LOCUS       NM_003563               3053 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens speckle type BTB/POZ protein (SPOP), transcript
            variant 2, mRNA.
ACCESSION   NM_003563
VERSION     NM_003563.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3053)
  AUTHORS   Li,M., Cui,Y., Qi,Q., Liu,J., Li,J., Huang,G., Yang,J., Sun,J.,
            Ma,Z., Liang,S., Zhang,D., Jiang,J., Zhu,R., Liu,Q., Huang,R. and
            Yan,J.
  TITLE     SPOP downregulation promotes bladder cancer progression based on
            cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is
            regulated by VEZF1
  JOURNAL   Theranostics 14 (17), 6543-6559 (2024)
   PUBMED   39479456
  REMARK    GeneRIF: SPOP downregulation promotes bladder cancer progression
            based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis
            and is regulated by VEZF1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3053)
  AUTHORS   Lee,C.J., Lee,H., Kim,S.R., Nam,S.B., Lee,G.E., Yang,K.E.,
            Lee,G.J., Chun,S.H., Kang,H.C., Lee,J.Y., Lee,H.S., Cho,S.J. and
            Cho,Y.Y.
  TITLE     ELK3 destabilization by speckle-type POZ protein suppresses
            prostate cancer progression and docetaxel resistance
  JOURNAL   Cell Death Dis 15 (4), 274 (2024)
   PUBMED   38632244
  REMARK    GeneRIF: ELK3 destabilization by speckle-type POZ protein
            suppresses prostate cancer progression and docetaxel resistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3053)
  AUTHORS   Li,K., Zhang,J., Lyu,H., Yang,J., Wei,W., Wang,Y., Luo,H.,
            Zhang,Y., Jiang,X., Yi,H., Wang,M., Zhang,C., Wu,K., Xiao,L.,
            Wen,W., Xu,H., Li,G., Wan,Y., Yang,F., Yang,R., Fu,X., Qin,B.,
            Zhou,Z., Zhang,H. and Lee,M.H.
  TITLE     CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression
            via YAP1 Activation
  JOURNAL   Adv Sci (Weinh) 11 (14), e2306827 (2024)
   PUBMED   38308184
  REMARK    GeneRIF: CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma
            Progression via YAP1 Activation.
REFERENCE   4  (bases 1 to 3053)
  AUTHORS   Liu,F., Zhang,T., Sun,X., Liu,Z., Xu,W., Dai,X. and Zhang,X.
  TITLE     Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1
            promotes gastric cancer progression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167032 (2024)
   PUBMED   38246227
  REMARK    GeneRIF: Deficiency in SPOP-mediated ubiquitination and degradation
            of TIAM1 promotes gastric cancer progression.
REFERENCE   5  (bases 1 to 3053)
  AUTHORS   Yu,Z., Wu,X., Zhu,J., Yan,H., Li,Y., Zhang,H., Zhong,Y., Lin,M.,
            Ye,G., Li,X., Jin,J., Li,K., Wang,J., Zhuang,H., Lin,T., He,J.,
            Lu,C., Xu,Z., Zhang,X., Li,H. and Jin,X.
  TITLE     BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development
            and immune escape of hepatocellular carcinoma
  JOURNAL   Cell Mol Life Sci 81 (1), 82 (2024)
   PUBMED   38340178
  REMARK    GeneRIF: BCLAF1 binds SPOP to stabilize PD-L1 and promotes the
            development and immune escape of hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3053)
  AUTHORS   Diefenbach,A., Tomasello,E., Lucas,M., Jamieson,A.M., Hsia,J.K.,
            Vivier,E. and Raulet,D.H.
  TITLE     Selective associations with signaling proteins determine
            stimulatory versus costimulatory activity of NKG2D
  JOURNAL   Nat Immunol 3 (12), 1142-1149 (2002)
   PUBMED   12426565
  REMARK    Erratum:[Nat Immunol. 2004 Jun;5(6):658]
REFERENCE   7  (bases 1 to 3053)
  AUTHORS   Gilfillan,S., Ho,E.L., Cella,M., Yokoyama,W.M. and Colonna,M.
  TITLE     NKG2D recruits two distinct adapters to trigger NK cell activation
            and costimulation
  JOURNAL   Nat Immunol 3 (12), 1150-1155 (2002)
   PUBMED   12426564
REFERENCE   8  (bases 1 to 3053)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   9  (bases 1 to 3053)
  AUTHORS   Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
            Phillips,J.H.
  TITLE     An activating immunoreceptor complex formed by NKG2D and DAP10
  JOURNAL   Science 285 (5428), 730-732 (1999)
   PUBMED   10426994
REFERENCE   10 (bases 1 to 3053)
  AUTHORS   Nagai,Y., Kojima,T., Muro,Y., Hachiya,T., Nishizawa,Y.,
            Wakabayashi,T. and Hagiwara,M.
  TITLE     Identification of a novel nuclear speckle-type protein, SPOP
  JOURNAL   FEBS Lett 418 (1-2), 23-26 (1997)
   PUBMED   9414087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX282325.1, BC001269.1,
            AK123385.1, W84567.1, BM693397.1, BQ226031.1 and AW449169.1.
            
            On Nov 29, 2004 this sequence version replaced NM_003563.2.
            
            Summary: This gene encodes a protein that may modulate the
            transcriptional repression activities of death-associated protein 6
            (DAXX), which interacts with histone deacetylase, core histones,
            and other histone-associated proteins. In mouse, the encoded
            protein binds to the putative leucine zipper domain of macroH2A1.2,
            a variant H2A histone that is enriched on inactivated X
            chromosomes. The BTB/POZ domain of this protein has been shown in
            other proteins to mediate transcriptional repression and to
            interact with components of histone deacetylase co-repressor
            complexes. Alternative splicing of this gene results in multiple
            transcript variants encoding the same protein. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Transcript variants 1-6 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001269.1, SRR14038196.1785107.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               BX282325.1         1-353
            354-1904            BC001269.1         238-1788
            1905-1914           AK123385.1         1615-1624
            1915-1915           W84567.1           272-272
            1916-1916           BM693397.1         322-322
            1917-2425           AK123385.1         1625-2133
            2426-2638           BQ226031.1         245-457
            2639-3053           AW449169.1         1-415               c
FEATURES             Location/Qualifiers
     source          1..3053
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..3053
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="speckle type BTB/POZ protein"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
     exon            1..231
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..353
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..497
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..1544
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="HIB homolog 1; roadkill homolog 1"
                     /codon_start=1
                     /product="speckle-type POZ protein"
                     /protein_id="NP_003554.1"
                     /db_xref="CCDS:CCDS11551.1"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
                     /translation="MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFC
                     REEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKF
                     KFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCE
                     VSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAIL
                     AARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAA
                     ADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLE
                     TSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS"
     exon            498..619
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..771
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..899
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1077
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1133
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1256
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1399
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..3038
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2617..2622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: TATAAA"
     polyA_site      2638
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="major polyA site"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: AATAAA"
     polyA_site      3038
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
ORIGIN      
        1 ggggaggagg ccgcgcgggg tggggtctgg cggtacgcgc tggctgcgtc gacgtgctga
       61 cgccatgacg ccccggctgg tgtgtgtcgg tgtgtatgtg tgtgtgtgag tgtgcgcgct
      121 ccgagtgtgt gtgtatttgt gtatcggcgg tcccgcaggt cccggatgtt gcggacagta
      181 tgaggcaagc gcagggggac ggggaccagc agctgtcgcc gccgctctca gatcgagtct
      241 tgctctgtca cccaggctgg agtgcagtgg cgcgatctca gctcactgcc acctttgcct
      301 cctgggttca agcgattctt ctgcctcagc ctcccgagta gctgggatta cagggtgaag
      361 agggaacaga aatctttgcc ccctgacttt ggaaatctcg tttaaccttc aaactggcga
      421 tgtcaagggt tccaagtcct ccacctccgg cagaaatgtc gagtggcccc gtagctgaga
      481 gttggtgcta cacacagatc aaggtagtga aattctccta catgtggacc atcaataact
      541 ttagcttttg ccgggaggaa atgggtgaag tcattaaaag ttctacattt tcatcaggag
      601 caaatgataa actgaaatgg tgtttgcgag taaaccccaa agggttagat gaagaaagca
      661 aagattacct gtcactttac ctgttactgg tcagctgtcc aaagagtgaa gttcgggcaa
      721 aattcaaatt ctccatcctg aatgccaagg gagaagaaac caaagctatg gagagtcaac
      781 gggcatatag gtttgtgcaa ggcaaagact ggggattcaa gaaattcatc cgtagagatt
      841 ttcttttgga tgaggccaac gggcttctcc ctgatgacaa gcttaccctc ttctgcgagg
      901 tgagtgttgt gcaagattct gtcaacattt ctggccagaa taccatgaac atggtaaagg
      961 ttcctgagtg ccggctggca gatgagttag gaggactgtg ggagaattcc cggttcacag
     1021 actgctgctt gtgtgttgcc ggccaggaat tccaggctca caaggctatc ttagcagctc
     1081 gttctccggt ttttagtgcc atgtttgaac atgaaatgga ggagagcaaa aagaatcgag
     1141 ttgaaatcaa tgatgtggag cctgaagttt ttaaggaaat gatgtgcttc atttacacgg
     1201 ggaaggctcc aaacctcgac aaaatggctg atgatttgct ggcagctgct gacaagtatg
     1261 ccctggagcg cttaaaggtc atgtgtgagg atgccctctg cagtaacctg tccgtggaga
     1321 acgctgcaga aattctcatc ctggccgacc tccacagtgc agatcagttg aaaactcagg
     1381 cagtggattt catcaactat catgcttcgg atgtcttgga gacctctggg tggaagtcaa
     1441 tggtggtgtc acatccccac ttggtggctg aggcataccg ctctctggct tcagcacagt
     1501 gcccttttct gggaccccca cgcaaacgcc tgaagcaatc ctaagatcct gcttgttgta
     1561 agactccgtt taatttccag aagcagcagc cactgttgct gccactgacc accaggtaga
     1621 cagcgcaatc tgtggagctt ttactctgtt gtgaggggaa gagactgcat tgtggcccca
     1681 gacttttaaa acagcactaa ataacttggg ggaaacgggg ggagggaaaa tgaaatgaaa
     1741 accctgttgc tgcgtcactg tgttcccttt ggcctggctg agtttgatac tgtggggatt
     1801 cagtttaggc gctggcccga ggatatccca gcggtggtac ttcggagaca cctgtctgca
     1861 tctgactgag cagaacaaat cgtcaggtgc ctggagcaaa aaggaaaaaa aaaaaagaaa
     1921 ggacattgag ttttaacaga agggaaaagg aaagaagaaa agatttttgc agaatttctc
     1981 aaaaatcagt ttgtggattc cagtagtatt tatattgaga gaaacaaatt ttagtccttc
     2041 taactgtgct aaaacttgga tatttgtgaa aactccttac caccatacaa gcatcagaag
     2101 agctctcttg ttgttagcac ttattgtttg caagaacaga atacatcctt ttatcctttt
     2161 atgaaaaatg acaagtgaag gcaaaagggg aaggttattt gatctggaag atgagtgttc
     2221 tgatgtggtg gcttttgcaa aaatctttat tggtgttgaa aactggaaaa aataactcat
     2281 ccagaattca tattgtcttg acaagaacta tggttctctg tttttagata ttgtggaaaa
     2341 tgtttttggg catttttctc tgattttatt tcttctcccc cacccctttt tctaaaaaac
     2401 aaacaaaaaa aaaaacacac aaaacaaaaa cagaacaaaa gaagagagaa ggaaatttta
     2461 tcaattaaaa atgctgtgtg ataaaatccc agcccagatt gctcagctgt ttgtacctga
     2521 cttgccgcct gcataggagc cagttctgtt ccttctgact agcccctctt cctccagggg
     2581 agaacttcca aatgttaatt tttttttttt tgaaaatata aataattact attttgtact
     2641 gtgtggtatc tctggtcttt tgtttcactc acctgccttg tctcttgggt ctgagtccct
     2701 tgcttaaggg attttgaagt cctagttttc agcttgcaga gattatgtct gaaatgccta
     2761 atgagtcgca gggatttgtt gagactccgt aatctcaagt tctctttgtg agctatcagc
     2821 atctgccagt ctcttgtcct ccctgagtat ctcacagtcc atatcctgat gagggatcag
     2881 gcccctacct ctgccaaggc aagtaatggt agtgggcttt taaactgccc cccgtatgtt
     2941 ttaagaccta atccccacct cccttcttct aactaaatat aaaaagatcc aggggacata
     3001 aatgtggaga ttaaataaag ggaaattatt gtctctaaaa aaaaaaaaaa aaa
//
