LOCUS       NM_001080525             812 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens serine peptidase inhibitor Kazal type 8 (putative)
            (SPINK8), mRNA.
ACCESSION   NM_001080525 XM_024453713 XM_929352
VERSION     NM_001080525.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Jalkanen,J., Kotimaki,M., Huhtaniemi,I. and Poutanen,M.
  TITLE     Novel epididymal protease inhibitors with Kazal or WAP family
            domain
  JOURNAL   Biochem Biophys Res Commun 349 (1), 245-254 (2006)
   PUBMED   16930550
REFERENCE   2  (bases 1 to 812)
  AUTHORS   Rawlings,N.D., Tolle,D.P. and Barrett,A.J.
  TITLE     Evolutionary families of peptidase inhibitors
  JOURNAL   Biochem J 378 (Pt 3), 705-716 (2004)
   PUBMED   14705960
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105267.3.
            
            On or before Jan 26, 2021 this sequence version replaced
            XM_024453713.1, NM_001080525.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: AW467501.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2149004, SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000434006.3/ ENSP00000407497.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC105267.3         133721-133847       c
            128-233             AC105267.3         132552-132657       c
            234-355             AC105267.3         129339-129460       c
            356-435             AC105267.3         128461-128540       c
            436-485             AC105267.3         121211-121260       c
            486-607             AC105267.3         119683-119804       c
            608-650             AC105267.3         110090-110132       c
            651-812             AC105267.3         107028-107189       c
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..812
                     /gene="SPINK8"
                     /note="serine peptidase inhibitor Kazal type 8 (putative)"
                     /db_xref="GeneID:646424"
                     /db_xref="HGNC:HGNC:33160"
     exon            1..127
                     /gene="SPINK8"
                     /inference="alignment:Splign:2.1.0"
     exon            128..233
                     /gene="SPINK8"
                     /inference="alignment:Splign:2.1.0"
     exon            234..355
                     /gene="SPINK8"
                     /inference="alignment:Splign:2.1.0"
     exon            356..435
                     /gene="SPINK8"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..662
                     /gene="SPINK8"
                     /note="serine protease inhibitor Kazal-type 8"
                     /codon_start=1
                     /product="serine protease inhibitor Kazal-type 8
                     precursor"
                     /protein_id="NP_001073994.1"
                     /db_xref="CCDS:CCDS46822.1"
                     /db_xref="GeneID:646424"
                     /db_xref="HGNC:HGNC:33160"
                     /translation="MKGICSDAILVLATSMWMAFAIDFPLPMASERGQLDKTIVECLK
                     NVNKCWFLSYIKPSEPICGSDQVTYSSDCHLCSKILFEGLNITKLYDGQCENS"
     exon            436..485
                     /gene="SPINK8"
                     /inference="alignment:Splign:2.1.0"
     exon            486..607
                     /gene="SPINK8"
                     /inference="alignment:Splign:2.1.0"
     exon            608..650
                     /gene="SPINK8"
                     /inference="alignment:Splign:2.1.0"
     exon            651..812
                     /gene="SPINK8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      790..795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPINK8"
                     /note="hexamer: AATAAA"
     polyA_site      812
                     /gene="SPINK8"
                     /note="major polyA site"
ORIGIN      
        1 agaactcact cctgagtgca aaggcaatgt caggcacgct ggtaaaggac cactagaatc
       61 cagcagccca gacccctttc tttgtggtca agaagggcag gaaaacaggt gcaggactgc
      121 tacatcggga aaggaagaaa atcctactgc ctttctggag agactaaggg aggcattgag
      181 gaagcatacc tctctgtcat ctggatctat tgaaggccaa ctaatcttaa agggcattgg
      241 aaccttgaaa agacaaataa gctttgcctt ccttcctagt tcattatgaa caaactatca
      301 acaaaaacca tcctgttcag ccagtttctc agagcaacca tgggagtcac agcagttctt
      361 ctgtcaccat gaaggggatc tgctcagacg ccatccttgt tctagctacc tccatgtgga
      421 tggcctttgc aattgacttc ccccttccta tggcctctga aagaggtcag ctagacaaaa
      481 caatagttga atgcctcaag aatgtaaata agtgctggtt tttatcctac atcaagccca
      541 gtgaacctat ttgtggcagt gaccaggtta cctacagtag tgactgccat ctgtgctcca
      601 aaattctatt tgaagggctt aacataacta aactgtatga tggacaatgt gaaaactctt
      661 gaacgtacga caaagaatta taaaacctac tgaatctcca gattgccaag tgaaacacaa
      721 tggttgcctc ttcaaatata tcccctttaa ttactaatgg ttggatcaaa ctcgttgatt
      781 tatgtcttca ataaatgatt cttagcagaa aa
//
