LOCUS       NM_001006681            1261 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens spindlin family member 2B (SPIN2B), transcript variant
            1, mRNA.
ACCESSION   NM_001006681
VERSION     NM_001006681.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1261)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1261)
  AUTHORS   Bae,N., Gao,M., Li,X., Premkumar,T., Sbardella,G., Chen,J. and
            Bedford,M.T.
  TITLE     A transcriptional coregulator, SPIN.DOC, attenuates the coactivator
            activity of Spindlin1
  JOURNAL   J Biol Chem 292 (51), 20808-20817 (2017)
   PUBMED   29061846
REFERENCE   3  (bases 1 to 1261)
  AUTHORS   Zhang,B., Abreu,J.G., Zhou,K., Chen,Y., Hu,Y., Zhou,T., He,X. and
            Ma,J.X.
  TITLE     Blocking the Wnt pathway, a unifying mechanism for an angiogenic
            inhibitor in the serine proteinase inhibitor family
  JOURNAL   Proc Natl Acad Sci U S A 107 (15), 6900-6905 (2010)
   PUBMED   20351274
  REMARK    GeneRIF: SERPINA3K is a high-affinity, endogenous antagonist of
            LRP6
REFERENCE   4  (bases 1 to 1261)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   5  (bases 1 to 1261)
  AUTHORS   Fletcher,B.S., Dragstedt,C., Notterpek,L. and Nolan,G.P.
  TITLE     Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with
            roles in cell cycle progression
  JOURNAL   Leukemia 16 (8), 1507-1518 (2002)
   PUBMED   12145692
REFERENCE   6  (bases 1 to 1261)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL022157.1, BQ221120.1 and BC071974.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001006681.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 2 and 3
            encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071974.1, SRR14038193.932741.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434397.3/ ENSP00000404314.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL022157.1         29581-29582
            3-70                BQ221120.1         13-80
            71-1261             BC071974.1         1-1191
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..1261
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN-2B;
                     SPIN2_duplicate; TDRD26"
                     /note="spindlin family member 2B"
                     /db_xref="GeneID:474343"
                     /db_xref="HGNC:HGNC:33147"
                     /db_xref="MIM:300517"
     exon            1..311
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN-2B;
                     SPIN2_duplicate; TDRD26"
                     /inference="alignment:Splign:2.1.0"
     exon            312..1261
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN-2B;
                     SPIN2_duplicate; TDRD26"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1090
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN-2B;
                     SPIN2_duplicate; TDRD26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     telomeric SPIN2 copy; spindlin family, member 2 duplicate;
                     spindlin-2B; spindlin-like protein 2B"
                     /codon_start=1
                     /product="spindlin-2B isoform 1"
                     /protein_id="NP_001006682.1"
                     /db_xref="CCDS:CCDS35311.1"
                     /db_xref="GeneID:474343"
                     /db_xref="HGNC:HGNC:33147"
                     /db_xref="MIM:300517"
                     /translation="MKTPNAQEAEGQQTRAAAGRATGSANMTKKKVSQKKQRGRPSSQ
                     PRRNIVGCRISHGWKEGDEPITQWKGTVLDQVPINPSLYLVKYDGIDCVYGLELHRDE
                     RVLSLKILSDRVASSHISDANLANTIIGKAVEHMFEGEHGSKDEWRGMVLAQAPIMKA
                     WFYITYEKDPVLYMYQLLDDYKEGDLRIMPESSESPPTEREPGGVVDGLIGKHVEYTK
                     EDGSKRIGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKKS"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN-2B;
                     SPIN2_duplicate; TDRD26"
                     /note="hexamer: AATACA"
     polyA_site      1261
                     /gene="SPIN2B"
                     /gene_synonym="dJ323P24.2; SPIN-2; SPIN-2B;
                     SPIN2_duplicate; TDRD26"
                     /note="major polyA site"
ORIGIN      
        1 aggagactgc cgcggcgaca gcagggactg gtggaatccc gatgtggctg aggggccgcc
       61 accgccagca gggaggcgga gggctagcga gccaagcggt ggggacgccg ctgccttcct
      121 ctttgcctgt ctcgccgccc tcctagacac gctcctcatc tacggatcct accctccccg
      181 ctcttgcaag cattcactcg gccggtcgcc tgctgaccct ccttcgccac aggctcgtag
      241 cggaggcagc agcgaggtgt ccgatttggg cacgtgaggc ccgcgatccc cggcggtgga
      301 cgccaggcag ggcatgaaga cccccaacgc acaggaagcc gaagggcaac aaaccagggc
      361 agctgcagga cgggccactg ggtctgcaaa catgacaaag aaaaaagtct cccaaaagaa
      421 gcagagaggc cgaccttcat cccagccccg caggaacatc gtgggctgca gaatttctca
      481 tggatggaag gaaggagatg agcccatcac gcagtggaaa ggaaccgttc tggatcaggt
      541 gcctataaat ccctctcttt atctggtgaa atatgatgga attgactgtg tctatggact
      601 ggaacttcac agagatgaaa gggttttgtc tcttaaaatt ctttctgaca gggtggcatc
      661 atctcacatt agtgatgcca accttgcaaa taccataatt ggcaaagcag tggaacatat
      721 gtttgaggga gagcatggtt ctaaggatga atggaggggg atggtcttag ctcaagcacc
      781 tatcatgaaa gcctggtttt atattaccta tgagaaagat cctgtcttgt acatgtacca
      841 gcttctagat gattataagg aaggtgacct ccgcatcatg ccagaatcca gtgagtctcc
      901 tccaacagag agggagccag gaggagttgt agatggccta ataggtaagc atgtggaata
      961 taccaaagaa gatggctcca aaaggatcgg catggtcatt caccaagtgg aagccaaacc
     1021 ctctgtgtat ttcatcaagt ttgatgatga tttccatatc tatgtctacg atttggtgaa
     1081 aaagtcctaa ctgttagggt aaaatttggc acatgtgtgg aaacaaatgt ataatttgta
     1141 gacatgcaaa aaatgttgcc tttcagtgta ttgaaagctt atggaatccc tgataactaa
     1201 acatctttgc cagcattaac tgttgttttg ctctaaaaaa tacaaacttg tgtgtacatg
     1261 a
//
