LOCUS       NM_001370732            2705 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens speckle type BTB/POZ protein (SPOP), transcript
            variant 9, mRNA.
ACCESSION   NM_001370732 XM_017025204
VERSION     NM_001370732.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2705)
  AUTHORS   Li,M., Cui,Y., Qi,Q., Liu,J., Li,J., Huang,G., Yang,J., Sun,J.,
            Ma,Z., Liang,S., Zhang,D., Jiang,J., Zhu,R., Liu,Q., Huang,R. and
            Yan,J.
  TITLE     SPOP downregulation promotes bladder cancer progression based on
            cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is
            regulated by VEZF1
  JOURNAL   Theranostics 14 (17), 6543-6559 (2024)
   PUBMED   39479456
  REMARK    GeneRIF: SPOP downregulation promotes bladder cancer progression
            based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis
            and is regulated by VEZF1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2705)
  AUTHORS   Lee,C.J., Lee,H., Kim,S.R., Nam,S.B., Lee,G.E., Yang,K.E.,
            Lee,G.J., Chun,S.H., Kang,H.C., Lee,J.Y., Lee,H.S., Cho,S.J. and
            Cho,Y.Y.
  TITLE     ELK3 destabilization by speckle-type POZ protein suppresses
            prostate cancer progression and docetaxel resistance
  JOURNAL   Cell Death Dis 15 (4), 274 (2024)
   PUBMED   38632244
  REMARK    GeneRIF: ELK3 destabilization by speckle-type POZ protein
            suppresses prostate cancer progression and docetaxel resistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2705)
  AUTHORS   Li,K., Zhang,J., Lyu,H., Yang,J., Wei,W., Wang,Y., Luo,H.,
            Zhang,Y., Jiang,X., Yi,H., Wang,M., Zhang,C., Wu,K., Xiao,L.,
            Wen,W., Xu,H., Li,G., Wan,Y., Yang,F., Yang,R., Fu,X., Qin,B.,
            Zhou,Z., Zhang,H. and Lee,M.H.
  TITLE     CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression
            via YAP1 Activation
  JOURNAL   Adv Sci (Weinh) 11 (14), e2306827 (2024)
   PUBMED   38308184
  REMARK    GeneRIF: CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma
            Progression via YAP1 Activation.
REFERENCE   4  (bases 1 to 2705)
  AUTHORS   Liu,F., Zhang,T., Sun,X., Liu,Z., Xu,W., Dai,X. and Zhang,X.
  TITLE     Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1
            promotes gastric cancer progression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167032 (2024)
   PUBMED   38246227
  REMARK    GeneRIF: Deficiency in SPOP-mediated ubiquitination and degradation
            of TIAM1 promotes gastric cancer progression.
REFERENCE   5  (bases 1 to 2705)
  AUTHORS   Yu,Z., Wu,X., Zhu,J., Yan,H., Li,Y., Zhang,H., Zhong,Y., Lin,M.,
            Ye,G., Li,X., Jin,J., Li,K., Wang,J., Zhuang,H., Lin,T., He,J.,
            Lu,C., Xu,Z., Zhang,X., Li,H. and Jin,X.
  TITLE     BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development
            and immune escape of hepatocellular carcinoma
  JOURNAL   Cell Mol Life Sci 81 (1), 82 (2024)
   PUBMED   38340178
  REMARK    GeneRIF: BCLAF1 binds SPOP to stabilize PD-L1 and promotes the
            development and immune escape of hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2705)
  AUTHORS   Diefenbach,A., Tomasello,E., Lucas,M., Jamieson,A.M., Hsia,J.K.,
            Vivier,E. and Raulet,D.H.
  TITLE     Selective associations with signaling proteins determine
            stimulatory versus costimulatory activity of NKG2D
  JOURNAL   Nat Immunol 3 (12), 1142-1149 (2002)
   PUBMED   12426565
  REMARK    Erratum:[Nat Immunol. 2004 Jun;5(6):658]
REFERENCE   7  (bases 1 to 2705)
  AUTHORS   Gilfillan,S., Ho,E.L., Cella,M., Yokoyama,W.M. and Colonna,M.
  TITLE     NKG2D recruits two distinct adapters to trigger NK cell activation
            and costimulation
  JOURNAL   Nat Immunol 3 (12), 1150-1155 (2002)
   PUBMED   12426564
REFERENCE   8  (bases 1 to 2705)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   9  (bases 1 to 2705)
  AUTHORS   Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
            Phillips,J.H.
  TITLE     An activating immunoreceptor complex formed by NKG2D and DAP10
  JOURNAL   Science 285 (5428), 730-732 (1999)
   PUBMED   10426994
REFERENCE   10 (bases 1 to 2705)
  AUTHORS   Nagai,Y., Kojima,T., Muro,Y., Hachiya,T., Nishizawa,Y.,
            Wakabayashi,T. and Hagiwara,M.
  TITLE     Identification of a novel nuclear speckle-type protein, SPOP
  JOURNAL   FEBS Lett 418 (1-2), 23-26 (1997)
   PUBMED   9414087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006487.9.
            
            On May 24, 2019 this sequence version replaced XM_017025204.1.
            
            Summary: This gene encodes a protein that may modulate the
            transcriptional repression activities of death-associated protein 6
            (DAXX), which interacts with histone deacetylase, core histones,
            and other histone-associated proteins. In mouse, the encoded
            protein binds to the putative leucine zipper domain of macroH2A1.2,
            a variant H2A histone that is enriched on inactivated X
            chromosomes. The BTB/POZ domain of this protein has been shown in
            other proteins to mediate transcriptional repression and to
            interact with components of histone deacetylase co-repressor
            complexes. Alternative splicing of this gene results in multiple
            transcript variants encoding the same protein. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14478891.320428.1, SRR1660803.63649.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC006487.9         154464-154483       c
            21-164              AC006487.9         137069-137212       c
            165-286             AC006487.9         136282-136403       c
            287-438             AC006487.9         133570-133721       c
            439-566             AC006487.9         133317-133444       c
            567-744             AC006487.9         125616-125793       c
            745-800             AC006487.9         122210-122265       c
            801-923             AC006487.9         121586-121708       c
            924-1066            AC006487.9         116201-116343       c
            1067-2705           AC006487.9         113220-114858       c
FEATURES             Location/Qualifiers
     source          1..2705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..2705
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="speckle type BTB/POZ protein"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
     exon            1..20
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            21..164
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1211
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="HIB homolog 1; roadkill homolog 1"
                     /codon_start=1
                     /product="speckle-type POZ protein"
                     /protein_id="NP_001357661.1"
                     /db_xref="CCDS:CCDS11551.1"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
                     /translation="MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFC
                     REEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKF
                     KFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCE
                     VSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAIL
                     AARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAA
                     ADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLE
                     TSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS"
     exon            165..286
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            287..438
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..566
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..744
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..800
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..923
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1066
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..2705
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2284..2289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: TATAAA"
     polyA_site      2305
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="major polyA site"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: AATAAA"
     polyA_site      2705
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
ORIGIN      
        1 ccaagtagct gggattacag ggtgaagagg gaacagaaat ctttgccccc tgactttgga
       61 aatctcgttt aaccttcaaa ctggcgatgt caagggttcc aagtcctcca cctccggcag
      121 aaatgtcgag tggccccgta gctgagagtt ggtgctacac acagatcaag gtagtgaaat
      181 tctcctacat gtggaccatc aataacttta gcttttgccg ggaggaaatg ggtgaagtca
      241 ttaaaagttc tacattttca tcaggagcaa atgataaact gaaatggtgt ttgcgagtaa
      301 accccaaagg gttagatgaa gaaagcaaag attacctgtc actttacctg ttactggtca
      361 gctgtccaaa gagtgaagtt cgggcaaaat tcaaattctc catcctgaat gccaagggag
      421 aagaaaccaa agctatggag agtcaacggg catataggtt tgtgcaaggc aaagactggg
      481 gattcaagaa attcatccgt agagattttc ttttggatga ggccaacggg cttctccctg
      541 atgacaagct taccctcttc tgcgaggtga gtgttgtgca agattctgtc aacatttctg
      601 gccagaatac catgaacatg gtaaaggttc ctgagtgccg gctggcagat gagttaggag
      661 gactgtggga gaattcccgg ttcacagact gctgcttgtg tgttgccggc caggaattcc
      721 aggctcacaa ggctatctta gcagctcgtt ctccggtttt tagtgccatg tttgaacatg
      781 aaatggagga gagcaaaaag aatcgagttg aaatcaatga tgtggagcct gaagttttta
      841 aggaaatgat gtgcttcatt tacacgggga aggctccaaa cctcgacaaa atggctgatg
      901 atttgctggc agctgctgac aagtatgccc tggagcgctt aaaggtcatg tgtgaggatg
      961 ccctctgcag taacctgtcc gtggagaacg ctgcagaaat tctcatcctg gccgacctcc
     1021 acagtgcaga tcagttgaaa actcaggcag tggatttcat caactatcat gcttcggatg
     1081 tcttggagac ctctgggtgg aagtcaatgg tggtgtcaca tccccacttg gtggctgagg
     1141 cataccgctc tctggcttca gcacagtgcc cttttctggg acccccacgc aaacgcctga
     1201 agcaatccta agatcctgct tgttgtaaga ctccgtttaa tttccagaag cagcagccac
     1261 tgttgctgcc actgaccacc aggtagacag cgcaatctgt ggagctttta ctctgttgtg
     1321 aggggaagag actgcattgt ggccccagac ttttaaaaca gcactaaata acttggggga
     1381 aacgggggga gggaaaatga aatgaaaacc ctgttgctgc gtcactgtgt tccctttggc
     1441 ctggctgagt ttgatactgt ggggattcag tttaggcgct ggcccgagga tatcccagcg
     1501 gtggtacttc ggagacacct gtctgcatct gactgagcag aacaaatcgt caggtgcctg
     1561 gagcaaaaag gaaaaaaaaa aaagaaagga cattgagttt taacagaagg gaaaaggaaa
     1621 gaagaaaaga tttttgcaga atttctcaaa aatcagtttg tggattccag tagtatttat
     1681 attgagagaa acaaatttta gtccttctaa ctgtgctaaa acttggatat ttgtgaaaac
     1741 tccttaccac catacaagca tcagaagagc tctcttgttg ttagcactta ttgtttgcaa
     1801 gaacagaata catcctttta tccttttatg aaaaatgaca agtgaaggca aaaggggaag
     1861 gttatttgat ctggaagatg agtgttctga tgtggtggct tttgcaaaaa tctttattgg
     1921 tgttgaaaac tggaaaaaat aactcatcca gaattcatat tgtcttgaca agaactatgg
     1981 ttctctgttt ttagatattg tggaaaatgt ttttgggcat ttttctctga ttttatttct
     2041 tctcccccac ccctttttct aaaaaacaaa caaaaaaaaa aacacacaaa acaaaaacag
     2101 aacaaaagaa gagagaagga aattttatca attaaaaatg ctgtgtgata aaatcccagc
     2161 ccagattgct cagctgtttg tacctgactt gccgcctgca taggagccag ttctgttcct
     2221 tctgactagc ccctcttcct ccaggggaga acttccaaat gttaattttt ttttttttga
     2281 aaatataaat aattactatt ttgtactgtg tggtatctct ggtcttttgt ttcactcacc
     2341 tgccttgtct cttgggtctg agtcccttgc ttaagggatt ttgaagtcct agttttcagc
     2401 ttgcagagat tatgtctgaa atgcctaatg agtcgcaggg atttgttgag actccgtaat
     2461 ctcaagttct ctttgtgagc tatcagcatc tgccagtctc ttgtcctccc tgagtatctc
     2521 acagtccata tcctgatgag ggatcaggcc cctacctctg ccaaggcaag taatggtagt
     2581 gggcttttaa actgcccccc gtatgtttta agacctaatc cccacctccc ttcttctaac
     2641 taaatataaa aagatccagg ggacataaat gtggagatta aataaaggga aattattgtc
     2701 tctaa
//
