LOCUS       NM_001007230            3034 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens speckle type BTB/POZ protein (SPOP), transcript
            variant 5, mRNA.
ACCESSION   NM_001007230
VERSION     NM_001007230.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3034)
  AUTHORS   Li,M., Cui,Y., Qi,Q., Liu,J., Li,J., Huang,G., Yang,J., Sun,J.,
            Ma,Z., Liang,S., Zhang,D., Jiang,J., Zhu,R., Liu,Q., Huang,R. and
            Yan,J.
  TITLE     SPOP downregulation promotes bladder cancer progression based on
            cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is
            regulated by VEZF1
  JOURNAL   Theranostics 14 (17), 6543-6559 (2024)
   PUBMED   39479456
  REMARK    GeneRIF: SPOP downregulation promotes bladder cancer progression
            based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis
            and is regulated by VEZF1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3034)
  AUTHORS   Lee,C.J., Lee,H., Kim,S.R., Nam,S.B., Lee,G.E., Yang,K.E.,
            Lee,G.J., Chun,S.H., Kang,H.C., Lee,J.Y., Lee,H.S., Cho,S.J. and
            Cho,Y.Y.
  TITLE     ELK3 destabilization by speckle-type POZ protein suppresses
            prostate cancer progression and docetaxel resistance
  JOURNAL   Cell Death Dis 15 (4), 274 (2024)
   PUBMED   38632244
  REMARK    GeneRIF: ELK3 destabilization by speckle-type POZ protein
            suppresses prostate cancer progression and docetaxel resistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3034)
  AUTHORS   Li,K., Zhang,J., Lyu,H., Yang,J., Wei,W., Wang,Y., Luo,H.,
            Zhang,Y., Jiang,X., Yi,H., Wang,M., Zhang,C., Wu,K., Xiao,L.,
            Wen,W., Xu,H., Li,G., Wan,Y., Yang,F., Yang,R., Fu,X., Qin,B.,
            Zhou,Z., Zhang,H. and Lee,M.H.
  TITLE     CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression
            via YAP1 Activation
  JOURNAL   Adv Sci (Weinh) 11 (14), e2306827 (2024)
   PUBMED   38308184
  REMARK    GeneRIF: CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma
            Progression via YAP1 Activation.
REFERENCE   4  (bases 1 to 3034)
  AUTHORS   Liu,F., Zhang,T., Sun,X., Liu,Z., Xu,W., Dai,X. and Zhang,X.
  TITLE     Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1
            promotes gastric cancer progression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167032 (2024)
   PUBMED   38246227
  REMARK    GeneRIF: Deficiency in SPOP-mediated ubiquitination and degradation
            of TIAM1 promotes gastric cancer progression.
REFERENCE   5  (bases 1 to 3034)
  AUTHORS   Yu,Z., Wu,X., Zhu,J., Yan,H., Li,Y., Zhang,H., Zhong,Y., Lin,M.,
            Ye,G., Li,X., Jin,J., Li,K., Wang,J., Zhuang,H., Lin,T., He,J.,
            Lu,C., Xu,Z., Zhang,X., Li,H. and Jin,X.
  TITLE     BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development
            and immune escape of hepatocellular carcinoma
  JOURNAL   Cell Mol Life Sci 81 (1), 82 (2024)
   PUBMED   38340178
  REMARK    GeneRIF: BCLAF1 binds SPOP to stabilize PD-L1 and promotes the
            development and immune escape of hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3034)
  AUTHORS   Diefenbach,A., Tomasello,E., Lucas,M., Jamieson,A.M., Hsia,J.K.,
            Vivier,E. and Raulet,D.H.
  TITLE     Selective associations with signaling proteins determine
            stimulatory versus costimulatory activity of NKG2D
  JOURNAL   Nat Immunol 3 (12), 1142-1149 (2002)
   PUBMED   12426565
  REMARK    Erratum:[Nat Immunol. 2004 Jun;5(6):658]
REFERENCE   7  (bases 1 to 3034)
  AUTHORS   Gilfillan,S., Ho,E.L., Cella,M., Yokoyama,W.M. and Colonna,M.
  TITLE     NKG2D recruits two distinct adapters to trigger NK cell activation
            and costimulation
  JOURNAL   Nat Immunol 3 (12), 1150-1155 (2002)
   PUBMED   12426564
REFERENCE   8  (bases 1 to 3034)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   9  (bases 1 to 3034)
  AUTHORS   Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
            Phillips,J.H.
  TITLE     An activating immunoreceptor complex formed by NKG2D and DAP10
  JOURNAL   Science 285 (5428), 730-732 (1999)
   PUBMED   10426994
REFERENCE   10 (bases 1 to 3034)
  AUTHORS   Nagai,Y., Kojima,T., Muro,Y., Hachiya,T., Nishizawa,Y.,
            Wakabayashi,T. and Hagiwara,M.
  TITLE     Identification of a novel nuclear speckle-type protein, SPOP
  JOURNAL   FEBS Lett 418 (1-2), 23-26 (1997)
   PUBMED   9414087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX282325.1, CB992730.1,
            BC001269.1, AK123385.1, W84567.1, BM693397.1, BQ226031.1 and
            AW449169.1.
            
            Summary: This gene encodes a protein that may modulate the
            transcriptional repression activities of death-associated protein 6
            (DAXX), which interacts with histone deacetylase, core histones,
            and other histone-associated proteins. In mouse, the encoded
            protein binds to the putative leucine zipper domain of macroH2A1.2,
            a variant H2A histone that is enriched on inactivated X
            chromosomes. The BTB/POZ domain of this protein has been shown in
            other proteins to mediate transcriptional repression and to
            interact with components of histone deacetylase co-repressor
            complexes. Alternative splicing of this gene results in multiple
            transcript variants encoding the same protein. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Transcript variants 1-6 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.50061.1,
                                           SRR1803611.154596.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               BX282325.1         1-231
            232-283             BX282325.1         354-405
            284-334             CB992730.1         256-306
            335-1885            BC001269.1         238-1788
            1886-1895           AK123385.1         1615-1624
            1896-1896           W84567.1           272-272
            1897-1897           BM693397.1         322-322
            1898-2406           AK123385.1         1625-2133
            2407-2619           BQ226031.1         245-457
            2620-3034           AW449169.1         1-415               c
FEATURES             Location/Qualifiers
     source          1..3034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..3034
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="speckle type BTB/POZ protein"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
     exon            1..231
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..283
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..334
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            335..478
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..1525
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="HIB homolog 1; roadkill homolog 1"
                     /codon_start=1
                     /product="speckle-type POZ protein"
                     /protein_id="NP_001007231.1"
                     /db_xref="CCDS:CCDS11551.1"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
                     /translation="MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFC
                     REEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKF
                     KFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCE
                     VSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAIL
                     AARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAA
                     ADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLE
                     TSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS"
     exon            479..600
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..752
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..880
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1058
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1114
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1237
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1380
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..3019
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2598..2603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: TATAAA"
     polyA_site      2619
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="major polyA site"
     regulatory      2995..3000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: AATAAA"
     polyA_site      3019
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
ORIGIN      
        1 ggggaggagg ccgcgcgggg tggggtctgg cggtacgcgc tggctgcgtc gacgtgctga
       61 cgccatgacg ccccggctgg tgtgtgtcgg tgtgtatgtg tgtgtgtgag tgtgcgcgct
      121 ccgagtgtgt gtgtatttgt gtatcggcgg tcccgcaggt cccggatgtt gcggacagta
      181 tgaggcaagc gcagggggac ggggaccagc agctgtcgcc gccgctctca ggctctggga
      241 accacccttc tactttctgt ctctaggaat ttcactactc tagagatttc ctgttagaca
      301 agacaaatta gagttttcct actgacttaa cttgggtgaa gagggaacag aaatctttgc
      361 cccctgactt tggaaatctc gtttaacctt caaactggcg atgtcaaggg ttccaagtcc
      421 tccacctccg gcagaaatgt cgagtggccc cgtagctgag agttggtgct acacacagat
      481 caaggtagtg aaattctcct acatgtggac catcaataac tttagctttt gccgggagga
      541 aatgggtgaa gtcattaaaa gttctacatt ttcatcagga gcaaatgata aactgaaatg
      601 gtgtttgcga gtaaacccca aagggttaga tgaagaaagc aaagattacc tgtcacttta
      661 cctgttactg gtcagctgtc caaagagtga agttcgggca aaattcaaat tctccatcct
      721 gaatgccaag ggagaagaaa ccaaagctat ggagagtcaa cgggcatata ggtttgtgca
      781 aggcaaagac tggggattca agaaattcat ccgtagagat tttcttttgg atgaggccaa
      841 cgggcttctc cctgatgaca agcttaccct cttctgcgag gtgagtgttg tgcaagattc
      901 tgtcaacatt tctggccaga ataccatgaa catggtaaag gttcctgagt gccggctggc
      961 agatgagtta ggaggactgt gggagaattc ccggttcaca gactgctgct tgtgtgttgc
     1021 cggccaggaa ttccaggctc acaaggctat cttagcagct cgttctccgg tttttagtgc
     1081 catgtttgaa catgaaatgg aggagagcaa aaagaatcga gttgaaatca atgatgtgga
     1141 gcctgaagtt tttaaggaaa tgatgtgctt catttacacg gggaaggctc caaacctcga
     1201 caaaatggct gatgatttgc tggcagctgc tgacaagtat gccctggagc gcttaaaggt
     1261 catgtgtgag gatgccctct gcagtaacct gtccgtggag aacgctgcag aaattctcat
     1321 cctggccgac ctccacagtg cagatcagtt gaaaactcag gcagtggatt tcatcaacta
     1381 tcatgcttcg gatgtcttgg agacctctgg gtggaagtca atggtggtgt cacatcccca
     1441 cttggtggct gaggcatacc gctctctggc ttcagcacag tgcccttttc tgggaccccc
     1501 acgcaaacgc ctgaagcaat cctaagatcc tgcttgttgt aagactccgt ttaatttcca
     1561 gaagcagcag ccactgttgc tgccactgac caccaggtag acagcgcaat ctgtggagct
     1621 tttactctgt tgtgagggga agagactgca ttgtggcccc agacttttaa aacagcacta
     1681 aataacttgg gggaaacggg gggagggaaa atgaaatgaa aaccctgttg ctgcgtcact
     1741 gtgttccctt tggcctggct gagtttgata ctgtggggat tcagtttagg cgctggcccg
     1801 aggatatccc agcggtggta cttcggagac acctgtctgc atctgactga gcagaacaaa
     1861 tcgtcaggtg cctggagcaa aaaggaaaaa aaaaaaagaa aggacattga gttttaacag
     1921 aagggaaaag gaaagaagaa aagatttttg cagaatttct caaaaatcag tttgtggatt
     1981 ccagtagtat ttatattgag agaaacaaat tttagtcctt ctaactgtgc taaaacttgg
     2041 atatttgtga aaactcctta ccaccataca agcatcagaa gagctctctt gttgttagca
     2101 cttattgttt gcaagaacag aatacatcct tttatccttt tatgaaaaat gacaagtgaa
     2161 ggcaaaaggg gaaggttatt tgatctggaa gatgagtgtt ctgatgtggt ggcttttgca
     2221 aaaatcttta ttggtgttga aaactggaaa aaataactca tccagaattc atattgtctt
     2281 gacaagaact atggttctct gtttttagat attgtggaaa atgtttttgg gcatttttct
     2341 ctgattttat ttcttctccc ccaccccttt ttctaaaaaa caaacaaaaa aaaaaacaca
     2401 caaaacaaaa acagaacaaa agaagagaga aggaaatttt atcaattaaa aatgctgtgt
     2461 gataaaatcc cagcccagat tgctcagctg tttgtacctg acttgccgcc tgcataggag
     2521 ccagttctgt tccttctgac tagcccctct tcctccaggg gagaacttcc aaatgttaat
     2581 tttttttttt ttgaaaatat aaataattac tattttgtac tgtgtggtat ctctggtctt
     2641 ttgtttcact cacctgcctt gtctcttggg tctgagtccc ttgcttaagg gattttgaag
     2701 tcctagtttt cagcttgcag agattatgtc tgaaatgcct aatgagtcgc agggatttgt
     2761 tgagactccg taatctcaag ttctctttgt gagctatcag catctgccag tctcttgtcc
     2821 tccctgagta tctcacagtc catatcctga tgagggatca ggcccctacc tctgccaagg
     2881 caagtaatgg tagtgggctt ttaaactgcc ccccgtatgt tttaagacct aatccccacc
     2941 tcccttcttc taactaaata taaaaagatc caggggacat aaatgtggag attaaataaa
     3001 gggaaattat tgtctctaaa aaaaaaaaaa aaaa
//
