LOCUS       NM_032566                554 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens serine peptidase inhibitor Kazal type 7 (SPINK7),
            mRNA.
ACCESSION   NM_032566
VERSION     NM_032566.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 554)
  AUTHORS   Pennacchiotti,G., Valdes-Gutierrez,F., Gonzalez-Arriagada,W.A.,
            Montes,H.F., Parra,J.M.R., Guida,V.A., Gomez,S.E.,
            Guerrero-Gimenez,M.E., Fernandez-Munoz,J.M., Zoppino,F.C.M.,
            Caron,R.W., Ezquer,M.E., Fernandez-Ramires,R. and Bruna,F.A.
  TITLE     SPINK7 expression changes accompanied by HER2, P53 and RB1 can be
            relevant in predicting oral squamous cell carcinoma at a molecular
            level
  JOURNAL   Sci Rep 11 (1), 6939 (2021)
   PUBMED   33767253
  REMARK    GeneRIF: SPINK7 expression changes accompanied by HER2, P53 and RB1
            can be relevant in predicting oral squamous cell carcinoma at a
            molecular level.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 554)
  AUTHORS   Patel,H., Sheikh,M.S. and Huang,Y.
  TITLE     ECRG2, a novel transcriptional target of p53, modulates cancer cell
            sensitivity to DNA damage
  JOURNAL   Cell Death Dis 11 (7), 543 (2020)
   PUBMED   32681017
  REMARK    GeneRIF: ECRG2, a novel transcriptional target of p53, modulates
            cancer cell sensitivity to DNA damage.
            GeneRIF: ECRG2/SPINK7 is a novel pro-apoptotic target of p53, which
            is induced by DNA damage in a p53-dependent manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 554)
  AUTHORS   Azouz,N.P., Ynga-Durand,M.A., Caldwell,J.M., Jain,A., Rochman,M.,
            Fischesser,D.M., Ray,L.M., Bedard,M.C., Mingler,M.K., Forney,C.,
            Eilerman,M., Kuhl,J.T., He,H., Biagini Myers,J.M., Mukkada,V.A.,
            Putnam,P.E., Khurana Hershey,G.K., Kottyan,L.C., Wen,T.,
            Martin,L.J. and Rothenberg,M.E.
  TITLE     The antiprotease SPINK7 serves as an inhibitory checkpoint for
            esophageal epithelial inflammatory responses
  JOURNAL   Sci Transl Med 10 (444) (2018)
   PUBMED   29875205
  REMARK    GeneRIF: SPINK7 (serine peptidase inhibitor, kazal type 7), is part
            of the differentiation program of human esophageal epithelium.
REFERENCE   4  (bases 1 to 554)
  AUTHORS   Weber,C., Fischer,J., Redelfs,L., Rademacher,F., Harder,J.,
            Weidinger,S., Wu,Z. and Meyer-Hoffert,U.
  TITLE     The serine protease inhibitor of Kazal-type 7 (SPINK7) is expressed
            in human skin
  JOURNAL   Arch Dermatol Res 309 (9), 767-771 (2017)
   PUBMED   28852849
  REMARK    GeneRIF: n cultured keratinocytes, SPINK7 mRNA expression was
            up-regulated by IL-17A together with IFNgamma
REFERENCE   5  (bases 1 to 554)
  AUTHORS   Hou,X.F., Xu,L.P., Song,H.Y., Li,S., Wu,C. and Wang,J.F.
  TITLE     ECRG2 enhances the anti-cancer effects of cisplatin in
            cisplatin-resistant esophageal cancer cells via upregulation of p53
            and downregulation of PCNA
  JOURNAL   World J Gastroenterol 23 (10), 1796-1803 (2017)
   PUBMED   28348485
  REMARK    GeneRIF: ECRG2 in combination with cisplatin (DDP) can inhibit
            viability and induce apoptosis in esophageal cancer DDP-resistant
            cells, possibly via upregulation of p53 expression and
            downregulation of PCNA expression.
REFERENCE   6  (bases 1 to 554)
  AUTHORS   Kaifi,J.T., Cataldegirmen,G., Wachowiak,R., Schurr,P.G.,
            Kleinhans,H., Kosti,G., Yekebas,E.F., Mann,O., Kutup,A.,
            Kalinin,V., Strate,T. and Izbicki,J.R.
  TITLE     Short tandem repeat polymorphisms of exon 4 in Kazal-type gene
            ECRG2 in pancreatic carcinoma and chronic pancreatitis
  JOURNAL   Anticancer Res 27 (1A), 69-73 (2007)
   PUBMED   17352218
  REMARK    GeneRIF: Observational study of genotype prevalence and
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 554)
  AUTHORS   Yue,C.M., Bi,M.X., Tan,W., Deng,D.J., Zhang,X.Y., Guo,L.P.,
            Lin,D.X. and Lu,S.H.
  TITLE     Short tandem repeat polymorphism in a novel esophageal
            cancer-related gene (ECRG2) implicates susceptibility to esophageal
            cancer in Chinese population
  JOURNAL   Int J Cancer 108 (2), 232-236 (2004)
   PUBMED   14639608
  REMARK    GeneRIF: Short tandem repeat polymorphism in a novel esophageal
            cancer-related gene (ECRG2) implicates susceptibility to esophageal
            cancer
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 554)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 554)
  AUTHORS   Cui,Y.P., Wang,J.B., Zhang,X.Y., Bi,M.X., Guo,L.P. and Lu,S.H.
  TITLE     Using yeast two-hybrid system to identify ECRG2 associated proteins
            and their possible interactions with ECRG2 gene
  JOURNAL   World J Gastroenterol 9 (9), 1892-1896 (2003)
   PUBMED   12970870
  REMARK    GeneRIF: Potential interaction partner for ECRG2 might be involved
            in regulation of cell proliferation and apoptosis and in various
            physiological processes.
REFERENCE   10 (bases 1 to 554)
  AUTHORS   Cui,Y., Wang,J., Zhang,X., Lang,R., Bi,M., Guo,L. and Lu,S.H.
  TITLE     ECRG2, a novel candidate of tumor suppressor gene in the esophageal
            carcinoma, interacts directly with metallothionein 2A and links to
            apoptosis
  JOURNAL   Biochem Biophys Res Commun 302 (4), 904-915 (2003)
   PUBMED   12646258
  REMARK    GeneRIF: Data suggest that the physical interaction of esophageal
            cancer related gene 2 (ECRG2) and metallothionein 2A (MT2A) may
            play an important role in the carcinogenesis of esophageal cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091948.3, AF268198.1 and AY359072.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032566.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF268198.1, ERR279835.10253.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274565.5/ ENSP00000274565.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC091948.3         62233-62236
            5-40                AF268198.1         1-36
            41-552              AY359072.1         24-535
            553-554             AF268198.1         552-553
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..554
                     /gene="SPINK7"
                     /gene_synonym="ECG2; ECRG2"
                     /note="serine peptidase inhibitor Kazal type 7"
                     /db_xref="GeneID:84651"
                     /db_xref="HGNC:HGNC:24643"
                     /db_xref="MIM:617288"
     exon            1..122
                     /gene="SPINK7"
                     /gene_synonym="ECG2; ECRG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..319
                     /gene="SPINK7"
                     /gene_synonym="ECG2; ECRG2"
                     /note="esophagus cancer-related gene-2; serine protease
                     inhibitor Kazal-type 7; ECRG-2; esophagus cancer-related
                     gene 2 protein; serine peptidase inhibitor, Kazal type 7
                     (putative)"
                     /codon_start=1
                     /product="serine protease inhibitor Kazal-type 7
                     precursor"
                     /protein_id="NP_115955.1"
                     /db_xref="CCDS:CCDS4289.1"
                     /db_xref="GeneID:84651"
                     /db_xref="HGNC:HGNC:24643"
                     /db_xref="MIM:617288"
                     /translation="MKITGGLLLLCTVVYFCSSSEAASLSPKKVDCSIYKKYPVVAIP
                     CPITYLPVCGSDYITYGNECHLCTESLKSNGRVQFLHDGSC"
     exon            123..148
                     /gene="SPINK7"
                     /gene_synonym="ECG2; ECRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..273
                     /gene="SPINK7"
                     /gene_synonym="ECG2; ECRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            274..554
                     /gene="SPINK7"
                     /gene_synonym="ECG2; ECRG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      531..536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPINK7"
                     /gene_synonym="ECG2; ECRG2"
                     /note="hexamer: AATAAA"
     polyA_site      554
                     /gene="SPINK7"
                     /gene_synonym="ECG2; ECRG2"
                     /note="major polyA site"
ORIGIN      
        1 atggtcgatg cagctgtagt gacaatctca gagcagcttc tacaccacag ccatttccag
       61 catgaagatc actgggggtc tccttctgct ctgtacagtg gtctatttct gtagcagctc
      121 agaagctgct agtctgtctc caaaaaaagt ggactgcagc atttacaaga agtatccagt
      181 ggtggccatc ccctgcccca tcacatacct accagtttgt ggttctgact acatcaccta
      241 tgggaatgaa tgtcacttgt gtaccgagag cttgaaaagt aatggaagag ttcagtttct
      301 tcacgatgga agttgctaaa ttctccatgg acatagagag aaaggaatga tattctcatc
      361 atcatcttca tcatcccagg ctctgactga gtttctttca gttttactga tgttctgggt
      421 gggggacaga gccagattca gagtaatctt gactgaatgg agaaagtttc tgtgctaccc
      481 ctacaaaccc atgcctcact gacagaccag catttttttt ttaacacgtc aataaaaaaa
      541 taatctccca gaaa
//
