LOCUS       NM_178455                516 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens serine peptidase inhibitor, Kunitz type 4 (SPINT4),
            mRNA.
ACCESSION   NM_178455 XM_372869 XM_938199
VERSION     NM_178455.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Clauss,A., Persson,M., Lilja,H. and Lundwall,A.
  TITLE     Three genes expressing Kunitz domains in the epididymis are related
            to genes of WFDC-type protease inhibitors and semen coagulum
            proteins in spite of lacking similarity between their protein
            products
  JOURNAL   BMC Biochem 12, 55 (2011)
   PUBMED   21988899
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Ferreira,Z., Hurle,B., Rocha,J. and Seixas,S.
  TITLE     Differing evolutionary histories of WFDC8 (short-term balancing) in
            Europeans and SPINT4 (incomplete selective sweep) in Africans
  JOURNAL   Mol Biol Evol 28 (10), 2811-2822 (2011)
   PUBMED   21536719
  REMARK    GeneRIF: We propose that the evolution of WFDC8 and SPINT4 has been
            shaped by complex selective scenarios due to the interdependence of
            variant fitness and ecological variables.
REFERENCE   3  (bases 1 to 516)
  AUTHORS   Li,J.Y., Wang,H.Y., Liu,J., Liu,Q., Zhang,J.S., Wan,F.C., Liu,F.J.,
            Jin,S.H. and Zhang,Y.L.
  TITLE     Transcriptome analysis of a cDNA library from adult human
            epididymis
  JOURNAL   DNA Res 15 (3), 115-122 (2008)
   PUBMED   18390568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO408459.1, AY372173.1, AW303354.1 and AL109656.12.
            
            On May 17, 2019 this sequence version replaced NM_178455.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW303354.1, AY372174.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279058.4/ ENSP00000279058.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CO408459.1         18-19
            3-382               AY372173.1         1-380
            383-433             AW303354.1         93-143              c
            434-434             AL109656.12        28794-28794
            435-516             AW303354.1         10-91               c
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..516
                     /gene="SPINT4"
                     /gene_synonym="C20orf137; dJ601O1.1; SPINT3"
                     /note="serine peptidase inhibitor, Kunitz type 4"
                     /db_xref="GeneID:391253"
                     /db_xref="HGNC:HGNC:16130"
                     /db_xref="MIM:619430"
     exon            1..136
                     /gene="SPINT4"
                     /gene_synonym="C20orf137; dJ601O1.1; SPINT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..321
                     /gene="SPINT4"
                     /gene_synonym="C20orf137; dJ601O1.1; SPINT3"
                     /note="kunitz-type protease inhibitor 4; serine protease
                     inhibitor, Kunitz type 1; serine protease inhibitor,
                     Kunitz type 4; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="kunitz-type protease inhibitor 4 precursor"
                     /protein_id="NP_848550.1"
                     /db_xref="CCDS:CCDS33477.1"
                     /db_xref="GeneID:391253"
                     /db_xref="HGNC:HGNC:16130"
                     /db_xref="MIM:619430"
                     /translation="MKSAKLGFLLRFFIFCSLNTLLLGGVNKIAEKICGDLKDPCKLD
                     MNFGSCYEVHFRYFYNRTSKRCETFVFSGCNGNLNNFKLKIEREVACVAKYKPPR"
     exon            137..314
                     /gene="SPINT4"
                     /gene_synonym="C20orf137; dJ601O1.1; SPINT3"
                     /inference="alignment:Splign:2.1.0"
     exon            315..516
                     /gene="SPINT4"
                     /gene_synonym="C20orf137; dJ601O1.1; SPINT3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcctgctg cttgctgcac catgaagtct gccaagctgg gatttcttct aagattcttc
       61 atcttctgct cattgaatac cctgttattg ggtggtgtta ataaaattgc ggagaagata
      121 tgtggagacc tcaaagatcc ctgcaaattg gacatgaatt ttggaagctg ctatgaagtt
      181 cactttagat atttctacaa cagaacctcc aaaagatgtg aaacttttgt cttctccggc
      241 tgtaatggca accttaacaa cttcaagctt aaaatagaac gtgaagtagc ctgtgttgca
      301 aaatacaaac caccgaggtg agaggatgtg aactcatgaa gttgtctgct gcaccatccg
      361 aaataaagac acaagaaaat tcagactgat tttgaaatct ttgtaatatt tccataatgc
      421 tttaagcttc catatgtttg ctattttcct gaccctagtt ttgtctttcc tggaaattaa
      481 ctgtatgatc attagaatga aagagtcttt ctgtca
//
