LOCUS       NM_003125                619 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens small proline rich protein 1B (SPRR1B), mRNA.
ACCESSION   NM_003125 XM_937483
VERSION     NM_003125.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 619)
  AUTHORS   Song,Y., Pan,H., Yang,L., Fan,Y., Zhang,H., Pan,M. and Zhang,Y.
  TITLE     DGUOK-AS1 promotes cervical squamous cell carcinoma progression by
            suppressing miR-499a-5p that targets SPRR1B in vitro
  JOURNAL   Biochem Biophys Res Commun 585, 177-184 (2021)
   PUBMED   34808501
  REMARK    GeneRIF: DGUOK-AS1 promotes cervical squamous cell carcinoma
            progression by suppressing miR-499a-5p that targets SPRR1B in
            vitro.
REFERENCE   2  (bases 1 to 619)
  AUTHORS   Sasahira,T., Kurihara-Shimomura,M., Shimomura,H., Bosserhoff,A.K.
            and Kirita,T.
  TITLE     Identification of oral squamous cell carcinoma markers MUC2 and
            SPRR1B downstream of TANGO
  JOURNAL   J Cancer Res Clin Oncol 147 (6), 1659-1672 (2021)
   PUBMED   33620575
  REMARK    GeneRIF: Identification of oral squamous cell carcinoma markers
            MUC2 and SPRR1B downstream of TANGO.
REFERENCE   3  (bases 1 to 619)
  AUTHORS   Zhang,Z., Shi,R., Xu,S., Li,Y., Zhang,H., Liu,M., Zhu,G., Chen,C.,
            Pan,Z., Liu,H. and Chen,J.
  TITLE     Identification of small proline-rich protein 1B (SPRR1B) as a
            prognostically predictive biomarker for lung adenocarcinoma by
            integrative bioinformatic analysis
  JOURNAL   Thorac Cancer 12 (6), 796-806 (2021)
   PUBMED   33501784
  REMARK    GeneRIF: Identification of small proline-rich protein 1B (SPRR1B)
            as a prognostically predictive biomarker for lung adenocarcinoma by
            integrative bioinformatic analysis.
REFERENCE   4  (bases 1 to 619)
  AUTHORS   Ramakrishnan,V.R., Gonzalez,J.R., Cooper,S.E., Barham,H.P.,
            Anderson,C.B., Larson,E.D., Cool,C.D., Diller,J.D., Jones,K. and
            Kinnamon,S.C.
  TITLE     RNA sequencing and pathway analysis identify tumor necrosis factor
            alpha driven small proline-rich protein dysregulation in chronic
            rhinosinusitis
  JOURNAL   Am J Rhinol Allergy 31 (5), 283-288 (2017)
   PUBMED   28859701
  REMARK    GeneRIF: Expression of SPRR1 and of SPRR2A is increased in mucosal
            samples from patients with chronic rhinosinusitis and appeared as a
            downstream result of TNF alpha modulation, which possibly resulted
            in epithelial barrier dysfunction.
REFERENCE   5  (bases 1 to 619)
  AUTHORS   Trzeciak,M., Sakowicz-Burkiewicz,M., Wesserling,M., Dobaczewska,D.,
            Glen,J., Nowicki,R. and Pawelczyk,T.
  TITLE     Expression of Cornified Envelope Proteins in Skin and Its
            Relationship with Atopic Dermatitis Phenotype
  JOURNAL   Acta Derm Venereol 97 (1), 36-41 (2017)
   PUBMED   27304082
  REMARK    GeneRIF: Levels SPRR1B proteins were significantly higher in AD
            skin compared with the levels of these proteins in the skin of
            healthy subjects.
REFERENCE   6  (bases 1 to 619)
  AUTHORS   Greco,M.A., Lorand,L., Lane,W.S., Baden,H.P., Parameswaran,K.N. and
            Kvedar,J.C.
  TITLE     The pancornulins: a group of small proline rich-related cornified
            envelope precursors with bifunctional capabilities in isopeptide
            bond formation
  JOURNAL   J Invest Dermatol 104 (2), 204-210 (1995)
   PUBMED   7829876
REFERENCE   7  (bases 1 to 619)
  AUTHORS   Marvin,K.W., George,M.D., Fujimoto,W., Saunders,N.A., Bernacki,S.H.
            and Jetten,A.M.
  TITLE     Cornifin, a cross-linked envelope precursor in keratinocytes that
            is down-regulated by retinoids
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 11026-11030 (1992)
   PUBMED   1438308
REFERENCE   8  (bases 1 to 619)
  AUTHORS   An,G., Huang,T.H., Tesfaigzi,J., Garcia-Heras,J., Ledbetter,D.H.,
            Carlson,D.M. and Wu,R.
  TITLE     An unusual expression of a squamous cell marker, small proline-rich
            protein gene, in tracheobronchial epithelium: differential
            regulation and gene mapping
  JOURNAL   Am J Respir Cell Mol Biol 7 (1), 104-111 (1992)
   PUBMED   1627333
REFERENCE   9  (bases 1 to 619)
  AUTHORS   Fornace,A.J. Jr.
  TITLE     Mammalian genes induced by radiation; activation of genes
            associated with growth control
  JOURNAL   Annu Rev Genet 26, 507-526 (1992)
   PUBMED   1482123
  REMARK    Review article
REFERENCE   10 (bases 1 to 619)
  AUTHORS   Kartasova,T. and van de Putte,P.
  TITLE     Isolation, characterization, and UV-stimulated expression of two
            families of genes encoding polypeptides of related structure in
            human epidermal keratinocytes
  JOURNAL   Mol Cell Biol 8 (5), 2195-2203 (1988)
   PUBMED   3133554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC056240.1 and CK300778.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003125.2.
            
            Summary: The protein encoded by this gene is an envelope protein of
            keratinocytes. The encoded protein is crosslinked to membrane
            proteins by transglutaminase, forming an insoluble layer under the
            plasma membrane. This protein is proline-rich and contains several
            tandem amino acid repeats. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M21300.1, BC056240.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307098.5/ ENSP00000306461.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BC056240.1         5-49
            46-399              CK300778.1         238-591             c
            400-619             BC056240.1         404-623
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..619
                     /gene="SPRR1B"
                     /gene_synonym="CORNIFIN; GADD33; SPR-IB; SPRR1"
                     /note="small proline rich protein 1B"
                     /db_xref="GeneID:6699"
                     /db_xref="HGNC:HGNC:11260"
                     /db_xref="MIM:182266"
     exon            1..45
                     /gene="SPRR1B"
                     /gene_synonym="CORNIFIN; GADD33; SPR-IB; SPRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            46..619
                     /gene="SPRR1B"
                     /gene_synonym="CORNIFIN; GADD33; SPR-IB; SPRR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..334
                     /gene="SPRR1B"
                     /gene_synonym="CORNIFIN; GADD33; SPR-IB; SPRR1"
                     /note="14.9 kDa pancornulin; small proline-rich protein
                     IB"
                     /codon_start=1
                     /product="cornifin-B"
                     /protein_id="NP_003116.2"
                     /db_xref="CCDS:CCDS30863.1"
                     /db_xref="GeneID:6699"
                     /db_xref="HGNC:HGNC:11260"
                     /db_xref="MIM:182266"
                     /translation="MSSQQQKQPCTPPPQLQQQQVKQPCQPPPQEPCIPKTKEPCHPK
                     VPEPCHPKVPEPCQPKVPEPCHPKVPEPCPSIVTPAPAQQKTKQK"
     regulatory      598..603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR1B"
                     /gene_synonym="CORNIFIN; GADD33; SPR-IB; SPRR1"
                     /note="hexamer: ATTAAA"
     polyA_site      619
                     /gene="SPRR1B"
                     /gene_synonym="CORNIFIN; GADD33; SPR-IB; SPRR1"
                     /note="major polyA site"
ORIGIN      
        1 accagttcta agggaccata cagagtattc ctctcttcac accaggacca gtcactgttg
       61 cagcatgagt tcccagcagc agaagcagcc ttgcacccca ccccctcagc ttcagcagca
      121 gcaggtgaaa cagccttgcc agcctccacc tcaggaacca tgcatcccca aaaccaagga
      181 gccctgccac cccaaggtgc ctgagccctg ccaccccaaa gtgcccgagc cctgccagcc
      241 caaggttcca gagccatgcc accccaaggt gcctgagccc tgcccttcaa tagtcactcc
      301 agcaccagcc cagcagaaga ccaagcagaa gtaatgtggt ccacagccat gcccttgagg
      361 agccggccac cagatgctga atcccctatc ccattctgcg tatgagtccc atttgccttg
      421 caattagcat tctgtctccc ccaaaaaaga atgtgctatg aagctttctt tcctacacac
      481 tctgagtctc tgaatgaagc tgaaggtctt agtaccagag ctagttttca gctgctcaga
      541 attcatctga agagagactt aagatgaaag caaatgattc agctccctta tacccccatt
      601 aaattcactt tcaattcca
//
