LOCUS       NM_001010862            4445 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens spindlin family member 3 (SPIN3), transcript variant
            1, mRNA.
ACCESSION   NM_001010862 XM_093024
VERSION     NM_001010862.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4445)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4445)
  AUTHORS   Bae,N., Gao,M., Li,X., Premkumar,T., Sbardella,G., Chen,J. and
            Bedford,M.T.
  TITLE     A transcriptional coregulator, SPIN.DOC, attenuates the coactivator
            activity of Spindlin1
  JOURNAL   J Biol Chem 292 (51), 20808-20817 (2017)
   PUBMED   29061846
REFERENCE   3  (bases 1 to 4445)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4445)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB151976.1, BX403408.2, AL139397.8 and AJ271379.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001010862.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.98017.1,
                                           SRR1803617.120880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374919.6/ ENSP00000364054.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               DB151976.1         15-314
            301-719             BX403408.2         263-681
            720-4344            AL139397.8         57154-60778         c
            4345-4445           AJ271379.1         1376-1476
FEATURES             Location/Qualifiers
     source          1..4445
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..4445
                     /gene="SPIN3"
                     /gene_synonym="bA445O16.1; SPIN-3; TDRD27"
                     /note="spindlin family member 3"
                     /db_xref="GeneID:169981"
                     /db_xref="HGNC:HGNC:27272"
     exon            1..326
                     /gene="SPIN3"
                     /gene_synonym="bA445O16.1; SPIN-3; TDRD27"
                     /inference="alignment:Splign:2.1.0"
     exon            327..4445
                     /gene="SPIN3"
                     /gene_synonym="bA445O16.1; SPIN-3; TDRD27"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1105
                     /gene="SPIN3"
                     /gene_synonym="bA445O16.1; SPIN-3; TDRD27"
                     /note="bA445O16.1 (DXF34); spindlin-like protein 3"
                     /codon_start=1
                     /product="spindlin-3"
                     /protein_id="NP_001010862.2"
                     /db_xref="CCDS:CCDS43963.1"
                     /db_xref="GeneID:169981"
                     /db_xref="HGNC:HGNC:27272"
                     /translation="MKTPFGKAAAGQRSRTGAGHGSVSVTMIKRKAAHKKHRSRPTSQ
                     PRGNIVGCRIQHGWKDGDEPLTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELHRDE
                     RVSSLEVLPNRVASSRISDTHLAEIMVGKAVEHIFETEEGSKNEWRGMVLAQAPVMNT
                     WFYITYEKDPVLYMYQLLDDYKDGDLRILQDSNDSPLAEREPGEVIDSLVGKQVEYAK
                     DDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS"
     regulatory      4421..4426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPIN3"
                     /gene_synonym="bA445O16.1; SPIN-3; TDRD27"
                     /note="hexamer: ATTAAA"
     polyA_site      4445
                     /gene="SPIN3"
                     /gene_synonym="bA445O16.1; SPIN-3; TDRD27"
                     /note="major polyA site"
ORIGIN      
        1 gagactgcgg cgcagcagcg actagtggga gtccgatgtg ggagaggggc tgcggccacc
       61 gccaccgccg ccgccaccag gaaggcggag gacgcaggag ccaagagcaa gggacgccgc
      121 cacggtcatc ttcgcctgcc ccgccgccct cttagagaca ctcattgcct atggatcatc
      181 ctctcccagc ttttgcaagc accgggctgc tcgcccgctg attttcctcc tccataggct
      241 cactgcggag gcaacggcga ggtgtccgat ttgtgcactt gaggcccgca atccgggacg
      301 gtggggaatc tgcgcctcct ggccgggcat gaagaccccg tttggaaagg cagctgcagg
      361 gcagcggtcc aggacgggcg ctggccacgg cagtgtgtct gttaccatga taaagaggaa
      421 ggctgcacac aagaagcata ggagccgacc cacctcccag cctcggggga acatcgtggg
      481 ctgcagaatt cagcacggat ggaaagatgg agatgaacct ctaacacagt ggaaaggaac
      541 cgttctggat caggtacctg taaatccctc tctgtatctt atcaaatatg atggatttga
      601 ctgtgtttat ggattggaac ttcacagaga tgaaagagtg tcatcacttg aagtccttcc
      661 taatagagtt gcatcatcta gaatcagtga tacacacttg gcagaaataa tggttggcaa
      721 agcagtggaa catatttttg agacagagga aggttccaaa aatgaatgga gggggatggt
      781 cttagctcag gcacctgtca tgaacacatg gttttacatt acctatgaga aagatcctgt
      841 attatatatg taccagctct tagatgatta taaagatggt gacctccgca tccttcaaga
      901 ttccaatgat tctcctctgg cagagaggga gccaggagaa gtcatagaca gcctggtagg
      961 caaacaggtg gaatacgcca aagacgatgg ctccaagaga actggcatgg tcattcatca
     1021 ggtagaagca aaaccctctg tgtacttcat caaatttgat gatgatttcc atatctatgt
     1081 ctacgatttg gtaaaaacat cttagaggtc atcttgaaat ttgccaaata tatgagactc
     1141 taaatctgta gacacagaaa gtcttgattg ctttccagtt tgtaagaacc atcttctccc
     1201 tttttgcacg ttttgcttgg caaaaaaatt ggaacttctg ccctctcata cgtttttgga
     1261 agaaaccttt tgcccatctg tccaaccttt tcactggttc ctctccgcaa tttaactgat
     1321 tagtgagaag ggtaaagtct gacatccatt ggctcatact tttttttatc ttgggtggtg
     1381 ttaatagatt aaaggtagct gaacacctct cacctcactc tttttggcac ttggactcta
     1441 cactcattga ggtgtgaagc ttgctgagat atcccatgtg actggctggg taagtgtctt
     1501 tgcaatctca aatctccccc aagtggcttc aaaaatctaa cttgggaaag agtgggaagc
     1561 ccattttggt ctcttgttca agttgcattc tcagttctaa ctgtactaaa agtaaggcta
     1621 ataattttgc tctctttccg gttctttcac ctattgctca actgttttag aattaagaag
     1681 gtaattactt tgcattttag tacctaacca taggctgaga aaccttgcaa aactgataag
     1741 aagacaagca tttggggacc aaactccaag tggagagatc aagatttctg gtggagctta
     1801 agtgaaaggt tttagtcatc agtggcatta gggtctctct tgtctccaat agctctggct
     1861 ggtatctgca gacatggagt aggttttaac tgatagaagc tgtgcaggca gactttagca
     1921 caaatggtct ttgccagccc agaggagcat taagccaggc tctagctaga gccctcagtc
     1981 acaggcaaag gctgggtttg gctgggtttg gacagatctg tccagaacct caaaatgaaa
     2041 gaggagaaac ctagaatcaa actgagatac agatttcttt gctgtgctaa gagagactca
     2101 agttttagat ttgattctta ggagactgaa ttcagagtcc cagcatgtga ggtgggcaag
     2161 gcacttgtga gaaccaagaa tggctgaaag caggctatac ttccttgcag ggactggtgg
     2221 gctcatctat tatggtatcc cagcaggact tggaacacag tcagtggtag gtaatctgta
     2281 ggcttaatga tgttttaagt gctggcattg gtagatagaa atctaataga tttttgttag
     2341 tgtttggatt tttaactatc ctgtttcttg gctggcccta agaaacttat atgcagataa
     2401 gggtgagttc tactgtggca gaaaagtaaa caatggaagg gcctttgagc tttccattat
     2461 taaagagcca ttggcggagg ttaaccaaag cctaggaaag aaaagttgaa gtacaagcat
     2521 ggtttttgag agaagcacct ggccaaaacc aaagctttct cattgaggtt ctcacagaag
     2581 ctccattagc agtaacagcc taataaggcc atggagttct gcacatttgg ggctgggact
     2641 caaggcagta caatcatatt gggactgtac tgcaagatat cttccaaatt agtttaagtt
     2701 cacaggtcat ggagtccaga ctaccggcac agattggcat cctgctgagg atgaaacaaa
     2761 gaagatgttc tcttttctcc tatgttttat ctgtctactt ttgctttttg atgccactaa
     2821 gtctctacta tgatgtttga ctgacaacag caatgtgggt ctgtattgcc ctatgttcta
     2881 agtcctgggg tcatatattt gcttaaaaaa actgttctag tggctgggga ctagtgtgct
     2941 ttctaatttt tttgatgtga ggttgatatt gtgataatct tatgtcttct tgaccctttg
     3001 gactctttaa tatgtatgac atgcaattgt ggggttagat taattcaact cctgaggtcc
     3061 tgaaggaact tcacccagtc aagaggaaga cagccaaggc tgcagctgct gaaggaaccc
     3121 catatctggg cagacatctt tgtgagatct atatggctga aatgagaaaa acgagaaatt
     3181 gggaaaggca gaattttgga ctttaattat tttggacttt gaattagaaa tttaattttg
     3241 ggcagtcctt tttcccttgg agtttaatag ttgatggggt gggggtgagg tcatatagtt
     3301 caaactaagg catttttatt atgttgttga tattgtatta tttggagtat tttaatgcta
     3361 tctttgggag tcattgtata attgttgtca gctatgtcag gaaatatggc tggacataat
     3421 tgtaaattag ggctgcaatt gtgatcaaat tttcagtcta gggtgtaatg tagccttaga
     3481 gttaatttaa ttactgttct attttgactt atttcagagc ctcttggggg caaaaacaac
     3541 tgctcaccaa tcttacattg atgggagcag aacttttcta agatactgtt ggtctccctg
     3601 gaaggggaca gccacagccc tgtttgttga ccagagtctt gagcattaac cattgtggct
     3661 taagagaatg aaaatgtaca agggtatgat gggatctatc ctcttcctct ctccatgctc
     3721 ctgactcaag aaaaggaaaa gacttgcatc tctcaaaaat gtttggaaga aagttctacc
     3781 catcttctct tacactcatt caatcttatg cttgggagga ggaataactt gatgagattg
     3841 agaaaatggt tataatggat aggcagctta ggccactctt ggatcttgag ttcgttccac
     3901 acagcaagat gtgggaaaga ctgcagtcct tcactacatg gctgggtaaa catctgcttt
     3961 ctagacccaa ctatctctcc ttggggtggg ggaatcccaa agtcgttaga cttatgatag
     4021 aagttcattt cagcctcagg tccaagccat gttctccaat ccagctctat cagctataaa
     4081 gctggtatct attttgattc ttttttacag ttttaatata taaattgttt tttagaaaaa
     4141 taacacatgc ctatggtaaa agtcaaacag tataaaaggg tatactatta aaaagtaagt
     4201 ctctcttcct ccttctcacc cctggcctca gttccctggt cccattttca aaaagtaaca
     4261 actgttacca gttactgatg tatcattcca gagatattcc atgtatttac aagcatattg
     4321 tgtgtgggta tgtgtgtatc aggttttttt ttttttttta cacaaatggt ggcatactat
     4381 acatgctgtt ctgaattttg cttttttcac tgaacaatat attaaagctg atatcttaat
     4441 cccta
//
