LOCUS       NM_001124758            3404 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens SPNS lysolipid transporter 2, sphingosine-1-phosphate
            (SPNS2), mRNA.
ACCESSION   NM_001124758 XM_001719788
VERSION     NM_001124758.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3404)
  AUTHORS   Liang,W., Liu,M., Su,Y., Wen,Y., Wang,L., Shan,J., Zhao,J., Xie,K.
            and Wang,J.
  TITLE     Spinster homolog 2 reduces malignancies of glioblastoma via
            PTEN/PI3K/AKT pathway
  JOURNAL   IUBMB Life 76 (3), 140-160 (2024)
   PUBMED   37728571
  REMARK    GeneRIF: Spinster homolog 2 reduces malignancies of glioblastoma
            via PTEN/PI3K/AKT pathway.
REFERENCE   2  (bases 1 to 3404)
  AUTHORS   Fang,C., Ren,P., Bian,G., Wang,J., Bai,J., Huang,J., Ding,Y.,
            Li,X., Li,M. and Hou,Z.
  TITLE     Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and
            prevents immunosuppression in sepsis
  JOURNAL   EMBO Rep 24 (8), e56635 (2023)
   PUBMED   37358015
  REMARK    GeneRIF: Enhancing Spns2/S1P in macrophages alleviates
            hyperinflammation and prevents immunosuppression in sepsis.
REFERENCE   3  (bases 1 to 3404)
  AUTHORS   Chen,H., Ahmed,S., Zhao,H., Elghobashi-Meinhardt,N., Dai,Y.,
            Kim,J.H., McDonald,J.G., Li,X. and Lee,C.H.
  TITLE     Structural and functional insights into Spns2-mediated transport of
            sphingosine-1-phosphate
  JOURNAL   Cell 186 (12), 2644-2655 (2023)
   PUBMED   37224812
  REMARK    GeneRIF: Structural and functional insights into Spns2-mediated
            transport of sphingosine-1-phosphate.
REFERENCE   4  (bases 1 to 3404)
  AUTHORS   Wang,D., Li,M., Shen,H., Yang,J., Gao,Z. and Tang,Y.
  TITLE     Iron Deficiency Increases Phosphorylation of SP1 to Upregulate
            SPNS2 Expression in Hepatocellular Carcinoma
  JOURNAL   Biol Trace Elem Res 201 (4), 1689-1694 (2023)
   PUBMED   35614326
  REMARK    GeneRIF: Iron Deficiency Increases Phosphorylation of SP1 to
            Upregulate SPNS2 Expression in Hepatocellular Carcinoma.
REFERENCE   5  (bases 1 to 3404)
  AUTHORS   Jiang,Y., Yu,X.Y., Sun,H.X., Gu,X.Y. and Geng,J.S.
  TITLE     Long non-coding RNA HOXA-AS3 facilitates the malignancy in
            colorectal cancer by miR-4319/SPNS2 axis
  JOURNAL   J Physiol Biochem 77 (4), 653-666 (2021)
   PUBMED   34671931
  REMARK    GeneRIF: Long non-coding RNA HOXA-AS3 facilitates the malignancy in
            colorectal cancer by miR-4319/SPNS2 axis.
REFERENCE   6  (bases 1 to 3404)
  AUTHORS   Bradley,E., Dasgupta,S., Jiang,X., Zhao,X., Zhu,G., He,Q.,
            Dinkins,M., Bieberich,E. and Wang,G.
  TITLE     Critical role of Spns2, a sphingosine-1-phosphate transporter, in
            lung cancer cell survival and migration
  JOURNAL   PLoS One 9 (10), e110119 (2014)
   PUBMED   25330231
  REMARK    GeneRIF: Spns2 plays key roles in regulating the cellular functions
            in non-small cell lung cancer (NSCLC) cells
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3404)
  AUTHORS   Nagahashi,M., Kim,E.Y., Yamada,A., Ramachandran,S., Allegood,J.C.,
            Hait,N.C., Maceyka,M., Milstien,S., Takabe,K. and Spiegel,S.
  TITLE     Spns2, a transporter of phosphorylated sphingoid bases, regulates
            their blood and lymph levels, and the lymphatic network
  JOURNAL   FASEB J 27 (3), 1001-1011 (2013)
   PUBMED   23180825
  REMARK    GeneRIF: Spns2 is an S1P transporter in vivo that plays a role in
            regulation not only of blood S1P but also lymph node and lymph S1P
            levels and consequently influences lymphocyte trafficking and
            lymphatic vessel network organization.
REFERENCE   8  (bases 1 to 3404)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
  REMARK    GeneRIF: The sphingosine 1-phosphate transporter, SPNS2, functions
            as a transporter of the phosphorylated form of the immunomodulating
            agent FTY720.
REFERENCE   9  (bases 1 to 3404)
  AUTHORS   Kawahara,A., Nishi,T., Hisano,Y., Fukui,H., Yamaguchi,A. and
            Mochizuki,N.
  TITLE     The sphingolipid transporter spns2 functions in migration of
            zebrafish myocardial precursors
  JOURNAL   Science 323 (5913), 524-527 (2009)
   PUBMED   19074308
REFERENCE   10 (bases 1 to 3404)
  AUTHORS   Yanagisawa,H., Miyashita,T., Nakano,Y. and Yamamoto,D.
  TITLE     HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL,
            induces a caspase-independent autophagic cell death
  JOURNAL   Cell Death Differ 10 (7), 798-807 (2003)
   PUBMED   12815463
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC041772.1, AC118754.6 and
            HY309474.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001124758.2.
            
            Summary: The protein encoded by this gene is a transporter of
            sphingosine 1-phosphate, a secreted lipid that is important in
            cardiovascular, immunological, and neural development. Defects in
            this gene are a cause of early onset progressive hearing loss.
            [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041772.1, SRR14038192.2057771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329078.8/ ENSP00000333292.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2843              BC041772.1         44-2886
            2844-2847           AC118754.6         122664-122667       c
            2848-3016           BC041772.1         2887-3055
            3017-3017           AC118754.6         122494-122494       c
            3018-3161           BC041772.1         3056-3199
            3162-3162           AC118754.6         122349-122349       c
            3163-3401           BC041772.1         3201-3439
            3402-3404           HY309474.1         34-36               c
FEATURES             Location/Qualifiers
     source          1..3404
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..3404
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /note="SPNS lysolipid transporter 2,
                     sphingosine-1-phosphate"
                     /db_xref="GeneID:124976"
                     /db_xref="HGNC:HGNC:26992"
                     /db_xref="MIM:612584"
     exon            1..537
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1817
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /note="protein spinster homolog 2; SPNS sphingolipid
                     transporter 2; solute carrier family 63 member 2"
                     /codon_start=1
                     /product="sphingosine-1-phosphate transporter SPNS2"
                     /protein_id="NP_001118230.1"
                     /db_xref="CCDS:CCDS42237.1"
                     /db_xref="GeneID:124976"
                     /db_xref="HGNC:HGNC:26992"
                     /db_xref="MIM:612584"
                     /translation="MMCLECASAAAGGAEEEEADAERRRRRRGAQRGAGGSGCCGARG
                     AGGAGVSAAGDEVQTLSGSVRRAPTGPPGTPGTPGCAATAKGPGAQQPKPASLGRGRG
                     AAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGY
                     LGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTII
                     GDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTL
                     ILILVPATKRGHADQLGDQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGM
                     WIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKT
                     QRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGETLLFSNWAITADILMYV
                     VIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLC
                     PFVVVLGGMFFLATALFFVSDRARAEQQVNQLAMPPASVKV"
     exon            538..603
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..740
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..892
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..959
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1102
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1255
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1445
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1511
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1610
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1774
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1821
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..3404
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3386..3391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /note="hexamer: AATAAA"
     polyA_site      3404
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgagct gagcggtggc agcgccgcag ccggggccgg agcgcaggag ccgacggggc
       61 ccgaccagga tggtgcagtg gcggctccgc ggcgcacgca cgcgctgagc gggcccagcc
      121 tgggccccgc gccccccgcg ccccccgccg ccccgatccg ggccggcatg atgtgcctgg
      181 aatgcgcctc ggcggcggcg ggcggcgcgg aggaggagga ggcggacgcg gagcggcggc
      241 gccggcgccg gggggcgcag cgaggggctg gcggtagcgg ttgctgcggg gcgcggggcg
      301 cgggcggcgc tggagtctcg gccgcgggcg atgaggtgca gacgctgtcg ggcagcgtaa
      361 ggcgggcccc gaccggaccc cccggcaccc ccggcacccc cggctgcgca gctactgcaa
      421 agggccccgg cgctcagcag cccaaaccgg ccagcttggg ccgcgggcgg ggggcagccg
      481 ccgccatcct cagcttgggc aacgtgctca actacctgga caggtacacc gtggcaggcg
      541 tccttctgga catccagcag cactttgggg tcaaggaccg aggcgccggc ctgctgcagt
      601 cagtgttcat ctgtagcttc atggtggctg cccccatctt cggctacctg ggcgaccgct
      661 tcaacaggaa ggtgattctc agctgcggca ttttcttctg gtcggccgtc accttctcca
      721 gctccttcat tccccagcag tacttctggc tgctggtcct gtcccggggg ctggtgggca
      781 tcggggaggc cagctactcc accatcgccc ccactatcat tggcgacctc ttcaccaaga
      841 acacgcgtac gctcatgctg tccgtcttct acttcgccat cccactgggc agtggcctgg
      901 gctacattac tggctccagc gtgaagcagg cagccggaga ctggcactgg gcattgcggg
      961 tgtcccctgt cctgggcatg atcacaggaa cactcatcct cattctggtc ccagccacta
     1021 aaaggggtca tgccgaccag ctcggggacc agctcaaggc ccggacctca tggctccgag
     1081 atatgaaggc cctgattcga aaccgcagct acgtcttctc ctccctggcc acgtcggctg
     1141 tctccttcgc cacgggggcc ctgggcatgt ggatcccgct ctacctgcac cgcgcccaag
     1201 ttgtgcagaa gacagcagag acgtgcaaca gcccgccctg tggggccaag gacagcctca
     1261 tctttggggc catcacctgc tttacgggat ttctgggcgt ggtcacgggg gcaggagcca
     1321 cgcgctggtg ccgcctgaag acccagcggg ccgacccact ggtgtgtgcc gtgggcatgc
     1381 tgggctctgc catcttcatc tgcctgatct tcgtggctgc caagagcagc atcgtaggag
     1441 cctatatctg tatcttcgtc ggggagacgc tgctgttttc taactgggcc atcactgcag
     1501 acatcctcat gtacgtggtc atccccacgc ggcgcgccac tgccgtggcc ttgcagagct
     1561 tcacctccca cctgctgggg gacgccggga gcccctacct cattggcttt atctcagacc
     1621 tgatccgcca gagcactaag gactccccgc tctgggagtt cctgagcctg ggctacgcgc
     1681 tcatgctctg ccctttcgtc gtggtcctgg gcggcatgtt cttcctcgcc actgcgctct
     1741 tcttcgtcag cgaccgcgcc agggctgagc agcaggtgaa ccagctggcg atgccgcccg
     1801 catctgtgaa agtctgaggt ggtgccattg ggacaatgaa gaacccacac tcccacctcg
     1861 tctgggaggt gtcctacagc gtccgggacc ggctgggctg ccccaaagct ttctgtgtga
     1921 tccacggcta ggcacccacc ctctctggcc caggcctgct gagtggccct ggcatcaaga
     1981 agaggctgtg tcctcagtta ccctggaagg atgtgtgtgt tggagccaca cggttggaca
     2041 ggttcccagc cctaggtttg ggccgcaggg cccctggggc caaggaagaa gacagcccca
     2101 agtgggtgtc cggggagagc ctggcctgcc accagcttat gtgatcttgg gcaagtccct
     2161 gccctccctg gaacgaaggg ccagggggct ggactttccc acacaacttg ctgggcaaag
     2221 cacgatctgc agctttgaag actcaacaga ccctggacca tacggagagc aggtggccca
     2281 ggcctcaggg cggcagtccc ggctttgagg ctcacgcgag ggcctggtat gcagggacca
     2341 ctgctcagct gggcctcgga ccttggggat attggacgca acctggcaaa tgaagctggg
     2401 cgcccaagtc tctgggtact ccctggagga cactgtctca ctgtctcggg ttggctccca
     2461 gcctggaggt cccagatggg gactgttctg acaagctggc atcaccaggg gtgaaggccc
     2521 tggctgcagc tgtacaccac ctgtgccccc aggctcaagg tctctggcag gtgcacacca
     2581 gcccaactct gcagggcttc tctccctgcc accacccccc aagccaggac cccactcctt
     2641 ccccgaggct gagctgagcc ttttccaggg gcagggccca ggagaccatt cccagaatcc
     2701 atggggcagt agccagggct ccggctgctg gaggaagcag ctatccacaa agcttcctgc
     2761 cccagagctg aggctgaggc cccgggagag gcggccccta cccaaacact ggctgctggc
     2821 attccaccaa gtgaccccag gggggggcca ggccttcgat cacccacctc ccatccatgc
     2881 acacaccagg atgcagctgc caacttcaca ccagccccaa cccgctttgg gggagcttag
     2941 ccccctgcgt cacccactcc ctgcacttct gctgcaatca aggtggttct ggtgcggggg
     3001 tggggtgggg ggtgaggcct tgtggccaat gggggacccc ccaagagcca gcttggacaa
     3061 tgctcttctt gccccttagt tactggctgg ctgtggcttc agtggtgtgt aagcaggtgg
     3121 aatactcacc caccaagctc tggggtaccc cgagggcctg acaagaggat ggggtggggg
     3181 tggcatcctc caaagaccag cctccacccc cactccagcc tcagcggggc cccagcgatg
     3241 ttttcttgtt gtacaagaac caggtccgag tgttgcctcc tcttccttcc ggaagccaaa
     3301 ctgctccttt attttttaga gctgctgatt gtgaatctca gagtcttaag agagaagcca
     3361 aatatattcc tcttgtaaat gaagaaataa acctatttaa atca
//
