766 (2020)
   PUBMED   31682009
  REMARK    GeneRIF: SPRR2F expression is significantly downregulated in
            healthy palatal mucosa of smokers
REFERENCE   2  (bases 1 to 675)
  AUTHORS   Kainu,K., Kivinen,K., Zucchelli,M., Suomela,S., Kere,J., Inerot,A.,
            Baker,B.S., Powles,A.V., Fry,L., Samuelsson,L. and
            Saarialho-Kere,U.
  TITLE     Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus
            on 1q shows heterogeneity between Finnish, Swedish and Irish
            families
  JOURNAL   Exp Dermatol 18 (2), 109-115 (2009)
   PUBMED   18643845
  REMARK    GeneRIF: Association of psoriasis to PGLYRP and SPRR genes at
            PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and
            Irish families.
REFERENCE   3  (bases 1 to 675)
  AUTHORS   Hong,S.H., Nah,H.Y., Lee,J.Y., Lee,Y.J., Lee,J.W., Gye,M.C.,
            Kim,C.H., Kang,B.M. and Kim,M.K.
  TITLE     Estrogen regulates the expression of the small proline-rich 2 gene
            family in the mouse uterus
  JOURNAL   Mol Cells 17 (3), 477-484 (2004)
   PUBMED   15232223
REFERENCE   4  (bases 1 to 675)
  AUTHORS   Cabral,A., Voskamp,P., Cleton-Jansen,A.M., South,A., Nizetic,D. and
            Backendorf,C.
  TITLE     Structural organization and regulation of the small proline-rich
            family of cornified envelope precursors suggest a role in adaptive
            barrier function
  JOURNAL   J Biol Chem 276 (22), 19231-19237 (2001)
   PUBMED   11279051
REFERENCE   5  (bases 1 to 675)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   6  (bases 1 to 675)
  AUTHORS   Davodeau,F., Houde,I., Boulot,G., Romagne,F., Necker,A., Canavo,N.,
            Peyrat,M.A., Hallet,M.M., Vie,H., Jacques,Y. et al.
  TITLE     Secretion of disulfide-linked human T-cell receptor gamma delta
            heterodimers
  JOURNAL   J Biol Chem 268 (21), 15455-15460 (1993)
   PUBMED   8340374
REFERENCE   7  (bases 1 to 675)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139417.9, AF333956.1 and AI051688.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001014450.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279873.4562.1, ERR279829.4815.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000468739.2/ ENSP00000418193.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL139417.9         44036-44036         c
            2-43                AF333956.1         409-450
            44-476              AF333956.1         1172-1604
            477-672             AI051688.1         1-196               c
            673-675             AL139417.9         42641-42643         c
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..675
                     /gene="SPRR2F"
                     /note="small proline rich protein 2F"
                     /db_xref="GeneID:6705"
                     /db_xref="HGNC:HGNC:11266"
                     /db_xref="MIM:617589"
     exon            1..43
                     /gene="SPRR2F"
                     /inference="alignment:Splign:2.1.0"
     exon            44..675
                     /gene="SPRR2F"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..281
                     /gene="SPRR2F"
                     /note="SPR-2F"
                     /codon_start=1
                     /product="small proline-rich protein 2F"
                     /protein_id="NP_001014450.1"
                     /db_xref="CCDS:CCDS30867.1"
                     /db_xref="GeneID:6705"
                     /db_xref="HGNC:HGNC:11266"
                     /db_xref="MIM:617589"
                     /translation="MSYQQQQCKQPCQPPPVCPAPKCPEPCPPPKCPEPCPPSKCPQS
                     CPPQQCQQKCPPVTPSPPCQPKCPPKSK"
     regulatory      655..660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR2F"
                     /note="hexamer: AATAAA"
     polyA_site      675
                     /gene="SPRR2F"
                     /note="major polyA site"
ORIGIN      
        1 taaactcctg gtacctaagc accgatctgc cttggagaac ctgattctga gactccagca
       61 ggatgtctta tcaacagcag cagtgcaagc agccctgcca gccacctcct gtgtgccccg
      121 cgccaaagtg cccagagcca tgtccacccc cgaagtgccc tgagccctgc ccaccatcaa
      181 agtgtccaca gtcctgccca cctcagcagt gccagcagaa atgtcctcct gtgacacctt
      241 ccccaccctg ccagccaaag tgtccaccca agagcaagta acagcttcag gattcatcag
      301 gagcatgaaa ggataaggat aattggctca cctcgttcca cagctccacc tgcatcttct
      361 catcaaagcc atccagggat acacagggag cttctttcct cttagcctgt gatcggcctg
      421 tgatgatctc tgatagcaaa aggttttctt tttgaggctg ccatactgcc actgtccagg
      481 tggagactga gcaaaggaag tcctgggctg tgccagctcc cagagcttca gaagaaagag
      541 cagctctctc cctgggaacc attagagaat tctgttgatg ttttctgtgt ctgtctgtcc
      601 cctgggcatg agcttccacc acctgtgcag ttgtcacttt cctttcactc cctgaataaa
      661 gaatctatgc atata
//
