LOCUS       XM_005260380            1816 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SPO11 initiator of meiotic double strand
            breaks (SPO11), transcript variant X2, mRNA.
ACCESSION   XM_005260380
VERSION     XM_005260380.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000020.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005260380.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
     gene            1..1816
                     /gene="SPO11"
                     /gene_synonym="CT35; SPATA43; TOPOVIA; TOPVIA"
                     /note="SPO11 initiator of meiotic double strand breaks;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 ESTs, 1 long SRA read, and 100% coverage
                     of the annotated genomic feature by RNAseq alignments,
                     including 5 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:23626"
                     /db_xref="HGNC:HGNC:11250"
                     /db_xref="MIM:605114"
     CDS             66..1283
                     /gene="SPO11"
                     /gene_synonym="CT35; SPATA43; TOPOVIA; TOPVIA"
                     /codon_start=1
                     /product="meiotic recombination protein SPO11 isoform X2"
                     /protein_id="XP_005260437.1"
                     /db_xref="GeneID:23626"
                     /db_xref="HGNC:HGNC:11250"
                     /db_xref="MIM:605114"
                     /translation="MAFAPMGPEASFFDVLDRHRESLLAALRRGGREPPTGGSRLASS
                     SEVLASIENIIQDIITSLARNEAPAFTIDNRSSWENIKFEDSVGLQMVSHCTTRKIKS
                     DSPKSAQKFSLILKILSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCM
                     LKVSRRSLHILSTSKGLIAGNLRYIEEDGTKVNCTCGATAVAVPSNIQGIRITDAKFV
                     LIVEKDATFQRLLDDNFCNKLSPCIMITSTPVFQHLKSKGKGVPDLNTRLLVKKLWDT
                     FHVPVFTLVDADPHGIEIMCIYKYGSMSMSFEAHHLTVPAIRWLGLLPSDLKRLNVPK
                     DSLIPLTKRDQMKLDSILRRPYVTCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSR
                     VYLPNKLKFGGWI"
ORIGIN      
        1 agccacgccc caagggcgca gcctaggaca ggggcttctg gagcttctgg cagccgtctg
       61 ccctcatggc ctttgcacct atggggcccg aggcctcgtt cttcgacgtt ttggaccgac
      121 acagggagtc cctgctggct gccctgagga gaggtggcag ggagccccca actgggggaa
      181 gccgcctggc ctccagttct gaggttcttg catctataga aaatattatc caagacataa
      241 tcacaagctt ggcaagaaat gaagcacctg cattcacgat agacaacaga tcaagctggg
      301 aaaacataaa gtttgaagat tctgtgggtc ttcagatggt atcccattgc accaccagaa
      361 agatcaaaag tgattcacca aaatcagctc aaaaattttc tctaatcctt aaaatattgt
      421 ccatgattta taaattagta cagagcaaca cttatgcaac caaaagggac atatattaca
      481 ctgacagtca actctttggt aaccagactg tcgtcgacaa tattatcaat gacatttctt
      541 gcatgttaaa agtgtcaagg aggagtctac atatattatc tacatcaaaa ggtttaattg
      601 ctggcaactt aagatacatc gaggaagatg gcaccaaagt gaattgtacc tgtggtgcaa
      661 cggctgttgc tgtgccatcg aatattcaag gaattcggat tacagatgca aagtttgtat
      721 taattgtaga aaaagatgca acatttcagc ggctcctaga tgacaacttt tgcaacaaat
      781 tgtctccttg catcatgatt acgtcaacac cagtctttca gcacctgaaa tccaagggaa
      841 agggagttcc tgatctaaac acaagacttt tagtcaagaa actgtgggat acatttcatg
      901 ttcctgtttt cactcttgta gatgctgatc cacatggcat agaaataatg tgcatctata
      961 agtatggatc tatgtctatg tcttttgaag ctcatcatct cacagttcca gctattagat
     1021 ggcttggtct tctcccttct gatcttaaaa gattaaatgt acctaaagat agtttgattc
     1081 cactgacaaa aagggaccaa atgaaacttg acagtatcct gaggagacct tatgttacct
     1141 gccaaccatt ttggagaaaa gaaatggaaa taatggcaga ctctaaaatg aaggcagaaa
     1201 ttcaagcttt gactttccta tcatcagatt atctttccag agtgtactta cctaacaaat
     1261 taaaatttgg aggatggata taaaaataaa tcagaagaac ttctgattgc cagaggcttt
     1321 tcattagttt tgttttgatt ggcaaatact attgtggaaa gaacatatat tatattctta
     1381 attctgtaaa agtgaaataa aataactttc cgttaattat atatttttgt caaaacaaat
     1441 gctgtactcc aattttcttt gcaaggcctt attcttgcct ctatagagac agatttctgt
     1501 cctatcttct aaagcaaatt ataaaagaat atgttatttt gacctttaaa ttatttttga
     1561 aaaaataata ttttatacat gtcatcaaag tctacaaaat atttaccttc tacgatacaa
     1621 ctaatgttaa cgcataaagt atcttactgg taacaaaaat cataatgatc tgaatttgag
     1681 atgttgcaaa tgaattgtgg tgtccggtag tttcttctta cattttcctt tgcctttata
     1741 ctttaggggt cttactccat taattcattt gttacattag taaaattcag tatgaataaa
     1801 tatttggatt gatgta
//
