LOCUS       NM_032596               1129 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sperm microtubule inner protein 6 (SPMIP6), transcript
            variant 1, mRNA.
ACCESSION   NM_032596
VERSION     NM_032596.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1129)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 1129)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1129)
  AUTHORS   Pleuger,C., Fietz,D., Hartmann,K., Schuppe,H.C., Weidner,W.,
            Kliesch,S., Baker,M., O'Bryan,M.K. and Bergmann,M.
  TITLE     Expression of ciliated bronchial epithelium 1 during human
            spermatogenesis
  JOURNAL   Fertil Steril 108 (1), 47-54 (2017)
   PUBMED   28601408
  REMARK    GeneRIF: Our data strongly suggest an influence of CBE1 in
            ciliogenesis in spermatids due to the localization at the
            microtubules of the elongating spermatids, indicating a role in the
            intramanchette and/or intraflagellar transport mechanism.
REFERENCE   4  (bases 1 to 1129)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1129)
  AUTHORS   Haitchi,H.M., Yoshisue,H., Ribbene,A., Wilson,S.J., Holloway,J.W.,
            Bucchieri,F., Hanley,N.A., Wilson,D.I., Zummo,G., Holgate,S.T. and
            Davies,D.E.
  TITLE     Chronological expression of Ciliated Bronchial Epithelium 1 during
            pulmonary development
  JOURNAL   Eur Respir J 33 (5), 1095-1104 (2009)
   PUBMED   19213785
  REMARK    GeneRIF: Chronological regulation of CBE1/Cbe1 expression during
            pulmonary differentiation suggests involvement in ciliogenesis,
            with an additional role during early lung development.
REFERENCE   6  (bases 1 to 1129)
  AUTHORS   Matsuoka,Y., Miyagawa,Y., Tokuhiro,K., Kitamura,K., Iguchi,N.,
            Maekawa,M., Takahashi,T., Tsujimura,A., Matsumiya,K., Okuyama,A.,
            Nishimune,Y. and Tanaka,H.
  TITLE     Isolation and characterization of the spermatid-specific Smrp1 gene
            encoding a novel manchette protein
  JOURNAL   Mol Reprod Dev 75 (6), 967-975 (2008)
   PUBMED   18163442
REFERENCE   7  (bases 1 to 1129)
  AUTHORS   Pope,S.N. and Lee,I.R.
  TITLE     Yeast two-hybrid identification of prostatic proteins interacting
            with human sex hormone-binding globulin
  JOURNAL   J Steroid Biochem Mol Biol 94 (1-3), 203-208 (2005)
   PUBMED   15862967
REFERENCE   8  (bases 1 to 1129)
  AUTHORS   Yoshisue,H., Puddicombe,S.M., Wilson,S.J., Haitchi,H.M.,
            Powell,R.M., Wilson,D.I., Pandit,A., Berger,A.E., Davies,D.E.,
            Holgate,S.T. and Holloway,J.W.
  TITLE     Characterization of ciliated bronchial epithelium 1, a ciliated
            cell-associated gene induced during mucociliary differentiation
  JOURNAL   Am J Respir Cell Mol Biol 31 (5), 491-500 (2004)
   PUBMED   15242845
  REMARK    GeneRIF: CBE1 may play an important role in the differentiation
            and/or function of ciliated cells in human airways
REFERENCE   9  (bases 1 to 1129)
  AUTHORS   Sha,J., Zhou,Z., Li,J., Yin,L., Yang,H., Hu,G., Luo,M., Chan,H.C.
            and Zhou,K.
  CONSRTM   Spermatogenesis study group
  TITLE     Identification of testis development and spermatogenesis-related
            genes in human and mouse testes using cDNA arrays
  JOURNAL   Mol Hum Reprod 8 (6), 511-517 (2002)
   PUBMED   12029067
REFERENCE   10 (bases 1 to 1129)
  AUTHORS   Adams,M.D., Soares,M.B., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     Rapid cDNA sequencing (expressed sequence tags) from a
            directionally cloned human infant brain cDNA library
  JOURNAL   Nat Genet 4 (4), 373-380 (1993)
   PUBMED   8401585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC029484.1 and AK058087.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032596.3.
            
            Summary: This gene encodes a nuclear- or perinuclear-localized
            protein with no predicted domains or similarity to other known
            proteins. Expression of this gene is induced during the
            differentiation of bronchial epithelial cells, and the encoded
            protein may play a role in ciliogenesis. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022084.1, SRR5189667.362332.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297623.7/ ENSP00000297623.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               BC029484.1         42-189
            149-917             AK058087.1         128-896
            918-1129            BC029484.1         959-1170
FEATURES             Location/Qualifiers
     source          1..1129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1129
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /note="sperm microtubule inner protein 6"
                     /db_xref="GeneID:84688"
                     /db_xref="HGNC:HGNC:19919"
                     /db_xref="MIM:619502"
     exon            1..312
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..966
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ciliated bronchial epithelium 1; testis development
                     protein NYD-SP22; ciliated bronchial epithelial protein 1;
                     spermatid-specific manchette-related protein 1"
                     /codon_start=1
                     /product="sperm microtubule inner protein 6 isoform 1"
                     /protein_id="NP_115985.2"
                     /db_xref="CCDS:CCDS6554.1"
                     /db_xref="GeneID:84688"
                     /db_xref="HGNC:HGNC:19919"
                     /db_xref="MIM:619502"
                     /translation="MFLFSRKTRTPISTYSDSYRAPTSIKEVYKDPPLCAWEANKFLT
                     PGLTHTMERHVDPEALQKMAKCAVQDYTYRGSISGHPYLPEKYWLSQEEADKCSPNYL
                     GSDWYNTWRMEPYNSSCCNKYTTYLPRLPKEARMETAVRGMPLECPPRPERLNAYERE
                     VMVNMLNSLSRNQQLPRITPRCGCVDPLPGRLPFHGYESACSGRHYCLRGMDYYASGA
                     PCTDRRLRPWCREQPTMCTSLRAPARNAVCCYNSPAVILPISEP"
     exon            313..457
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..573
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..649
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..879
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..966
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1129
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1109..1114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /note="hexamer: AATAAA"
     polyA_site      1129
                     /gene="SPMIP6"
                     /gene_synonym="bA573M23.4; C9orf24; CBE1; NYD-SP22; SMRP1"
                     /note="major polyA site"
ORIGIN      
        1 gggagcagga aggctgttgg ggaaggaagc tgagagatcc tctgcaggag gggattatag
       61 cagctaaggg cacctgccag gctggaggtg tggcctgtct aggggaaggg tggtcactga
      121 tgtccagcag gagcccttga caggtagagc ccaccacggc atctccaaga ccacaccatg
      181 ttcctgttct cccgtaagac caggacccct atcagtacct acagtgactc ctacagggct
      241 cccacctcca tcaaggaggt ctataaggac ccacccctgt gtgcctggga agccaacaag
      301 tttctgactc cgggtctgac tcataccatg gagcgacatg tggatcccga agccctgcag
      361 aagatggcca aatgtgctgt acaggactac acttataggg ggtccatatc aggccacccc
      421 tacttgcctg agaagtactg gctttctcaa gaggaagcag acaaatgcag cccaaactac
      481 ctgggcagtg actggtacaa cacatggagg atggaacctt acaacagcag ctgctgcaac
      541 aagtatacca cctaccttcc tcggctgcct aaggaggcca ggatggagac agcagttcga
      601 ggaatgccct tggaatgccc tcctaggccg gagcggctca atgcctacga gcgcgaagtg
      661 atggtgaaca tgctgaactc actgtcgcgg aaccagcagc tgccgcggat cacgccccga
      721 tgcgggtgcg tggacccgct gcccggccgc ctgcccttcc atggttacga aagtgcttgc
      781 tcgggccgcc actactgtct gcgcgggatg gactactacg ccagcggggc gccctgcacc
      841 gaccgccgcc tgcggccttg gtgccgggag caaccgacta tgtgtacctc cctacgagca
      901 ccggcccgga atgcagtgtg ctgttacaac tcccccgccg tcatactacc catatccgaa
      961 ccttagatgg gacacaagtc acttcaagaa gtctggtggt ccccagagaa acaactatgt
     1021 tatccatcct gagtttgtgt ctgagaccta tcccgactat cgttgctggt agagcctggg
     1081 cttgctgtgc caagggggca gagcaataaa taaactcttc aaccccaaa
//
