LOCUS       NM_001040129             620 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens serine peptidase inhibitor Kazal type 13 (SPINK13),
            transcript variant 1, mRNA.
ACCESSION   NM_001040129
VERSION     NM_001040129.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 620)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 620)
  AUTHORS   Xu,W.H., Shi,S.N., Wang,J., Xu,Y., Tian,X., Wan,F.N., Cao,D.L.,
            Qu,Y.Y., Zhang,H.L. and Ye,D.W.
  TITLE     The Role of Serine Peptidase Inhibitor Kazal Type 13 (SPINK13) as a
            Clinicopathological and Prognostic Biomarker in Patients with Clear
            Cell Renal Cell Carcinoma
  JOURNAL   Med Sci Monit 25, 9458-9470 (2019)
   PUBMED   31825950
  REMARK    GeneRIF: Gene set enrichment analysis (GSEA) showed that SPINK13
            expression was involved in complement, apical junction,
            epithelial-mesenchymal transition (EMT), glycolysis, hypoxia, and
            inflammation signaling pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 620)
  AUTHORS   Wei,L., Lun,Y., Zhou,X., He,S., Gao,L., Liu,Y., He,Z., Li,B. and
            Wang,C.
  TITLE     Novel urokinase-plasminogen activator inhibitor SPINK13 inhibits
            growth and metastasis of hepatocellular carcinoma in vivo
  JOURNAL   Pharmacol Res 143, 73-85 (2019)
   PUBMED   30862605
  REMARK    GeneRIF: The results of the study indicated that SPINK13 could
            function as a promising therapeutic approach for patients with
            advanced hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 620)
  AUTHORS   Cai,S., Zhang,P., Dong,S., Li,L., Cai,J. and Xu,M.
  TITLE     Downregulation of SPINK13 Promotes Metastasis by Regulating uPA in
            Ovarian Cancer Cells
  JOURNAL   Cell Physiol Biochem 45 (3), 1061-1071 (2018)
   PUBMED   29439245
  REMARK    GeneRIF: SPINK13 inhibited cell migration and epithelial to
            mesenchymal transition (EMT). SPINK13 was found to inhibit the
            expression of urokinase-type plasminogen activator (uPA), while
            recombinant uPA protein could reverse the inhibitory effect of
            SPINK13 on OC metastasis.
REFERENCE   5  (bases 1 to 620)
  AUTHORS   Ma,L., Yu,H., Ni,Z., Hu,S., Ma,W., Chu,C., Liu,Q. and Zhang,Y.
  TITLE     Spink13, an epididymis-specific gene of the Kazal-type serine
            protease inhibitor (SPINK) family, is essential for the acrosomal
            integrity and male fertility
  JOURNAL   J Biol Chem 288 (14), 10154-10165 (2013)
   PUBMED   23430248
REFERENCE   6  (bases 1 to 620)
  AUTHORS   Li,J.Y., Wang,H.Y., Liu,J., Liu,Q., Zhang,J.S., Wan,F.C., Liu,F.J.,
            Jin,S.H. and Zhang,Y.L.
  TITLE     Transcriptome analysis of a cDNA library from adult human
            epididymis
  JOURNAL   DNA Res 15 (3), 115-122 (2008)
   PUBMED   18390568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011346.5 and BC128164.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001040129.2.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128164.1, SRR14038193.719912.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398450.5/ ENSP00000381468.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC011346.5         79633-79698
            67-575              BC128164.1         1-509
            576-620             AC011346.5         97050-97094
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..620
                     /gene="SPINK13"
                     /gene_synonym="HBVDNAPTP1; HESPINTOR; LiESP6; SPINK5L3"
                     /note="serine peptidase inhibitor Kazal type 13"
                     /db_xref="GeneID:153218"
                     /db_xref="HGNC:HGNC:27200"
                     /db_xref="MIM:615205"
     exon            1..95
                     /gene="SPINK13"
                     /gene_synonym="HBVDNAPTP1; HESPINTOR; LiESP6; SPINK5L3"
                     /inference="alignment:Splign:2.1.0"
     exon            96..198
                     /gene="SPINK13"
                     /gene_synonym="HBVDNAPTP1; HESPINTOR; LiESP6; SPINK5L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..413
                     /gene="SPINK13"
                     /gene_synonym="HBVDNAPTP1; HESPINTOR; LiESP6; SPINK5L3"
                     /note="hepatitis B virus DNA polymerase transactivated
                     human serine protease inhibitor; serine protease inhibitor
                     Kazal-type 5-like 3; serine protease inhibitor Kazal-type
                     13; hepatitis B virus DNA polymerase transactivated serine
                     protease inhibitor; Hepatitis B Virus (HBV) DNA polymerase
                     transactivated protein 1; serine peptidase inhibitor,
                     Kazal type 13 (putative)"
                     /codon_start=1
                     /product="serine protease inhibitor Kazal-type 13
                     precursor"
                     /protein_id="NP_001035218.1"
                     /db_xref="CCDS:CCDS43383.1"
                     /db_xref="GeneID:153218"
                     /db_xref="HGNC:HGNC:27200"
                     /db_xref="MIM:615205"
                     /translation="MAAFPHKIIFFLVCSTLTHVAFSGIFNKRDFTRWPKPRCKMYIP
                     LDPDYNADCPNVTAPVCASNGHTFQNECFFCVEQREFHYRIKFEKYGKCD"
     exon            199..236
                     /gene="SPINK13"
                     /gene_synonym="HBVDNAPTP1; HESPINTOR; LiESP6; SPINK5L3"
                     /inference="alignment:Splign:2.1.0"
     exon            237..364
                     /gene="SPINK13"
                     /gene_synonym="HBVDNAPTP1; HESPINTOR; LiESP6; SPINK5L3"
                     /inference="alignment:Splign:2.1.0"
     exon            365..620
                     /gene="SPINK13"
                     /gene_synonym="HBVDNAPTP1; HESPINTOR; LiESP6; SPINK5L3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      594..599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPINK13"
                     /gene_synonym="HBVDNAPTP1; HESPINTOR; LiESP6; SPINK5L3"
                     /note="hexamer: AATAAA"
     polyA_site      620
                     /gene="SPINK13"
                     /gene_synonym="HBVDNAPTP1; HESPINTOR; LiESP6; SPINK5L3"
                     /note="major polyA site"
ORIGIN      
        1 agttgtgaca gactcctgga acagcagctc ttctcaaggc tagttgtgac atccaaagtg
       61 acaagagcag gcccatattc agccacctca tccaggcctt atcaaagaag agtcttatat
      121 gagatcaaat ggctgccttt ccccacaaga ttatattttt cctggtatgc tctactttga
      181 cacatgtggc tttctcagga attttcaata aacgtgactt cactaggtgg cctaagcccc
      241 gatgtaaaat gtatatccca ctggaccctg attacaatgc agactgcccc aatgtgacag
      301 cacctgtttg tgcctcaaat ggccacactt tccagaatga gtgtttcttt tgtgttgaac
      361 agagggaatt tcattatcgt ataaaatttg aaaaatatgg aaaatgtgat taatgggtac
      421 cagagtaact acacttgctt attctttttc tacttaattc agaatagtat ttcttttaga
      481 gtgtgagaat gtaaattaaa taacatccct atgctgtact taaatgtcga acaaaatgag
      541 agacaaaaat gaaggaatca aactgacaag aaccaaatat cacatttgtt acaaataaac
      601 aacaaaagag ctgatattca
//
