LOCUS       NM_001012970            1151 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sperm microtubule inner protein 3 (SPMIP3), transcript
            variant 1, mRNA.
ACCESSION   NM_001012970 XM_114129
VERSION     NM_001012970.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1151)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 1151)
  AUTHORS   Forno,E., Lasky-Su,J., Himes,B., Howrylak,J., Ramsey,C., Brehm,J.,
            Klanderman,B., Ziniti,J., Melen,E., Pershagen,G., Wickman,M.,
            Martinez,F., Mauger,D., Sorkness,C., Tantisira,K., Raby,B.A.,
            Weiss,S.T. and Celedon,J.C.
  TITLE     Genome-wide association study of the age of onset of childhood
            asthma
  JOURNAL   J Allergy Clin Immunol 130 (1), 83-90 (2012)
   PUBMED   22560479
REFERENCE   3  (bases 1 to 1151)
  AUTHORS   David,S.P., Hamidovic,A., Chen,G.K., Bergen,A.W., Wessel,J.,
            Kasberger,J.L., Brown,W.M., Petruzella,S., Thacker,E.L., Kim,Y.,
            Nalls,M.A., Tranah,G.J., Sung,Y.J., Ambrosone,C.B., Arnett,D.,
            Bandera,E.V., Becker,D.M., Becker,L., Berndt,S.I., Bernstein,L.,
            Blot,W.J., Broeckel,U., Buxbaum,S.G., Caporaso,N., Casey,G.,
            Chanock,S.J., Deming,S.L., Diver,W.R., Eaton,C.B., Evans,D.S.,
            Evans,M.K., Fornage,M., Franceschini,N., Harris,T.B.,
            Henderson,B.E., Hernandez,D.G., Hitsman,B., Hu,J.J., Hunt,S.C.,
            Ingles,S.A., John,E.M., Kittles,R., Kolb,S., Kolonel,L.N., Le
            Marchand,L., Liu,Y., Lohman,K.K., McKnight,B., Millikan,R.C.,
            Murphy,A., Neslund-Dudas,C., Nyante,S., Press,M., Psaty,B.M.,
            Rao,D.C., Redline,S., Rodriguez-Gil,J.L., Rybicki,B.A.,
            Signorello,L.B., Singleton,A.B., Smoller,J., Snively,B., Spring,B.,
            Stanford,J.L., Strom,S.S., Swan,G.E., Taylor,K.D., Thun,M.J.,
            Wilson,A.F., Witte,J.S., Yamamura,Y., Yanek,L.R., Yu,K., Zheng,W.,
            Ziegler,R.G., Zonderman,A.B., Jorgenson,E., Haiman,C.A. and
            Furberg,H.
  TITLE     Genome-wide meta-analyses of smoking behaviors in African Americans
  JOURNAL   Transl Psychiatry 2 (5), e119 (2012)
   PUBMED   22832964
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054479.1, HY055397.1, BX099227.1 and AL645465.15.
            
            On May 17, 2019 this sequence version replaced NM_001012970.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY042088.1, SRR5189667.242397.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308105.5/ ENSP00000311218.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BC054479.1         5-48
            45-503              HY055397.1         1-459
            504-576             BX099227.1         317-389
            577-1151            AL645465.15        47491-48065
FEATURES             Location/Qualifiers
     source          1..1151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..1151
                     /gene="SPMIP3"
                     /gene_synonym="C1orf100"
                     /note="sperm microtubule inner protein 3"
                     /db_xref="GeneID:200159"
                     /db_xref="HGNC:HGNC:30435"
     exon            1..100
                     /gene="SPMIP3"
                     /gene_synonym="C1orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            101..169
                     /gene="SPMIP3"
                     /gene_synonym="C1orf100"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..557
                     /gene="SPMIP3"
                     /gene_synonym="C1orf100"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C1orf100; sperm associated
                     microtubule inner protein 3; protein SPMIP3"
                     /codon_start=1
                     /product="protein SPMIP3 isoform 1"
                     /protein_id="NP_001012988.1"
                     /db_xref="CCDS:CCDS31079.1"
                     /db_xref="GeneID:200159"
                     /db_xref="HGNC:HGNC:30435"
                     /translation="MTAIRLREFIERRPVIPPSIFIAHQGRDVQGYYPGQLARLHFDH
                     SAKRAPRPLIDLTIPPKTKYHYQPQLDQQTLIRYICLRRHSKPAEPWYKETTYRRDYS
                     LPFYEIDWNQKLATVSLNPRPLNSLPELYCCEERSSFERNAFKLK"
     exon            170..265
                     /gene="SPMIP3"
                     /gene_synonym="C1orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            266..438
                     /gene="SPMIP3"
                     /gene_synonym="C1orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            439..1151
                     /gene="SPMIP3"
                     /gene_synonym="C1orf100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      548..553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMIP3"
                     /gene_synonym="C1orf100"
                     /note="hexamer: ACTAAA"
     polyA_site      576
                     /gene="SPMIP3"
                     /gene_synonym="C1orf100"
                     /note="major polyA site"
ORIGIN      
        1 actctgcagt tgatccagca gcaggaggca gctgtaccca tcactgtcct cagagtactt
       61 ttaagaacaa ggaggtctct gcccacggca gcccaagcag attcccatcc atcatgactg
      121 ccatccgact acgagaattt attgagcgtc gcccagtgat cccgccaagt atattcatcg
      181 ctcaccaagg aagagacgtt caaggctatt accctgggca gctggcaaga ctccattttg
      241 atcatagtgc aaagagagct cccagaccgc tcatagactt gacaattcca cccaagacaa
      301 aatatcacta tcagcctcaa ttagaccaac aaacactcat tcgatatatt tgtcttcgaa
      361 gacattcaaa gcctgccgag ccatggtata aagaaaccac ttaccgacga gactattctc
      421 tgccatttta tgagattgat tggaaccaga aattagccac agtttcgctg aatcctcgac
      481 cgcttaattc actgccagag ctctactgtt gtgaagagag aagcagcttt gaaagaaatg
      541 cttttaaact aaaataacca cggcattcga acaaaataac gtttggcatt cttaggtggc
      601 ccttttagac taagttaatg gcagcagaac tactttcagt ttcagtgtgt atacagatgg
      661 ctataatcct aaaatattta catgttgcaa attctttgca gattaagttg gtcagcttag
      721 aacagggaat caagatctat ccttaagaga acttgaattt aagccccact cccagtctta
      781 ttgctgatgc tggcaagcta tcttacattt aggccaatgt atacgcagga tcaggtaaga
      841 agatcattgt gtctgcacaa taattgcatc gctgttggga aaaataaaaa aaagaaccgg
      901 ggggacatgg ccaattataa agaaaactgg cactggagac cctcaagggg ctctggatgg
      961 agaaacccag gtgtagcctg aggctgtagc gagatgtggg actgataaaa aggattaact
     1021 gagagtctgt gtccaggagt tagcacccct atcttggcaa gaagaaagcc tgacaactag
     1081 gcatcagctc ctcaggcaga aagctaaagg gtcttctcta gggagaggaa agaatcccaa
     1141 aggaaaaaaa c
//
