LOCUS       NM_004598               4824 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens SPARC (osteonectin), cwcv and kazal like domains
            proteoglycan 1 (SPOCK1), mRNA.
ACCESSION   NM_004598
VERSION     NM_004598.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4824)
  AUTHORS   Xiao,M., Xue,J. and Jin,E.
  TITLE     SPOCK: Master regulator of malignant tumors (Review)
  JOURNAL   Mol Med Rep 30 (6) (2024)
   PUBMED   39392048
  REMARK    GeneRIF: SPOCK: Master regulator of malignant tumors (Review).
            Review article
REFERENCE   2  (bases 1 to 4824)
  AUTHORS   Liu,Y., Han,T., Wu,J., Zhou,J., Guo,J., Miao,R., Xu,Z., Xing,Y.,
            Bai,Y. and Hu,D.
  TITLE     SPOCK1, as a potential prognostic and therapeutic biomarker for
            lung adenocarcinoma, is associated with epithelial-mesenchymal
            transition and immune evasion
  JOURNAL   J Transl Med 21 (1), 909 (2023)
   PUBMED   38087364
  REMARK    GeneRIF: SPOCK1, as a potential prognostic and therapeutic
            biomarker for lung adenocarcinoma, is associated with
            epithelial-mesenchymal transition and immune evasion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4824)
  AUTHORS   Lin,Y.W., Wen,Y.C., Hsiao,C.H., Lai,F.R., Yang,S.F., Yang,Y.C.,
            Ho,K.H., Hsieh,F.K., Hsiao,M., Lee,W.J. and Chien,M.H.
  TITLE     Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes Malignant
            Progression of Clear Cell Renal Cell Carcinoma via Triggering the
            Snail/Slug-MMP-2 Axis-Mediated Epithelial-to-Mesenchymal Transition
  JOURNAL   Cells 12 (3), 352 (2023)
   PUBMED   36766694
  REMARK    GeneRIF: Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes
            Malignant Progression of Clear Cell Renal Cell Carcinoma via
            Triggering the Snail/Slug-MMP-2 Axis-Mediated
            Epithelial-to-Mesenchymal Transition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4824)
  AUTHORS   Gan,C., Li,M., Lu,Y., Peng,G., Li,W., Wang,H., Peng,Y., Hu,Q.,
            Wei,W., Wang,F., Liu,L. and Zhao,Q.
  TITLE     SPOCK1 and POSTN are valuable prognostic biomarkers and correlate
            with tumor immune infiltrates in colorectal cancer
  JOURNAL   BMC Gastroenterol 23 (1), 4 (2023)
   PUBMED   36611136
  REMARK    GeneRIF: SPOCK1 and POSTN are valuable prognostic biomarkers and
            correlate with tumor immune infiltrates in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4824)
  AUTHORS   Qu,Y.L., Liu,X.L., Zhao,S.Y. and Zhai,X.F.
  TITLE     SPOCK1 silencing decreases 5-FU resistance through PRRX1 in
            colorectal cancer
  JOURNAL   Pathol Res Pract 234, 153895 (2022)
   PUBMED   35462225
  REMARK    GeneRIF: SPOCK1 silencing decreases 5-FU resistance through PRRX1
            in colorectal cancer.
REFERENCE   6  (bases 1 to 4824)
  AUTHORS   Marr,H.S., Basalamah,M.A. and Edgell,C.J.
  TITLE     Endothelial cell expression of testican mRNA
  JOURNAL   Endothelium 5 (3), 209-219 (1997)
   PUBMED   9272383
REFERENCE   7  (bases 1 to 4824)
  AUTHORS   Charbonnier,F., Perin,J.P., Roussel,G., Nussbaum,J.L. and
            Alliel,P.M.
  TITLE     [Cloning of testican/SPOCK in man and mouse. Neuromuscular
            expression perspectives in pathology]
  JOURNAL   C R Seances Soc Biol Fil 191 (1), 127-133 (1997)
   PUBMED   9181134
  REMARK    Review article
REFERENCE   8  (bases 1 to 4824)
  AUTHORS   Bonnet,F., Perin,J.P., Charbonnier,F., Camuzat,A., Roussel,G.,
            Nussbaum,J.L. and Alliel,P.M.
  TITLE     Structure and cellular distribution of mouse brain testican.
            Association with the postsynaptic area of hippocampus pyramidal
            cells
  JOURNAL   J Biol Chem 271 (8), 4373-4380 (1996)
   PUBMED   8626787
REFERENCE   9  (bases 1 to 4824)
  AUTHORS   Perin,J.P., Alliel,P.M., Jolles,P. and Bonnet,F.
  TITLE     Proteoglycans in male reproductive tract
  JOURNAL   EXS 70, 191-197 (1994)
   PUBMED   7507743
  REMARK    Review article
REFERENCE   10 (bases 1 to 4824)
  AUTHORS   Alliel,P.M., Perin,J.P., Jolles,P. and Bonnet,F.J.
  TITLE     Testican, a multidomain testicular proteoglycan resembling
            modulators of cell social behaviour
  JOURNAL   Eur J Biochem 214 (1), 347-350 (1993)
   PUBMED   8389704
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI550122.1, AF231124.1,
            AC005213.1 and BC030691.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004598.3.
            
            Summary: This gene encodes the protein core of a seminal plasma
            proteoglycan containing chondroitin- and heparan-sulfate chains.
            The protein's function is unknown, although similarity to
            thyropin-type cysteine protease-inhibitors suggests its function
            may be related to protease inhibition. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030691.2, AF231124.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394945.6/ ENSP00000378401.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               BI550122.1         25-190
            167-1678            AF231124.1         40-1551
            1679-4819           AC005213.1         11743-14883
            4820-4824           BC030691.2         4805-4809
FEATURES             Location/Qualifiers
     source          1..4824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..4824
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /note="SPARC (osteonectin), cwcv and kazal like domains
                     proteoglycan 1"
                     /db_xref="GeneID:6695"
                     /db_xref="HGNC:HGNC:11251"
                     /db_xref="MIM:602264"
     exon            1..148
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1468
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /note="sparc/osteonectin, cwcv and kazal-like domains
                     proteoglycan (testican) 1; SPARC/osteonectin, cwcv and
                     kazal like domains proteoglycan 1"
                     /codon_start=1
                     /product="testican-1 precursor"
                     /protein_id="NP_004589.1"
                     /db_xref="CCDS:CCDS4191.1"
                     /db_xref="GeneID:6695"
                     /db_xref="HGNC:HGNC:11251"
                     /db_xref="MIM:602264"
                     /translation="MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQW
                     LSTVSQYDRDKYWNRFRDDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDY
                     QTALCVSRKHLLPRQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCK
                     LEFHACSTGKSLATLCDGPCPCLPEPEPPKHKAERSACTDKELRNLASRLKDWFGALH
                     EDANRVIKPTSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDK
                     YEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFI
                     PRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSV
                     VLLDDLEYERELGPKDKEGKLRVHTRAVTEDDEDEDDDKEDEVGYIW"
     exon            149..334
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..380
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..495
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..622
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..737
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..854
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1076
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1139
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1277
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..4824
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4802..4807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /note="hexamer: AATAAA"
     polyA_site      4824
                     /gene="SPOCK1"
                     /gene_synonym="SPOCK; TESTICAN; TIC1"
                     /note="major polyA site"
ORIGIN      
        1 acatcgctgc gggctcacaa agcggccaga cgctcggcgg cggcgtgtgg caggagcgca
       61 ggggcgcgag ccggcgatca gccttcccgg cgaccgtgcc gcgggagctc gagcaactcg
      121 gactagggga cccgggccgg cccccaagat gccggcgatc gcggtgttgg cggcggccgc
      181 cgcggcgtgg tgcttcctcc aagtcgagag ccggcacctg gacgcgctcg ccggaggcgc
      241 gggccccaac cacggcaatt tcctagacaa tgaccagtgg ctgagcaccg tctcccagta
      301 cgaccgggac aagtactgga accgctttcg agacgatgat tatttcagaa actggaatcc
      361 caacaagccc tttgaccaag ccctggaccc atccaaggac ccctgcctga aggtaaaatg
      421 cagccctcac aaagtgtgtg tgacccagga ctaccagacc gccctgtgtg tcagccgcaa
      481 gcacctgctc cccaggcaaa agaaggggaa cgtggcccag aaacactggg ttggaccttc
      541 gaatttggtc aagtgcaagc cctgtcccgt ggcacagtca gccatggtct gcggctcaga
      601 tggccactcc tacacatcca agtgcaaatt ggagttccat gcttgttcta ctggcaaaag
      661 cctcgccacc ctctgtgatg ggccctgtcc ctgtctccca gagcctgagc caccaaagca
      721 caaggcagaa aggagtgcct gcacagacaa ggagttgcgg aaccttgcct cccggctgaa
      781 ggattggttt ggagctctcc acgaggatgc gaacagagtc atcaagccca ccagctccaa
      841 cacagcccaa ggcaggtttg acactagcat cctgcccatc tgcaaggact ccctgggctg
      901 gatgttcaac aagttggaca tgaactatga cctcctgctt gacccttcag agatcaatgc
      961 catctacctg gataagtacg agccctgtat caagcctctt ttcaactcgt gtgactcctt
     1021 caaggatggc aagctttcta acaatgagtg gtgctactgc ttccagaagc ctggaggtct
     1081 cccttgccag aatgaaatga acagaattca gaagctgagt aaggggaaaa gcctgttggg
     1141 ggccttcata cctcggtgta atgaggaggg ctattacaaa gccacacagt gccacggcag
     1201 cacggggcag tgctggtgtg tggacaaata tgggaatgag ttggctggct ccaggaaaca
     1261 gggtgctgtg agctgtgaag aggagcagga aacctcaggg gattttggca gtggtgggtc
     1321 cgtggtcctg ctggatgacc tagaatatga acgggagctg ggaccaaagg acaaagaggg
     1381 gaagctgagg gtgcacaccc gagccgtgac agaggatgat gaggatgagg atgatgacaa
     1441 agaggatgag gtcgggtaca tatggtagtg cccacaagaa agaggacaca agttttgcac
     1501 aaaattgcaa gtcacttcct attcctgcat ttgtatctaa gactccaagg caccaaggtc
     1561 tcttctccat tgttgctctc tatacccgac ctaaggtttg gaagacaact gcttgttccc
     1621 agaggattct gattttgcat atgtttgtat gggagaaagg gtgttgtgtt ttttttttgt
     1681 tgttgtttat tttttggata gggaagtcat tggcttaatt agagcctcct tcctttctgt
     1741 gagatttttc caacaagcat gtgatttacg tggaattctg acagtgcagg gagccccaac
     1801 cctcttaaat gtcaaagacc ctttttgatt acccacactg gtggttatta cagcatggtt
     1861 cccagcctta cagtgtctaa gtgcttctct tgtgtcctgt agatgttgtg aaaaagaaaa
     1921 aaacaaaaaa tacaccacac tgtacttttt ccccctgccc ccgttactgc cggtgattat
     1981 tattaaaaat tagttttttt cacatcatta tatctggctt cctataaaca acagccttaa
     2041 ttcagtcaag actccctttg gggaattcat tttattaaaa attggtgtct ggatacttcc
     2101 ctgtacatgc ataaatatgc atgcatgtac agaaagactg tatgtgtgtg ccttgcacac
     2161 acacccatac ctctcagaaa aagtgtttgg gtatcttaaa aactcgaaaa acaatgataa
     2221 atttctcagc ttgtccagac ctggaacaaa atttctggaa taagaaattt gtattaaagt
     2281 ccttttttgc actaacagtt ggctcttgta gcctgcaggc tgaggaagtc tcttctctgt
     2341 gcatcagcag agttactgaa agcctctgat tgagaaaaaa cctccgtctg cctaaatcac
     2401 ttttctcgca gaagccatgc gactcccaca cgacacgggc agcttcacaa gccatctctt
     2461 tcatttctgc ttgaagcccc ttggctgcag caatcctgtc tgccataggt ttcttccttc
     2521 cttacctact caagggcttt ttctaaggca tgcacacata tctcctgttc tctgagagta
     2581 ccatggtgtt ccttaaaaga agaaaatttc taattctgaa ctcaatgttt tgcttttact
     2641 ccctttctac tgacaaatca tgataagggc acaaaagctg tacagatttt tttttttaac
     2701 cactcaatcc caaatggagg cctacaaaga acatcgtaat aacacatgga agcaaaccct
     2761 gggtttttaa gagcaaattc tgtccccccc tcactccccc aagtgacaag atactaatga
     2821 agaaagttct tcaccatagt gtttgtttta actaaactca ttggagtcta gttccaaatt
     2881 tggtagggtc atcatctcta cattccttag gatttctctc cctatcaagc tggcccagat
     2941 acaagtacca aacagtagtc tctgaagttc ccccatttcc ttcagtacca gtctataagc
     3001 tactgtccgc cactgatttt catttatcag ggtgtcctaa tcagaatcag ccacccaagc
     3061 aagcctctct ggcccacata tctatctctt gccttccccc atgaacttca gcctgtccac
     3121 acaaaagcca cataaactca agcaagaaat atgttcagcc aaaacatgat tatagtggca
     3181 gctgaccaat cccccatccc aaattgacca tttagatgta ccaactcacc ttaaattagc
     3241 atgttccaat ccagtcggca ttgcctgaat acagtagcat catacctata gttggtctta
     3301 gataagaaat gaactacttg atatagcaaa gtcctttggc ttcgtaaata accctgaggt
     3361 tttgtactta ctttccccat aggaagacag accataggca aactctgttt tgggatctca
     3421 actccatcac ctttgtttca atattttttt tctctcttga acaaaactga gataatttag
     3481 aaaacaggtg cttaattgca ataaaattac tatgaagtat attaaaaatc acgacattgt
     3541 aaaatctcac tttagatcat caaagaaaac cattgttact atctcctttg agcttaggaa
     3601 aatgtacaag agaacaaatt aaaattgaaa aattgatttc acttagaaaa acttctagga
     3661 acagggtgaa ccactgattt taatttgcct aattatctta tgacaagtat caaattaaga
     3721 tgacacttaa agatccttag cattaactta atgatggaga agagtgctca atagacagtt
     3781 cccagtaagg taatgagatg ccattttcag agacattcta agaagatatt ttgattcatt
     3841 aaaacattaa ataaaaagcc ctcctcagat tggaaccccc aaatcgatgg agccacatta
     3901 ataatacttt tcatgcctca ctttgacatg acagcattcg atttttttaa agatctttaa
     3961 tactttccat gagtactaaa gattgtaatg agttacctta tccttagaag tagaatgttt
     4021 gctttcttct tcttggaaat agtcctccaa aaagtccact tgtaccagtg acaagaagtc
     4081 acttgtatag tgaccaagta cacataaaat actgattata aaaatattgt aataaaccac
     4141 ttcctcattt gatacaggta ttaagctgaa tcctcactaa ttcacttttg aaaagttctt
     4201 aatgaacagt tttattctta ttccatgaac agctctttta atacaatttc cttggtatcc
     4261 aacttaaatc ccagaatttt gttccaccat ggttagttat ttgccatatg aatgtattct
     4321 tgtttctacc aatattctag gcatgagaat accttaatac tgagttggag attttgtatc
     4381 tgtttctcct cctttacgcc cattttccta cccacagcag caaatgacaa cgtgtctgtc
     4441 caggtctgtc cccctgctca tcccaggatg ccactcacat ttttttcttc ttgttacctt
     4501 gaccacgctg tacagtaaca tccaagagcc cattctacag tgggtggttt tggtcttttt
     4561 ataacttttt ctcaaagtca ctgatgtttg ttcctgttaa atgtatagca ttgtaatgag
     4621 agcccatcaa atcctgagtg tcagtttgtt gtccctattg tagatgaaat agtgatgtag
     4681 caaaaaccta gtaaattctg aatgcttttc cacgtagact tatctggaat gtgaacacaa
     4741 ctctttggtt aatagtaaat gcttaactgt agtcctgagt aggtgcattt ctgtctgtct
     4801 caataaattt tactttgtct gcaa
//
