LOCUS       NM_001007226            3105 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens speckle type BTB/POZ protein (SPOP), transcript
            variant 1, mRNA.
ACCESSION   NM_001007226
VERSION     NM_001007226.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3105)
  AUTHORS   Li,M., Cui,Y., Qi,Q., Liu,J., Li,J., Huang,G., Yang,J., Sun,J.,
            Ma,Z., Liang,S., Zhang,D., Jiang,J., Zhu,R., Liu,Q., Huang,R. and
            Yan,J.
  TITLE     SPOP downregulation promotes bladder cancer progression based on
            cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is
            regulated by VEZF1
  JOURNAL   Theranostics 14 (17), 6543-6559 (2024)
   PUBMED   39479456
  REMARK    GeneRIF: SPOP downregulation promotes bladder cancer progression
            based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis
            and is regulated by VEZF1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3105)
  AUTHORS   Lee,C.J., Lee,H., Kim,S.R., Nam,S.B., Lee,G.E., Yang,K.E.,
            Lee,G.J., Chun,S.H., Kang,H.C., Lee,J.Y., Lee,H.S., Cho,S.J. and
            Cho,Y.Y.
  TITLE     ELK3 destabilization by speckle-type POZ protein suppresses
            prostate cancer progression and docetaxel resistance
  JOURNAL   Cell Death Dis 15 (4), 274 (2024)
   PUBMED   38632244
  REMARK    GeneRIF: ELK3 destabilization by speckle-type POZ protein
            suppresses prostate cancer progression and docetaxel resistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3105)
  AUTHORS   Li,K., Zhang,J., Lyu,H., Yang,J., Wei,W., Wang,Y., Luo,H.,
            Zhang,Y., Jiang,X., Yi,H., Wang,M., Zhang,C., Wu,K., Xiao,L.,
            Wen,W., Xu,H., Li,G., Wan,Y., Yang,F., Yang,R., Fu,X., Qin,B.,
            Zhou,Z., Zhang,H. and Lee,M.H.
  TITLE     CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression
            via YAP1 Activation
  JOURNAL   Adv Sci (Weinh) 11 (14), e2306827 (2024)
   PUBMED   38308184
  REMARK    GeneRIF: CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma
            Progression via YAP1 Activation.
REFERENCE   4  (bases 1 to 3105)
  AUTHORS   Liu,F., Zhang,T., Sun,X., Liu,Z., Xu,W., Dai,X. and Zhang,X.
  TITLE     Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1
            promotes gastric cancer progression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167032 (2024)
   PUBMED   38246227
  REMARK    GeneRIF: Deficiency in SPOP-mediated ubiquitination and degradation
            of TIAM1 promotes gastric cancer progression.
REFERENCE   5  (bases 1 to 3105)
  AUTHORS   Yu,Z., Wu,X., Zhu,J., Yan,H., Li,Y., Zhang,H., Zhong,Y., Lin,M.,
            Ye,G., Li,X., Jin,J., Li,K., Wang,J., Zhuang,H., Lin,T., He,J.,
            Lu,C., Xu,Z., Zhang,X., Li,H. and Jin,X.
  TITLE     BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development
            and immune escape of hepatocellular carcinoma
  JOURNAL   Cell Mol Life Sci 81 (1), 82 (2024)
   PUBMED   38340178
  REMARK    GeneRIF: BCLAF1 binds SPOP to stabilize PD-L1 and promotes the
            development and immune escape of hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3105)
  AUTHORS   Diefenbach,A., Tomasello,E., Lucas,M., Jamieson,A.M., Hsia,J.K.,
            Vivier,E. and Raulet,D.H.
  TITLE     Selective associations with signaling proteins determine
            stimulatory versus costimulatory activity of NKG2D
  JOURNAL   Nat Immunol 3 (12), 1142-1149 (2002)
   PUBMED   12426565
  REMARK    Erratum:[Nat Immunol. 2004 Jun;5(6):658]
REFERENCE   7  (bases 1 to 3105)
  AUTHORS   Gilfillan,S., Ho,E.L., Cella,M., Yokoyama,W.M. and Colonna,M.
  TITLE     NKG2D recruits two distinct adapters to trigger NK cell activation
            and costimulation
  JOURNAL   Nat Immunol 3 (12), 1150-1155 (2002)
   PUBMED   12426564
REFERENCE   8  (bases 1 to 3105)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   9  (bases 1 to 3105)
  AUTHORS   Wu,J., Song,Y., Bakker,A.B., Bauer,S., Spies,T., Lanier,L.L. and
            Phillips,J.H.
  TITLE     An activating immunoreceptor complex formed by NKG2D and DAP10
  JOURNAL   Science 285 (5428), 730-732 (1999)
   PUBMED   10426994
REFERENCE   10 (bases 1 to 3105)
  AUTHORS   Nagai,Y., Kojima,T., Muro,Y., Hachiya,T., Nishizawa,Y.,
            Wakabayashi,T. and Hagiwara,M.
  TITLE     Identification of a novel nuclear speckle-type protein, SPOP
  JOURNAL   FEBS Lett 418 (1-2), 23-26 (1997)
   PUBMED   9414087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX282325.1, BC001269.1,
            AK123385.1, W84567.1, BM693397.1, BQ226031.1 and AW449169.1.
            
            Summary: This gene encodes a protein that may modulate the
            transcriptional repression activities of death-associated protein 6
            (DAXX), which interacts with histone deacetylase, core histones,
            and other histone-associated proteins. In mouse, the encoded
            protein binds to the putative leucine zipper domain of macroH2A1.2,
            a variant H2A histone that is enriched on inactivated X
            chromosomes. The BTB/POZ domain of this protein has been shown in
            other proteins to mediate transcriptional repression and to
            interact with components of histone deacetylase co-repressor
            complexes. Alternative splicing of this gene results in multiple
            transcript variants encoding the same protein. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Transcript variants 1-6 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.95139.1,
                                           SRR1803616.131754.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               BX282325.1         1-405
            406-1956            BC001269.1         238-1788
            1957-1966           AK123385.1         1615-1624
            1967-1967           W84567.1           272-272
            1968-1968           BM693397.1         322-322
            1969-2477           AK123385.1         1625-2133
            2478-2690           BQ226031.1         245-457
            2691-3105           AW449169.1         1-415               c
FEATURES             Location/Qualifiers
     source          1..3105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..3105
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="speckle type BTB/POZ protein"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
     exon            1..231
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..353
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..405
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            406..549
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..1596
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="HIB homolog 1; roadkill homolog 1"
                     /codon_start=1
                     /product="speckle-type POZ protein"
                     /protein_id="NP_001007227.1"
                     /db_xref="CCDS:CCDS11551.1"
                     /db_xref="GeneID:8405"
                     /db_xref="HGNC:HGNC:11254"
                     /db_xref="MIM:602650"
                     /translation="MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFC
                     REEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKF
                     KFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCE
                     VSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAIL
                     AARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAA
                     ADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLE
                     TSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS"
     exon            550..671
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..823
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..951
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1129
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1185
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1308
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1451
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..3090
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2669..2674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: TATAAA"
     polyA_site      2690
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="major polyA site"
     regulatory      3066..3071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
                     /note="hexamer: AATAAA"
     polyA_site      3090
                     /gene="SPOP"
                     /gene_synonym="BTBD32; NEDMACE; NEDMIDF; NSDVS1; NSDVS2;
                     TEF2"
ORIGIN      
        1 ggggaggagg ccgcgcgggg tggggtctgg cggtacgcgc tggctgcgtc gacgtgctga
       61 cgccatgacg ccccggctgg tgtgtgtcgg tgtgtatgtg tgtgtgtgag tgtgcgcgct
      121 ccgagtgtgt gtgtatttgt gtatcggcgg tcccgcaggt cccggatgtt gcggacagta
      181 tgaggcaagc gcagggggac ggggaccagc agctgtcgcc gccgctctca gatcgagtct
      241 tgctctgtca cccaggctgg agtgcagtgg cgcgatctca gctcactgcc acctttgcct
      301 cctgggttca agcgattctt ctgcctcagc ctcccgagta gctgggatta caggctctgg
      361 gaaccaccct tctactttct gtctctagga atttcactac tctagggtga agagggaaca
      421 gaaatctttg ccccctgact ttggaaatct cgtttaacct tcaaactggc gatgtcaagg
      481 gttccaagtc ctccacctcc ggcagaaatg tcgagtggcc ccgtagctga gagttggtgc
      541 tacacacaga tcaaggtagt gaaattctcc tacatgtgga ccatcaataa ctttagcttt
      601 tgccgggagg aaatgggtga agtcattaaa agttctacat tttcatcagg agcaaatgat
      661 aaactgaaat ggtgtttgcg agtaaacccc aaagggttag atgaagaaag caaagattac
      721 ctgtcacttt acctgttact ggtcagctgt ccaaagagtg aagttcgggc aaaattcaaa
      781 ttctccatcc tgaatgccaa gggagaagaa accaaagcta tggagagtca acgggcatat
      841 aggtttgtgc aaggcaaaga ctggggattc aagaaattca tccgtagaga ttttcttttg
      901 gatgaggcca acgggcttct ccctgatgac aagcttaccc tcttctgcga ggtgagtgtt
      961 gtgcaagatt ctgtcaacat ttctggccag aataccatga acatggtaaa ggttcctgag
     1021 tgccggctgg cagatgagtt aggaggactg tgggagaatt cccggttcac agactgctgc
     1081 ttgtgtgttg ccggccagga attccaggct cacaaggcta tcttagcagc tcgttctccg
     1141 gtttttagtg ccatgtttga acatgaaatg gaggagagca aaaagaatcg agttgaaatc
     1201 aatgatgtgg agcctgaagt ttttaaggaa atgatgtgct tcatttacac ggggaaggct
     1261 ccaaacctcg acaaaatggc tgatgatttg ctggcagctg ctgacaagta tgccctggag
     1321 cgcttaaagg tcatgtgtga ggatgccctc tgcagtaacc tgtccgtgga gaacgctgca
     1381 gaaattctca tcctggccga cctccacagt gcagatcagt tgaaaactca ggcagtggat
     1441 ttcatcaact atcatgcttc ggatgtcttg gagacctctg ggtggaagtc aatggtggtg
     1501 tcacatcccc acttggtggc tgaggcatac cgctctctgg cttcagcaca gtgccctttt
     1561 ctgggacccc cacgcaaacg cctgaagcaa tcctaagatc ctgcttgttg taagactccg
     1621 tttaatttcc agaagcagca gccactgttg ctgccactga ccaccaggta gacagcgcaa
     1681 tctgtggagc ttttactctg ttgtgagggg aagagactgc attgtggccc cagactttta
     1741 aaacagcact aaataacttg ggggaaacgg ggggagggaa aatgaaatga aaaccctgtt
     1801 gctgcgtcac tgtgttccct ttggcctggc tgagtttgat actgtgggga ttcagtttag
     1861 gcgctggccc gaggatatcc cagcggtggt acttcggaga cacctgtctg catctgactg
     1921 agcagaacaa atcgtcaggt gcctggagca aaaaggaaaa aaaaaaaaga aaggacattg
     1981 agttttaaca gaagggaaaa ggaaagaaga aaagattttt gcagaatttc tcaaaaatca
     2041 gtttgtggat tccagtagta tttatattga gagaaacaaa ttttagtcct tctaactgtg
     2101 ctaaaacttg gatatttgtg aaaactcctt accaccatac aagcatcaga agagctctct
     2161 tgttgttagc acttattgtt tgcaagaaca gaatacatcc ttttatcctt ttatgaaaaa
     2221 tgacaagtga aggcaaaagg ggaaggttat ttgatctgga agatgagtgt tctgatgtgg
     2281 tggcttttgc aaaaatcttt attggtgttg aaaactggaa aaaataactc atccagaatt
     2341 catattgtct tgacaagaac tatggttctc tgtttttaga tattgtggaa aatgtttttg
     2401 ggcatttttc tctgatttta tttcttctcc cccacccctt tttctaaaaa acaaacaaaa
     2461 aaaaaaacac acaaaacaaa aacagaacaa aagaagagag aaggaaattt tatcaattaa
     2521 aaatgctgtg tgataaaatc ccagcccaga ttgctcagct gtttgtacct gacttgccgc
     2581 ctgcatagga gccagttctg ttccttctga ctagcccctc ttcctccagg ggagaacttc
     2641 caaatgttaa tttttttttt tttgaaaata taaataatta ctattttgta ctgtgtggta
     2701 tctctggtct tttgtttcac tcacctgcct tgtctcttgg gtctgagtcc cttgcttaag
     2761 ggattttgaa gtcctagttt tcagcttgca gagattatgt ctgaaatgcc taatgagtcg
     2821 cagggatttg ttgagactcc gtaatctcaa gttctctttg tgagctatca gcatctgcca
     2881 gtctcttgtc ctccctgagt atctcacagt ccatatcctg atgagggatc aggcccctac
     2941 ctctgccaag gcaagtaatg gtagtgggct tttaaactgc cccccgtatg ttttaagacc
     3001 taatccccac ctcccttctt ctaactaaat ataaaaagat ccaggggaca taaatgtgga
     3061 gattaaataa agggaaatta ttgtctctaa aaaaaaaaaa aaaaa
//
