LOCUS       NM_005987                648 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens small proline rich protein 1A (SPRR1A), transcript
            variant 2, mRNA.
ACCESSION   NM_005987
VERSION     NM_005987.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 648)
  AUTHORS   Kawaguchi,S., Moukette,B., Sepulveda,M.N., Hayasaka,T., Aonuma,T.,
            Haskell,A.K., Mah,J., Liangpunsakul,S., Tang,Y., Conway,S.J. and
            Kim,I.M.
  TITLE     SPRR1A is a key downstream effector of MiR-150 during both
            maladaptive cardiac remodeling in mice and human cardiac fibroblast
            activation
  JOURNAL   Cell Death Dis 14 (7), 446 (2023)
   PUBMED   37468478
  REMARK    GeneRIF: SPRR1A is a key downstream effector of MiR-150 during both
            maladaptive cardiac remodeling in mice and human cardiac fibroblast
            activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 648)
  AUTHORS   Li,J., Tang,L.L. and Ma,J.
  TITLE     Survival-related indicators ALOX12B and SPRR1A are associated with
            DNA damage repair and tumor microenvironment status in HPV
            16-negative head and neck squamous cell carcinoma patients
  JOURNAL   BMC Cancer 22 (1), 714 (2022)
   PUBMED   35768785
  REMARK    GeneRIF: Survival-related indicators ALOX12B and SPRR1A are
            associated with DNA damage repair and tumor microenvironment status
            in HPV 16-negative head and neck squamous cell carcinoma patients.
            Erratum:[BMC Cancer. 2022 Jul 11;22(1):755. doi:
            10.1186/s12885-022-09865-x.. PMID: 35820802]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 648)
  AUTHORS   Wang,S. and Zhang,W.
  TITLE     Small proline-rich protein 1A promotes lung adenocarcinoma
            progression and indicates unfavorable clinical outcomes
  JOURNAL   Biochem Cell Biol 100 (3), 199-212 (2022)
   PUBMED   35263193
  REMARK    GeneRIF: Small proline-rich protein 1A promotes lung adenocarcinoma
            progression and indicates unfavorable clinical outcomes.
REFERENCE   4  (bases 1 to 648)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 648)
  AUTHORS   Pavon,M.A., Arroyo-Solera,I., Leon,X., Tellez-Gabriel,M., Viros,D.,
            Gallardo,A., Cespedes,M.V., Casanova,I., Lopez-Pousa,A.,
            Barnadas,A., Quer,M. and Mangues,R.
  TITLE     The combined use of EFS, GPX2, and SPRR1A expression could
            distinguish favorable from poor clinical outcome among
            epithelial-like head and neck carcinoma subtypes
  JOURNAL   Head Neck 41 (6), 1830-1845 (2019)
   PUBMED   30652380
  REMARK    GeneRIF: The combined use of EFS, GPX2, and SPRR1A expression could
            distinguish favorable from poor clinical outcome among
            epithelial-like head and neck carcinoma subtypes.
REFERENCE   6  (bases 1 to 648)
  AUTHORS   Fujimoto,W., Nakanishi,G., Arata,J. and Jetten,A.M.
  TITLE     Differential expression of human cornifin alpha and beta in
            squamous differentiating epithelial tissues and several skin
            lesions
  JOURNAL   J Invest Dermatol 108 (2), 200-204 (1997)
   PUBMED   9008234
REFERENCE   7  (bases 1 to 648)
  AUTHORS   Steinert,P.M. and Marekov,L.N.
  TITLE     The proteins elafin, filaggrin, keratin intermediate filaments,
            loricrin, and small proline-rich proteins 1 and 2 are isodipeptide
            cross-linked components of the human epidermal cornified cell
            envelope
  JOURNAL   J Biol Chem 270 (30), 17702-17711 (1995)
   PUBMED   7543090
REFERENCE   8  (bases 1 to 648)
  AUTHORS   Greco,M.A., Lorand,L., Lane,W.S., Baden,H.P., Parameswaran,K.N. and
            Kvedar,J.C.
  TITLE     The pancornulins: a group of small proline rich-related cornified
            envelope precursors with bifunctional capabilities in isopeptide
            bond formation
  JOURNAL   J Invest Dermatol 104 (2), 204-210 (1995)
   PUBMED   7829876
REFERENCE   9  (bases 1 to 648)
  AUTHORS   Robinson,P.A., Marley,J.J., High,A.S. and Hume,W.J.
  TITLE     Differential expression of protease inhibitor and small
            proline-rich protein genes between normal human oral tissue and
            odontogenic keratocysts
  JOURNAL   Arch Oral Biol 39 (3), 251-259 (1994)
   PUBMED   8018055
REFERENCE   10 (bases 1 to 648)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356867.23, BC105083.1 and AW204307.1.
            
            On Jun 2, 2019 this sequence version replaced NM_005987.3.
            
            Transcript Variant: This variant (2) has an alternate splice site,
            resulting in a shorter 5' UTR, compared to variant 1. Variants 1
            and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279829.6493.1, ERR279863.1958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368762.2/ ENSP00000357751.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL356867.23        60404-60410
            8-189               BC105083.1         1-182
            190-320             AL356867.23        61679-61809
            321-648             AW204307.1         17-344              c
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..648
                     /gene="SPRR1A"
                     /gene_synonym="SPRK"
                     /note="small proline rich protein 1A"
                     /db_xref="GeneID:6698"
                     /db_xref="HGNC:HGNC:11259"
                     /db_xref="MIM:182265"
     exon            1..45
                     /gene="SPRR1A"
                     /gene_synonym="SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            46..648
                     /gene="SPRR1A"
                     /gene_synonym="SPRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..334
                     /gene="SPRR1A"
                     /gene_synonym="SPRK"
                     /note="SPR-IA; 19 kDa pancornulin; small proline-rich
                     protein IA"
                     /codon_start=1
                     /product="cornifin-A"
                     /protein_id="NP_005978.2"
                     /db_xref="CCDS:CCDS1032.1"
                     /db_xref="GeneID:6698"
                     /db_xref="HGNC:HGNC:11259"
                     /db_xref="MIM:182265"
                     /translation="MNSQQQKQPCTPPPQPQQQQVKQPCQPPPQEPCIPKTKEPCHPK
                     VPEPCHPKVPEPCQPKVPEPCQPKVPEPCPSTVTPAPAQQKTKQK"
     regulatory      628..633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRR1A"
                     /gene_synonym="SPRK"
                     /note="hexamer: AATAAA"
     polyA_site      648
                     /gene="SPRR1A"
                     /gene_synonym="SPRK"
                     /note="major polyA site"
ORIGIN      
        1 accaaaccca agggaccaca cagcccattc tgctccgtat accagaaaaa aacacatttg
       61 aagcatgaat tctcagcagc agaagcagcc ttgcacccca ccccctcagc ctcagcagca
      121 gcaggtgaaa caaccttgcc agcctccacc ccaggaacca tgcatcccca aaaccaagga
      181 gccctgccac cccaaggtgc ctgagccctg ccaccccaaa gtgcctgagc cctgccagcc
      241 caaggttcca gagccctgcc agcccaaggt gcctgagccc tgcccttcaa cggtcactcc
      301 agcaccagcc cagcagaaga ccaagcagaa gtaatgtggt ccacagccat gcccttgagg
      361 agctggccac tggatactga acaccctact ccattctgct tatgaatccc atttgcctat
      421 tgaccctgca gttagcatgc tgtcaccctg aatcataatc gctcctttgc acctctaaaa
      481 agatgtccct taccctcatt ctggagggct cctgagcctc tgcgtaaggc tgaacgtctc
      541 actgactgag ctagtcttct tgttgctcgg gtgcatttga ggatggattt ggggaaggat
      601 caagtgaacc atccctagtc ttccttcaat aaataacttt taactcca
//
