LOCUS       NM_019003               1091 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens spindlin family member 2A (SPIN2A), mRNA.
ACCESSION   NM_019003
VERSION     NM_019003.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1091)
  AUTHORS   Bae,N., Gao,M., Li,X., Premkumar,T., Sbardella,G., Chen,J. and
            Bedford,M.T.
  TITLE     A transcriptional coregulator, SPIN.DOC, attenuates the coactivator
            activity of Spindlin1
  JOURNAL   J Biol Chem 292 (51), 20808-20817 (2017)
   PUBMED   29061846
REFERENCE   2  (bases 1 to 1091)
  AUTHORS   Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
            Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
            Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
            Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
            Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
            Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
            Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
            Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
            Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
            Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
            Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
            Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
            Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
            Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
            Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
            Futreal,P.A. and Stratton,M.R.
  TITLE     A systematic, large-scale resequencing screen of X-chromosome
            coding exons in mental retardation
  JOURNAL   Nat Genet 41 (5), 535-543 (2009)
   PUBMED   19377476
REFERENCE   3  (bases 1 to 1091)
  AUTHORS   Fletcher,B.S., Dragstedt,C., Notterpek,L. and Nolan,G.P.
  TITLE     Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with
            roles in cell cycle progression
  JOURNAL   Leukemia 16 (8), 1507-1518 (2002)
   PUBMED   12145692
  REMARK    GeneRIF: SPIN-2. SPIN-2 is a novel nuclear protein from HL-60 cells
            that functions to regulate cell cycle progression and this activity
            is related to the inhibition of apoptosis following the removal of
            essential growth factors
REFERENCE   4  (bases 1 to 1091)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1091)
  AUTHORS   Laval,S.H., Reed,V., Blair,H.J. and Boyd,Y.
  TITLE     The structure of DXF34, a human X-linked sequence family with
            homology to a transcribed mouse Y-linked repeat
  JOURNAL   Mamm Genome 8 (9), 689-691 (1997)
   PUBMED   9271673
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022157.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 13, 2021 this sequence version replaced NM_019003.4.
            
            Summary: This gene encodes one of three members of the DXF34 gene
            family, located in a 100-kb region of chromosome Xp11.21. [provided
            by RefSeq, Nov 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071694.1, SRR3476690.266824.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374906.4/ ENSP00000364041.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL022157.1         13732-13869
            139-1091            AL022157.1         14527-15479
FEATURES             Location/Qualifiers
     source          1..1091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..1091
                     /gene="SPIN2A"
                     /gene_synonym="dJ323P24.1; DXF34; SPIN2; TDRD25"
                     /note="spindlin family member 2A"
                     /db_xref="GeneID:54466"
                     /db_xref="HGNC:HGNC:20694"
                     /db_xref="MIM:300621"
     exon            1..138
                     /gene="SPIN2A"
                     /gene_synonym="dJ323P24.1; DXF34; SPIN2; TDRD25"
                     /inference="alignment:Splign:2.1.0"
     exon            139..1091
                     /gene="SPIN2A"
                     /gene_synonym="dJ323P24.1; DXF34; SPIN2; TDRD25"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..920
                     /gene="SPIN2A"
                     /gene_synonym="dJ323P24.1; DXF34; SPIN2; TDRD25"
                     /note="centromeric spin2 copy; spindlin homolog 2;
                     spindlin-like protein 2; spindlin-like protein 2A"
                     /codon_start=1
                     /product="spindlin-2A"
                     /protein_id="NP_061876.3"
                     /db_xref="CCDS:CCDS35312.1"
                     /db_xref="GeneID:54466"
                     /db_xref="HGNC:HGNC:20694"
                     /db_xref="MIM:300621"
                     /translation="MKTPNAQEAEGQQTRAAAGRATGSANMTKKKVSQKKQRGRPSSQ
                     PRRNIVGCRISHGWKEGDEPITQWKGTVLDQVPINPSLYLVKYDGIDCVYGLELHRDE
                     RVLSLKILSDRVASSHISDANLANTIIGKAVEHMFEGEHGSKDEWRGMVLAQAPIMKA
                     WFYITYEKDPVLYMYQLLDDYKEGDLRIMPESSESPPTEREPGGVVDGLIGKHVEYTK
                     EDGSKRIGMVIHQVETKPSVYFIKFDDDFHIYVYDLVKKS"
     regulatory      1069..1074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPIN2A"
                     /gene_synonym="dJ323P24.1; DXF34; SPIN2; TDRD25"
                     /note="hexamer: AATACA"
     polyA_site      1091
                     /gene="SPIN2A"
                     /gene_synonym="dJ323P24.1; DXF34; SPIN2; TDRD25"
                     /note="major polyA site"
ORIGIN      
        1 ctctttgcct gtctcgccgc gctcctacac acgctcctca tctatggatc ctaccctccc
       61 cgctcttgca agcagtcact cagcgagtcg cctgttgacc ctccttcgcc acaggctcac
      121 agcagaggca gcatcgagca ggcatgaaga cccccaacgc acaggaagcc gaagggcaac
      181 aaaccagggc agctgcagga cgggccactg ggtctgcaaa catgacaaag aaaaaagtct
      241 cccaaaagaa gcagagaggc cgaccttcat cccagccccg caggaacatc gtgggctgca
      301 gaatttctca tggatggaag gaaggagatg agcccatcac gcagtggaaa ggaaccgttc
      361 tggatcaggt gcctataaat ccctctcttt atctggtgaa atatgatgga attgactgtg
      421 tctatggact ggaacttcac agagatgaaa gggttttgtc tcttaaaatt ctttctgaca
      481 gggtggcatc atctcacatt agtgatgcca accttgcaaa taccataatt ggcaaagcag
      541 tggaacacat gtttgaggga gagcatggtt ctaaggatga atggaggggg atggtcttag
      601 ctcaagcacc tatcatgaaa gcctggtttt atattaccta tgagaaagat cctgtcttgt
      661 acatgtacca gcttctagat gattataagg aaggtgacct ccgcatcatg ccagaatcca
      721 gtgagtctcc tccaacagag agggagccag gaggagttgt agatggccta ataggtaagc
      781 atgtggaata taccaaagaa gatggctcca aaaggatcgg catggtcatt caccaagtgg
      841 aaaccaaacc ctctgtgtat ttcatcaagt ttgatgatga tttccatatc tatgtctacg
      901 atttggtgaa aaagtcctaa ctgttagggt aaaatttggc acatgtgtgg aaacaaatgt
      961 ataatttgta gacatgcaaa aaatgttgcc tttcagtgta ctgaaagctt atggaatccc
     1021 tgataactaa acatctttgc cagcattaac tgttgttttg ctctaaaaaa tacaaatttg
     1081 tgaatacatg a
//
