LOCUS       NM_001012968            4105 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens spindlin family member 4 (SPIN4), mRNA.
ACCESSION   NM_001012968 XM_066946
VERSION     NM_001012968.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4105)
  AUTHORS   Lui,J.C., Wagner,J., Zhou,E., Dong,L., Barnes,K.M., Jee,Y.H. and
            Baron,J.
  TITLE     Loss-of-function variant in SPIN4 causes an X-linked overgrowth
            syndrome
  JOURNAL   JCI Insight 8 (9), e167074 (2023)
   PUBMED   36927955
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4105)
  AUTHORS   Zhang,X., Thielert,M., Li,H. and Cravatt,B.F.
  TITLE     SPIN4 Is a Principal Endogenous Substrate of the E3 Ubiquitin
            Ligase DCAF16
  JOURNAL   Biochemistry 60 (9), 637-642 (2021)
   PUBMED   33636084
REFERENCE   3  (bases 1 to 4105)
  AUTHORS   Bae,N., Gao,M., Li,X., Premkumar,T., Sbardella,G., Chen,J. and
            Bedford,M.T.
  TITLE     A transcriptional coregulator, SPIN.DOC, attenuates the coactivator
            activity of Spindlin1
  JOURNAL   J Biol Chem 292 (51), 20808-20817 (2017)
   PUBMED   29061846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158203.12.
            
            On May 17, 2019 this sequence version replaced NM_001012968.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AL833314.1, SRR6380201.92858.7
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374884.3/ ENSP00000364018.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4105              AL158203.12        21125-25229         c
FEATURES             Location/Qualifiers
     source          1..4105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq11.1"
     gene            1..4105
                     /gene="SPIN4"
                     /gene_synonym="LJBS; TDRD28"
                     /note="spindlin family member 4"
                     /db_xref="GeneID:139886"
                     /db_xref="HGNC:HGNC:27040"
                     /db_xref="MIM:301113"
     exon            1..4105
                     /gene="SPIN4"
                     /gene_synonym="LJBS; TDRD28"
                     /inference="alignment:Splign:2.1.0"
     CDS             514..1263
                     /gene="SPIN4"
                     /gene_synonym="LJBS; TDRD28"
                     /codon_start=1
                     /product="spindlin-4"
                     /protein_id="NP_001012986.2"
                     /db_xref="CCDS:CCDS43964.1"
                     /db_xref="GeneID:139886"
                     /db_xref="HGNC:HGNC:27040"
                     /db_xref="MIM:301113"
                     /translation="MSPPTVPPMGVDGVSAYLMKKRHTHRKQRRKPTFLTRRNIVGCR
                     IQHGWKEGNEPVEQWKGTVLEQVSVKPTLYIIKYDGKDSVYGLELHRDKRVLALEILP
                     ERVPTPRIDSRLADSLIGKAVEHVFEGEHGTKDEWKGMVLARAPVMDTWFYITYEKDP
                     VLYMYTLLDDYKDGDLRIIPDSNYYFPTAEQEPGEVVDSLVGKQVEHAKDDGSKRTGI
                     FIHQVVAKPSVYFIKFDDDIHIYVYGLVKTP"
     regulatory      4081..4086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPIN4"
                     /gene_synonym="LJBS; TDRD28"
                     /note="hexamer: AATAAA"
     polyA_site      4105
                     /gene="SPIN4"
                     /gene_synonym="LJBS; TDRD28"
                     /note="major polyA site"
ORIGIN      
        1 agagtgaagc caagccagct agcgctgcga agcccaggcc gcgcggactc cccagagact
       61 tgccgccgcc tgcgcctttg ccgctgcagc catccctctt actccttgcc tttcgtcccc
      121 gtcgtctcct ctgccgccgt gccgcagccg caccagcatc gacaacagct aagtggccga
      181 ttcggggact tggggtcggg gttggggcgg acgcaaggca cgaacagcac tcgcgagccc
      241 gccatctcta cgtcagccgc cactgctgca gtaacccttc tagggcgaga gaggaaagca
      301 ctgtggagag gcacacgctg tcccagtgct cacggttaga gttcgagcgt ttctgccaaa
      361 accttggtga gagccttgca cttggagaag ggagcacaga ccaggtcttt gagatcgcaa
      421 aaaatatata tatcatattg catagtgttg actttttgtc agtttaatcg accagggcag
      481 cagctttccc caagccctct taatccctga gctatgtctc ctccaaccgt gcctccgatg
      541 ggggtagatg gcgtgtccgc atacctgatg aagaaaaggc acacccacag gaagcaacgg
      601 cgcaagccca ctttcctcac tcgtaggaac atcgtgggct gccgcattca acacggctgg
      661 aaggaaggca acgagccagt ggagcagtgg aagggtactg tgctcgagca ggtttccgtg
      721 aagcccactc tttacatcat taaatatgat ggcaaagata gtgtgtatgg actagaactg
      781 caccgcgata agagagtttt agcgctagag atccttcctg agagagtgcc aactcctcgt
      841 atcgattcac gactggcaga ttccctgatt ggcaaggcag tggagcatgt gtttgaaggt
      901 gaacatggta ccaaggatga atggaagggt atggtcctgg cgcgagctcc tgtgatggat
      961 acttggtttt acatcaccta cgagaaagat cctgttctct atatgtacac gctgcttgat
     1021 gactacaaag atggtgactt acgcattatt ccagattcca actactattt ccctacagca
     1081 gaacaggagc ctggagaggt ggtcgacagt ctcgtgggca agcaggtgga gcatgccaaa
     1141 gatgacgggt ccaagagaac tggcattttt atacatcaag tggtggcgaa gccatctgtt
     1201 tacttcatta agtttgatga tgatattcac atttatgtct atggtttggt gaaaactcct
     1261 taaattcttt gtgctcttta gagaagttgt ggatctgtta gatgtgaatt attttgtgtt
     1321 ctcgtagttg tgaacgcaga gaagagttta ggtgtcagaa attcaggaaa gtggataaat
     1381 tttattgtgc caacaaatct taccttgact agtttcacaa ttttgcctca agtgtacttt
     1441 gctacttttg atattgcctt gttctgtaac ttaacagtta aattgggtgc taatagaaaa
     1501 ttaaaaagtg tttgcaacca ttggaacaat gcaaaaatag attaagaaaa attaatggtg
     1561 taaacccaca ccccgtcctt accccttcct ttccttacct tgtttcttcc cagaaaacaa
     1621 gtgttgagga tgcgaagtac atccttccac ctattttccc catcttcatg cagaaagtat
     1681 gttctagtag tttctgtaaa aatggcaagc cacatgcttt tctcacttga catgtagatg
     1741 atatctcttc ttatcagtag cttcagtctt tcttgctctc tctggctctc tctggccctc
     1801 actcttactc tcttgcactc ttgctctccc cctccctccc ttactctaac agctgaatac
     1861 acagtacttg ttgatgtacc aaaaaggcat tcaaccattt cgttattgat cgtcttttat
     1921 ttcctttttt tatttttttt caaaataaca ctgctgtaat acatactggt gcttttattt
     1981 atataggttg gattcccaga aatactatgt aggcatatgt ttcagaaata ttacaagatt
     2041 actatccaaa atgaaagcgc ccgttccagc gtcctctcca gcactcttta atgcttgaaa
     2101 atatgaaagg ctaaaaattg cattgtattg cttgttagtt taattgcctt ttgtctgagt
     2161 tcaaagaggt ttgttgttgt tgctgtcctt gtttctgttt ggatttttct ctgatttgcc
     2221 tgttcttacc ctttgctcat gtatctattg atgtttttca ttataaattt gtagaaattc
     2281 ttactacata gtgcatatta atcatttgta gctctaatgt gttatgacgt tttcatcttg
     2341 actttattga tgatatattt tcctttaaaa tttttaaact ttttaggtag acccttatct
     2401 cttttataga ttttggtttc ctttttttat cacatggatg cccccaccca aagtcataca
     2461 aatattcacc tacattttct tctaataact ttattatttt taatgtttaa atgtttgatc
     2521 catctgaaat ttatttttgt atatggtgta agatggggat ccagctataa cattttgttc
     2581 acattggata cctgattgtg acatttattt aaaatgttac ccattttcaa atttctgagc
     2641 caatatcatg atttaattat agtggcttca tcgtaagttt tagaatccga taaagcaagt
     2701 cccacttcat tagttttttt tttctttata taatatgtcc tagacattca ttttttcatg
     2761 tgaaaaaatg aaatgcagaa ttttaataaa attctaatta tgatggctga catcacaatt
     2821 aaaatcctgc atttttgttt agagggctct ttaataatat taaatcttag cactcaagag
     2881 tcttcgtaca tcattgaaat cttttggtct tgttattgga atattcttca cgtaagtata
     2941 tcatagctaa ctgaatttat ttctaagtat ttttacagtt ttatttcata ttttgacatt
     3001 gtgaattggt ttttttcttc tcatttgtaa ttagctattt ttgacaatat agacaaccta
     3061 tagatttttg tatttttatc ttctgtctaa tgagcttatt taatcattga aattacagta
     3121 gatttttaag aatataatat tttgggtttt ctagatatga aattatttca cctgaacata
     3181 tagatcattt tatttcctct taatgtttat actgattact gttacattag ctggattttt
     3241 caaaacaatg ttgaagagtg atgacagacg tgactgtctt gttcttaatt ttcatggaag
     3301 taagaatgca aaatattaat agggaatagt attccctatt agtatgacat ttacttttgg
     3361 ttattagtag gtagtcatta acatgtttaa gagtttccgc tattcctgtt ttatagtgtt
     3421 attgctagaa gtggttcctg aattttataa aatgcctttt cagcatctat tgataaaatt
     3481 gtatgatttt ttttctcttt aatttgttga tgtaatgaat tagaatggta ggcatttgat
     3541 gtggaaccaa acttgtattt ctggaacaaa tactacttgg tcattgtgaa ataatgattt
     3601 gctacatgag tggattttat ttaccagtat ttaatttaga attattgcat tttcattcca
     3661 aagtaaaatt gtattttgtc cttctgatgc tatctttatc aagttttgtt attgaagttg
     3721 tgctagcttt aaaaaaatat gaatatgtga gttttcaatt tttttcctgt ggtctggaat
     3781 aatttaaata gcattagaat tatttgtttg ttaaaagtta gctaggacaa agtgtaaaac
     3841 aatctaatcc tgatgacact tttaatagta gatttttaat cagctttgtg atttctttaa
     3901 tagttattgg tttattcagg ctttttatta aaaaggtata tacattctct gtgacataca
     3961 aagttaaaag ttctctatta ttgctgattg tactggttgt tgcttgttga ctgtactatt
     4021 cagatggctt tatgcttttg tgtattttat gtcacctaga tctaattctg aaaacattgt
     4081 aataaaataa ttagctataa tggta
//
