LOCUS       NM_199456               1434 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens sperm microtubule inner protein 8 (SPMIP8), transcript
            variant 2, mRNA.
ACCESSION   NM_199456 XM_351073
VERSION     NM_199456.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Hahn,Y.
  TITLE     Molecular evolution of TEPP protein genes in metazoans
  JOURNAL   Biochem Genet 47 (9-10), 651-664 (2009)
   PUBMED   19548082
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Bera,T.K., Hahn,Y., Lee,B. and Pastan,I.H.
  TITLE     TEPP, a new gene specifically expressed in testis, prostate, and
            placenta and well conserved in chordates
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1209-1215 (2003)
   PUBMED   14652002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC104459.1, HM005509.1 and AC010543.9.
            
            On Mar 17, 2020 this sequence version replaced NM_199456.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region compared to variant 1. The resulting protein
            (isoform 2) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY363222.1, BC104458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441824.4/ ENSP00000401917.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-615               BC104459.1         101-715
            616-626             HM005509.1         806-816
            627-764             BC104459.1         727-864
            765-1434            AC010543.9         150315-150984
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..1434
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /note="sperm microtubule inner protein 8"
                     /db_xref="GeneID:374739"
                     /db_xref="HGNC:HGNC:33745"
                     /db_xref="MIM:610264"
     exon            1..91
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            92..316
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..744
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     testis, prostate and placenta-expressed protein;
                     testis/prostate/placenta-expressed protein; testicular
                     tissue protein Li 196; testis, prostate and placenta
                     expressed"
                     /codon_start=1
                     /product="sperm microtubule inner protein 8 isoform 2"
                     /protein_id="NP_955535.3"
                     /db_xref="CCDS:CCDS45496.2"
                     /db_xref="GeneID:374739"
                     /db_xref="HGNC:HGNC:33745"
                     /db_xref="MIM:610264"
                     /translation="MARIIDLVPWDDGSTHVYASPAILLPMERQRNQLAGVKQQLYHP
                     ALPTLRHMDRDTVKACLPDEHCQSTTYCRKDEFDNAHFTLLGVPNKPLQCLDITATGQ
                     KLRNRYHEGKLAPIAPGINRVDWPCFTRAIEDWSHFVSSAGEFKLPCLRKRAEGLSGY
                     AVRYLKPDVTQTWRYCLSQNPSLDRYGQKPLPFDSLNTFRSFGSSYSRVNYLTPWH"
     exon            317..378
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            379..553
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            554..615
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            616..680
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            681..713
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            714..1434
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      861..866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /note="hexamer: AATAAA"
     polyA_site      889
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /note="major polyA site"
     regulatory      1410..1415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
                     /note="hexamer: AATAAA"
     polyA_site      1434
                     /gene="SPMIP8"
                     /gene_synonym="TEPP"
ORIGIN      
        1 ctcttctgcc cattgagcag tcaaagaact gaaagtcctt ataagcctgt gcacctgggc
       61 ctgggcccta cagataaggt agctgctatt gctatggccc gcatcattga cctggtgccc
      121 tgggacgatg gctccacaca tgtgtatgcc tccccggcca tcctgcttcc catggagcgg
      181 cagcgcaacc agctggcggg cgtgaagcag cagctctacc acccagccct gcccaccctg
      241 cgccacatgg acagggacac cgtcaaggcc tgccttcctg atgagcactg ccagtccacc
      301 acctactgcc gcaaagatga atttgacaac gcccatttta cactccttgg ggtccccaac
      361 aaacccctgc agtgtttgga catcaccgcc acaggccaga agcttcgcaa caggtaccac
      421 gagggaaagc tggcgcccat cgcgccaggc atcaaccgag tggactggcc ctgcttcacg
      481 cgcgccatcg aggactggtc ccacttcgtg tcctcggccg gggagttcaa gctgccttgc
      541 ctgaggaagc gagcggaggg tctcagcggc tacgcggtgc ggtacttgaa gcccgacgtg
      601 acccagacct ggcggtactg cctcagccag aaccccagcc tggaccgcta cggacagaag
      661 cccctgcctt tcgactccct gaacactttc cgaagcttcg gctccagcta cagtcgtgtc
      721 aactacctga ccccctggca ttaatctctg gaaaggaggc tgactcccag gctgccggac
      781 ggtgccacct caggtcccct ggccagacag aggacttatg gtggcaccag ccatctcccc
      841 aggagttcag cctaactaga aataaaccta atgctccctt agagacacac gcaattgtct
      901 ctgtctgtgt gtgttgcaca gcctgggaga gggtcagggc cacaggatga cagtatctta
      961 cccttgcccg tccccggcca actcctggag gactggtggg gggttggaga aaaatgtctg
     1021 gtgacctggt ttgagagtca gggtgtaagc cgcaaggtcc agccagaatt gagatccaag
     1081 agcaagagat gtgctccagc cccttgcctg cagccccaca cccaagcccc ctccatttca
     1141 gatcctgaat ttgagcccta agaagaaagg gagagggcta gaaagctatt tttaggtgcc
     1201 tttttgaagc tcttgtcata ctggtgtgct ctggggggct tccctgtgcc tggggtcccc
     1261 ctgaaggtgt gggagcaggc tggggcaagg ggagctggcc aggcctatgg ccttgattcc
     1321 tgtgacgcaa cagaatgtag agtctaaact tgcatgagat gcatgaagcc actcagagaa
     1381 gaaagttccc cgctctccaa agcaccacca ataaacatgt catttaagca aaaa
//
