LOCUS       NM_016585               1649 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sperm microtubule associated protein 2 (SPMAP2),
            transcript variant 1, mRNA.
ACCESSION   NM_016585
VERSION     NM_016585.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1649)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 1649)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1649)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1649)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1649)
  AUTHORS   Mannan,A.U., Nayernia,K., Mueller,C., Burfeind,P., Adham,I.M. and
            Engel,W.
  TITLE     Male mice lacking the Theg (testicular haploid expressed gene)
            protein undergo normal spermatogenesis and are fertile
  JOURNAL   Biol Reprod 69 (3), 788-796 (2003)
   PUBMED   12748127
  REMARK    GeneRIF: Functional analysis of the mouse counterpart.
REFERENCE   6  (bases 1 to 1649)
  AUTHORS   Yanaka,N., Kobayashi,K., Wakimoto,K., Yamada,E., Imahie,H., Imai,Y.
            and Mori,C.
  TITLE     Insertional mutation of the murine kisimo locus caused a defect in
            spermatogenesis
  JOURNAL   J Biol Chem 275 (20), 14791-14794 (2000)
   PUBMED   10747865
  REMARK    GeneRIF: Functional analysis of the mouse counterpart.
REFERENCE   7  (bases 1 to 1649)
  AUTHORS   Mannan,A., Lucke,K., Dixkens,C., Neesen,J., Kamper,M., Engel,W. and
            Burfeind,P.
  TITLE     Alternative splicing, chromosome assignment and subcellular
            localization of the testicular haploid expressed gene (THEG)
  JOURNAL   Cytogenet Cell Genet 91 (1-4), 171-179 (2000)
   PUBMED   11173852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016588.9, AB033129.1 and
            AF268610.1.
            
            On May 17, 2019 this sequence version replaced NM_016585.4.
            
            Summary: This gene is specifically expressed in the nucleus of
            haploid male germ cells. The orthologous gene in mice encodes a
            protein that may play a role in protein assembly through
            interactions with T-complex protein 1 subunit epsilon.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Nov
            2011].
            
            Transcript Variant: This variant (1, also known as THEG major)
            represents the longer transcript and encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF268610.1, AB033129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342640.9/ ENSP00000340088.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC016588.9         143946-143958       c
            14-1233             AB033129.1         1-1220
            1234-1339           AF268610.1         1187-1292
            1340-1649           AC016588.9         129679-129988       c
FEATURES             Location/Qualifiers
     source          1..1649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1649
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /note="sperm microtubule associated protein 2"
                     /db_xref="GeneID:51298"
                     /db_xref="HGNC:HGNC:13706"
                     /db_xref="MIM:609503"
     exon            1..364
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1196
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 56; testis-specific; theg spermatid
                     protein; testicular haploid expressed gene protein; Theg
                     homolog"
                     /codon_start=1
                     /product="sperm microtubule associated protein 2 isoform
                     1"
                     /protein_id="NP_057669.1"
                     /db_xref="CCDS:CCDS12025.1"
                     /db_xref="GeneID:51298"
                     /db_xref="HGNC:HGNC:13706"
                     /db_xref="MIM:609503"
                     /translation="MGDSRRRSLGNQPSSEAAGRSEREQDGDPRGLQSSVYESRRVTD
                     PERQDLDNAELGPEDPEEELPPEEVAGEEFPETLDPKEALSELERVLDKDLEEDIPEI
                     SRLSISQKLPSTTMTKARKRRRRRRLMELAEPKINWQVLKDRKGRCGKGYAWISPCKM
                     SLHFCLCWPSVYWTERFLEDTTLTITVPAVSRRVEELSRPKRFYLEYYNNNRTTPVWP
                     IPRSSLEYRASSRLKELAAPKIRDNFWSMPMSEVSQVSRAAQMAVPSSRILQLSKPKA
                     PATLLEEWDPVPKPKPHVSDHNRLLHLARPKAQSDKCVPDRDPRWEVLDVTKKVVASP
                     RIISLAKPKVRKGLNEGYDRRPLASMSLPPPKASPEKCDQPRPGL"
     exon            365..487
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..559
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..621
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..691
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..809
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..969
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1649
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /note="hexamer: AGTAAA"
     polyA_site      1233
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /note="major polyA site"
     regulatory      1316..1321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
                     /note="hexamer: AATAAT"
     polyA_site      1339
                     /gene="SPMAP2"
                     /gene_synonym="CT56; THEG; THEG1"
ORIGIN      
        1 agacacattt gggtgccggg agagtgaggc cgcgggggct gggaagggac cggtgtatgg
       61 gggacagcag gcgaaggtca ctcgggaacc agcccagctc tgaggctgcg ggcaggtcgg
      121 aaagggagca ggacggcgac ccccgtggcc tccagagctc tgtgtacgag agccggcggg
      181 tcacagaccc cgaacgccag gacctggaca atgcagagct gggaccagaa gacccagaag
      241 aggagcttcc ccccgaggag gtggccgggg aggagttccc ggagaccctg gatcccaaag
      301 aggcactttc tgagttggag agagtcctgg acaaggactt ggaagaggac attcctgaaa
      361 tcagccggct gtccatcagc cagaagctcc ccagcaccac catgaccaaa gcaaggaaga
      421 ggaggaggcg gaggaggctc atggagctgg cagagcccaa gataaactgg caagtcctga
      481 aagacaggaa gggacgctgt ggtaaggggt atgcctggat ctccccatgt aagatgagct
      541 tgcacttctg tctctgctgg ccctctgtgt actggaccga gcggttcctt gaggacacca
      601 ccctcaccat cacagtgccc gcggtgtccc gccgcgtgga ggaactgtct cggcccaaga
      661 gattctacct ggaatattac aacaacaaca ggacgactcc tgtctggccc attcctcggt
      721 cctccctgga atacagagcg tcgagtcgcc tgaaggaact ggccgccccg aagattcgtg
      781 ataacttctg gagcatgccc atgtctgagg tgtcccaggt atccagggca gcccaaatgg
      841 cagtccccag ctcgcggatc ctccagttgt caaagccgaa ggccccagcc accctcttgg
      901 aagagtggga ccccgtgcca aaacccaagc cacatgtgtc agaccataac cgcctccttc
      961 acttggccag gcccaaagct cagtcggaca agtgcgttcc tgaccgagat cctcgctggg
     1021 aggtgctgga tgtcaccaag aaggtggtgg ccagcccccg gatcatctcc ctggccaagc
     1081 ccaaagtgcg caagggcctc aacgagggat acgacaggcg tcccctcgcc tctatgagct
     1141 tgccaccccc aaaagcatca ccagaaaagt gtgatcaacc caggcctggc ctctaagacc
     1201 tccgctccca gtaaacaccc tcaggcaccc taaccctgtg tatgtgatta ttctgagctt
     1261 tttggcctgg agaagggagg gcgggctaga aggccaaaag aaggatgagg aggacaataa
     1321 tatttatttt tgcatccaac ctgcgacttg tccagctgtt tattttccga gtcactttca
     1381 ttgaccatct cgagcgcctt ctgaatctct tcagtccaga cttattcgtc cattcctgag
     1441 ggcccacggg accgtcggag tcggaacgac agccacagtc aaaccagccg acgctcctgc
     1501 tgaggggcca cgggaccgtc ggagtcggaa cgacagccac agtcaaacca gccgacgctc
     1561 ctgctgaggg gccacgggac cgtcggagtc ggaacgacag ccacagtcaa agcagccgac
     1621 gctcctgctg agggcccacg ggaccgtcg
//
