LOCUS       NM_001024209             679 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens small proline rich protein 2E (SPRR2E), mRNA.
ACCESSION   NM_001024209
VERSION     NM_001024209.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 679)
  AUTHORS   Kainu,K., Kivinen,K., Zucchelli,M., Suomela,S., Kere,J., Inerot,A.,
            Baker,B.S., Powles,A.V., Fry,L., Samuelsson,L. and
            Saarialho-Kere,U.
  TITLE     Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus
            on 1q shows heterogeneity between Finnish, Swedish and Irish
            families
  JOURNAL   Exp Dermatol 18 (2), 109-115 (2009)
   PUBMED   18643845
  REMARK    GeneRIF: Association of psoriasis to PGLYRP and SPRR genes at
            PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and
            Irish families.
REFERENCE   2  (bases 1 to 679)
  AUTHORS   Hong,S.H., Nah,H.Y., Lee,J.Y., Lee,Y.J., Lee,J.W., Gye,M.C.,
            Kim,C.H., Kang,B.M. and Kim,M.K.
  TITLE     Estrogen regulates the expression of the small proline-rich 2 gene
            family in the mouse uterus
  JOURNAL   Mol Cells 17 (3), 477-484 (2004)
   PUBMED   15232223
REFERENCE   3  (bases 1 to 679)
  AUTHORS   Cabral,A., Voskamp,P., Cleton-Jansen,A.M., South,A., Nizetic,D. and
            Backendorf,C.
  TITLE     Structural organization and regulation of the small proline-rich
            family of cornified envelope precursors suggest a role in adaptive
            barrier function
  JOURNAL   J Biol Chem 276 (22), 19231-19237 (2001)
   PUBMED   11279051
REFERENCE   4  (bases 1 to 679)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   5  (bases 1 to 679)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   6  (bases 1 to 679)
  AUTHORS   Tarcsa,E., Candi,E., Kartasova,T., Idler,W.W., Marekov,L.N. and
            Steinert,P.M.
  TITLE     Structural and transglutaminase substrate properties of the small
            proline-rich 2 family of cornified cell envelope proteins
  JOURNAL   J Biol Chem 273 (36), 23297-23303 (1998)
   PUBMED   9722562
REFERENCE   7  (bases 1 to 679)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     The proteins elafin, filaggrin, keratin intermediate filaments,
            loricrin, and small proline-rich proteins 1 and 2 are isodipeptide
            cross-linked components of the human epidermal cornified cell
            envelope
  JOURNAL   J Biol Chem 270 (30), 17702-17711 (1995)
   PUBMED   7543090
REFERENCE   8  (bases 1 to 679)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
REFERENCE   9  (bases 1 to 679)
  AUTHORS   Kartasova,T. and van de Putte,P.
  TITLE     Isolation, characterization, and UV-stimulated expression of two
            families of genes encoding polypeptides of related structure in
            human epidermal keratinocytes
  JOURNAL   Mol Cell Biol 8 (5), 2195-2203 (1988)
   PUBMED   3133554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE714447.1, DA761769.1,
            DA761491.1 and BG185829.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001024209.3.
            
            Summary: This gene encodes a member of a family of small
            proline-rich proteins clustered in the epidermal differentiation
            complex on chromosome 1q21. The encoded protein, along with other
            family members, is a component of the cornified cell envelope that
            forms beneath the plasma membrane in terminally differentiated
            stratified squamous epithelia. This envelope serves as a barrier
            against extracellular and environmental factors. The seven SPRR2
            genes (A-G) appear to have been homogenized by gene conversion
            compared to others in the cluster that exhibit greater differences
            in protein structure. [provided by RefSeq, Feb 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: M20030.1, DA761491.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368750.8/ ENSP00000357739.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BE714447.1         71-120
            51-374              DA761769.1         52-375
            375-505             DA761491.1         376-506
            506-679             BG185829.1         13-186              c
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..679
                     /gene="SPRR2E"
                     /note="small proline rich protein 2E"
                     /db_xref="GeneID:6704"
                     /db_xref="HGNC:HGNC:11265"
                     /db_xref="MIM:617588"
     exon            1..43
                     /gene="SPRR2E"
                     /inference="alignment:Splign:2.1.0"
     exon            44..679
                     /gene="SPRR2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..281
                     /gene="SPRR2E"
                     /note="SPR-2E; SPR-II; small proline-rich protein II"
                     /codon_start=1
                     /product="small proline-rich protein 2E"
                     /protein_id="NP_001019380.2"
                     /db_xref="CCDS:CCDS30866.1"
                     /db_xref="GeneID:6704"
                     /db_xref="HGNC:HGNC:11265"
                     /db_xref="MIM:617588"
                     /translation="MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQP
                     CPPQQCQQKCPPVTPSPPCQPKCPPKSK"
     regulatory      657..662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR2E"
                     /note="hexamer: AATAAA"
     polyA_site      679
                     /gene="SPRR2E"
                     /note="major polyA site"
ORIGIN      
        1 taaactcctg gtacttgagc actgatctgc tttggagaac ctgattctga gactccagca
       61 ggatgtctta tcaacagcag cagtgcaagc agccctgcca gccacctcct gtgtgcccca
      121 cgccaaagtg cccagagcca tgtccacccc cgaagtgccc tgagccctgc ccaccaccaa
      181 agtgtccaca gccctgccca cctcagcagt gccagcaaaa atgtcctcct gtgacacctt
      241 ccccaccctg ccagccaaag tgtccaccca agagcaagta acagcttcag aattcatcag
      301 gagcatgaaa ggataaggat aattggctca ccttgttcca cagcttcacc tgcatcttct
      361 catcaaagcc taccatggat acacagttag cttctttcct cttagccagt gatctgccca
      421 tgatgatccc tgatagcaaa aggtttcctt tctgaggctg ccatattgcc actgtccagg
      481 tggagactga gaaaggaagt cctcagcagt gtcagttccc agagctttgg aagaaggacc
      541 agcagctctg tccctgggaa ccatcaaaaa atgctgttga tgttttctgt gtctgtctgt
      601 cacctgggca tgggcttcta acacctgtgc aattgtcact tttctttcac tccctgaata
      661 aaatatcttt gcatacgta
//
