LOCUS       NP_001118230             549 aa            linear   PRI 27-APR-2025
DEFINITION  sphingosine-1-phosphate transporter SPNS2 [Homo sapiens].
ACCESSION   NP_001118230 XP_001719840
VERSION     NP_001118230.1
DBSOURCE    REFSEQ: accession NM_001124758.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 549)
  AUTHORS   Liang,W., Liu,M., Su,Y., Wen,Y., Wang,L., Shan,J., Zhao,J., Xie,K.
            and Wang,J.
  TITLE     Spinster homolog 2 reduces malignancies of glioblastoma via
            PTEN/PI3K/AKT pathway
  JOURNAL   IUBMB Life 76 (3), 140-160 (2024)
   PUBMED   37728571
  REMARK    GeneRIF: Spinster homolog 2 reduces malignancies of glioblastoma
            via PTEN/PI3K/AKT pathway.
REFERENCE   2  (residues 1 to 549)
  AUTHORS   Fang,C., Ren,P., Bian,G., Wang,J., Bai,J., Huang,J., Ding,Y.,
            Li,X., Li,M. and Hou,Z.
  TITLE     Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and
            prevents immunosuppression in sepsis
  JOURNAL   EMBO Rep 24 (8), e56635 (2023)
   PUBMED   37358015
  REMARK    GeneRIF: Enhancing Spns2/S1P in macrophages alleviates
            hyperinflammation and prevents immunosuppression in sepsis.
REFERENCE   3  (residues 1 to 549)
  AUTHORS   Chen,H., Ahmed,S., Zhao,H., Elghobashi-Meinhardt,N., Dai,Y.,
            Kim,J.H., McDonald,J.G., Li,X. and Lee,C.H.
  TITLE     Structural and functional insights into Spns2-mediated transport of
            sphingosine-1-phosphate
  JOURNAL   Cell 186 (12), 2644-2655 (2023)
   PUBMED   37224812
  REMARK    GeneRIF: Structural and functional insights into Spns2-mediated
            transport of sphingosine-1-phosphate.
REFERENCE   4  (residues 1 to 549)
  AUTHORS   Wang,D., Li,M., Shen,H., Yang,J., Gao,Z. and Tang,Y.
  TITLE     Iron Deficiency Increases Phosphorylation of SP1 to Upregulate
            SPNS2 Expression in Hepatocellular Carcinoma
  JOURNAL   Biol Trace Elem Res 201 (4), 1689-1694 (2023)
   PUBMED   35614326
  REMARK    GeneRIF: Iron Deficiency Increases Phosphorylation of SP1 to
            Upregulate SPNS2 Expression in Hepatocellular Carcinoma.
REFERENCE   5  (residues 1 to 549)
  AUTHORS   Jiang,Y., Yu,X.Y., Sun,H.X., Gu,X.Y. and Geng,J.S.
  TITLE     Long non-coding RNA HOXA-AS3 facilitates the malignancy in
            colorectal cancer by miR-4319/SPNS2 axis
  JOURNAL   J Physiol Biochem 77 (4), 653-666 (2021)
   PUBMED   34671931
  REMARK    GeneRIF: Long non-coding RNA HOXA-AS3 facilitates the malignancy in
            colorectal cancer by miR-4319/SPNS2 axis.
REFERENCE   6  (residues 1 to 549)
  AUTHORS   Bradley,E., Dasgupta,S., Jiang,X., Zhao,X., Zhu,G., He,Q.,
            Dinkins,M., Bieberich,E. and Wang,G.
  TITLE     Critical role of Spns2, a sphingosine-1-phosphate transporter, in
            lung cancer cell survival and migration
  JOURNAL   PLoS One 9 (10), e110119 (2014)
   PUBMED   25330231
  REMARK    GeneRIF: Spns2 plays key roles in regulating the cellular functions
            in non-small cell lung cancer (NSCLC) cells
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 549)
  AUTHORS   Nagahashi,M., Kim,E.Y., Yamada,A., Ramachandran,S., Allegood,J.C.,
            Hait,N.C., Maceyka,M., Milstien,S., Takabe,K. and Spiegel,S.
  TITLE     Spns2, a transporter of phosphorylated sphingoid bases, regulates
            their blood and lymph levels, and the lymphatic network
  JOURNAL   FASEB J 27 (3), 1001-1011 (2013)
   PUBMED   23180825
  REMARK    GeneRIF: Spns2 is an S1P transporter in vivo that plays a role in
            regulation not only of blood S1P but also lymph node and lymph S1P
            levels and consequently influences lymphocyte trafficking and
            lymphatic vessel network organization.
REFERENCE   8  (residues 1 to 549)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
  REMARK    GeneRIF: The sphingosine 1-phosphate transporter, SPNS2, functions
            as a transporter of the phosphorylated form of the immunomodulating
            agent FTY720.
REFERENCE   9  (residues 1 to 549)
  AUTHORS   Kawahara,A., Nishi,T., Hisano,Y., Fukui,H., Yamaguchi,A. and
            Mochizuki,N.
  TITLE     The sphingolipid transporter spns2 functions in migration of
            zebrafish myocardial precursors
  JOURNAL   Science 323 (5913), 524-527 (2009)
   PUBMED   19074308
REFERENCE   10 (residues 1 to 549)
  AUTHORS   Yanagisawa,H., Miyashita,T., Nakano,Y. and Yamamoto,D.
  TITLE     HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL,
            induces a caspase-independent autophagic cell death
  JOURNAL   Cell Death Differ 10 (7), 798-807 (2003)
   PUBMED   12815463
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC041772.1, AC118754.6 and
            HY309474.1.
            
            On Apr 23, 2008 this sequence version replaced XP_001719840.1.
            
            Summary: The protein encoded by this gene is a transporter of
            sphingosine 1-phosphate, a secreted lipid that is important in
            cardiovascular, immunological, and neural development. Defects in
            this gene are a cause of early onset progressive hearing loss.
            [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041772.1, SRR14038192.2057771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329078.8/ ENSP00000333292.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     Protein         1..549
                     /product="sphingosine-1-phosphate transporter SPNS2"
                     /note="protein spinster homolog 2; SPNS sphingolipid
                     transporter 2; solute carrier family 63 member 2"
                     /calculated_mol_wt=57913
     Region          14..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Region          61..97
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Region          106..520
                     /region_name="MFS_spinster_like"
                     /note="Protein spinster and spinster homologs of the Major
                     Facilitator Superfamily of transporters; cd17328"
                     /db_xref="CDD:340886"
     Site            order(115..116,119..120,123,155,207..208,210..212,215,235,
                     238..239,242,322,325..326,329..331,334,374,378,431..432,
                     436,440,460,463..464,467..468,471)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340886"
     Site            141..161
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            169..189
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            202..222
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            229..249
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            261..281
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            320..340
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            364..384
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            398..418
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            422..442
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            466..486
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     Site            507..527
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IVW8.2)"
     CDS             1..549
                     /gene="SPNS2"
                     /gene_synonym="DFNB115; SLC62A2; SLC63A2"
                     /coded_by="NM_001124758.3:168..1817"
                     /db_xref="CCDS:CCDS42237.1"
                     /db_xref="GeneID:124976"
                     /db_xref="HGNC:HGNC:26992"
                     /db_xref="MIM:612584"
ORIGIN      
        1 mmclecasaa aggaeeeead aerrrrrrga qrgaggsgcc gargaggagv saagdevqtl
       61 sgsvrraptg ppgtpgtpgc aatakgpgaq qpkpaslgrg rgaaaailsl gnvlnyldry
      121 tvagvlldiq qhfgvkdrga gllqsvfics fmvaapifgy lgdrfnrkvi lscgiffwsa
      181 vtfsssfipq qyfwllvlsr glvgigeasy stiaptiigd lftkntrtlm lsvfyfaipl
      241 gsglgyitgs svkqaagdwh walrvspvlg mitgtlilil vpatkrghad qlgdqlkart
      301 swlrdmkali rnrsyvfssl atsavsfatg algmwiplyl hraqvvqkta etcnsppcga
      361 kdslifgait cftgflgvvt gagatrwcrl ktqradplvc avgmlgsaif iclifvaaks
      421 sivgayicif vgetllfsnw aitadilmyv viptrratav alqsftshll gdagspylig
      481 fisdlirqst kdsplwefls lgyalmlcpf vvvlggmffl atalffvsdr araeqqvnql
      541 amppasvkv
//
