LOCUS       NM_001388198             676 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens small proline rich protein 2B (SPRR2B), transcript
            variant 2, mRNA.
ACCESSION   NM_001388198 XM_017002174
VERSION     NM_001388198.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 676)
  AUTHORS   Burke,R.M., Lighthouse,J.K., Quijada,P., Dirkx,R.A. Jr.,
            Rosenberg,A., Moravec,C.S., Alexis,J.D. and Small,E.M.
  TITLE     Small proline-rich protein 2B drives stress-dependent p53
            degradation and fibroblast proliferation in heart failure
  JOURNAL   Proc Natl Acad Sci U S A 115 (15), E3436-E3445 (2018)
   PUBMED   29581288
  REMARK    GeneRIF: Knockdown of the Sprr2b gene or inhibition of SPRR2B
            phosphorylation attenuates USP7/MDM2 binding and p53 degradation,
            leading to fibroblasts cell cycle arrest.
REFERENCE   2  (bases 1 to 676)
  AUTHORS   Epstein,T.G., LeMasters,G.K., Bernstein,D.I., Ericksen,M.B.,
            Martin,L.J., Ryan,P.H., Biagini Myers,J.M., Butsch Kovacic,M.S.,
            Lindsey,M.A., He,H., Reponen,T., Villareal,M.S., Lockey,J.E.,
            Bernstein,C.K. and Khurana Hershey,G.K.
  TITLE     Genetic variation in small proline rich protein 2B as a predictor
            for asthma among children with eczema
  JOURNAL   Ann Allergy Asthma Immunol 108 (3), 145-150 (2012)
   PUBMED   22374195
  REMARK    GeneRIF: An SNP in SPRR2B was predictive of asthma among white
            children with eczema from 2 independent populations.
REFERENCE   3  (bases 1 to 676)
  AUTHORS   Pasini,F.S., Maistro,S., Snitcovsky,I., Barbeta,L.P., Rotea
            Mangone,F.R., Lehn,C.N., Walder,F., Carvalho,M.B., Brentani,M.M.
            and Federico,M.H.
  TITLE     Four-gene expression model predictive of lymph node metastases in
            oral squamous cell carcinoma
  JOURNAL   Acta Oncol 51 (1), 77-85 (2012)
   PUBMED   21985131
  REMARK    GeneRIF: We showed that just four genes, G3BP2, SCARB2, CSNK1A1 and
            SPRR2B, can classify patients as presence of lymph node metastasis
            negative or positive, with 80.0% accuracy.
REFERENCE   4  (bases 1 to 676)
  AUTHORS   Kainu,K., Kivinen,K., Zucchelli,M., Suomela,S., Kere,J., Inerot,A.,
            Baker,B.S., Powles,A.V., Fry,L., Samuelsson,L. and
            Saarialho-Kere,U.
  TITLE     Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus
            on 1q shows heterogeneity between Finnish, Swedish and Irish
            families
  JOURNAL   Exp Dermatol 18 (2), 109-115 (2009)
   PUBMED   18643845
  REMARK    GeneRIF: Association of psoriasis to PGLYRP and SPRR genes at
            PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and
            Irish families.
REFERENCE   5  (bases 1 to 676)
  AUTHORS   Tong,L., Corrales,R.M., Chen,Z., Villarreal,A.L., De Paiva,C.S.,
            Beuerman,R., Li,D.Q. and Pflugfelder,S.C.
  TITLE     Expression and regulation of cornified envelope proteins in human
            corneal epithelium
  JOURNAL   Invest Ophthalmol Vis Sci 47 (5), 1938-1946 (2006)
   PUBMED   16639001
REFERENCE   6  (bases 1 to 676)
  AUTHORS   Lehr,E., Hohl,D., Huber,M. and Brown,D.
  TITLE     Infection with Human Papillomavirus alters expression of the small
            proline rich proteins 2 and 3
  JOURNAL   J Med Virol 72 (3), 478-483 (2004)
   PUBMED   14748073
  REMARK    GeneRIF: SPR2B transcripts and protein were moderately increased in
            the human papillomaviurs 11- and 59-infected tissues.
REFERENCE   7  (bases 1 to 676)
  AUTHORS   Cabral,A., Voskamp,P., Cleton-Jansen,A.M., South,A., Nizetic,D. and
            Backendorf,C.
  TITLE     Structural organization and regulation of the small proline-rich
            family of cornified envelope precursors suggest a role in adaptive
            barrier function
  JOURNAL   J Biol Chem 276 (22), 19231-19237 (2001)
   PUBMED   11279051
REFERENCE   8  (bases 1 to 676)
  AUTHORS   Tarcsa,E., Candi,E., Kartasova,T., Idler,W.W., Marekov,L.N. and
            Steinert,P.M.
  TITLE     Structural and transglutaminase substrate properties of the small
            proline-rich 2 family of cornified cell envelope proteins
  JOURNAL   J Biol Chem 273 (36), 23297-23303 (1998)
   PUBMED   9722562
REFERENCE   9  (bases 1 to 676)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
REFERENCE   10 (bases 1 to 676)
  AUTHORS   Kartasova,T. and van de Putte,P.
  TITLE     Isolation, characterization, and UV-stimulated expression of two
            families of genes encoding polypeptides of related structure in
            human epidermal keratinocytes
  JOURNAL   Mol Cell Biol 8 (5), 2195-2203 (1988)
   PUBMED   3133554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139417.9 and AL356867.23.
            
            On Oct 21, 2020 this sequence version replaced XM_017002174.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368755.3/ ENSP00000357744.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL139417.9         2089-2131           c
            44-676              AL356867.23        146549-147181       c
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..676
                     /gene="SPRR2B"
                     /note="small proline rich protein 2B"
                     /db_xref="GeneID:6701"
                     /db_xref="HGNC:HGNC:11262"
                     /db_xref="MIM:182268"
     exon            1..43
                     /gene="SPRR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            44..676
                     /gene="SPRR2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..281
                     /gene="SPRR2B"
                     /note="SPR-2B"
                     /codon_start=1
                     /product="small proline-rich protein 2B"
                     /protein_id="NP_001375127.1"
                     /db_xref="CCDS:CCDS30865.1"
                     /db_xref="GeneID:6701"
                     /db_xref="HGNC:HGNC:11262"
                     /db_xref="MIM:182268"
                     /translation="MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQP
                     CPPQQCQQKYPPVTPSPPCQPKYPPKSK"
     regulatory      656..661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR2B"
                     /note="hexamer: AATAAA"
     polyA_site      674
                     /gene="SPRR2B"
                     /note="major polyA site"
ORIGIN      
        1 taaactcctg gtactcgagc accgatctgc tttggagaaa ctgatcctga gactccagca
       61 ggatgtctta tcaacagcag cagtgcaagc agccctgcca gccacctcct gtgtgcccca
      121 cgccaaagtg cccagagcca tgtccacccc cgaagtgccc tgagccctgc ccaccaccaa
      181 agtgtccaca gccctgccca cctcagcagt gccagcagaa atatcctcct gtgacacctt
      241 ccccaccctg ccagccaaag tatccaccga agagcaagta acagcttcag gattcatcag
      301 gagcatgaga ggataaggat aattggctca cctcgttcca cagctccacc ttcatcttct
      361 catcaaagct tatcatggat tcatagggag cttctttccc cttagcctgt gatctgccca
      421 tgatgttccc tgatagcaaa aggtttcctt tctaaggctg ccatactgcc actgtccagg
      481 tggagactga gcaaaggaac cttggctttg tcagttccca gagcttcagc agaaagagct
      541 gcagctgtgt gcctgggaac catcagagaa ttctgttgat gtgttctgtg tctgtctttc
      601 acctgggcat gagcttctac cacctgtgca attgtcactt ttctttcact ccctgaataa
      661 agtatctatg catata
//
