LOCUS       NM_001394336            4790 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens sprouty related EVH1 domain containing 3 (SPRED3),
            transcript variant 3, mRNA.
ACCESSION   NM_001394336
VERSION     NM_001394336.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4790)
  AUTHORS   Chen,Z., Wang,C., Li,M., Cai,S. and Liu,X.
  TITLE     SPRED3 regulates the NF-kappaB signaling pathway in thyroid cancer
            and promotes the proliferation
  JOURNAL   Sci Rep 14 (1), 20506 (2024)
   PUBMED   39227612
  REMARK    GeneRIF: SPRED3 regulates the NF-kappaB signaling pathway in
            thyroid cancer and promotes the proliferation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4790)
  AUTHORS   Zhang,X., Meng,X., Wang,P., Luan,C. and Wang,H.
  TITLE     Bioinformatics analysis for the identification of Sprouty-related
            EVH1 domain-containing protein 3 expression and its clinical
            significance in thyroid carcinoma
  JOURNAL   Sci Rep 14 (1), 4549 (2024)
   PUBMED   38402263
  REMARK    GeneRIF: Bioinformatics analysis for the identification of
            Sprouty-related EVH1 domain-containing protein 3 expression and its
            clinical significance in thyroid carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4790)
  AUTHORS   Guy,G.R., Jackson,R.A., Yusoff,P. and Chow,S.Y.
  TITLE     Sprouty proteins: modified modulators, matchmakers or missing
            links?
  JOURNAL   J Endocrinol 203 (2), 191-202 (2009)
   PUBMED   19423641
  REMARK    Review article
REFERENCE   4  (bases 1 to 4790)
  AUTHORS   Lock,P., I,S.T., Straffon,A.F., Schieb,H., Hovens,C.M. and
            Stylli,S.S.
  TITLE     Spred-2 steady-state levels are regulated by phosphorylation and
            Cbl-mediated ubiquitination
  JOURNAL   Biochem Biophys Res Commun 351 (4), 1018-1023 (2006)
   PUBMED   17094949
REFERENCE   5  (bases 1 to 4790)
  AUTHORS   King,J.A., Corcoran,N.M., D'Abaco,G.M., Straffon,A.F., Smith,C.T.,
            Poon,C.L., Buchert,M., I,S., Hall,N.E., Lock,P. and Hovens,C.M.
  TITLE     Eve-3: a liver enriched suppressor of Ras/MAPK signaling
  JOURNAL   J Hepatol 44 (4), 758-767 (2006)
   PUBMED   16478641
  REMARK    GeneRIF: Eve-3 may act as an inhibitor of proliferation pathways in
            the mature liver and be involved in modulating the unique
            regenerative capacity of this organ
REFERENCE   6  (bases 1 to 4790)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     FGF signaling inhibitor, SPRY4, is evolutionarily conserved target
            of WNT signaling pathway in progenitor cells
  JOURNAL   Int J Mol Med 17 (3), 529-532 (2006)
   PUBMED   16465403
REFERENCE   7  (bases 1 to 4790)
  AUTHORS   Mizoguchi,M., Nutt,C.L. and Louis,D.N.
  TITLE     Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma
  JOURNAL   Neurogenetics 5 (1), 81-82 (2004)
   PUBMED   14618415
REFERENCE   8  (bases 1 to 4790)
  AUTHORS   Kato,R., Nonami,A., Taketomi,T., Wakioka,T., Kuroiwa,A., Matsuda,Y.
            and Yoshimura,A.
  TITLE     Molecular cloning of mammalian Spred-3 which suppresses tyrosine
            kinase-mediated Erk activation
  JOURNAL   Biochem Biophys Res Commun 302 (4), 767-772 (2003)
   PUBMED   12646235
  REMARK    GeneRIF: The finding of Spred-3 revealed the presence of a novel
            family of regulators for the Ras/MAP kinase pathway, each member of
            which may have different specificities for extracellular signals.
            [Spred-3]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005789.1.
            
            Summary: This gene encodes a protein with a C-terminal Sprouty-like
            cysteine-rich domain (SRY) and an N-terminal
            Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1)
            domain. The encoded protein is a member of a family of proteins
            that negatively regulates mitogen-activated protein (MAP) kinase
            signaling, particularly during organogenesis. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2012].
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ323928.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN03465404 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000691638.1/ ENSP00000510478.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC005789.1         23188-23298
            112-292             AC005789.1         24790-24970
            293-461             AC005789.1         26437-26605
            462-538             AC005789.1         26703-26779
            539-682             AC005789.1         29134-29277
            683-4790            AC005789.1         29971-34078
FEATURES             Location/Qualifiers
     source          1..4790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..4790
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /note="sprouty related EVH1 domain containing 3"
                     /db_xref="GeneID:399473"
                     /db_xref="HGNC:HGNC:31041"
                     /db_xref="MIM:609293"
     exon            1..111
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /inference="alignment:Splign:2.1.0"
     exon            112..292
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1348
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /note="isoform 1 is encoded by transcript variant 3;
                     sprouty-related, EVH1 domain-containing protein 3"
                     /codon_start=1
                     /product="sprouty-related, EVH1 domain-containing protein
                     3 isoform 1"
                     /protein_id="NP_001381265.1"
                     /db_xref="CCDS:CCDS42560.1"
                     /db_xref="GeneID:399473"
                     /db_xref="HGNC:HGNC:31041"
                     /db_xref="MIM:609293"
                     /translation="MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGAR
                     QGHYVIHGERLRDQKTTLECTLKPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEF
                     QKSLLAALAALGRGSLTPSSSSSSSSPSQDTAETPCPLTSHVDSDSSSSHSRQETPPS
                     AAAAPIITMESASGFGPTTPPQRRRSSAQSYPPLLPFTGIPEPSEPLAGAGGLGWGGR
                     GYEDYRRSGPPAPLALSTCVVRFAKTGALRGAALGPPAALPAPLTEAAPPAPPARPPP
                     GPGPSSAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWC
                     AESLLYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWV
                     AARCGCAGCGGRHEEAAR"
     exon            293..461
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /inference="alignment:Splign:2.1.0"
     exon            462..538
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /inference="alignment:Splign:2.1.0"
     exon            539..682
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /inference="alignment:Splign:2.1.0"
     exon            683..4790
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4766..4771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /note="hexamer: AAGAAA"
     polyA_site      4790
                     /gene="SPRED3"
                     /gene_synonym="Eve-3; spred-3"
                     /note="major polyA site"
ORIGIN      
        1 ggctcccggt gcccgtctcc agcgccgccg gagccagcca gggagccgga acgaaaagga
       61 ggaggaggag gccgcgtcgc cgccgctcgg agcccggccg gagcctcgca ggtacatggt
      121 gcgggtccga gctgtggtga tggcccgaga tgactccagt gggggctggc tgcctgtggg
      181 gggcgggggc ctcagccagg tgagcgtgtg tcgggtccga ggggccaggc ccgagggggg
      241 ggcccgccag gggcactacg tcatccacgg ggaacgcctc cgggaccaga aaacaacctt
      301 ggagtgtaca ctgaagccag gcttggttta caacaaggtg aatcccatct ttcaccactg
      361 gagcctgggt gactgcaagt ttggactgac gtttcagagc cctgcagagg ctgatgagtt
      421 ccagaagagc ctgctggctg cgctggccgc actgggtcga ggctcactca ccccctcctc
      481 ctcctcctcc tcctcctctc cttcccagga tactgcagag accccctgcc ctctgacgtc
      541 ccacgtggac agcgactcct cctccagtca cagccgccag gagactcctc ccagcgccgc
      601 tgcggccccc atcatcacga tggagtcagc ttcaggcttc gggccgacca cgccccccca
      661 gcgccgccgc tcctccgctc agagctaccc tccgcttcta ccgttcacgg ggattccgga
      721 accctcagag cccctggcag gggcaggggg cctggggtgg ggcggccgcg gctacgagga
      781 ttaccggcgc tccgggccac ccgcgcccct cgccctgtcc acctgcgtcg tgcgcttcgc
      841 caagaccggc gcgttgaggg gcgctgccct gggtccccca gcggcactac ctgccccttt
      901 gaccgaggct gcgcccccag cgccccccgc tcgcccaccc cccggcccgg gcccatcctc
      961 tgcgcctgcc aaggcctccc cggaagcgga ggaggcagcg cgctgcgtgc attgccgcgc
     1021 gctcttccgt cgcagagcag acgggcgtgg cggccgctgc gcagaggccc cggacccggg
     1081 tcgcctcctg gtgcgccgtc taagctgcct gtggtgcgcc gagagcttgc tctaccactg
     1141 cctgtcggac gccgagggcg acttctcgga cccgtgcgcc tgcgagccgg gccacccgcg
     1201 ccccgccgcg cgctgggccg cgctggccgc gctctccctg gcagtgccct gcctctgctg
     1261 ctacgcgccc ctgcgcgcgt gccactgggt cgcagcgcga tgcggctgcg ccggctgcgg
     1321 gggtcgccac gaggaggctg cgcggtgagg acggcctggt gggtccccta gccggcccga
     1381 ggacccaaaa ttgagggtcc aggaccccgg actccgttcg gacctaaaac ccaaacctag
     1441 gcacatccgg aacttggagc ttgagtttgg attgagagat ctcagacctg gaacctggaa
     1501 cccaaaccta ggactgagag accccagccc cagcttcatt ggggtgtctg tctaagaagt
     1561 cccaggcgtc ctgagttctg gcgttccccc acccccacac cccacgagga ggctccaggc
     1621 gtccccatac tttgcatctc agaaaggcca gggagcacat agatcccgaa aagggcaggt
     1681 ccctgttgaa atgaacaacc tagaacccgg tcacgcctgg caccatgtcc ctcagattac
     1741 agccccacaa ttagtcagga cttgcccata actggctctg cctttattca actcccagat
     1801 cagatcttga gaccatagga cctggagtca cccacaaaca gttcctgaat attcacctaa
     1861 gacctggtgc ccccacatct gagacattct catagtccca ggacccctga gacagcagga
     1921 cccctgagaa agtttcaaac agagtttgaa actctgttat gctctggaat ctccagatgc
     1981 tgcccctcaa atctacccac gacttagtgc ccacagacct ggcctccagt ccgggaacac
     2041 tgaagtctaa gatgtccagg gaactcccag acaccctggg accccagact cttaagatgc
     2101 actgagtgct cggatatact gaaacacgag ctgttctctt accaaaatga cttgggagac
     2161 ccatcccaga gcccccaaga tccagatatc agacaccaag atgctctgga agccagggat
     2221 caaagacctc cataggtcca cccaccccca agccagggtt ctcaggagct ttggatatca
     2281 tttataggac tcagaggtgc ctggggtcct cagatgtgcg actgaaggcc accaacacct
     2341 caggacccga gatactggtc tcgagttctc aaatagccct ctcttgcagt ccctcctgga
     2401 cctggatttt gagaccccaa atgtcctgga atcttcagct tctttctacc cacagattcc
     2461 caacccctta agggctggga gtccagctcc cagaagaggg gatgctcatg gtgacccaga
     2521 cctctgatgc ccttggccct cagcccttga gtgaccctaa ggtactttag gagcactgga
     2581 tccaataccc caaaggtgcc actgaccccc aaatgcaagg ctcaagaccc tacaacattg
     2641 ggattgttcc tgatccaaga ccttcatccc tccataccag aggcgttcag attcgaggtg
     2701 ccccaagacc ccagcaccct cagaccccag atttctttgg attcaaacct ctctagtctg
     2761 atgaacccca agttgcctct acacctgatt cccccatccc cacttgtcgg acctcagaga
     2821 cctgctgccc cttgaatcct gtcatccata ggcccctaaa accccaaggt tccagcctct
     2881 ggaattctgg tcccaaggat cccagcccaa gcccccagca atcctcagaa ttaccccttt
     2941 atcttagggt gggatcccta ccatttggaa ctcattgtag gaccacccag ggtggggcac
     3001 agtggctcat gccttgtaat cccagcactt tgggaggcca agggaggagg atcgcttaag
     3061 gccaggagtt tgagaccagc ctgggcaatg tagtgagacc gtctctaaaa aaaaaaaaaa
     3121 aggaccaagt aggagctccc tcactgtcac gtctaggacc cagcattgtc acagatgatt
     3181 atgcagggtc ttcattaagt gaaggcacac agcccagggt ttcgaggagc tggaagtcac
     3241 accagtctgc tggccacact gtgccctcag aagaagtgtg tgcaatggaa actttcaggc
     3301 tagttatggc tctgctgtcc cacagccccc agtcttgcag accttccttc aagcacaacc
     3361 ttaattccta gtccaggttc aagtcccacc ttttatgttc tccccctcca ttaacccctt
     3421 ctcttcctat ttatttattt atttatttat ttattttgag acagagtctc gctgtatcac
     3481 ccaggctgga gtgcagtggc acaatctcgg ctcaccacaa cctccccctc ccgggttcaa
     3541 gccattcgtc tgcctcagcc tcccgagtag ctgggataac aggcatgtgc caccacaccc
     3601 agctaatttt ttgtattttg agtagagaca gggtttcacc atgttggcca ggatggtctc
     3661 aaactcctga cctcatgatc cacctgcctc agcctcccaa agtgctggga ttacaggcat
     3721 gagccactgc acctggctct cttccacttt agagtgagaa gttgcttcag gaagtttgaa
     3781 agcctgtttc atggcccact gagtctcttc tgtgcaaagg ggggtgccac aggctttttt
     3841 cccccaagtg aaatggggct tccagtggat cgaagatctg gtgtcctgta tgggggcctc
     3901 aaggtcttgg agcaagacag tctcaatgtt gtatgggctt gggacctgca tctggcccca
     3961 agcatctgga actgtgcact taacctttct tcattaccca gacttggatg gccttgttgg
     4021 ggttcaaggg ataggtcctc tgtctcttcc tttaaattat taactattta ttacatccgg
     4081 aacctgtgag attcagcact cccaaccaga ccctgggatg ggtgagagaa aagcgggggt
     4141 gtctctcccc tccccactct gcccagctct catcactgtc agacccacca gagctgaggg
     4201 cggagggatt gggggctggg gcagcctggg tccccatgcc cctctctgtg cctcggtctc
     4261 cccccttcca tggtgggcgg gggggaagct ccattcttaa cctacctcgt tttggggagg
     4321 ggtgggacgg gggaccagag tgctgtacgg tgctgtggga tctgcagatg aagcggtggg
     4381 ggctaaggaa aggtcccctg gccgccactt cccagcagcg cctctcccag gtcccccagt
     4441 cctgctccct gctgagaccc acctctgatc catgattccc cttcattgcc cccaaatcag
     4501 gggtacatgg agggccgccc tgggagccag gcagacctca gaccctggag cccccaggcc
     4561 caatttccca gccgcttgcc cctcagatcg gatgcttggc ccccagattt gggggaggca
     4621 ccccaacata tatcttcctg atcttgtttc taagccagtc tgtgacctca atattgttag
     4681 tgtcagtgca ggctgaagtg gtgggggagg atgggggcca aagacccagc cttgtcatcg
     4741 ggggaggggg cacgagatct gctccaagaa atgtctgtga caaagtctca
//
