LOCUS       NM_138471               1954 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens spindlin interactor and repressor of chromatin binding
            (SPINDOC), mRNA.
ACCESSION   NM_138471 XM_290508
VERSION     NM_138471.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Zhao,F., Deng,Y., Yang,F., Yan,Y., Feng,F., Peng,B., Gao,J.,
            Bedford,M.T. and Li,H.
  TITLE     Molecular Basis for SPINDOC-Spindlin1 Engagement and Its Role in
            Transcriptional Attenuation
  JOURNAL   J Mol Biol 436 (7), 168371 (2024)
   PUBMED   37977297
  REMARK    GeneRIF: Molecular Basis for SPINDOC-Spindlin1 Engagement and Its
            Role in Transcriptional Attenuation.
REFERENCE   2  (bases 1 to 1954)
  AUTHORS   Yang,F., Chen,J., Liu,B., Gao,G., Sebastian,M., Jeter,C., Shen,J.,
            Person,M.D. and Bedford,M.T.
  TITLE     SPINDOC binds PARP1 to facilitate PARylation
  JOURNAL   Nat Commun 12 (1), 6362 (2021)
   PUBMED   34737271
  REMARK    GeneRIF: SPINDOC binds PARP1 to facilitate PARylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1954)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1954)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1954)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1954)
  AUTHORS   Devi,M.S., Meiguilungpou,R., Sharma,A.L., Anjali,C., Devi,K.M.,
            Singh,L.S. and Singh,T.R.
  TITLE     Spindlin docking protein (SPIN.DOC) interaction with SPIN1 (a
            histone code reader) regulates Wnt signaling
  JOURNAL   Biochem Biophys Res Commun 511 (3), 498-503 (2019)
   PUBMED   30803761
  REMARK    GeneRIF: SPINDOC Interacts with SPIN1 in DNA independent manner.
            SPINDOC regulates expression and chromatin loading of SPIN1.
REFERENCE   7  (bases 1 to 1954)
  AUTHORS   Bae,N., Gao,M., Li,X., Premkumar,T., Sbardella,G., Chen,J. and
            Bedford,M.T.
  TITLE     A transcriptional coregulator, SPIN.DOC, attenuates the coactivator
            activity of Spindlin1
  JOURNAL   J Biol Chem 292 (51), 20808-20817 (2017)
   PUBMED   29061846
  REMARK    GeneRIF: identified SPIN.DOC as a transcriptional repressor that
            binds SPIN1 and masks its ability to engage the H3-Lys-4
            trimethylation activation mark
REFERENCE   8  (bases 1 to 1954)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   9  (bases 1 to 1954)
  AUTHORS   Kang,S.J., Rangaswamy,M., Manz,N., Wang,J.C., Wetherill,L.,
            Hinrichs,T., Almasy,L., Brooks,A., Chorlian,D.B., Dick,D.,
            Hesselbrock,V., Kramer,J., Kuperman,S., Nurnberger,J. Jr., Rice,J.,
            Schuckit,M., Tischfield,J., Bierut,L.J., Edenberg,H.J., Goate,A.,
            Foroud,T. and Porjesz,B.
  TITLE     Family-based genome-wide association study of frontal theta;
            oscillations identifies potassium channel gene KCNJ6
  JOURNAL   Genes Brain Behav 11 (6), 712-719 (2012)
   PUBMED   22554406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY013538.1 and BC002782.2.
            
            On Nov 23, 2018 this sequence version replaced NM_138471.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056402.1, SRR7346977.1007577.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294244.9/ ENSP00000294244.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               HY013538.1         84-243
            161-1954            BC002782.2         1-1794
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1954
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /note="spindlin interactor and repressor of chromatin
                     binding"
                     /db_xref="GeneID:144097"
                     /db_xref="HGNC:HGNC:25115"
     exon            1..358
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1377
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /note="hypothetical protein BC007540; SPIN1 docking
                     protein; uncharacterized protein C11orf84"
                     /codon_start=1
                     /product="spindlin interactor and repressor of
                     chromatin-binding protein"
                     /protein_id="NP_612480.1"
                     /db_xref="CCDS:CCDS31594.1"
                     /db_xref="GeneID:144097"
                     /db_xref="HGNC:HGNC:25115"
                     /translation="MALKAEGAALDCFEVTLKCEEGEDEEEAMVVAVIPRPEPMLRVT
                     QQEKTPPPRPSPLEAGSDGCEEPKQQVSWEQEFLVGSSPGGSGRALCMVCGAEIRAPS
                     ADTARSHILEQHPHTLDLSPSEKSNILEAWSEGVALLQDVRAEQPSPPNSDSGQDAHP
                     DPDANPDAARMPAEIVVLLDSEDNPSLPKRSRPRGLRPLELPAVPATEPGNKKPRGQR
                     WKEPPGEEPVRKKRGRPMTKNLDPDPEPPSPDSPTETFAAPAEVRHFTDGSFPAGFVL
                     QLFSHTQLRGPDSKDSPKDREVAEGGLPRAESPSPAPPPGLRGTLDLQVIRVRMEEPP
                     AVSLLQDWSRHPQGTKRVGAGDTSDWPTVLSESSTTVAGKPEKGNGV"
     exon            359..688
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /inference="alignment:Splign:2.1.0"
     exon            689..838
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /inference="alignment:Splign:2.1.0"
     exon            839..964
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1165
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1954
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1932..1937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /note="hexamer: AATAAA"
     polyA_site      1954
                     /gene="SPINDOC"
                     /gene_synonym="C11orf84; SPIN-DOC"
                     /note="major polyA site"
ORIGIN      
        1 ggattgagcc ctccccgccc gggctcccga cgcgccgagg tctcggggag gcccggacgc
       61 gccggtcgca ggcccggccg gcgagcggcg ggcgggcggc ggggaggggg ctgcgcgggg
      121 cgggcggcgg gcccggcgct attccggcca ggaggcggga ggcggttgcc ggctgcgcgc
      181 cgaagcctgc gcgccagtcc tccggccact gctatcgccc acggccgcac catggcccta
      241 aaggccgagg gcgccgcact cgactgcttc gaggtgacgc tgaaatgcga ggaaggggag
      301 gacgaggagg aggccatggt ggtggccgta attccgcggc ccgagccgat gctcagagtg
      361 acccaacagg agaagacccc accgcctaga cccagcccgc tagaggcagg cagtgatggc
      421 tgtgaggagc cgaagcagca ggtgtcttgg gagcaggagt tcctggtggg cagcagccca
      481 ggaggcagcg ggcgggcact gtgcatggtg tgtggcgctg agatccgggc accctcggcc
      541 gacacagctc gctcgcacat cttggagcag caccctcaca ccttggacct gagcccttct
      601 gagaagagca atatcctgga ggcctggagt gaaggggtgg ccctcttgca agacgtgaga
      661 gctgagcagc cgtccccacc caactcagac tcgggccagg atgcccaccc agacccagac
      721 gccaacccag acgctgccag aatgccagcc gaaatcgtcg ttctccttga ctctgaggat
      781 aacccatccc tccctaaaag gagccggccc aggggactcc gccccctcga gcttcctgct
      841 gtccctgcca cagagccagg aaataagaag ccccgtggtc agagatggaa ggaaccccca
      901 ggggaagagc cagtcagaaa gaaaagaggc agacctatga ccaaaaacct ggaccctgac
      961 ccagagcccc catcgccaga ctcgcccacg gagactttcg cagcaccagc cgaggtccga
     1021 cacttcactg acggcagctt ccccgccggc ttcgtcttgc agctcttctc ccacacccag
     1081 ctcaggggcc cagacagcaa ggactcaccc aaagacaggg aagtggcaga aggaggcctt
     1141 ccccgggcgg agagcccctc tccagctccc cctccggggc tccgcgggac actggatctc
     1201 caggttatcc gcgtgcggat ggaggagccc ccagcggtca gcctcctgca agactggtcc
     1261 aggcaccccc agggcaccaa gcgtgtggga gcaggtgaca cctcagactg gcccacagtt
     1321 ctgtcagaat ccagcaccac tgtggcaggg aagccggaaa aagggaatgg agtgtaaatt
     1381 cttgctttcc tggggaggga gggagggatg aggcagcgtc ccccagtggc ttataactca
     1441 gagctgcctg gctcacccac ctggtggaga gagtagaaac aggtgccagg gcaggagggg
     1501 gctggggcag catccactgt tatttcgggg cactggaaag tgtctgttcc tggccaggcc
     1561 tgaggtcggc gagggtggct gaggctgttg tgcagtaggg cactgggcct gtggagaaca
     1621 cctaccccag tccttcgctg acccccacct ctgtttgtcc cccatgacct cctcccaccc
     1681 tccccctgct ccccaccatt ctcccttggc acagtgcctt acacaagagt ggtcataagg
     1741 gggtttgaac tgagtcccac tacctcgggg gacacctctc ctccccactt gttcaggctt
     1801 ctaaaccagg aggcctccat tacctcttcc tgtcccaccc ctgcagaggc ctgaagctgg
     1861 gcctgggcac cccattcact cccgttctca tttacatctg ttttcctgtt gtatatatca
     1921 cctttgttga caataaatta ttttttttta ttaa
//
