LOCUS       NM_005988                677 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens small proline rich protein 2A (SPRR2A), mRNA.
ACCESSION   NM_005988
VERSION     NM_005988.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 677)
  AUTHORS   Hu,Z., Zhang,C., Sifuentes-Dominguez,L., Zarek,C.M.,
            Propheter,D.C., Kuang,Z., Wang,Y., Pendse,M., Ruhn,K.A.,
            Hassell,B., Behrendt,C.L., Zhang,B., Raj,P., Harris-Tryon,T.A.,
            Reese,T.A. and Hooper,L.V.
  TITLE     Small proline-rich protein 2A is a gut bactericidal protein
            deployed during helminth infection
  JOURNAL   Science 374 (6568), eabe6723 (2021)
   PUBMED   34735226
REFERENCE   2  (bases 1 to 677)
  AUTHORS   Xu,X., Wei,S., Chen,Y., Yu,D., Wang,X. and Dong,X.
  TITLE     Serum Small Proline-Rich Protein 2A (SPRR2A) Is a Noninvasive
            Biomarker in Gastric Cancer
  JOURNAL   Dis Markers 2020, 8493796 (2020)
   PUBMED   32908616
  REMARK    GeneRIF: Serum Small Proline-Rich Protein 2A (SPRR2A) Is a
            Noninvasive Biomarker in Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 677)
  AUTHORS   Nisa,L., Barras,D., Medova,M., Aebersold,D.M., Medo,M.,
            Poliakova,M., Koch,J., Bojaxhiu,B., Elicin,O., Dettmer,M.S.,
            Angelino,P., Giger,R., Borner,U., Caversaccio,M.D., Carey,T.E.,
            Ho,L., McKee,T.A., Delorenzi,M. and Zimmer,Y.
  TITLE     Comprehensive Genomic Profiling of Patient-matched Head and Neck
            Cancer Cells: A Preclinical Pipeline for Metastatic and Recurrent
            Disease
  JOURNAL   Mol Cancer Res 16 (12), 1912-1926 (2018)
   PUBMED   30108165
  REMARK    GeneRIF: Assessment of SPRR2A protein expression in a clinical
            cohort of patients with head and neck squamous cell carcinoma
            (HNSCC) confirmed common SPRR2A downregulation in primary tumors
            and lymph node metastases, but not in normal tissue. High
            expression of SPRR2A in lymph node metastases was, along with
            nonoropharyngeal location of the primary tumor, an independent
            prognostic factor for regional disease recurrence.
REFERENCE   4  (bases 1 to 677)
  AUTHORS   Ramakrishnan,V.R., Gonzalez,J.R., Cooper,S.E., Barham,H.P.,
            Anderson,C.B., Larson,E.D., Cool,C.D., Diller,J.D., Jones,K. and
            Kinnamon,S.C.
  TITLE     RNA sequencing and pathway analysis identify tumor necrosis factor
            alpha driven small proline-rich protein dysregulation in chronic
            rhinosinusitis
  JOURNAL   Am J Rhinol Allergy 31 (5), 283-288 (2017)
   PUBMED   28859701
  REMARK    GeneRIF: Expression of SPRR1 and of SPRR2A is increased in mucosal
            samples from patients with chronic rhinosinusitis and appeared as a
            downstream result of TNF alpha modulation, which possibly resulted
            in epithelial barrier dysfunction.
REFERENCE   5  (bases 1 to 677)
  AUTHORS   Mizuguchi,Y., Isse,K., Specht,S., Lunz,J.G. 3rd, Corbitt,N.,
            Takizawa,T. and Demetris,A.J.
  TITLE     Small proline rich protein 2a in benign and malignant liver disease
  JOURNAL   Hepatology 59 (3), 1130-1143 (2014)
   PUBMED   24123265
  REMARK    GeneRIF: SPRR2a modulates ZEB-1 signaling by way of
            miR-200c/141-associated epithelial mesenchyme transition through
            SH3-domain networks and contributes to benign and malignant
            wound-healing responses.
REFERENCE   6  (bases 1 to 677)
  AUTHORS   Fischer,D.F., van Drunen,C.M., Winkler,G.S., van de Putte,P. and
            Backendorf,C.
  TITLE     Involvement of a nuclear matrix association region in the
            regulation of the SPRR2A keratinocyte terminal differentiation
            marker
  JOURNAL   Nucleic Acids Res 26 (23), 5288-5294 (1998)
   PUBMED   9826750
REFERENCE   7  (bases 1 to 677)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     Direct evidence that involucrin is a major early isopeptide
            cross-linked component of the keratinocyte cornified cell envelope
  JOURNAL   J Biol Chem 272 (3), 2021-2030 (1997)
   PUBMED   8999895
REFERENCE   8  (bases 1 to 677)
  AUTHORS   Fischer,D.F., Gibbs,S., van De Putte,P. and Backendorf,C.
  TITLE     Interdependent transcription control elements regulate the
            expression of the SPRR2A gene during keratinocyte terminal
            differentiation
  JOURNAL   Mol Cell Biol 16 (10), 5365-5374 (1996)
   PUBMED   8816448
REFERENCE   9  (bases 1 to 677)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
REFERENCE   10 (bases 1 to 677)
  AUTHORS   Gibbs,S., Lohman,F., Teubel,W., van de Putte,P. and Backendorf,C.
  TITLE     Characterization of the human spr2 promoter: induction after UV
            irradiation or TPA treatment and regulation during differentiation
            of cultured primary keratinocytes
  JOURNAL   Nucleic Acids Res 18 (15), 4401-4407 (1990)
   PUBMED   2388825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE710686.1, X53064.1 and CA433267.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005988.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA766540.1, DA763239.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392653.3/ ENSP00000376423.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BE710686.1         220-280
            62-267              X53064.1           2215-2420
            268-677             CA433267.1         16-425              c
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..677
                     /gene="SPRR2A"
                     /note="small proline rich protein 2A"
                     /db_xref="GeneID:6700"
                     /db_xref="HGNC:HGNC:11261"
                     /db_xref="MIM:182267"
     exon            1..42
                     /gene="SPRR2A"
                     /inference="alignment:Splign:2.1.0"
     exon            43..677
                     /gene="SPRR2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..280
                     /gene="SPRR2A"
                     /note="2-1; SPR-2A"
                     /codon_start=1
                     /product="small proline-rich protein 2A"
                     /protein_id="NP_005979.1"
                     /db_xref="CCDS:CCDS1034.1"
                     /db_xref="GeneID:6700"
                     /db_xref="HGNC:HGNC:11261"
                     /db_xref="MIM:182267"
                     /translation="MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQP
                     CPPQQCQQKYPPVTPSPPCQSKYPPKSK"
     regulatory      657..662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR2A"
                     /note="hexamer: AATAAA"
     polyA_site      677
                     /gene="SPRR2A"
                     /note="major polyA site"
ORIGIN      
        1 aaacccctgg tacctgagca ctgatctgcc ttggagaacc tgatcctgag actccagcag
       61 gatgtcttat caacagcagc agtgcaagca gccctgccag ccacctcctg tgtgccccac
      121 gccaaagtgc ccagagccat gtccaccccc gaagtgccct gagccctgcc caccaccaaa
      181 gtgtccacag ccctgcccac ctcagcagtg ccagcagaaa tatcctcctg tgacaccttc
      241 cccaccctgc cagtcaaagt atccaccgaa gagcaagtaa cagcttcaga attcatcagg
      301 accaagaaag gataaggata tttggctcac ctcgttccac agctccacct tcatcttctc
      361 atcaaagcct accatggata cacagggagc ttctttctcc ttagccagta atctgcccat
      421 gatgatccct gacagcaaaa agtttctttt ctgaggctgc catactgcca ctgtccaggt
      481 ggagactgag caaaggaagt cctgggctgt gccagctccc agagcttcgg aagaaagagc
      541 agcagctctc tccctgggaa ccatcagaga attctgttga tgtgttctgt gtctgtctgt
      601 cacctggtca cgagcttcta ccacctttgc aattgtcact tatctttcac tccctgaata
      661 aagtatctat gcatata
//
