LOCUS       NM_006944               1021 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens secreted phosphoprotein 2 (SPP2), mRNA.
ACCESSION   NM_006944
VERSION     NM_006944.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1021)
  AUTHORS   Peng,H., Liu,Y. and Song,Z.
  TITLE     SPP2 plays a role in the tumorigenesis of hepatocellular carcinoma:
            A bioinformatic based analysis
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (12), 1779-1792 (2023)
   PUBMED   38448371
  REMARK    GeneRIF: SPP2 plays a role in the tumorigenesis of hepatocellular
            carcinoma: A bioinformatic based analysis.
REFERENCE   2  (bases 1 to 1021)
  AUTHORS   Chen,H., Li,C., Zhou,T., Li,X., Duarte,M.E.L., Daubs,M.D.,
            Buser,Z., Brochmann,E.J., Wang,J.C., Murray,S.S., Jiao,L. and
            Tian,H.
  TITLE     Secreted phosphoprotein 24 kD (Spp24) inhibits the growth of human
            osteosarcoma through the BMP-2/Smad signaling pathway
  JOURNAL   J Orthop Res 41 (8), 1803-1814 (2023)
   PUBMED   36883270
  REMARK    GeneRIF: Secreted phosphoprotein 24 kD (Spp24) inhibits the growth
            of human osteosarcoma through the BMP-2/Smad signaling pathway.
REFERENCE   3  (bases 1 to 1021)
  AUTHORS   Turner,M.E., White,C.A., Taylor,S.M., Neville,K., Rees-Milton,K.,
            Hopman,W.M., Adams,M.A., Anastassiades,T. and Holden,R.M.
  TITLE     Secreted Phosphoprotein 24 is a Biomarker of Mineral Metabolism
  JOURNAL   Calcif Tissue Int 108 (3), 354-363 (2021)
   PUBMED   33481052
  REMARK    GeneRIF: Secreted Phosphoprotein 24 is a Biomarker of Mineral
            Metabolism.
REFERENCE   4  (bases 1 to 1021)
  AUTHORS   Tu,Y., Chen,C. and Fan,G.
  TITLE     Association between the expression of secreted phosphoprotein -
            related genes and prognosis of human cancer
  JOURNAL   BMC Cancer 19 (1), 1230 (2019)
   PUBMED   31849319
  REMARK    GeneRIF: SPP2 expression was decreased in colorectal cancer,
            leukemia, liver cancer and pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1021)
  AUTHORS   Lao,L., Shen,J., Tian,H., Yao,Q., Li,Y., Qian,L., Murray,S.S. and
            Wang,J.C.
  TITLE     Secreted Phosphoprotein 24 kD Inhibits Growth of Human Prostate
            Cancer Cells Stimulated by BMP-2
  JOURNAL   Anticancer Res 36 (11), 5773-5780 (2016)
   PUBMED   27793899
  REMARK    GeneRIF: Spp24 can inhibit the growth of prostate cancer and its
            bone metastasis induced by BMP2; spp24 may have great potential to
            be a therapeutic agent in clinical situations
REFERENCE   6  (bases 1 to 1021)
  AUTHORS   Hsu,Y.H., Zillikens,M.C., Wilson,S.G., Farber,C.R., Demissie,S.,
            Soranzo,N., Bianchi,E.N., Grundberg,E., Liang,L., Richards,J.B.,
            Estrada,K., Zhou,Y., van Nas,A., Moffatt,M.F., Zhai,G., Hofman,A.,
            van Meurs,J.B., Pols,H.A., Price,R.I., Nilsson,O., Pastinen,T.,
            Cupples,L.A., Lusis,A.J., Schadt,E.E., Ferrari,S.,
            Uitterlinden,A.G., Rivadeneira,F., Spector,T.D., Karasik,D. and
            Kiel,D.P.
  TITLE     An integration of genome-wide association study and gene expression
            profiling to prioritize the discovery of novel susceptibility Loci
            for osteoporosis-related traits
  JOURNAL   PLoS Genet 6 (6), e1000977 (2010)
   PUBMED   20548944
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1021)
  AUTHORS   Brochmann,E.J., Behnam,K. and Murray,S.S.
  TITLE     Bone morphogenetic protein-2 activity is regulated by secreted
            phosphoprotein-24 kd, an extracellular pseudoreceptor, the gene for
            which maps to a region of the human genome important for bone
            quality
  JOURNAL   Metabolism 58 (5), 644-650 (2009)
   PUBMED   19375587
  REMARK    GeneRIF: spp24 contains at least 2 single nucleotide polymorphisms.
            Given its mechanism of action and sequence variability, SPP24 may
            be an interesting candidate for future studies of the genetic
            regulation of bone mass.
            Review article
REFERENCE   8  (bases 1 to 1021)
  AUTHORS   Bennett,C.S., Khorram Khorshid,H.R., Kitchen,J.A., Arteta,D. and
            Dalgleish,R.
  TITLE     Characterization of the human secreted phosphoprotein 24 gene
            (SPP2) and comparison of the protein sequence in nine species
  JOURNAL   Matrix Biol 22 (8), 641-651 (2004)
   PUBMED   15062857
  REMARK    GeneRIF: Results describe the localization of the human secreted
            phosphoprotein 24 gene, its structure and the start of
            transcription in liver.
REFERENCE   9  (bases 1 to 1021)
  AUTHORS   Hu,B., Coulson,L., Moyer,B. and Price,P.A.
  TITLE     Isolation and molecular cloning of a novel bone phosphoprotein
            related in sequence to the cystatin family of thiol protease
            inhibitors
  JOURNAL   J Biol Chem 270 (1), 431-436 (1995)
   PUBMED   7814406
  REMARK    Erratum:[J Biol Chem 1995 Apr 28;270(17):10359]
REFERENCE   10 (bases 1 to 1021)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ308099.1 and AC006037.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006944.2.
            
            Summary: This gene encodes a secreted phosphoprotein that is a
            member of the cystatin superfamily. [provided by RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.151662.1,
                                           SRR5189664.41883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000168148.8/ ENSP00000168148.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1019              AJ308099.1         1-1019
            1020-1021           AC006037.2         51249-51250         c
FEATURES             Location/Qualifiers
     source          1..1021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..1021
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /note="secreted phosphoprotein 2"
                     /db_xref="GeneID:6694"
                     /db_xref="HGNC:HGNC:11256"
                     /db_xref="MIM:602637"
     exon            1..170
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..721
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /note="secreted phosphoprotein 24; secreted phosphoprotein
                     2, 24kD; secreted phosphoprotein 2, 24kDa"
                     /codon_start=1
                     /product="secreted phosphoprotein 24 precursor"
                     /protein_id="NP_008875.1"
                     /db_xref="CCDS:CCDS2511.1"
                     /db_xref="GeneID:6694"
                     /db_xref="HGNC:HGNC:11256"
                     /db_xref="MIM:602637"
                     /translation="MISRMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDAL
                     SASVVKVNSQSLSPYLFRAFRSSLKRVEVLDENNLVMNLEFSIRETTCRKDSGEDPAT
                     CAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSWSSSTSESYSSEEMIFGDMLGSHKW
                     RNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTDFE"
     exon            171..295
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /inference="alignment:Splign:2.1.0"
     exon            296..418
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /inference="alignment:Splign:2.1.0"
     exon            419..529
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /inference="alignment:Splign:2.1.0"
     exon            530..584
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /inference="alignment:Splign:2.1.0"
     exon            585..635
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /inference="alignment:Splign:2.1.0"
     exon            636..731
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /inference="alignment:Splign:2.1.0"
     exon            732..1021
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      997..1002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /note="hexamer: AATAAA"
     polyA_site      1021
                     /gene="SPP2"
                     /gene_synonym="SPP-24; SPP24"
                     /note="major polyA site"
ORIGIN      
        1 agtgtttgat aaagacagct cctcttagga agaactgtca tccccaaaca catagagaga
       61 cactctctgt ctctcgatta caatcatgat ttccagaatg gagaagatga cgatgatgat
      121 gaagatattg attatgtttg ctcttggaat gaactactgg tcttgctcag gtttcccagt
      181 gtacgactac gatccatcct ccttaaggga tgccctcagt gcctctgtgg taaaagtgaa
      241 ttcccagtca ctgagtccgt atctgtttcg ggcattcaga agctcattaa aaagagttga
      301 ggtcctagat gagaacaact tggtcatgaa tttagagttc agcatccggg agactacatg
      361 caggaaggat tctggagaag atcccgctac atgtgccttc cagagggact actatgtgtc
      421 cacagctgtt tgcagaagca ccgtgaaggt atctgcccag caggtgcagg gcgtgcatgc
      481 tcgctgcagc tggtcctcct ccacgtctga gtcttacagc agcgaagaga tgatttttgg
      541 ggacatgttg ggatctcata aatggagaaa caattatcta tttggtctca tttcagacga
      601 gtccataagt gaacaatttt atgatcggtc acttgggatc atgagaaggg tattgcctcc
      661 tggaaacaga aggtacccaa accaccggca cagagcaaga ataaatactg actttgagta
      721 acggccttga ggtgtccctc gcccttttgg tttgttcaag gagctgctgc tttgcatagc
      781 tgctctagtg tctggtatca tcggatctgg ttttgaataa ttcccaggag tcctgggtcc
      841 ctggcctcca aagctggaat gtgaacgcat gccacggtgg tctgaccctc acactccttt
      901 tctcttaaca gcaaaatgca atggaaggaa gaaaagttcc aacaaagaat gattttgtga
      961 attctgtgat ttttcttctg atcagtttca atctgtaata aatgccttat ttttcctgta
     1021 a
//
