LOCUS       NM_006652                474 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serine peptidase inhibitor, Kunitz type 3 (SPINT3),
            mRNA.
ACCESSION   NM_006652
VERSION     NM_006652.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Clauss,A., Persson,M., Lilja,H. and Lundwall,A.
  TITLE     Three genes expressing Kunitz domains in the epididymis are related
            to genes of WFDC-type protease inhibitors and semen coagulum
            proteins in spite of lacking similarity between their protein
            products
  JOURNAL   BMC Biochem 12, 55 (2011)
   PUBMED   21988899
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Stein,J.L., Hua,X., Lee,S., Ho,A.J., Leow,A.D., Toga,A.W.,
            Saykin,A.J., Shen,L., Foroud,T., Pankratz,N., Huentelman,M.J.,
            Craig,D.W., Gerber,J.D., Allen,A.N., Corneveaux,J.J.,
            Dechairo,B.M., Potkin,S.G., Weiner,M.W. and Thompson,P.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Voxelwise genome-wide association study (vGWAS)
  JOURNAL   Neuroimage 53 (3), 1160-1174 (2010)
   PUBMED   20171287
REFERENCE   3  (bases 1 to 474)
  AUTHORS   Lundwall,A.
  TITLE     A locus on chromosome 20 encompassing genes that are highly
            expressed in the epididymis
  JOURNAL   Asian J Androl 9 (4), 540-544 (2007)
   PUBMED   17589793
  REMARK    GeneRIF: Identifies genes on chromosome 20q12-13.1, including the
            gene encoding this kunitz domain-containing serine protease
            inhibitor.
            Review article
REFERENCE   4  (bases 1 to 474)
  AUTHORS   Fossey,S.C., Mychaleckyj,J.C., Pendleton,J.K., Snyder,J.R.,
            Bensen,J.T., Hirakawa,S., Rich,S.S., Freedman,B.I. and Bowden,D.W.
  TITLE     A high-resolution 6.0-megabase transcript map of the type 2
            diabetes susceptibility region on human chromosome 20
  JOURNAL   Genomics 76 (1-3), 45-57 (2001)
   PUBMED   11549316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY372172.2, AL031663.2 and BX088813.1.
            
            On May 17, 2019 this sequence version replaced NM_006652.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY372172.2, BX088813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162946, SAMEA2163623
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217428.7/ ENSP00000217428.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AY372172.2         3-369
            368-373             AL031663.2         76314-76319         c
            374-474             BX088813.1         320-420
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..474
                     /gene="SPINT3"
                     /gene_synonym="HKIB9"
                     /note="serine peptidase inhibitor, Kunitz type 3"
                     /db_xref="GeneID:10816"
                     /db_xref="HGNC:HGNC:11248"
                     /db_xref="MIM:613941"
     exon            1..90
                     /gene="SPINT3"
                     /gene_synonym="HKIB9"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..284
                     /gene="SPINT3"
                     /gene_synonym="HKIB9"
                     /note="serine protease inhibitor, Kunitz type, 3;
                     kunitz-type protease inhibitor 3"
                     /codon_start=1
                     /product="kunitz-type protease inhibitor 3 precursor"
                     /protein_id="NP_006643.1"
                     /db_xref="CCDS:CCDS46608.1"
                     /db_xref="GeneID:10816"
                     /db_xref="HGNC:HGNC:11248"
                     /db_xref="MIM:613941"
                     /translation="MQLQASLSFLLILTLCLELRSELARDTIKDLLPNVCAFPMEKGP
                     CQTYMTRWFFNFETGECELFAYGGCGGNSNNFLRKEKCEKFCKFT"
     exon            91..474
                     /gene="SPINT3"
                     /gene_synonym="HKIB9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgagtgg caccatgcag cttcaggcct ctctctcgtt tctcctgatt ctcactctct
       61 gcctagagct tcgatcagaa ctagcacgag acactatcaa ggatctcctc ccaaatgtat
      121 gcgcttttcc tatggaaaag ggcccttgtc aaacctacat gacgcgatgg tttttcaact
      181 ttgaaactgg tgaatgtgag ttatttgctt acggaggctg cggaggcaac agcaacaact
      241 ttttgaggaa agaaaaatgt gagaaattct gcaagttcac ctgattttct aacaagaaca
      301 cagccctcca tggattcggg attgctctga gggccataga aggcatttgc gtgtgtgtgt
      361 gtgtgtgtgt gtgaacaaga ggttcattcc tctaccccca catttattct ccctgatgtg
      421 ctcctacaag tgcttcatct ctgtgcctga aattctataa atgttgcaat catg
//
