LOCUS       NM_006945                677 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens small proline rich protein 2D (SPRR2D), transcript
            variant 1, mRNA.
ACCESSION   NM_006945
VERSION     NM_006945.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 677)
  AUTHORS   Kainu,K., Kivinen,K., Zucchelli,M., Suomela,S., Kere,J., Inerot,A.,
            Baker,B.S., Powles,A.V., Fry,L., Samuelsson,L. and
            Saarialho-Kere,U.
  TITLE     Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus
            on 1q shows heterogeneity between Finnish, Swedish and Irish
            families
  JOURNAL   Exp Dermatol 18 (2), 109-115 (2009)
   PUBMED   18643845
  REMARK    GeneRIF: Association of psoriasis to PGLYRP and SPRR genes at
            PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and
            Irish families.
REFERENCE   2  (bases 1 to 677)
  AUTHORS   Tong,L., Corrales,R.M., Chen,Z., Villarreal,A.L., De Paiva,C.S.,
            Beuerman,R., Li,D.Q. and Pflugfelder,S.C.
  TITLE     Expression and regulation of cornified envelope proteins in human
            corneal epithelium
  JOURNAL   Invest Ophthalmol Vis Sci 47 (5), 1938-1946 (2006)
   PUBMED   16639001
REFERENCE   3  (bases 1 to 677)
  AUTHORS   Hong,S.H., Nah,H.Y., Lee,J.Y., Lee,Y.J., Lee,J.W., Gye,M.C.,
            Kim,C.H., Kang,B.M. and Kim,M.K.
  TITLE     Estrogen regulates the expression of the small proline-rich 2 gene
            family in the mouse uterus
  JOURNAL   Mol Cells 17 (3), 477-484 (2004)
   PUBMED   15232223
REFERENCE   4  (bases 1 to 677)
  AUTHORS   Katou,F., Shirai,N., Kamakura,S., Tagami,H., Nagura,H. and
            Motegi,K.
  TITLE     Differential expression of cornified cell envelope precursors in
            normal skin, intraorally transplanted skin and normal oral mucosa
  JOURNAL   Br J Dermatol 148 (5), 898-905 (2003)
   PUBMED   12786819
REFERENCE   5  (bases 1 to 677)
  AUTHORS   Cabral,A., Voskamp,P., Cleton-Jansen,A.M., South,A., Nizetic,D. and
            Backendorf,C.
  TITLE     Structural organization and regulation of the small proline-rich
            family of cornified envelope precursors suggest a role in adaptive
            barrier function
  JOURNAL   J Biol Chem 276 (22), 19231-19237 (2001)
   PUBMED   11279051
REFERENCE   6  (bases 1 to 677)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   7  (bases 1 to 677)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   8  (bases 1 to 677)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
REFERENCE   9  (bases 1 to 677)
  AUTHORS   Kartasova,T. and van de Putte,P.
  TITLE     Isolation, characterization, and UV-stimulated expression of two
            families of genes encoding polypeptides of related structure in
            human epidermal keratinocytes
  JOURNAL   Mol Cell Biol 8 (5), 2195-2203 (1988)
   PUBMED   3133554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356867.23, M21302.1, BC120938.1 and AI383975.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006945.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279841.1758.1, M21302.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360379.4/ ENSP00000353542.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL356867.23        117442-117443       c
            3-127               M21302.1           1-125
            128-342             BC120938.1         110-324
            343-677             AI383975.1         16-350              c
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..677
                     /gene="SPRR2D"
                     /note="small proline rich protein 2D"
                     /db_xref="GeneID:6703"
                     /db_xref="HGNC:HGNC:11264"
                     /db_xref="MIM:617587"
     exon            1..43
                     /gene="SPRR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            44..677
                     /gene="SPRR2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..281
                     /gene="SPRR2D"
                     /note="SPR-2D; SPR-II; small proline-rich protein II"
                     /codon_start=1
                     /product="small proline-rich protein 2D"
                     /protein_id="NP_008876.3"
                     /db_xref="CCDS:CCDS30864.1"
                     /db_xref="GeneID:6703"
                     /db_xref="HGNC:HGNC:11264"
                     /db_xref="MIM:617587"
                     /translation="MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPSPKCPQP
                     CPPQQCQQKYPPVTPSPPCQPKCPPKSK"
     regulatory      657..662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR2D"
                     /note="hexamer: AATAAA"
     polyA_site      677
                     /gene="SPRR2D"
                     /note="major polyA site"
ORIGIN      
        1 taaactcctg gtactctagc accgatctgc tttggagaac ctgatcctga gactccagca
       61 ggatgtctta tcaacagcag cagtgcaagc agccctgcca gccacctcct gtgtgcccca
      121 cgccaaagtg cccagagcca tgtccacccc cgaagtgccc tgagccctgc ccatcaccaa
      181 agtgtccaca gccctgccca cctcagcagt gccagcagaa atatcctcct gtgacacctt
      241 ccccaccctg ccagccaaag tgtccaccca agagcaagta acagcttcag gattcatcag
      301 gagcatgaga ggataaggat aattggctca cctcgttcca cagctccact tgcatcttct
      361 caccaaagcc ttccatggat gcacagggag cttctttctc cttaacctgt ggcctgcctg
      421 tgatgatctg tgacagcaaa agattccctt tctgaggctg ccatactgcc actgtccagg
      481 tggagctaag aaaaggaagt cctcagctgt gccagctccc agagcttcgg aagaaagagc
      541 agcagctctc tccctgggaa ccatcagaca attctgttga tgtgttctgt gtctgtctgt
      601 cacctggtca tgagcttcta ccacctttgc aattgtcatt tatctttcac tccctgaata
      661 aagtatctat gcatata
//
