LOCUS       NM_182538               1877 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SPNS lysolipid transporter 3, sphingosine-1-phosphate
            (putative) (SPNS3), transcript variant 1, mRNA.
ACCESSION   NM_182538
VERSION     NM_182538.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1877)
  AUTHORS   Eshibona,N., Giwa,A., Rossouw,S.C., Gamieldien,J., Christoffels,A.
            and Bendou,H.
  TITLE     Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in
            pediatric acute myeloid leukemia patients with FLT3-ITD mutation
  JOURNAL   Leuk Lymphoma 63 (8), 1897-1906 (2022)
   PUBMED   35249471
  REMARK    GeneRIF: Upregulation of FHL1, SPNS3, and MPZL2 predicts poor
            prognosis in pediatric acute myeloid leukemia patients with
            FLT3-ITD mutation.
REFERENCE   2  (bases 1 to 1877)
  AUTHORS   Hong,Y., Tian,X., Wang,M., Chen,C. and Sun,A.
  TITLE     Bioinformatics-based identification of SPNS3 (Spinster homolog 3)
            as a prognostic biomarker of apoptosis resistance in acute myeloid
            leukemia
  JOURNAL   Bioengineered 12 (1), 7837-7848 (2021)
   PUBMED   34608834
  REMARK    GeneRIF: Bioinformatics-based identification of SPNS3 (Spinster
            homolog 3) as a prognostic biomarker of apoptosis resistance in
            acute myeloid leukemia.
REFERENCE   3  (bases 1 to 1877)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1877)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1877)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 1877)
  AUTHORS   Jacobsson,J.A., Haitina,T., Lindblom,J. and Fredriksson,R.
  TITLE     Identification of six putative human transporters with structural
            similarity to the drug transporter SLC22 family
  JOURNAL   Genomics 90 (5), 595-609 (2007)
   PUBMED   17714910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK172832.1, AC116910.11 and AC127521.11.
            
            On Nov 22, 2018 this sequence version replaced NM_182538.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172832.1, SRR7410570.629035.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355530.7/ ENSP00000347721.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-904               AK172832.1         17-920
            905-951             AC116910.11        130733-130779
            952-1141            AC116910.11        134408-134597
            1142-1207           AC127521.11        15491-15556         c
            1208-1306           AC127521.11        7802-7900           c
            1307-1478           AC127521.11        7545-7716           c
            1479-1859           AC127521.11        5942-6322           c
            1860-1877           AK172832.1         1876-1893
FEATURES             Location/Qualifiers
     source          1..1877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..1877
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /note="SPNS lysolipid transporter 3,
                     sphingosine-1-phosphate (putative)"
                     /db_xref="GeneID:201305"
                     /db_xref="HGNC:HGNC:28433"
                     /db_xref="MIM:611701"
     exon            1..227
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1567
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein spinster homolog 3; sphingolipid transporter 3
                     (putative); solute carrier family 63 member 3; SPNS
                     sphingolipid transporter 3 (putative)"
                     /codon_start=1
                     /product="protein spinster homolog 3 isoform 1"
                     /protein_id="NP_872344.3"
                     /db_xref="CCDS:CCDS11045.1"
                     /db_xref="GeneID:201305"
                     /db_xref="HGNC:HGNC:28433"
                     /db_xref="MIM:611701"
                     /translation="MAGGMSAECPEPGPGGLQGQSPGPGRQCPPPITPTSWSLPPWRA
                     YVAAAVLCYINLLNYMNWFIIAGVLLDIQEVFQISDNHAGLLQTVFVSCLLLSAPVFG
                     YLGDRHSRKATMSFGILLWSGAGLSSSFISPRYSWLFFLSRGIVGTGSASYSTIAPTV
                     LGDLFVRDQRTRVLAVFYIFIPVGSGLGYVLGSAVTMLTGNWRWALRVMPCLEAVALI
                     LLILLVPDPPRGAAETQGEGAVGGFRSSWCEDVRYLGKNWSFVWSTLGVTAMAFVTGA
                     LGFWAPKFLLEARVVHGLQPPCFQEPCSNPDSLIFGALTIMTGVIGVILGAEAARRYK
                     KVIPGAEPLICASSLLATAPCLYLALVLAPTTLLASYVFLGLGELLLSCNWAVVADIL
                     LSVVVPRCRGTAEALQITVGHILGDAGSPYLTGLISSVLRARRPDSYLQRFRSLQQSF
                     LCCAFVIALGGGCFLLTALYLERDETRAWQPVTGTPDSNDVDSNDLERQGLLSGAGAS
                     TEEP"
     exon            228..293
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            294..430
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            431..582
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..649
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            650..798
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..951
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1141
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1207
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1306
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1478
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1877
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1834..1839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /note="hexamer: AATAAA"
     polyA_site      1877
                     /gene="SPNS3"
                     /gene_synonym="SLC62A3; SLC63A3"
                     /note="major polyA site"
ORIGIN      
        1 agtctcaggc caagagctgc aggctggcat ggctgggggg atgtcagcgg agtgccctga
       61 gcctgggcca ggaggtctgc agggccagtc cccagggcca ggcaggcagt gtccccctcc
      121 catcacgccc acctcctgga gcctgccccc gtggagggcc tacgtggctg ccgccgtcct
      181 ctgctacatc aacctcctga attacatgaa ctggttcatc attgcaggag tgctgctgga
      241 tatacaggag gttttccaga tcagtgacaa ccatgctggt ttgcttcaga ctgtcttcgt
      301 tagctgcctg ctgctgtctg cacctgtgtt tggctacctg ggcgaccgac atagccgcaa
      361 ggctaccatg agcttcggta tcttgctgtg gtcaggagct ggcctctcta gctccttcat
      421 ctccccccgg tattcttggc tcttcttcct gtcccggggc atcgtgggca ctggctcggc
      481 cagctactcc accatcgcgc ccaccgtcct gggcgacctc ttcgtgaggg accagcgcac
      541 ccgcgtgctg gctgtcttct acatctttat ccccgttgga agtggtctgg gctacgtgct
      601 ggggtcggct gtgacgatgc tgactgggaa ctggcgctgg gccctccgag tcatgccctg
      661 cctggaggcc gtggccttga tcctgcttat cctgctggtt ccagacccac cccggggagc
      721 tgccgagaca cagggggagg gggccgtggg aggcttcagg agcagctggt gtgaggacgt
      781 cagatacctg gggaaaaact ggagtttcgt gtggtcgacc ctcggagtga ccgccatggc
      841 ctttgtgact ggagccctgg ggttctgggc ccccaagttt ctgctcgagg cacgcgtggt
      901 tcacgggctg cagcctccct gcttccagga gccgtgcagc aaccccgaca gcctgatttt
      961 tggggcactg accatcatga ccggcgtcat tggggtcatc ttgggggcag aagctgcgag
     1021 gaggtacaag aaagtcattc caggagctga gcccctcatc tgcgcctcca gcctgcttgc
     1081 cacagccccc tgcctctacc tggctctcgt cctggccccg accaccctgc tggcctccta
     1141 tgtgttcctg ggccttgggg agctgcttct gtcctgcaac tgggcagtgg ttgccgacat
     1201 cctgctgtct gtggtggtgc ccagatgccg ggggacggca gaggcacttc agatcacggt
     1261 gggccacatc ctgggagacg ctggcagccc ctatctcaca ggacttatct ctagtgtcct
     1321 gcgggccagg cgccctgact cctatctgca gcgcttccgc agcctgcagc agagcttcct
     1381 gtgctgcgcc tttgtcatcg ccctgggggg cggctgcttc ctgctgactg cgctgtacct
     1441 ggagagagac gagacccggg cctggcagcc tgtcacaggg accccagaca gcaatgatgt
     1501 ggacagcaac gacctggaga gacaaggcct actttcgggc gctggcgcct ctacagagga
     1561 gccctgaggt ccctgcctac actcgtcctg cctgcaagcc tcccgttggt ccccacagca
     1621 gcagtgcctc ggttcctctt tggctgtcct cggggactcc ggctgaggca catctgccac
     1681 ttttgaattc ccggctggag agctggcagg accctgtggc tgggctggga atggagctgt
     1741 cagcactctg cgtgggaggc ctgggcctgt gcctgcatcc cgctcaaggc tgccccagcc
     1801 tggggtctcc agcctggctg ctgctgggcc ctgaataaag agaggccagt acaaagccca
     1861 tggattttgg gcctgta
//
