LOCUS       NM_152594               7270 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens sprouty related EVH1 domain containing 1 (SPRED1),
            mRNA.
ACCESSION   NM_152594
VERSION     NM_152594.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7270)
  AUTHORS   Zhao,P., Wang,Y., Yu,X., Nan,Y., Liu,S., Li,B., Cui,Z. and Liu,Z.
  TITLE     Long noncoding RNA LOC646029 functions as a ceRNA to suppress
            ovarian cancer progression through the miR-627-3p/SPRED1 axis
  JOURNAL   Front Med 17 (5), 924-938 (2023)
   PUBMED   37434064
  REMARK    GeneRIF: Long noncoding RNA LOC646029 functions as a ceRNA to
            suppress ovarian cancer progression through the miR-627-3p/SPRED1
            axis.
REFERENCE   2  (bases 1 to 7270)
  AUTHORS   Liu,Y., Fan,X., Jiang,C. and Xu,S.
  TITLE     SPOCK2 and SPRED1 function downstream of EZH2 to impede the
            malignant progression of lung adenocarcinoma in vitro and in vivo
  JOURNAL   Hum Cell 36 (2), 812-821 (2023)
   PUBMED   36629984
  REMARK    GeneRIF: SPOCK2 and SPRED1 function downstream of EZH2 to impede
            the malignant progression of lung adenocarcinoma in vitro and in
            vivo.
REFERENCE   3  (bases 1 to 7270)
  AUTHORS   Ablain,J., Liu,S., Moriceau,G., Lo,R.S. and Zon,L.I.
  TITLE     SPRED1 deletion confers resistance to MAPK inhibition in melanoma
  JOURNAL   J Exp Med 218 (3) (2021)
   PUBMED   33306107
  REMARK    GeneRIF: SPRED1 deletion confers resistance to MAPK inhibition in
            melanoma.
REFERENCE   4  (bases 1 to 7270)
  AUTHORS   Pabst,L., Carroll,J., Lo,W. and Truxal,K.V.
  TITLE     Moyamoya syndrome in a child with Legius syndrome: Introducing a
            cerebral vasculopathy to the SPRED1 phenotype?
  JOURNAL   Am J Med Genet A 185 (1), 223-227 (2021)
   PUBMED   33078527
  REMARK    GeneRIF: Moyamoya syndrome in a child with Legius syndrome:
            Introducing a cerebral vasculopathy to the SPRED1 phenotype?
REFERENCE   5  (bases 1 to 7270)
  AUTHORS   Liu,W., Fang,S. and Zuo,G.
  TITLE     A Study on the Expression of SPRED1 and PBRM1 (Baf180) and their
            Clinical Significances in Patients with Gastric Cancer
  JOURNAL   Clin Lab 66 (10) (2020)
   PUBMED   33073945
  REMARK    GeneRIF: A Study on the Expression of SPRED1 and PBRM1 (Baf180) and
            their Clinical Significances in Patients with Gastric Cancer.
REFERENCE   6  (bases 1 to 7270)
  AUTHORS   Nonami,A., Kato,R., Taniguchi,K., Yoshiga,D., Taketomi,T.,
            Fukuyama,S., Harada,M., Sasaki,A. and Yoshimura,A.
  TITLE     Spred-1 negatively regulates interleukin-3-mediated
            ERK/mitogen-activated protein (MAP) kinase activation in
            hematopoietic cells
  JOURNAL   J Biol Chem 279 (50), 52543-52551 (2004)
   PUBMED   15465815
REFERENCE   7  (bases 1 to 7270)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   8  (bases 1 to 7270)
  AUTHORS   Kato,R., Nonami,A., Taketomi,T., Wakioka,T., Kuroiwa,A., Matsuda,Y.
            and Yoshimura,A.
  TITLE     Molecular cloning of mammalian Spred-3 which suppresses tyrosine
            kinase-mediated Erk activation
  JOURNAL   Biochem Biophys Res Commun 302 (4), 767-772 (2003)
   PUBMED   12646235
REFERENCE   9  (bases 1 to 7270)
  AUTHORS   Wakioka,T., Sasaki,A., Kato,R., Shouda,T., Matsumoto,A.,
            Miyoshi,K., Tsuneoka,M., Komiya,S., Baron,R. and Yoshimura,A.
  TITLE     Spred is a Sprouty-related suppressor of Ras signalling
  JOURNAL   Nature 412 (6847), 647-651 (2001)
   PUBMED   11493923
REFERENCE   10 (bases 1 to 7270)
  AUTHORS   Legius,E. and Stevenson,D.
  TITLE     Legius Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20945555
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069381.8, DA405650.1 and
            AY299089.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152594.2.
            
            Summary: The protein encoded by this gene is a member of the
            Sprouty family of proteins and is phosphorylated by tyrosine kinase
            in response to several growth factors. The encoded protein can act
            as a homodimer or as a heterodimer with SPRED2 to regulate
            activation of the MAP kinase cascade. Defects in this gene are a
            cause of neurofibromatosis type 1-like syndrome (NFLS). [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.119512.1,
                                           SRR1660809.82757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299084.9/ ENSP00000299084.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC069381.8         86060-86074
            16-577              DA405650.1         1-562
            578-1718            AY299089.1         563-1703
            1719-7270           AC069381.8         184922-190473
FEATURES             Location/Qualifiers
     source          1..7270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..7270
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /note="sprouty related EVH1 domain containing 1"
                     /db_xref="GeneID:161742"
                     /db_xref="HGNC:HGNC:20249"
                     /db_xref="MIM:609291"
     exon            1..382
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1685
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /note="protein phosphatase 1, regulatory subunit 147;
                     suppressor of Ras/MAPK activation"
                     /codon_start=1
                     /product="sprouty-related, EVH1 domain-containing protein
                     1"
                     /protein_id="NP_689807.1"
                     /db_xref="CCDS:CCDS32193.1"
                     /db_xref="GeneID:161742"
                     /db_xref="HGNC:HGNC:20249"
                     /db_xref="MIM:609291"
                     /translation="MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTV
                     FKVPHQEENGCADFFIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLT
                     FQSPADARAFDRGIRRAIEDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQE
                     TVVTSEPYRSSNIRPSPFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISK
                     ECGSLKSQNRVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDA
                     DSSIQFSKPDSKKSDYLYSCGDETKLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSR
                     CVYCQERFNHEENVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCS
                     CDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG"
     exon            383..557
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..726
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..773
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..932
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1034
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..7270
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4052..4057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /note="hexamer: ATTAAA"
     polyA_site      4073
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /note="major polyA site"
     regulatory      6455..6460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6479
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
     regulatory      7247..7252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /note="hexamer: AATAAA"
     polyA_site      7270
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
ORIGIN      
        1 gctgcgctcc accccagtgg ctggaggagc agctctccag tcagcctttg cagcccctct
       61 ctttttccct ttccaccggg cctcctcgga tcccttggct gggcactgag gcgggggaag
      121 aggctggggt cgccacggcg gaggttgctg ccgccacccc cctgcggggg tggccggggt
      181 tcccggctgg gggggtaccg ttctgggtga ggcatccacc atggtgaggc ccctgtgccg
      241 ctgcccccgc gcccccccgg ccgccgctgc ctcctgcccc tcggtgctgc tgttgctccc
      301 ccgcctgctg ttgctcctcc atctccagat cggatcacgg tgagggaaag atgagcgagg
      361 agacggcgac ttctgacaac gataatagtt atgcacgagt gcgagctgtg gtgatgaccc
      421 gagatgactc aagtggtgga tggttaccac ttggagggag tggactaagc agcgtcactg
      481 tcttcaaagt ccctcatcag gaagagaatg gctgtgctga cttttttatc cgtggagagc
      541 gactcaggga caaaatggtg gttttggaat gtatgcttaa aaaagacctc atttataata
      601 aggtcactcc aacatttcac cactggaaga ttgatgacaa gaagtttggt cttacgtttc
      661 aaagtcctgc tgatgctagg gcttttgata gaggtatccg aagagctata gaggatattt
      721 ctcaaggatg ccccgaatca aaaaatgaag ctgaaggggc agatgactta caagcaaatg
      781 aagaggattc ttccagttct ctagtgaagg atcacctttt tcagcaagag acagttgtta
      841 ccagtgagcc ttatagaagc tcaaatataa gaccttctcc ctttgaagat ctgaatgcca
      901 gaagagtcta catgcaaagc caagccaatc agataacatt tggtcagcca ggcttggaca
      961 ttcagagcag aagtatggaa tacgtacagc ggcaaatatc caaggaatgt ggaagcctaa
     1021 agtcccaaaa tagggtccct ttgaaatcaa tcagacatgt cagctttcaa gatgaggatg
     1081 agattgtcag aataaaccct cgagatatct taatacgtcg ctatgcagac tacagacatc
     1141 ctgacatgtg gaaaaatgac ttggaaagag atgatgctga ttccagtatt cagttttcta
     1201 aaccagacag taaaaaatca gactatctgt actcttgtgg ggatgagact aagttaagtt
     1261 cacccaaaga ctctgtggta tttaagacgc agccttcctc attaaaaatt aagaagtcaa
     1321 aacgaagaaa agaggatggt gaacgttctc gctgcgtata ctgccaggaa aggtttaatc
     1381 atgaagaaaa tgttagggga aaatgtcagg atgctccaga ccctattaaa agatgcatat
     1441 atcaagttag ttgcatgctc tgtgcagaga gcatgttgta tcattgtatg tcagactcag
     1501 agggagattt ttctgatccc tgttcgtgtg acactagcga cgacaagttc tgcttgcgat
     1561 ggttagccct ggtagctttg tctttcattg taccatgtat gtgctgctac gtccctttga
     1621 gaatgtgcca tcgctgtggt gaggcatgtg gttgctgtgg tgggaaacat aaagctgctg
     1681 gatgaaatgg tccagtgcca aaatgagctt aaaatctttg tttccaggaa ttagctaact
     1741 tggatttgtg gaagcttttg gcaagcaata tggaatcttg cctggtatca ttgagcccac
     1801 acatggagga agcagaactc atcagttctt ggcgtttcac gccatgccta acttttccct
     1861 tgagtgcatg gcatgttttg ttacaggttg tagagtattt gcagaaggaa accatttctg
     1921 gttatttggc tataaaaagt cagcataaaa tatgatccaa ctaaaaggga ttaatttttg
     1981 gcatttttgt atatttatgc attaggtgat gggactttta aaggtttgaa tttattagga
     2041 cacgaactaa aaataaaagt gcactagggg acagttgatt tcaatctaag aaaagttaac
     2101 acttgggaat tacaagaagt aaaacaagtg caactaaatc atttattagt tgttttttga
     2161 aagcagtttt atgtataaat aacaaatgtt tatatttaac taaatgtaag gtacgaatta
     2221 ttacatatta aacttttctt ccccttccta gttctgaagt agatatatat atatatatat
     2281 ctactgtcac attccatata ttttgaatat ttaactcatc tagttaataa tgtttttatt
     2341 ccatgcgaat gatttgatat tttcatcctt atttctcttt ggctacaatt tatattgagt
     2401 tatatctgta cattctggta atctaaaatc cttaaaaata ctctaatagc cttgagtgac
     2461 caactttttt tttaaagcac agatgtaatt gtctaatgtt ctgatgggaa cgtaacactt
     2521 atttttatat aaaaagagac tgagtaaaca aacattatag aaaaaaagtg aagtttttta
     2581 gttgtttttt gtggtattca accagcaagt tgttttcttt cagagtttcc tccttcaaaa
     2641 agttatattg catttacaaa tgttttacaa ggcagaaagt ttgactggat agttagtgta
     2701 aaagcttcat gttgagatct tcacgtatca ttctgctaaa ccagaatatg ttcagctgtg
     2761 ttactaattt ttcagcttaa tcctcagtgc ttattattta cataacaata actttttatc
     2821 agttacattt tatttttatt taaactggcc aaaagcaaaa ttattttatg ttaaaatgtg
     2881 tgctaaacta tcccaggaaa gtatttaatc caacattgta aatgaagtat cttgtacata
     2941 taaatttatt tcttttgcag agcattatat tactggatgt ttaatttaca aaatagttgg
     3001 gtaaatgttc caacaaactt taaagtacct tgaagtcaaa ttgtctgttt ttgttttgtt
     3061 gttgttgttg ttgttttctt aagtgttaca ttaaaactct aaccaaggaa agggttcttt
     3121 aagaacattc ccttagaggg ataaagttga gaagtgtgcc ttttttttaa tggcttgaag
     3181 tttcagaggt gataaaaatt aaaatcacac tactatttga agctcatttt ctatgcaggt
     3241 ttttaaacgt catttatgta tcattctttt tatatatcac acttaagctt gtgttagctt
     3301 ttttcttttg ccccagatca aactgaacaa tgtatataac actatctgtc tgtaaaatac
     3361 tttttttaag aaagcattta tatttatatg acagcttgaa ctgacaacat tgtgtatata
     3421 gatcatcttg aagtattatt tcacattgaa aagaagaaaa tatattgata actatagatg
     3481 ttatgaagaa gagggtattt ctagttttgt actaaaaatc aattggatga actaaatcca
     3541 aaacatgaca ctgtaggcag cagttttaag tcttattttt actgtttata tatttgaatg
     3601 ctgctacaac agatgatctt catccctgaa gttttcagct aaacttggtt tcctagaata
     3661 gactgttaac tttcaaaatt tttattggtg aaatggaaat actgtttttc cttgtgaatg
     3721 aattttcata tttgtaagtg ctaagtttat aattcaggtt tgatcaaggt gtgaataact
     3781 gaagaaaata acttgctggc tatataggaa aatgctgtgg aaatgaactg tgtatatact
     3841 tctgggagga acaaatttaa tcatttcttc tgttaagcac taatcagtat agtgcaactc
     3901 ctggttctgt actgtatttt atatgcaaca tatatgcttt aatattttaa tgtttgtgca
     3961 ttaatatttt caatttgttt aaccactttg ctgctaagat tttgccgtcc cattcccatt
     4021 ttttccttta caattttaaa caagtttctt cattaaaaac tatggtgatg aaatggtttt
     4081 tattttacct tggatcttta tagttaacat acccagtttc ttaatcagtc tacaagacta
     4141 actgatgata taatgttctc tgaatcccta tatggaaatt ttcttttgag taaatgagaa
     4201 ttcctttgtg aaagcaaatg ggtagtttaa atcactgatt cttaaacatg tgtataggca
     4261 ccttcaggaa cattttctca ttctctgtac agattcggca ctgccaattg gcttttcctc
     4321 taaaactttt ctttgttttt atctgatata agcagatggc tcaagacaac tgcttgagta
     4381 atagtattga aaatggaatc atctagacgg catgacaagc aagactggtc tgatgaactt
     4441 gttcagaatt gataattctt aaatatttct cttggcttca aaagggacat catttgattt
     4501 ctgaagaagt atgtcgtgtg gagcttcagc accacctact ggatgatttc caggccagag
     4561 acatgagatg gcaataggga tctgacaggg ttcatcacta ctaccattaa agggctattt
     4621 atgtggtgac cacctctacc agggaaacca ggaataagaa ctgtctcaaa ggaattgtaa
     4681 aatggttatt tacctaatgt gtcttgttgg cttgctgaaa gattttaagc acttttttct
     4741 tacatatcct gttttaaaat atttgttgat atttgggact ggcaatcaaa cttaatggat
     4801 gtactgaggc atttatagaa ccagttgctt taactctcaa aagccattac caaaatggta
     4861 tttttttcct ccttccgcca gtcagggaga atttttaaaa ataataatca aaacatgaaa
     4921 aaacataatc acacctgtat tttatcatga cagcttcaga gagtgtgtgt gtacgttttt
     4981 ctctctttta tttgagacgg agtttcactc ttgttgccca ggctggagtg caatggtgcg
     5041 atctcagctc actgcaacct ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc
     5101 caagtagctg ggattacagg cacccaccac catgcccagc taagttttgg tattttagta
     5161 gagatggggt ttcaccatgt tggccaggct ggtcttgaac tcctgacctt aggtgatcca
     5221 cccacctcgg cctcccaaag tgctgggatt acaggcatga gctactgcgc ccagccgtgt
     5281 gtatgtttct gaaatgatga tggggtgggg ttaaaatcta aagggaaaaa cttgaaacta
     5341 cctattttca ttggttattc agcagtgcct aaaatgagct tttgaagtaa tgtaaatgca
     5401 ctttcaattc atgtgtatag tgccatctga tatcttgggt aagtcttgct ttttcttttc
     5461 tttttcctct cccctgcccc cttaattaaa tggcacggaa atgtttctta atatgcacgt
     5521 gagtctccag agtacaggaa atgtgctttc ctctaaatgg tcaatgtaaa gaatcttaag
     5581 gatatttctt gtgttgaaat ttacattcga ttttgtgatt acacttggaa gtatgtgtta
     5641 aattgggttt ttaattgtag cccaaaggtg cattaagcaa gtgtaacatt ttttccacat
     5701 aaaacttaga aaactttagt tacctgaaaa gcaaggattc tttactaatt attatgctca
     5761 ttcttgattt gacttccatg ttcacacttc aaagtgtaag aggaagcact agaaactggc
     5821 attattgttg cactaaaaaa gtctataaat cataatagca ccatgaggtg ttttgcaatg
     5881 agacaaacat gaagaatgaa tttctttaag agagaaacac aaccggaggt gatttatata
     5941 aaccaaaaga aaaaaaaagg ctttaaggta ttaggtactg tttgcctagc agccaggtgg
     6001 ttataaaaga ttcatatgct ttggtacact gataaatgtt agccattatt cctgaaagct
     6061 tcttaaattg catcagttgt tttgaaattt tttcaagaat aaactagttg aaaagtcttt
     6121 gtattaaaaa tacacataga tttttgtgaa catttccagt gtgtagtgtc gtttgctttc
     6181 tatttctgac ctcaaaagtg cctcacttgt atattatttc cattaaaagc ttgactgcat
     6241 tctttctaat gaacaatgaa aaactgttta actcatgtca taatgtgtct cctcagatat
     6301 agttaactag cttgatagtt ttgagtatat aatgtaaata atacattata agtttgtaac
     6361 catttctgtt acttcatacc cgtgtaattg gacatagcag atgattatca taagaatttg
     6421 ttttaatggt ttttttccct cctggaatta cctgattaaa cctgtcatga attataaaag
     6481 gactttttct tattctccta gagcttatca aattatcaca taagagataa ttactggagg
     6541 agaaagtaaa aatggaagct tttgataatt agctctgttc tttaaaagta tacttttaaa
     6601 ctgaaagttc acatatagtt catcttaata acatatttat tcatccttaa ttgtattcag
     6661 attttttttt aagtctctaa gctaataatg ttatatttat tggtttggta acatgttgca
     6721 gctaagctaa tgaccttaag tggcaattgt ttaacccagg actactgatt tttttatatt
     6781 caagtcagtt tcatcgtttt acttaactcg ccatataacc aaaaataacg aataatctaa
     6841 aggaaaggtt attaggacag taataaaaaa ttatagtgta tctcaacact agaataagtt
     6901 ggattactat attatagttt atttgaaaaa tcaaggagta actgtatctt taccattaat
     6961 tatgaaatgt agtctcatgt gcttatttac aggtttttca gaatttgctt tacattcttc
     7021 acatcaagtt aatacccaca agtaagtaga atagctttta taacaaggaa attgaaacta
     7081 gggttctagc ttggctatca atataagtgt catgcacata gtgctcctta aagaaaaaga
     7141 catcgacatc aatggtatga aagctgtagt cactctttaa attgaactgc tctaagattt
     7201 gcagttttag tgagatctga aatgatggtt caaaaaatac attcataata aaagtcttaa
     7261 caaaatcaca
//
