LOCUS       NM_001040159            2884 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens SPARC (osteonectin), cwcv and kazal like domains
            proteoglycan 3 (SPOCK3), transcript variant 1, mRNA.
ACCESSION   NM_001040159
VERSION     NM_001040159.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2884)
  AUTHORS   Xiao,M., Xue,J. and Jin,E.
  TITLE     SPOCK: Master regulator of malignant tumors (Review)
  JOURNAL   Mol Med Rep 30 (6) (2024)
   PUBMED   39392048
  REMARK    GeneRIF: SPOCK: Master regulator of malignant tumors (Review).
            Review article
REFERENCE   2  (bases 1 to 2884)
  AUTHORS   Oveisgharan,S., Yu,L., de Paiva Lopes,K., Tasaki,S., Wang,Y.,
            Menon,V., Schneider,J.A., Seyfried,N.T. and Bennett,D.A.
  TITLE     Proteins linking APOE varepsilon4 with Alzheimer's disease
  JOURNAL   Alzheimers Dement 20 (7), 4499-4511 (2024)
   PUBMED   38856164
  REMARK    GeneRIF: Proteins linking APOE varepsilon4 with Alzheimer's
            disease.
REFERENCE   3  (bases 1 to 2884)
  AUTHORS   Luo,J., Lai,C., Xu,X., Shi,J., Hu,J., Guo,K., Mulati,Y., Xiao,Y.,
            Kong,D., Liu,C. and Xu,K.
  TITLE     Mechanism of prognostic marker SPOCK3 affecting malignant
            progression of prostate cancer and construction of prognostic model
  JOURNAL   BMC Cancer 23 (1), 741 (2023)
   PUBMED   37563543
  REMARK    GeneRIF: Mechanism of prognostic marker SPOCK3 affecting malignant
            progression of prostate cancer and construction of prognostic
            model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2884)
  AUTHORS   Ouni,E., Ruys,S.P.D., Dolmans,M.M., Herinckx,G., Vertommen,D. and
            Amorim,C.A.
  TITLE     Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An
            MS-Friendly Approach to Proteomic Matrisome Characterization
  JOURNAL   Int J Mol Sci 21 (23), 9141 (2020)
   PUBMED   33266304
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2884)
  AUTHORS   Weber,H., Scholz,C.J., Jacob,C.P., Heupel,J., Kittel-Schneider,S.,
            Erhardt,A., Hempel,S., Schmidt,B., Kiel,T., Gessner,A., Lesch,K.P.
            and Reif,A.
  TITLE     SPOCK3, a risk gene for adult ADHD and personality disorders
  JOURNAL   Eur Arch Psychiatry Clin Neurosci 264 (5), 409-421 (2014)
   PUBMED   24292267
  REMARK    GeneRIF: The results of this study suggest that SPOCK3 may modify
            the genetic risk for Attention-deficit/hyperactivity disorder and
            personality disorders
REFERENCE   6  (bases 1 to 2884)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   7  (bases 1 to 2884)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 2884)
  AUTHORS   Kamioka,M., Imamura,J., Komatsu,N., Daibata,M. and Sugiura,T.
  TITLE     Testican 3 expression in adult T-cell leukemia
  JOURNAL   Leuk Res 33 (7), 913-918 (2009)
   PUBMED   19144404
  REMARK    GeneRIF: High expression of testican 3 is associated with adult
            T-cell leukemia.
REFERENCE   9  (bases 1 to 2884)
  AUTHORS   Nakada,M., Miyamori,H., Yamashita,J. and Sato,H.
  TITLE     Testican 2 abrogates inhibition of membrane-type matrix
            metalloproteinases by other testican family proteins
  JOURNAL   Cancer Res 63 (12), 3364-3369 (2003)
   PUBMED   12810672
REFERENCE   10 (bases 1 to 2884)
  AUTHORS   Nakada,M., Yamada,A., Takino,T., Miyamori,H., Takahashi,T.,
            Yamashita,J. and Sato,H.
  TITLE     Suppression of membrane-type 1 matrix metalloproteinase
            (MMP)-mediated MMP-2 activation and tumor invasion by testican 3
            and its splicing variant gene product, N-Tes
  JOURNAL   Cancer Res 61 (24), 8896-8902 (2001)
   PUBMED   11751414
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003017.1 and AC020599.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001040159.1.
            
            Summary: This gene encodes a member of a novel family of
            calcium-binding proteoglycan proteins that contain thyroglobulin
            type-1 and Kazal-like domains. The encoded protein and may play a
            role in adult T-cell leukemia by inhibiting the activity of
            membrane-type matrix metalloproteinases. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon compared to variant 2. The resulting isoform (1) has the same
            N- and C-termini but is shorter compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.54445.1,
                                           SRR1660803.106898.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357545.9/ ENSP00000350153.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1397              BC003017.1         48-1444
            1398-2884           AC020599.4         126579-128065
FEATURES             Location/Qualifiers
     source          1..2884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     gene            1..2884
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /note="SPARC (osteonectin), cwcv and kazal like domains
                     proteoglycan 3"
                     /db_xref="GeneID:50859"
                     /db_xref="HGNC:HGNC:13565"
                     /db_xref="MIM:607989"
     exon            1..45
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1347
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sparc/osteonectin, cwcv and kazal-like domains
                     proteoglycan (testican) 3; SPARC/osteonectin, cwcv and
                     kazal like domains proteoglycan 3"
                     /codon_start=1
                     /product="testican-3 isoform 1 precursor"
                     /protein_id="NP_001035249.1"
                     /db_xref="CCDS:CCDS34095.1"
                     /db_xref="GeneID:50859"
                     /db_xref="HGNC:HGNC:13565"
                     /db_xref="MIM:607989"
                     /translation="MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQW
                     LTTISQYDKEVGQWNKFRDDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQD
                     SQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCK
                     LEYQACVLGKQISVKCEGHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALH
                     ESGSQNKKTKTLLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLD
                     KNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQY
                     IPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDF
                     HEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHDVYI"
     exon            46..234
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     exon            235..280
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     exon            281..395
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     exon            396..519
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     exon            520..634
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..754
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     exon            755..976
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1039
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1177
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..2884
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2863..2868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /note="hexamer: AATAAA"
     polyA_site      2884
                     /gene="SPOCK3"
                     /gene_synonym="HSAJ1454; TES-3; TICN3"
                     /note="major polyA site"
ORIGIN      
        1 gcatttccag caggagctgc gagcacagtg ctggctcaca acaagatgct caaggtgtca
       61 gccgtactgt gtgtgtgtgc agccgcttgg tgcagtcagt ctctcgcagc tgccgcggcg
      121 gtggctgcag ccggggggcg gtcggacggc ggtaattttc tggatgataa acaatggctc
      181 accacaatct ctcagtatga caaggaagtc ggacagtgga acaaattccg agacgatgat
      241 tatttccgca cttggagtcc aggaaaaccc ttcgatcagg ctttagatcc agctaaggat
      301 ccatgcttaa agatgaaatg tagtcgccat aaagtatgca ttgctcaaga ttctcagact
      361 gcagtctgca ttagtcaccg gaggcttaca cacaggatga aagaagcagg agtagaccat
      421 aggcagtgga ggggtcccat attatccacc tgcaagcagt gcccagtggt ctatcccagc
      481 cctgtttgtg gttcagatgg tcatacctac tcttttcagt gcaaactaga atatcaggca
      541 tgtgtcttag gaaaacagat ctcagtcaaa tgtgaaggac attgcccatg tccttcagat
      601 aagcccacca gtacaagcag aaatgttaag agagcatgca gtgacctgga gttcagggaa
      661 gtggcaaaca gattgcggga ctggttcaag gcccttcatg aaagtggaag tcaaaacaag
      721 aagacaaaaa cattgctgag gcctgagaga agcagattcg ataccagcat cttgccaatt
      781 tgcaaggact cacttggctg gatgtttaac agacttgata caaactatga cctgctattg
      841 gaccagtcag agctcagaag catttacctt gataagaatg aacagtgtac caaggcattc
      901 ttcaattctt gtgacacata caaggacagt ttaatatcta ataatgagtg gtgctactgc
      961 ttccagagac agcaagaccc accttgccag actgagctca gcaatattca gaagcggcaa
     1021 ggggtaaaga agctcctagg acagtatatc cccctgtgtg atgaagatgg ttactacaag
     1081 ccaacacaat gtcatggcag tgttggacag tgctggtgtg ttgacagata tggaaatgaa
     1141 gtcatgggat ccagaataaa tggtgttgca gattgtgcta tagattttga gatctccgga
     1201 gattttgcta gtggcgattt tcatgaatgg actgatgatg aggatgatga agacgatatt
     1261 atgaatgatg aagatgaaat tgaagatgat gatgaagatg aaggggatga tgatgatggt
     1321 ggtgatgacc atgatgtata catttgattg atgacagttg aaatcaataa attctacatt
     1381 tctaatattt acaaaaatga tagcctattt aaaattatct tcttccccaa taacaaaatg
     1441 attctaaacc tcacatatat tttgtataat tatttgaaaa attgcagcta aagttataga
     1501 actttatgtt taaataagaa tcatttgctt tgagttttta tattccttac acaaaaagaa
     1561 aatacatatg cagtctagtc agacaaaata aagttttgaa gtgctactat aataagtttt
     1621 tcacgagaac aaactttgta aatcttccat aagcaaaatg acagctagtg cttgggatcg
     1681 tacatgttaa ttttctgaaa gataattcta agtgaaattt aaaataaata aatttttaat
     1741 gacctgggtc ttaaggattt aggaaaaata tgcatgcttt aattgcattt ccaaagtagc
     1801 atcttgctag acctagttga gtcaggataa cagagagata ccacatggca agaaaaacaa
     1861 agtgacaatt gtagagtcct caattgtgtt tacattaata gtggtgtttt tacctatgaa
     1921 attattctgg atctaatagg acattttaca aaatggcaag tatggaaaac catggattct
     1981 gaaagttaaa aatttagttg ttctccccaa tgtgtatttt aatttggatg gcagtctcat
     2041 gcagattttt taaaagattc tttaataaca tgatttgttt gcctttctag atttctttat
     2101 ctttctgacc agcaacttag ggagcagaat ttaaattagg aagacaaagg gaaagattca
     2161 tttaaaccat atttttacaa agtttgtcat ttgccccaag gtcaaatttt aaattcttaa
     2221 ttttcatttt atttcccatt ttaggtaaaa gtttgcattt aatcttagaa ttatgttatt
     2281 tttgttagta gtgtggaaac ttagagaact tattgtatgg tgccttgcaa aaatagagat
     2341 agaaagattt tagcatgcat accaatatag tatattacgc aatatataag cacacctaat
     2401 taacagatta atatcagtaa aggtattgct gctggaatga agaaaatggg atacgtttgt
     2461 ttcttttttt ctattgttac ataattgcca tgtggacttg tttatgatta ttgtgtagag
     2521 tagcatttaa gatttaactg tagcaaaaat tactttaacc gctgtattta agttagcatg
     2581 ttaattaatt gtgtagacat tttggcacac catcactttt aactatatca taccaatggt
     2641 tttgtgccca taataaaaat ggaaaaacct gttgaatgtt acgtattggt atctttaatt
     2701 tcaacagtgg gtaaactggt ttcccagtat acaattcatt gaaagcaaaa ttgattaatt
     2761 atttccattt aatttataca cactcaatac aaaatttaat gttgacttta cgtaataaag
     2821 tataatgcat tttctttttt actgtttatg tatagtttac aaaataaaga atcttgtaac
     2881 caaa
//
