LOCUS       NM_001007228            2850 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens speckle type BTB/POZ protein (SPOP), transcript
            variant 4, mRNA.
ACCESSION   NM_001007228
VERSION     NM_001007228.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2850)
  AUTHORS   Li,M., Cui,Y., Qi,Q., Liu,J., Li,J., Huang,G., Yang,J., Sun,J.,
            Ma,Z., Liang,S., Zhang,D., Jiang,J., Zhu,R., Liu,Q., Huang,R. and
            Yan,J.
  TITLE     SPOP downregulation promotes bladder cancer progression based on
            cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is
            regulated by VEZF1
  JOURNAL   Theranostics 14 (17), 6543-6559 (2024)
   PUBMED   39479456
  REMARK    GeneRIF: SPOP downregulation promotes bladder cancer progression
            based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis
            and is regulated by VEZF1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2850)
  AUTHORS   Lee,C.J., Lee,H., Kim,S.R., Nam,S.B., Lee,G.E., Yang,K.E.,
            Lee,G.J., Chun,S.H., Kang,H.C., Lee,J.Y., Lee,H.S., Cho,S.J. and
            Cho,Y.Y.
  TITLE     ELK3 destabilization by speckle-type POZ protein suppresses
            prostate cancer progression and docetaxel resistance
  JOURNAL   Cell Death Dis 15 (4), 274 (2024)
   PUBMED   38632244
  REMARK    GeneRIF: ELK3 destabilization by speckle-type POZ protein
            suppresses prostate cancer progression and docetaxel resistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2850)
  AUTHORS   Li,K., Zhang,J., Lyu,H., Yang,J., Wei,W., Wang,Y., Luo,H.,
            Zhang,Y., Jiang,X., Yi,H., Wang,M., Zhang,C., Wu,K., Xiao,L.,
            Wen,W., Xu,H., Li,G., Wan,Y., Yang,F., Yang,R., Fu,X., Qin,B.,
            Zhou,Z., Zhang,H. and Lee,M.H.
  TITLE     CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression
            via YAP1 Activation
  JOURNAL   Adv Sci (Weinh) 11 (14), e2306827 (2024)
   PUBMED   38308184
  REMARK    GeneRIF: CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma
            Progression via YAP1 Activation.
REFERENCE   4  (bases 1 to 2850)
  AUTHORS   Liu,F., Zhang,T., Sun,X., Liu,Z., Xu,W., Dai,X. and Zhang,X.
  TITLE     Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1
            promotes gastric cancer progression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167032 (2024)
   PUBMED   38246227
  REMARK    GeneRIF: Deficiency in SPOP-mediated ubiquitination and degradation
            of TIAM1 promotes gastric cancer progression.
REFERENCE   5  (bases 1 to 2850)
  AUTHORS   Yu,Z., Wu,X., Zhu,J., Yan,H., Li,Y., Zhang,H., Zhong,Y., Lin,M.,
            Ye,G., Li,X., Jin,J., Li,K., Wang,J., Zhuang,H., Lin,T., He,J.,
            Lu,C., Xu,Z., Zhang,X., Li,H. and Jin,X.
  TITLE     BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development
            and immune escape of hepatocellular carcinoma
  JOURNAL   Cell Mol Life Sci 81 (1), 82 (2024)
   PUBMED   38340178
  REMARK    GeneRIF: BCLAF1 binds SPOP to stabilize PD-L1 and promotes the
            development and immune escape of hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2850)
  AUTHORS   Diefenbach,A., Tomasello,E., Lucas,M., Jamieson,A.M., Hsia,J.K.,
            Vivier,E. and Raulet,D.H.
  TITLE     Selective associations with signaling proteins determine
            stimulatory versus costimulatory activity of NKG2D
  JOURNAL   Nat Immunol 3 (12), 1142-1149 (2002)
   PUBMED   12426565
  REMARK    Erratum:[Nat Immunol. 2004 Jun;5(6):658]
REFERENCE   7  (bases 1 to 2850)
  AUTHORS   Gilfillan,S., Ho,E.L., Cella,M., Yokoyama,W.M. and Colonna,M.
  TITLE     NKG2D recruits two distinct adapters to trigger NK cell activation
            and costimulation
  JOURNAL   Nat Immunol 3 (12), 1150-1155 (2002)
   PUBMED   12426564
REFERENCE   8  (bases 1 to 2850)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   9  (bases 1 to 2850)
  AUTHORS   Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
            Phillips,J.H.
  TITLE     An activating immunoreceptor complex formed by NKG2D and DAP10
  JOURNAL   Science 285 (5428), 730-732 (1999)
   PUBMED   10426994
REFERENCE   10 (bases 1 to 2850)
  AUTHORS   Nagai,Y., Kojima,T., Muro,Y., Hachiya,T., Nishizawa,Y.,
            Wakabayashi,T. and Hagiwara,M.
  TITLE     Identification of a novel nuclear speckle-type protein, SPOP
  JOURNAL   FEBS Lett 418 (1-2), 23-26 (1997)
   PUBMED   9414087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX282325.1, BC001269.1,
            AK123385.1, W84567.1, BM693397.1, BQ226031.1 and AW449169.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001007228.1.
            
            Summary: This gene encodes a protein that may modulate the
            transcriptional repression activities of death-associated protein 6
            (DAXX), which interacts with histone deacetylase, core histones,
            and other histone-associated proteins. In mouse, the encoded
            protein binds to the putative leucine zipper domain of macroH2A1.2,
            a variant H2A histone that is enriched on inactivated X
            chromosomes. The BTB/POZ domain of this protein has been shown in
            other proteins to mediate transcriptional repression and to
            interact with components of histone deacetylase co-repressor
            complexes. Alternative splicing of this gene results in multiple
            transcript variants encoding the same protein. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Transcript variants 1-6 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1597123.1,
                                           SRR18074967.2351554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504102.6/ ENSP00000425905.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               BX282325.1         67-231
            166-1716            BC001269.1         238-1788
            1717-1726           AK123385.1         1615-1624
            1727-1727           W84567.1           272-272
            1728-1728           BM693397.1         322-322
            1729-2237           AK123385.1         1625-2133
            2238-2450           BQ226031.1         245-457
            2451-2850           AW449169.1         16-415              c
FEATURES             Location/Qualifiers
     source          1..2850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..2850
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="speckle type BTB/POZ protein"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
     exon            1..165
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            166..309
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1356
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="HIB homolog 1; roadkill homolog 1"
                     /codon_start=1
                     /product="speckle-type POZ protein"
                     /protein_id="NP_001007229.1"
                     /db_xref="CCDS:CCDS11551.1"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
                     /translation="MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFC
                     REEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKF
                     KFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCE
                     VSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAIL
                     AARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAA
                     ADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLE
                     TSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS"
     exon            310..431
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..583
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..711
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..889
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..945
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1068
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1211
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..2850
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2429..2434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: TATAAA"
     polyA_site      2450
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="major polyA site"
     regulatory      2826..2831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: AATAAA"
     polyA_site      2850
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
ORIGIN      
        1 gacgccccgg ctggtgtgtg tcggtgtgta tgtgtgtgtg tgagtgtgcg cgctccgagt
       61 gtgtgtgtat ttgtgtatcg gcggtcccgc aggtcccgga tgttgcggac agtatgaggc
      121 aagcgcaggg ggacggggac cagcagctgt cgccgccgct ctcagggtga agagggaaca
      181 gaaatctttg ccccctgact ttggaaatct cgtttaacct tcaaactggc gatgtcaagg
      241 gttccaagtc ctccacctcc ggcagaaatg tcgagtggcc ccgtagctga gagttggtgc
      301 tacacacaga tcaaggtagt gaaattctcc tacatgtgga ccatcaataa ctttagcttt
      361 tgccgggagg aaatgggtga agtcattaaa agttctacat tttcatcagg agcaaatgat
      421 aaactgaaat ggtgtttgcg agtaaacccc aaagggttag atgaagaaag caaagattac
      481 ctgtcacttt acctgttact ggtcagctgt ccaaagagtg aagttcgggc aaaattcaaa
      541 ttctccatcc tgaatgccaa gggagaagaa accaaagcta tggagagtca acgggcatat
      601 aggtttgtgc aaggcaaaga ctggggattc aagaaattca tccgtagaga ttttcttttg
      661 gatgaggcca acgggcttct ccctgatgac aagcttaccc tcttctgcga ggtgagtgtt
      721 gtgcaagatt ctgtcaacat ttctggccag aataccatga acatggtaaa ggttcctgag
      781 tgccggctgg cagatgagtt aggaggactg tgggagaatt cccggttcac agactgctgc
      841 ttgtgtgttg ccggccagga attccaggct cacaaggcta tcttagcagc tcgttctccg
      901 gtttttagtg ccatgtttga acatgaaatg gaggagagca aaaagaatcg agttgaaatc
      961 aatgatgtgg agcctgaagt ttttaaggaa atgatgtgct tcatttacac ggggaaggct
     1021 ccaaacctcg acaaaatggc tgatgatttg ctggcagctg ctgacaagta tgccctggag
     1081 cgcttaaagg tcatgtgtga ggatgccctc tgcagtaacc tgtccgtgga gaacgctgca
     1141 gaaattctca tcctggccga cctccacagt gcagatcagt tgaaaactca ggcagtggat
     1201 ttcatcaact atcatgcttc ggatgtcttg gagacctctg ggtggaagtc aatggtggtg
     1261 tcacatcccc acttggtggc tgaggcatac cgctctctgg cttcagcaca gtgccctttt
     1321 ctgggacccc cacgcaaacg cctgaagcaa tcctaagatc ctgcttgttg taagactccg
     1381 tttaatttcc agaagcagca gccactgttg ctgccactga ccaccaggta gacagcgcaa
     1441 tctgtggagc ttttactctg ttgtgagggg aagagactgc attgtggccc cagactttta
     1501 aaacagcact aaataacttg ggggaaacgg ggggagggaa aatgaaatga aaaccctgtt
     1561 gctgcgtcac tgtgttccct ttggcctggc tgagtttgat actgtgggga ttcagtttag
     1621 gcgctggccc gaggatatcc cagcggtggt acttcggaga cacctgtctg catctgactg
     1681 agcagaacaa atcgtcaggt gcctggagca aaaaggaaaa aaaaaaaaga aaggacattg
     1741 agttttaaca gaagggaaaa ggaaagaaga aaagattttt gcagaatttc tcaaaaatca
     1801 gtttgtggat tccagtagta tttatattga gagaaacaaa ttttagtcct tctaactgtg
     1861 ctaaaacttg gatatttgtg aaaactcctt accaccatac aagcatcaga agagctctct
     1921 tgttgttagc acttattgtt tgcaagaaca gaatacatcc ttttatcctt ttatgaaaaa
     1981 tgacaagtga aggcaaaagg ggaaggttat ttgatctgga agatgagtgt tctgatgtgg
     2041 tggcttttgc aaaaatcttt attggtgttg aaaactggaa aaaataactc atccagaatt
     2101 catattgtct tgacaagaac tatggttctc tgtttttaga tattgtggaa aatgtttttg
     2161 ggcatttttc tctgatttta tttcttctcc cccacccctt tttctaaaaa acaaacaaaa
     2221 aaaaaaacac acaaaacaaa aacagaacaa aagaagagag aaggaaattt tatcaattaa
     2281 aaatgctgtg tgataaaatc ccagcccaga ttgctcagct gtttgtacct gacttgccgc
     2341 ctgcatagga gccagttctg ttccttctga ctagcccctc ttcctccagg ggagaacttc
     2401 caaatgttaa tttttttttt tttgaaaata taaataatta ctattttgta ctgtgtggta
     2461 tctctggtct tttgtttcac tcacctgcct tgtctcttgg gtctgagtcc cttgcttaag
     2521 ggattttgaa gtcctagttt tcagcttgca gagattatgt ctgaaatgcc taatgagtcg
     2581 cagggatttg ttgagactcc gtaatctcaa gttctctttg tgagctatca gcatctgcca
     2641 gtctcttgtc ctccctgagt atctcacagt ccatatcctg atgagggatc aggcccctac
     2701 ctctgccaag gcaagtaatg gtagtgggct tttaaactgc cccccgtatg ttttaagacc
     2761 taatccccac ctcccttctt ctaactaaat ataaaaagat ccaggggaca taaatgtgga
     2821 gattaaataa agggaaatta ttgtctctaa
//
