LOCUS       NM_006108               5052 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens spondin 1 (SPON1), mRNA.
ACCESSION   NM_006108 NM_032720
VERSION     NM_006108.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5052)
  AUTHORS   Miyakawa,R., Kobayashi,M., Sugimoto,K., Endo,Y., Kojima,M.,
            Kobayashi,Y., Furukawa,S., Honda,T., Watanabe,T., Asano,S.,
            Soeda,S., Hashimoto,Y., Fujimori,K. and Chiba,H.
  TITLE     SPON1 is an independent prognostic biomarker for ovarian cancer
  JOURNAL   J Ovarian Res 16 (1), 95 (2023)
   PUBMED   37179355
  REMARK    GeneRIF: SPON1 is an independent prognostic biomarker for ovarian
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5052)
  AUTHORS   Huo,Y., Yang,J., Zheng,J., Xu,D., Yang,M., Tao,L., Yao,H., Fu,X.,
            Yang,J., Liu,D., Hua,R., Zhang,J., Sun,Y., Hu,L. and Liu,W.
  TITLE     Increased SPON1 promotes pancreatic ductal adenocarcinoma
            progression by enhancing IL-6 trans-signalling
  JOURNAL   Cell Prolif 55 (5), e13237 (2022)
   PUBMED   35487760
  REMARK    GeneRIF: Increased SPON1 promotes pancreatic ductal adenocarcinoma
            progression by enhancing IL-6 trans-signalling.
REFERENCE   3  (bases 1 to 5052)
  AUTHORS   Tamjidifar,R., Akbari,M., Tarzi,S., Sadeghzadeh,M., Abolghasemi,M.,
            Poursaei,E., Shomali,N. and Mahdavi,F.
  TITLE     Prognostic and Diagnostic Values of miR-506 and SPON 1 in
            Colorectal Cancer with Clinicopathological Considerations
  JOURNAL   J Gastrointest Cancer 52 (1), 125-129 (2021)
   PUBMED   31927744
  REMARK    GeneRIF: Prognostic and Diagnostic Values of miR-506 and SPON 1 in
            Colorectal Cancer with Clinicopathological Considerations.
REFERENCE   4  (bases 1 to 5052)
  AUTHORS   Ma,W., Chen,K., Xiao,W., Tang,H., Wang,S. and Wang,K.
  TITLE     Evaluation of relationship between SPON1 gene and genetic
            susceptibility of postmenopausal osteoporosis
  JOURNAL   Artif Cells Nanomed Biotechnol 48 (1), 818-823 (2020)
   PUBMED   32484721
  REMARK    GeneRIF: Evaluation of relationship between SPON1 gene and genetic
            susceptibility of postmenopausal osteoporosis.
REFERENCE   5  (bases 1 to 5052)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5052)
  AUTHORS   Pyle-Chenault,R.A., Stolk,J.A., Molesh,D.A., Boyle-Harlan,D.,
            McNeill,P.D., Repasky,E.A., Jiang,Z., Fanger,G.R. and Xu,J.
  TITLE     VSGP/F-spondin: a new ovarian cancer marker
  JOURNAL   Tumour Biol 26 (5), 245-257 (2005)
   PUBMED   16103746
  REMARK    GeneRIF: expression profile of VSGP/F-spondin identifies this
            molecule as a potential diagnostic marker or target for developing
            therapeutic strategies to treat ovarian carcinoma
REFERENCE   7  (bases 1 to 5052)
  AUTHORS   Ho,A. and Sudhof,T.C.
  TITLE     Binding of F-spondin to amyloid-beta precursor protein: a candidate
            amyloid-beta precursor protein ligand that modulates amyloid-beta
            precursor protein cleavage
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2548-2553 (2004)
   PUBMED   14983046
REFERENCE   8  (bases 1 to 5052)
  AUTHORS   Gonzalez de Peredo,A., Klein,D., Macek,B., Hess,D.,
            Peter-Katalinic,J. and Hofsteenge,J.
  TITLE     C-mannosylation and o-fucosylation of thrombospondin type 1 repeats
  JOURNAL   Mol Cell Proteomics 1 (1), 11-18 (2002)
   PUBMED   12096136
REFERENCE   9  (bases 1 to 5052)
  AUTHORS   Miyamoto,K., Morishita,Y., Yamazaki,M., Minamino,N., Kangawa,K.,
            Matsuo,H., Mizutani,T., Yamada,K. and Minegishi,T.
  TITLE     Isolation and characterization of vascular smooth muscle cell
            growth promoting factor from bovine ovarian follicular fluid and
            its cDNA cloning from bovine and human ovary
  JOURNAL   Arch Biochem Biophys 390 (1), 93-100 (2001)
   PUBMED   11368520
REFERENCE   10 (bases 1 to 5052)
  AUTHORS   Klar,A., Baldassare,M. and Jessell,T.M.
  TITLE     F-spondin: a gene expressed at high levels in the floor plate
            encodes a secreted protein that promotes neural cell adhesion and
            neurite extension
  JOURNAL   Cell 69 (1), 95-110 (1992)
   PUBMED   1555244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291780.1, AB018305.2 and BQ026865.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006108.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.147701.1,
                                           SRR1803611.213743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000576479.4/ ENSP00000460236.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2821              AK291780.1         35-2855
            2822-4730           AB018305.2         2393-4301
            4731-5052           BQ026865.1         17-338              c
FEATURES             Location/Qualifiers
     source          1..5052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..5052
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /note="spondin 1"
                     /db_xref="GeneID:10418"
                     /db_xref="HGNC:HGNC:11252"
                     /db_xref="MIM:604989"
     exon            1..420
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2606
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /note="spondin 1, (f-spondin) extracellular matrix
                     protein; vascular smooth muscle cell growth-promoting
                     factor; spondin 1, extracellular matrix protein"
                     /codon_start=1
                     /product="spondin-1 precursor"
                     /protein_id="NP_006099.2"
                     /db_xref="CCDS:CCDS73262.1"
                     /db_xref="GeneID:10418"
                     /db_xref="HGNC:HGNC:11252"
                     /db_xref="MIM:604989"
                     /translation="MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYC
                     SRILRAQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENR
                     EGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILK
                     ASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEK
                     THPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQS
                     DEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAED
                     LCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDP
                     EGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSP
                     WSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWI
                     TWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGE
                     WDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWS
                     DCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSECNK
                     SCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRS
                     EQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKE
                     IRACNVHPC"
     exon            421..527
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            528..661
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            662..735
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            736..858
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1007
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1072
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1274
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1415
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1491
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1674
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1845
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2013
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2178
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2442
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..5052
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4705..4710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /note="hexamer: AATAAA"
     polyA_site      4728
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /note="major polyA site"
     regulatory      4988..4993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /note="hexamer: AATAAA"
     regulatory      5024..5029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /note="hexamer: AATAAA"
     polyA_site      5029
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
                     /note="major polyA site"
     polyA_site      5052
                     /gene="SPON1"
                     /gene_synonym="f-spondin; VSGP/F-spondin"
ORIGIN      
        1 agctcagcgc agctccgcgg ccgccaagcc gaggcgggca cggtctccga gtcgcggacg
       61 ccagctccga gctccctctc tccgccgcgc ctccgccagg tcgcgccttc gtcgggacca
      121 cttcgggcag gagtcgcgtg gcgaaggcct gcggccgcgg cacaaagttg ggggccgcga
      181 agatgaggct gtccccggcg cccctgaagc tgagccggac tccggcactg ctggccctgg
      241 cgctgcccct ggccgcggcg ctggccttct ccgacgagac cctggacaaa gtgcccaagt
      301 cagagggcta ctgcagccgt atcctgcgcg cccagggcac gcggcgcgag ggctacaccg
      361 agttcagcct ccgcgtggag ggcgaccccg acttctacaa gccgggaacc agctaccgcg
      421 taacactttc agctgctcct ccctcctact tcagaggatt cacattaatt gccctcagag
      481 agaacagaga gggtgataag gaagaagacc atgctgggac cttccagatc atagacgaag
      541 aagaaactca gtttatgagc aattgccctg ttgcagtcac tgaaagcact ccacggagga
      601 ggacccggat ccaggtgttt tggatagcac caccagcggg aacaggctgc gtgattctga
      661 aggccagcat cgtacaaaaa cgcattattt attttcaaga tgagggctct ctgaccaaga
      721 aactttgtga acaagattcc acatttgatg gggtgactga caaacccatc ttagactgct
      781 gtgcctgcgg aactgccaag tacagactca cattttatgg gaattggtcc gagaagacac
      841 acccaaagga ttaccctcgt cgggccaacc actggtctgc gatcatcgga ggatcccact
      901 ccaagaatta tgtactgtgg gaatatggag gatatgccag cgaaggcgtc aaacaagttg
      961 cagaattggg ctcacccgtg aaaatggagg aagaaattcg acaacagagt gatgaggtcc
     1021 tcaccgtcat caaagccaaa gcccaatggc cagcctggca gcctctcaac gtgagagcag
     1081 caccttcagc tgaattttcc gtggacagaa cgcgccattt aatgtccttc ctgaccatga
     1141 tgggccctag tcccgactgg aacgtaggct tatctgcaga agatctgtgc accaaggaat
     1201 gtggctgggt ccagaaggtg gtgcaagacc tgattccctg ggacgctggc accgacagcg
     1261 gggtgaccta tgagtcaccc aacaaaccca ccattcccca ggagaaaatc cggcccctga
     1321 ccagcctgga ccatcctcag agtcctttct atgacccaga gggtgggtcc atcactcaag
     1381 tagccagagt tgtcatcgag agaatcgcac ggaagggtga acaatgcaat attgtacctg
     1441 acaatgtcga tgatattgta gctgacctgg ctccagaaga gaaagatgaa gatgacaccc
     1501 ctgaaacctg catctactcc aactggtccc catggtccgc ctgcagctcc tccacctgtg
     1561 acaaaggcaa gaggatgcga cagcgcatgc tgaaagcaca gctggacctc agcgtcccct
     1621 gccctgacac ccaggacttc cagccctgca tgggccctgg ctgcagtgac gaagacggct
     1681 ccacctgcac catgtccgag tggatcacct ggtcgccctg cagcatctcc tgcggcatgg
     1741 gcatgaggtc ccgggagagg tatgtgaagc agttcccgga ggacggctcc gtgtgcacgc
     1801 tgcccactga ggaaacggag aagtgcacgg tcaacgagga gtgctctccc agcagctgcc
     1861 tgatgaccga gtggggcgag tgggacgagt gcagcgccac ctgcggcatg ggcatgaaga
     1921 agcggcaccg catgatcaag atgaaccccg cagatggctc catgtgcaaa gccgagacat
     1981 cacaggcaga gaagtgcatg atgccagagt gccacaccat cccatgcttg ctgtccccat
     2041 ggtccgagtg gagtgactgc agcgtgacct gcgggaaggg catgcgaacc cgacagcgga
     2101 tgctcaagtc tctggcagaa cttggagact gcaatgagga tctggagcag gtggagaagt
     2161 gcatgctccc tgaatgcccc attgactgtg agctcaccga gtggtcccag tggtcggaat
     2221 gtaacaagtc atgtgggaaa ggccacgtga ttcgaacccg gatgatccaa atggagcctc
     2281 agtttggagg tgcaccctgc ccagagactg tgcagcgaaa aaagtgccgc atccgaaaat
     2341 gccttcgaaa tccatccatc caaaagctac gctggaggga ggcccgagag agccggcgga
     2401 gtgagcagct gaaggaagag tctgaagggg agcagttccc aggttgtagg atgcgcccat
     2461 ggacggcctg gtcagaatgc accaaactgt gcggaggtgg aattcaggaa cgttacatga
     2521 ctgtaaagaa gagattcaaa agctcccagt ttaccagctg caaagacaag aaggagatca
     2581 gagcatgcaa tgttcatcct tgttagcaag ggtacgagtt ccccagggct gcactctaga
     2641 ttccagagtc accaatggct ggattatttg cttgtttaag acaatttaaa ttgtgtacgc
     2701 tagttttcat ttttgcagtg tggttcgccc agtagtcttg tggatgccag agacatcctt
     2761 tctgaatact tcttgatggg tacaggctga gtggggcgcc ctcacctcca gccagcctct
     2821 tcctgcagag gagtagtgtc agccaccttg tactaagctg aaacatgtcc ctctggagct
     2881 tccacctggc cagggaggac ggagactttg acctactcca catggagagg caaccatgtc
     2941 tggaagtgac tatgcctgag tcccagggtg cggcaggtag gaaacattca cagatgaaga
     3001 cagcagattc cccacattct catctttggc ctgttcaatg aaaccattgt ttgcccatct
     3061 cttcttagtg gaactttagg tctcttttca agtctcctca gtcatcaata gttcctgggg
     3121 aaaaacagag ctggtagact tgaagaggag cattgatgtt gggtggcttt tgttctttca
     3181 ctgagaaatt cggaatacat ttgtctcacc cctgatattg gttcctgatg cccccccaac
     3241 aaaaataaat aaataaatta tggctgcttt atttaaatat aaggtagcta gtttttacac
     3301 ctgagataaa taataagctt agagtgtatt tttcccttgc ttttgggggt tcagaggagt
     3361 atgtacaatt cttctgggaa gccagccttc tgaacttttt ggtactaaat ccttattgga
     3421 accaagacaa aggaagcaaa attggtctct ttagagacca atttgcctaa attttaaaat
     3481 cttcctacac acatctagac gttcaagttt gcaaatcagt ttttagcaag aaaacatttt
     3541 tgctatacaa acattttgct aagtctgccc aaagcccccc caatgcattc cttcaacaaa
     3601 atacaatctc tgtactttaa agttatttta gtcatgaaat tttatatgca gagagaaaaa
     3661 gttaccgaga cagaaaacaa atctaaggga aaggaatatt atgggattaa gctgagcaag
     3721 caattctggt ggaaagtcaa acctgtcagt gctccacacc agggctgtgg tcctcccaga
     3781 catgcatagg aatggccaca ggtttacact gccttcccag caattataag cacaccagat
     3841 tcagggagac tgaccaccaa gggatagtgt aaaaggacat tttctcagtt gggtccatca
     3901 gcagtttttc ttcctgcatt tattgttgaa aactattgtt tcatttcttc ttttataggc
     3961 cttattactg cttaatccaa atgtgtacca ttggtgagac acatacaatg ctctgaatac
     4021 actacgaatt tgtattaaac acatcagaat atttccaaat acaacatagt atagtcctga
     4081 atatgtactt ttaacacaag agagactatt caataaaaac tcactgggtc tttcatgtct
     4141 ttaagctaag taagtgttca gaaggttctt ttttatattg tcctccacct ccatcatttt
     4201 caataaaaga tagggctttt gctcccttgt tcttggaggg accattatta catctctgaa
     4261 ctacctttgt atccaacatg ttttaaatcc ttaaatgaat tgctttctcc caaaaaaagc
     4321 acaatataaa gaaacacaag atttaattat ttttctactt ggggggaaaa aagtcctcat
     4381 gtagaagcac ccacttttgc aatgttgttc taagctatct atctaactct cagcccatga
     4441 taaagttcct taagctggtg attcctaatc aaggacaagc caccctagtg tctcatgttt
     4501 gtatttggtc ccagttgggt acattttaaa atcctgattt tggagactta aaaccaggtt
     4561 aatggctaag aatgggtaac atgactcttg ttggattgtt attttttgtt tgcaatgggg
     4621 aatttataag aagcatcaag tctctttctt accaaagtct tgttaggtgg tttatagttc
     4681 ttttggctaa caaatcattt tggaaataaa gattttttac tacaaaaatg aaatttgttt
     4741 ggacttccac ttgagacagt aaagagagta ttagacaccc agtaaaaact gccatataaa
     4801 gaagttgtaa ttgtttgttg tgtatgtatt tttttcaatg ccaaaccagc tgtgatccaa
     4861 tttacatcca cattttaggt ccaacagcaa gaagttcaga gagagatttc ccaaccagac
     4921 attgggtcac tcactggtca ccttgccagt gcattttatt agaagggaat ctgttgtagc
     4981 aaatgggaat aaacctgggt ttctatagac ccagaactga aaaaataaac atcgtgctgt
     5041 ttttaatttg aa
//
