LOCUS       NM_138811               3770 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sperm microtubule inner protein 4 (SPMIP4), transcript
            variant 1, mRNA.
ACCESSION   NM_138811
VERSION     NM_138811.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3770)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 3770)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3770)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3770)
  AUTHORS   Liu,S., Xu,Y. and Zhang,S.
  TITLE     LINGO1, C7orf31 and VEGFA are prognostic genes of primary
            glioblastoma: analysis of gene expression microarray
  JOURNAL   Neoplasma 65 (4), 532-541 (2018)
   PUBMED   30064229
  REMARK    GeneRIF: LINGO1 might be a positive primary glioblastoma prognostic
            gene and C7orf31 and VEGFA might be negative prognosticators.
REFERENCE   5  (bases 1 to 3770)
  AUTHORS   Firat-Karalar,E.N., Sante,J., Elliott,S. and Stearns,T.
  TITLE     Proteomic analysis of mammalian sperm cells identifies new
            components of the centrosome
  JOURNAL   J Cell Sci 127 (Pt 19), 4128-4133 (2014)
   PUBMED   25074808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004129.2, BC043269.2, BI830207.1, BC060879.1 and BX640851.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138811.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060879.1, SRR1803612.109165.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283905.8/ ENSP00000283905.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC004129.2         55333-55488         c
            157-941             BC043269.2         104-888
            942-1297            BI830207.1         323-678
            1298-2268           BC060879.1         1055-2025
            2269-2725           BC043269.2         2216-2672
            2726-3765           BX640851.1         1640-2679
            3766-3770           AC004129.2         9826-9830           c
FEATURES             Location/Qualifiers
     source          1..3770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..3770
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /note="sperm microtubule inner protein 4"
                     /db_xref="GeneID:136895"
                     /db_xref="HGNC:HGNC:21722"
                     /db_xref="MIM:616071"
     exon            1..693
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     exon            694..851
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     CDS             718..2490
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /note="uncharacterized protein C7orf31; sperm associated
                     microtubule inner protein 4"
                     /codon_start=1
                     /product="sperm-associated microtubule inner protein 4"
                     /protein_id="NP_620166.3"
                     /db_xref="CCDS:CCDS5394.1"
                     /db_xref="GeneID:136895"
                     /db_xref="HGNC:HGNC:21722"
                     /db_xref="MIM:616071"
                     /translation="MEVIHGRPYCCRELEGADILSNTFYSNELHNPLQTVTRPTASED
                     RYQELRESLQQCRLPWGAEREYGGIIPISLPEDHRPKYEPPRVMGKGHQHYGFGGETW
                     PRKLPVEQFYYLTQNKKSDVYGNDSLIPKPPNSTVGEICLPYPIEHPYHTHICRGAMF
                     PTFTSPEDLYTGIKARTQQPFPPTVPTKAYDSTVLKTRGNPYRYELIDIPMDSKKKAL
                     TWPGQGVYYDFPRGVEKNKPVFYPKPPKTFAPNTSLNSWDPICSAKEANIQRNLERSH
                     WLTSYTHDFTGLGPMDPLELDDYHEKMVAELTRKIGFDPEPQEKFHPVFKPPRPLEGR
                     IARLIQNRRSLEAIVQQRPRSCPDCTPRVLCNFHTFVPSSKEMVALSDNIPAGVTHKN
                     QDIEEKIIEEQSLLSTYELPSCYPTKDLTSIYDIKPFPKITDTKKTEDLYWRQQSLKT
                     QPTPYCKPDHWIHYENLKSPLRDQYNMCPDPVSLSKPSVLQNKQDTEAFTLEHFLSKP
                     EEELFLNMENNEETRPVLGWIPRAGVTKPQTNLLELKNSFSKTGAQKRFHKSILEDHK
                     DLRDNEHSGMKHQFYGHNSYYFYN"
     exon            852..1028
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1100
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1130
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1312
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1401
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1576
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1668
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..3770
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2702..2707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /note="hexamer: AATAAA"
     polyA_site      2725
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /note="major polyA site"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /note="hexamer: AATAAA"
     polyA_site      2918
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
     regulatory      3179..3184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /note="hexamer: GATAAA"
     polyA_site      3198
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
     regulatory      3734..3739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
                     /note="hexamer: AATAAA"
     polyA_site      3770
                     /gene="SPMIP4"
                     /gene_synonym="C7orf31"
ORIGIN      
        1 agagcccctc tcgcctccga cccggcgcct cgcactccgt tcactctcgg ttcctcttcg
       61 cattcttgcc agtcccgtag cgctgggctg gtttcctccg aggtctctaa gagcctccta
      121 ctgcgccccg ctcgccgccc ggaagccccc agcccctcaa ggacgcatca cctaatgccg
      181 cggtcacggc caccgtcaca agcgccccca gccccacccc accccggcct gcccgccgtc
      241 cttctcccgc ccccgcccct gcctgccagc tccaccgggc cgtaggtgcg gacgacctca
      301 aaattcctcg gcccgcgaag gccgccagct gcggggaggg gaggggaggc gcggtcccgc
      361 agcgccccca ggctcatgtc ccaggtatgt ccagaccccc gaggcaccgc ttgcagggca
      421 gtgacagccc gtgaggctcg gcctcgaccc ctggcaccct tggtcccagc tacgccggct
      481 cctggccttc ccccaagtcc gagagagagg tgggattctc cccgacgcag ttggaaaccg
      541 ggaatcccct ttagggtccc gttcgtgctg cactactgac tccaccatct gcaaagggat
      601 tcttgtccag aatccccgaa ggctttagga cagcgcttat tttgttgaat gaagagtctc
      661 taattttcgg aaagaccaca ggctaaaagt caagttgtgc ctttttagcc aagaagcatg
      721 gaagtcattc acggcaggcc ctactgttgc agggagcttg aaggagctga catactgtcc
      781 aacacctttt actctaatga attgcacaac cccctccaga cggttactcg cccaactgcc
      841 tcagaggaca ggtatcagga attaagggag tcacttcaac aatgtaggct tccttggggc
      901 gctgaaagag agtatggtgg gataataccg atttcactcc ccgaggacca caggccaaag
      961 tatgagcctc ctcgtgtcat gggcaaagga catcagcatt atggatttgg tggagaaacc
     1021 tggccaagaa agcttcctgt tgaacaattt tattatttga cccagaacaa aaaaagtgat
     1081 gtctatggaa atgattcttt gatacccaag ccgcctaatt caacagtagg agagatctgc
     1141 ttgccatatc caattgaaca cccctaccac acacacatct gtcgcggcgc catgttcccc
     1201 accttcacgt cacctgagga cctctacacg ggcattaaag cccgcaccca gcagcccttt
     1261 cctcccacgg tgccaaccaa ggcttatgat tcaacagttt tgaagacaag aggtaatcct
     1321 tatagatatg aactgattga tattcccatg gattcaaaga agaaagcact gacttggcca
     1381 ggtcaaggtg tatattatga ttttcccaga ggtgttgaga aaaataagcc agtattctac
     1441 ccaaaacctc ctaaaacctt cgctcctaac acttctttaa attcatggga ccctatttgc
     1501 tctgccaaag aagccaacat acaaagaaat cttgagaggt cccactggct cacttcgtac
     1561 actcatgatt ttacaggtct ggggcccatg gacccccttg aactggatga ttaccatgaa
     1621 aagatggtag cagagttaac acgaaagata ggatttgacc cagagccgca agaaaaattc
     1681 caccctgtct tcaaacctcc cagaccgttg gaaggacgaa ttgcccgatt aattcagaac
     1741 cgacgttctc tggaggctat agtccagcaa agaccacgtt cctgtccaga ttgtactcct
     1801 agagttttgt gtaattttca tacctttgta cccagttcta aagaaatggt ggcacttagt
     1861 gataacatac cagccggtgt gacccataaa aaccaggata ttgaagagaa gatcatagaa
     1921 gaacagagct tgctgtctac ctatgaactc ccatcttgtt acccaacaaa agacctaact
     1981 agcatttatg acataaagcc atttccaaaa atcacagata ctaaaaagac agaagattta
     2041 tactggagac agcagtcact aaaaacccaa cccacacctt actgtaaacc agaccactgg
     2101 attcactatg aaaatcttaa atctccccta cgtgatcagt ataatatgtg tccagaccct
     2161 gttagcctta gtaaacctag tgttttacaa aataaacaag acacggaagc tttcacttta
     2221 gaacattttt taagtaagcc agaagaagag ttgttcttga atatggaaaa caatgaagaa
     2281 acaagacctg ttcttggttg gattcctaga gctggagtga ccaaacctca gaccaacctg
     2341 ctggagctta agaactcttt ttcaaaaact ggtgcacaaa agcgtttcca taaatcaatt
     2401 ctagaagacc ataaagacct cagggataat gagcattcgg ggatgaagca ccaattctat
     2461 ggccataatt cctattattt ctataattga gatactcatt cttcccttca aaacccagcc
     2521 tcttgcaaga agctaaaaaa tataacagaa tttccttcgt attgctggat tctgttttct
     2581 agattaaacc acaaggacct tgttagtgag gtttacattt tcaggaattt aagttagtat
     2641 ctggttggag gaacccagaa aaggtgatgt tatgacttct tgaaaagttt aacaatttgg
     2701 caataaaata ttagaactag aaaaatttat agtctttaat ctctcatctt cagattatac
     2761 aaggaaattt tccaaaatca caaaaagcaa tgtgtacaac aaagtttaca tcattgtttc
     2821 accaaaaaaa attgaaaagc tggaaagaac tcaaatgatc aataattaat gaatgactat
     2881 acaaattata gtatcttaat aaaaatgaga acactgtccc tttatgtaaa tttttgtaca
     2941 tagtagcatt aggtagaaaa gacaaaaccc aaacacctag ttaattgagg gatggacacc
     3001 tctaaaaact atattgtctt aaaagtatgt ggactctgtt cctttatgta aacatgtaaa
     3061 gaaaataagt cagcgaaaaa aatgaaaccc aaaactctct gcatgtacac attacaaatt
     3121 gaattgtttg cttaccctta accttctgat tgagaaacat aactgtttct tttatgcaga
     3181 taaaattatt ttactgaaga tctagcaatg gccttaatta gcaactggtg agttctaatt
     3241 atagcaagaa aggatggctt ggtatcagtt attacagagc cccaaatctt catttctgga
     3301 gtgtgttctc taagagtttg gctaactccc atatgcaagt caattcattt aatgtgccaa
     3361 gaggtagatt ttaaacatag tctatcgtgg aagttcaaga ggaatttctt taagtatttt
     3421 gtgaatattt attttaattt tatgaccaac atgtcatttg gttgtaacct ccttaaaact
     3481 attctgggct aaagttagag aatttttttc caactgcatt ctgtacagca ctagttacat
     3541 tatgacagga agtaaaagtt tacatggtga aataatactg gggaaatcgg agcaacaatg
     3601 tcagttgcat gccttggtca ctgggttctc tatagccttt aatatgtaat gcaattggga
     3661 gtgtctgaag tgagggagat atagtgtaca cactttttat cacagagtag atcactggaa
     3721 tggaattcca aataataaac tttggaaggt gtaactctcc agtataaaaa
//
