LOCUS       NM_152543               1263 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sperm microtubule inner protein 2 (SPMIP2), mRNA.
ACCESSION   NM_152543
VERSION     NM_152543.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1263)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 1263)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093700.4, BP369394.1, DB037602.1 and AC109823.4.
            
            On May 17, 2019 this sequence version replaced NM_152543.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK058100.1, SRR5189652.16643.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434826.3/ ENSP00000412215.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC093700.4         136250-136297       c
            49-346              BP369394.1         1-298
            347-411             AC093700.4         74166-74230         c
            412-619             BP369394.1         364-571
            620-865             DB037602.1         274-519
            866-1263            AC109823.4         72410-72807         c
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..1263
                     /gene="SPMIP2"
                     /gene_synonym="C4orf45"
                     /note="sperm microtubule inner protein 2"
                     /db_xref="GeneID:152940"
                     /db_xref="HGNC:HGNC:26342"
     exon            1..197
                     /gene="SPMIP2"
                     /gene_synonym="C4orf45"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..694
                     /gene="SPMIP2"
                     /gene_synonym="C4orf45"
                     /note="uncharacterized protein C4orf45; sperm associated
                     microtubule inner protein 2"
                     /codon_start=1
                     /product="protein SPMIP2"
                     /protein_id="NP_689756.2"
                     /db_xref="CCDS:CCDS47156.1"
                     /db_xref="GeneID:152940"
                     /db_xref="HGNC:HGNC:26342"
                     /translation="MASVSYQKPTSTTVGKQMIFTGPDYIKDYLPKIHQHTSYVGEQH
                     LALEKTGDLRYLWRPASNRSLPAKYKHEYVSEIGWRIPQYNFINKSRLGSGFHIKYEE
                     LSQASLDSITHRYQNPWQPKPHVLDMQGKQSRASFAWHMSAFEDTDQRNSKWAILVRQ
                     CKSSLPRASKPPKLPKLPKKEKKRKH"
     exon            198..430
                     /gene="SPMIP2"
                     /gene_synonym="C4orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            431..489
                     /gene="SPMIP2"
                     /gene_synonym="C4orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            490..679
                     /gene="SPMIP2"
                     /gene_synonym="C4orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            680..1263
                     /gene="SPMIP2"
                     /gene_synonym="C4orf45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      844..849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMIP2"
                     /gene_synonym="C4orf45"
                     /note="hexamer: AATAAA"
     polyA_site      863
                     /gene="SPMIP2"
                     /gene_synonym="C4orf45"
                     /note="major polyA site"
ORIGIN      
        1 attagcaacc acctggtgca ggtcacaagc agggagagga aagactgcag agtctttcgt
       61 tctttctggt gcagcttaac tgatttgaag aagccgaaga agaaaatcca gtagcacggt
      121 taagacttta gccatggcat ctgtatcata ccaaaagcca acatctacta ctgtgggaaa
      181 acaaatgatt tttacaggtc cagactacat aaaggattat ttacccaaaa ttcatcagca
      241 cacctcctat gtaggagaac agcatctggc gttagaaaaa actggagatc tcagatattt
      301 atggaggcct gcctcaaata gaagcttgcc agcaaaatat aaacatgagt acgtcagtga
      361 aattggttgg agaataccac agtataattt tatcaacaaa tcaagactgg ggagtggctt
      421 tcatatcaag tatgaagaac taagtcaagc ttctcttgat tcaataaccc acagatatca
      481 aaacccatgg caaccaaaac ctcatgtcct ggatatgcaa ggaaaacaga gtcgcgcttc
      541 ttttgcctgg catatgagtg ctttcgagga cactgatcag agaaattcca aatgggctat
      601 tcttgttagg cagtgtaagt catcattgcc aagagcttcc aaaccaccta agctgccgaa
      661 gctaccaaaa aaggaaaaga aaaggaaaca ttaacctcta aatcagcata actcaacctg
      721 cttttagaag gagaaactgc ctactactgt ataacaaaaa ataagatcat aataatccac
      781 aagtgcttct catattgccc caggacagat gtcttgcaag agtacgcttc agcttaaagc
      841 ccaaataaac agtttggaaa aaaggtgttg tcagtctttg caaccattaa tattgtttca
      901 tgaaactaat tgttattgac tatcatacta atagtagctg tttactgagt gcttataaca
      961 tctaacacta ttccaagtgc tttacattca ttctctaata taatttcata accataggag
     1021 ataggttcta ttatttcccc agctttgcag ataaggaaat taaggctttg aaagagtaca
     1081 tggttaggaa gtagcagaac ttggatttga ccccaggtta tggggctcta aagctaacat
     1141 atatggcttt taaagtattt tataatattg gcatggtgct ttagcagtaa aaagcagtta
     1201 tatccctaat tttcagaaga ttctcacagc acccttgttg aacaggtact atctttcttt
     1261 tac
//
