LOCUS       NM_144569               3933 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens SPOC domain containing 1 (SPOCD1), transcript variant
            1, mRNA.
ACCESSION   NM_144569
VERSION     NM_144569.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3933)
  AUTHORS   Zoch,A., Konieczny,G., Auchynnikava,T., Stallmeyer,B., Rotte,N.,
            Heep,M., Berrens,R.V., Schito,M., Kabayama,Y., Schopp,T.,
            Kliesch,S., Houston,B., Nagirnaja,L., O'Bryan,M.K., Aston,K.I.,
            Conrad,D.F., Rappsilber,J., Allshire,R.C., Cook,A.G., Tuttelmann,F.
            and O'Carroll,D.
  TITLE     C19ORF84 connects piRNA and DNA methylation machineries to defend
            the mammalian germ line
  JOURNAL   Mol Cell 84 (6), 1021-1035 (2024)
   PUBMED   38359823
REFERENCE   2  (bases 1 to 3933)
  AUTHORS   Takamatsu,G., Yanagi,K., Koganebuchi,K., Yoshida,F., Lee,J.S.,
            Toyama,K., Hattori,K., Katagiri,C., Kondo,T., Kunugi,H., Kimura,R.,
            Kaname,T. and Matsushita,M.
  TITLE     Haplotype phasing of a bipolar disorder pedigree revealed rare
            multiple mutations of SPOCD1 gene in the 1p36-35 susceptibility
            locus
  JOURNAL   J Affect Disord 310, 96-105 (2022)
   PUBMED   35504398
  REMARK    GeneRIF: Haplotype phasing of a bipolar disorder pedigree revealed
            rare multiple mutations of SPOCD1 gene in the 1p36-35
            susceptibility locus.
REFERENCE   3  (bases 1 to 3933)
  AUTHORS   Wang,C., Wang,J., Shen,X., Li,M., Yue,Y., Cheng,X., Lu,W., Wang,X.
            and Xie,X.
  TITLE     LncRNA SPOCD1-AS from ovarian cancer extracellular vesicles
            remodels mesothelial cells to promote peritoneal metastasis via
            interacting with G3BP1
  JOURNAL   J Exp Clin Cancer Res 40 (1), 101 (2021)
   PUBMED   33726799
  REMARK    GeneRIF: LncRNA SPOCD1-AS from ovarian cancer extracellular
            vesicles remodels mesothelial cells to promote peritoneal
            metastasis via interacting with G3BP1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3933)
  AUTHORS   Liang,J., Zhao,H., Hu,J., Liu,Y. and Li,Z.
  TITLE     SPOCD1 promotes cell proliferation and inhibits cell apoptosis in
            human osteosarcoma
  JOURNAL   Mol Med Rep 17 (2), 3218-3225 (2018)
   PUBMED   29257309
  REMARK    GeneRIF: SPOCD1 promoted cell proliferation and inhibited cell
            apoptosis through regulation of VEGFA in osteosarcoma.
REFERENCE   5  (bases 1 to 3933)
  AUTHORS   Zhu,M., Yan,C., Ren,C., Huang,X., Zhu,X., Gu,H., Wang,M., Wang,S.,
            Gao,Y., Ji,Y., Miao,X., Yang,M., Chen,J., Du,J., Huang,T.,
            Jiang,Y., Dai,J., Ma,H., Zhou,J., Wang,Z., Hu,Z., Ji,G., Zhang,Z.,
            Shen,H., Shi,Y. and Jin,G.
  TITLE     Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That
            Affect Risk for Gastric Cancer
  JOURNAL   Gastroenterology 152 (8), 2011-2021 (2017)
   PUBMED   28246015
  REMARK    GeneRIF: SPOCD1 genetic variants have role in gastric
            carcinogenesis.
REFERENCE   6  (bases 1 to 3933)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: SPOCD1 expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   7  (bases 1 to 3933)
  AUTHORS   Fardilha,M., Esteves,S.L., Korrodi-Gregorio,L., Vintem,A.P.,
            Domingues,S.C., Rebelo,S., Morrice,N., Cohen,P.T., da Cruz e
            Silva,O.A. and da Cruz e Silva,E.F.
  TITLE     Identification of the human testis protein phosphatase 1
            interactome
  JOURNAL   Biochem Pharmacol 82 (10), 1403-1415 (2011)
   PUBMED   21382349
REFERENCE   8  (bases 1 to 3933)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354919.16.
            
            On Apr 19, 2021 this sequence version replaced NM_144569.6.
            
            Summary: This gene encodes a protein that belongs to the TFIIS
            family of transcription factors. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131447.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360482.7/ ENSP00000353670.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AL354919.16        68392-68453         c
            63-1484             AL354919.16        66382-67803         c
            1485-1526           AL354919.16        54095-54136         c
            1527-1703           AL354919.16        52872-53048         c
            1704-1829           AL354919.16        52447-52572         c
            1830-1884           AL354919.16        52240-52294         c
            1885-1969           AL354919.16        51832-51916         c
            1970-2129           AL354919.16        50873-51032         c
            2130-2246           AL354919.16        50638-50754         c
            2247-2372           AL354919.16        49021-49146         c
            2373-2484           AL354919.16        46555-46666         c
            2485-2635           AL354919.16        46178-46328         c
            2636-2786           AL354919.16        45709-45859         c
            2787-2876           AL354919.16        45109-45198         c
            2877-3063           AL354919.16        44646-44832         c
            3064-3933           AL354919.16        42853-43722         c
FEATURES             Location/Qualifiers
     source          1..3933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..3933
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /note="SPOC domain containing 1"
                     /db_xref="GeneID:90853"
                     /db_xref="HGNC:HGNC:26338"
                     /db_xref="MIM:619038"
     exon            1..62
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            63..1484
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..3752
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /note="isoform 1 is encoded by transcript variant 1; SPOC
                     domain-containing protein 1; protein phosphatase 1,
                     regulatory subunit 146"
                     /codon_start=1
                     /product="SPOC domain-containing protein 1 isoform 1"
                     /protein_id="NP_653170.3"
                     /db_xref="CCDS:CCDS347.1"
                     /db_xref="GeneID:90853"
                     /db_xref="HGNC:HGNC:26338"
                     /db_xref="MIM:619038"
                     /translation="MSQAGDVEGPSTGDPVLSPQHNCELLQNMEGASSMPGLSPDGPG
                     ASSGPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHM
                     QLPSVPTQGRALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVS
                     CLRPREARDGGMSSPGCDRRSPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSEC
                     EEGAGDFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGA
                     GCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASA
                     QASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSRE
                     PLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRP
                     EEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLM
                     EVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSLALG
                     DPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRL
                     RELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKV
                     VHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKEPCRLPASKMTHKGE
                     VEIQRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTGQHDHHFLDPNCHICKDWEP
                     SNELLGSFEAAKSCGDNIFQKALSQTPMPAPEMPKTRELSPTEPQDRVPPSGLHVPAA
                     PTKALPCLPPWEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWD
                     LLASICPAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLASVEHMGMVLLPLP
                     AFQPLPTRLRPLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLLPKEGLPDTAGSSPWL
                     GKVQKMVSFNSKVEKRYYQPDDRRPNVPLKGTPPPGGAWQQSQGRGSIAPRGISAWQR
                     PPRGRGRLWPEPENWQHPGRGQWPPEPGLRQSQHPYSVAPAGHGFGRGQHFHRDSCPH
                     QALLRHLESLATMSHQLQALLCPQTKSSIPRPLQRLSSALAAPEPPGPARDSSLGPTD
                     EAGSECPFPRKA"
     exon            1485..1526
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1703
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1829
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1884
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1969
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2129
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2246
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2372
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2484
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2635
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2786
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2876
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3063
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3933
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3909..3914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /note="hexamer: AATAAA"
     polyA_site      3933
                     /gene="SPOCD1"
                     /gene_synonym="PPP1R146"
                     /note="major polyA site"
ORIGIN      
        1 gatctcagct ccttttcagc tagtgggtgg aaccccagga gggaaaactc agggaagccc
       61 agggcccgtg ttgtgctttt ggcccaggta ggtggacaga catgtcccag gcgggggacg
      121 tagaaggccc cagcacagga gaccctgtgc tcagtcccca acacaactgt gagcttttac
      181 agaacatgga aggagccagc tccatgccag gcctgtcacc agatgggccg ggagcaagct
      241 ctgggcccgg agtcagggct ggcagcagaa ggaagatccc caggaaggag gcccttcgag
      301 gtggcagctc ccgggctgca ggtgctgctg aggtccggcc aggggtcttg gagctgctag
      361 ctgtggtaca gagccggggc tcgatgctgg ctcctgggct ccacatgcag ctgccctcgg
      421 tgcctactca ggggagagct ctgacctcca agaggctcca ggtttctctg tgtgacatct
      481 tagatgacag ttgccccagg aaactttgta gcaggtctgc tggcctccca gagagagctc
      541 tggcctgcag ggagaggctt gcaggagtgg aggaggtgag ctgcctcagg cccagggagg
      601 ccagagacgg tggaatgagt tctccagggt gtgacagaag aagccccaca ctcagcaaag
      661 aggagccccc tggaaggccc ctgacatcct caccagaccc agtccctgtg agggtaagaa
      721 agaaatggag gaggcaaggg gctcattcag agtgtgagga aggggctggt gacttcctgt
      781 ggcttgatca gagccctcgt ggggacaacc tcctgtctgt gggagaccct ccccaagttg
      841 ctgacctgga gtccttggga ggcccttgca gacctccctc tccaaaagac actgggtctg
      901 ggcctggaga gccaggtgga agtggggcag gatgtgcctc agggactgag aaatttggat
      961 atttgcccgc tacaggggat gggccccagc caggcagccc ctgtggccct gtcgggttcc
     1021 cagtgcccag tggaggggag tccctcagtt cagctgcaca ggctcctcca cagagcgcag
     1081 cactgtgcct gggggcgtca gcacaggcct ctgcagagca gcaagaagct gtgtgtgtcg
     1141 tgcggactgg cagcgatgaa ggccaggctc cagcacagga ccaggaggag ctggaggcca
     1201 aggctcagcc agcttccagg ggaaggctgg agcaaggact cgctgccccc gctgacacct
     1261 gtgccagctc ccgggagccc ttgggcggcc tcagctcctc cctggatact gaagccagca
     1321 gggcctgctc aggcccattc atggagcaga gaagatccaa gggcactaag aacctgaaga
     1381 aaggtccagt gccctgtgcc caagaccggg gcacagacag aagctcagac aactcccacc
     1441 aggacaggcc agaggaaccc agcccaggag gctgccccag actggaggaa gtgaaaatac
     1501 cccatggagt gaagcttgtg tgctacctgg gttccgggcc agtgatccag ctcctggggg
     1561 ccatcagcca cggccaggca ggggggcagc tgccaccaaa gctggaggtt ctagaggact
     1621 tgatggaggt cagctcaccc tcacctgccc agaggctcag aaggaagaaa aggcccatgg
     1681 tgcagggccc tgctgggtgc caggttttcc agccttctcc ttcaggaggc acagcagggg
     1741 accctggtgg cctctctgac cccttctacc ctccaagaag cggttccctg gcccttggcg
     1801 accccagctc ggaccctgca tgttcccaga gtggcccaat ggaggctgaa gaggattctc
     1861 ttccggagca gccagaggac tcagctcagc tccaacagga gaagccatcc ctgtatattg
     1921 gggtgcgggg cactgttgtc cgttccatgc aggaggtact atggactcgc cttcgggagc
     1981 tcccagaccc agtgctgagt gaggaggtgg tggagggcat tgctgctggc attgaggcag
     2041 ccctctggga cctgacacaa ggcaccaatg gccggtacaa gaccaagtat cgcagcctgc
     2101 tgttcaacct gcgggacccc aggaacctgg acttgtttct caaagtggtt catggagatg
     2161 tcacccccta cgacctggtg cggatgagct cgatgcagct ggccccccag gagctggccc
     2221 gctggcggga ccaggaggag aaaaggggcc tgaatatcat tgagcagcaa cagaaggagc
     2281 cgtgcagact tccagcctcc aaaatgaccc acaagggcga agtggagatt cagcgggaca
     2341 tggaccagac actgaccctg gaggatctgg tgggaccgca gatgttcatg gactgcagcc
     2401 cacaggccct gcccatcgca tcagaggaca ccacggggca gcatgaccac cacttcttag
     2461 accccaactg ccacatctgc aaggactggg agccctcgaa tgagctgcta ggctccttcg
     2521 aagccgccaa gagctgcggg gacaatatct tccagaaagc cctaagccaa actcctatgc
     2581 ctgctccaga gatgcccaaa accagggagt tgtctcccac ggaaccacag gacagggtcc
     2641 ctccatctgg gctccatgtg cctgctgcac ccacaaaggc cctgccctgc ctgccaccct
     2701 gggaaggtgt tctggacatg ttctccatca agcggttccg ggccagggcc cagctggtct
     2761 cgggacacag ctgtcggctt gtccaggctc tgcccaccgt gatccgctcg gcaggctgca
     2821 tcccctccaa cattgtctgg gaccttctgg ccagcatctg cccagccaag gccaaggacg
     2881 tctgcgtggt cagactgtgc ccacatgggg cccgggacac ccagaactgc cgcctgctct
     2941 actcatacct caatgatagg cagcgccacg ggctggcctc tgtggagcac atggggatgg
     3001 tcctgctgcc cctgcctgcc ttccagcccc tgcccaccag gctgcgccct ttggggggcc
     3061 caggcctttg ggctcttcct gtctcccctc tcctttcccc aggtctggag gtcactcact
     3121 caagtctgtt gctggctgtg ctgctcccca aggaagggct tccagacaca gcagggtcca
     3181 gcccctggtt ggggaaggtt caaaagatgg tctccttcaa cagtaaggtg gagaagagat
     3241 actatcagcc agatgacagg aggccgaatg tgcccctgaa gggcacccct cccccaggag
     3301 gtgcctggca gcagagccag ggcaggggca gtatagctcc aaggggaatc tctgcttggc
     3361 agaggccccc cagaggcagg gggaggctct ggccagagcc tgaaaactgg cagcatcctg
     3421 ggcgagggca gtggccccca gagccaggct tgcgccagtc ccagcatccc tattcagtag
     3481 caccagctgg tcatggcttt ggccgtggcc agcacttcca cagggactcc tgtccccacc
     3541 aagccctgct ccggcacctc gaatccctgg cgaccatgag tcaccagctc caagccttac
     3601 tgtgccccca gaccaagagc tccatccccc gccctctgca gcgtttgtct agcgcccttg
     3661 cagctccaga gccccctggc ccagcccgtg actcctcttt ggggcctaca gatgaagctg
     3721 gctctgagtg tcccttccct agaaaggcct gaccctcctt acccaccaga acaggggttt
     3781 tgatgccctc actagtgttg aagcctgttc cagagagagg tgggactgca aggagaggat
     3841 ggtcagccct acccacctgc cctgtttgaa cttcctgttt gacaatgttt gctgttgatt
     3901 ttttgttcaa taaagaattt ggtaaaattg gga
//
