LOCUS       NM_006717               4459 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens spindlin 1 (SPIN1), mRNA.
ACCESSION   NM_006717
VERSION     NM_006717.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4459)
  AUTHORS   Wang,Y., Li,M., Chen,Y., Jiang,Y., Zhang,Z., Yan,Z., Liu,X. and
            Wu,C.
  TITLE     SPIN1 facilitates chemoresistance and HR repair by promoting Tip60
            binding to H3K9me3
  JOURNAL   EMBO Rep 25 (9), 3970-3989 (2024)
   PUBMED   39090319
  REMARK    GeneRIF: SPIN1 facilitates chemoresistance and HR repair by
            promoting Tip60 binding to H3K9me3.
REFERENCE   2  (bases 1 to 4459)
  AUTHORS   Zhao,F., Deng,Y., Yang,F., Yan,Y., Feng,F., Peng,B., Gao,J.,
            Bedford,M.T. and Li,H.
  TITLE     Molecular Basis for SPINDOC-Spindlin1 Engagement and Its Role in
            Transcriptional Attenuation
  JOURNAL   J Mol Biol 436 (7), 168371 (2024)
   PUBMED   37977297
  REMARK    GeneRIF: Molecular Basis for SPINDOC-Spindlin1 Engagement and Its
            Role in Transcriptional Attenuation.
REFERENCE   3  (bases 1 to 4459)
  AUTHORS   Li,D., Guo,J. and Jia,R.
  TITLE     Epigenetic Control of Cancer Cell Proliferation and Cell Cycle
            Progression by HNRNPK via Promoting Exon 4 Inclusion of Histone
            Code Reader SPIN1
  JOURNAL   J Mol Biol 435 (6), 167993 (2023)
   PUBMED   36736887
  REMARK    GeneRIF: Epigenetic Control of Cancer Cell Proliferation and Cell
            Cycle Progression by HNRNPK via Promoting Exon 4 Inclusion of
            Histone Code Reader SPIN1.
REFERENCE   4  (bases 1 to 4459)
  AUTHORS   Porzberg,M.R.B., Moesgaard,L., Johansson,C., Oppermann,U.,
            Kongsted,J. and Mecinovic,J.
  TITLE     Recognition of Dimethylarginine Analogues by Tandem Tudor Domain
            Protein Spindlin1
  JOURNAL   Molecules 27 (3), 983 (2022)
   PUBMED   35164245
  REMARK    GeneRIF: Recognition of Dimethylarginine Analogues by Tandem Tudor
            Domain Protein Spindlin1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4459)
  AUTHORS   Zhou,L., Wang,H., Fang,Z., Zhong,M., He,Y., Zou,J., Huang,S.,
            Li,J., Xiang,X. and Fang,Z.
  TITLE     The microRNA-381(miR-381)/Spindlin1(SPIN1) axis contributes to cell
            proliferation and invasion of colorectal cancer cells by regulating
            the Wnt/beta-catenin pathway
  JOURNAL   Bioengineered 12 (2), 12036-12048 (2021)
   PUBMED   34753384
  REMARK    GeneRIF: The microRNA-381(miR-381)/Spindlin1(SPIN1) axis
            contributes to cell proliferation and invasion of colorectal cancer
            cells by regulating the Wnt/beta-catenin pathway.
REFERENCE   6  (bases 1 to 4459)
  AUTHORS   Jiang,F., Zhao,Q., Qin,L., Pang,H., Pei,X. and Rao,Z.
  TITLE     Expression, purification, crystallization and preliminary X-ray
            analysis of human spindlin1, an ovarian cancer-related protein
  JOURNAL   Protein Pept Lett 13 (2), 203-205 (2006)
   PUBMED   16472086
  REMARK    GeneRIF: recombinant human spindlin1 has been overexpressed in
            Escherichia coli BL21, purified and crystallized using the
            hanging-drop vapour-diffusion method
REFERENCE   7  (bases 1 to 4459)
  AUTHORS   Gao,Y., Yue,W., Zhang,P., Li,L., Xie,X., Yuan,H., Chen,L., Liu,D.,
            Yan,F. and Pei,X.
  TITLE     Spindlin1, a novel nuclear protein with a role in the
            transformation of NIH3T3 cells
  JOURNAL   Biochem Biophys Res Commun 335 (2), 343-350 (2005)
   PUBMED   16098913
  REMARK    GeneRIF: spindlin1 gene may contribute to tumorigenesis
REFERENCE   8  (bases 1 to 4459)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 4459)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 4459)
  AUTHORS   Oh,B., Hwang,S.Y., Solter,D. and Knowles,B.B.
  TITLE     Spindlin, a major maternal transcript expressed in the mouse during
            the transition from oocyte to embryo
  JOURNAL   Development 124 (2), 493-503 (1997)
   PUBMED   9053325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB465491.2, AF087864.1 and AL353748.13.
            
            On Nov 22, 2018 this sequence version replaced NM_006717.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136719.1, SRR1803616.23846.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375859.4/ ENSP00000365019.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               DB465491.2         64-569
            507-1692            AF087864.1         449-1634
            1693-4459           AL353748.13        135628-138394
FEATURES             Location/Qualifiers
     source          1..4459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.1"
     gene            1..4459
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /note="spindlin 1"
                     /db_xref="GeneID:10927"
                     /db_xref="HGNC:HGNC:11243"
                     /db_xref="MIM:609936"
     exon            1..95
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            96..305
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1042
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /note="ovarian cancer-related protein; spindlin1"
                     /codon_start=1
                     /product="spindlin-1"
                     /protein_id="NP_006708.2"
                     /db_xref="CCDS:CCDS43843.1"
                     /db_xref="GeneID:10927"
                     /db_xref="HGNC:HGNC:11243"
                     /db_xref="MIM:609936"
                     /translation="MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSK
                     PVSQPRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLEL
                     NKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAP
                     VMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQV
                     EYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS"
     exon            306..354
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            355..608
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            609..842
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /inference="alignment:Splign:2.1.0"
     exon            843..4459
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4440..4445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /note="hexamer: AATAAA"
     polyA_site      4459
                     /gene="SPIN1"
                     /gene_synonym="SPIN; TDRD24"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgccgt ctggctcagg ctggggccgg cgggagcgcg aacgagcgac ggcggaaccc
       61 gtgggcctgt ggactgcagc ctcggcggtc agcagagtgc ttgtgatttc acgtattttt
      121 gctgaactcg taaaagagac acttggatgg tggattaacc agaacactaa cattctgtga
      181 aaagtttcaa attggagaat attgaatttt caccctagtc cagcagctcc gctgctcact
      241 taaatacaga tgaatgaaga ccccattcgg aaagacacct ggccagcggt ccagagctga
      301 tgcaggccat gctggagtat ctgccaacat gatgaagaag aggacatccc acaaaaaaca
      361 tcggagcagt gtgggtccga gcaaacctgt ttcccagccc cggcggaaca tcgtaggctg
      421 caggattcag catgggtgga aagaggggaa tggccctgtt acccagtgga aaggaaccgt
      481 tctggaccag gtgcctgtaa atccttcttt gtatcttata aaatacgatg gatttgactg
      541 tgtttatgga ctagaactta ataaagatga aagagtttct gcgcttgaag tcctccctga
      601 tagagttgcg acatctcgaa tcagcgatgc acacttggca gacacaatga ttggcaaagc
      661 agtggaacat atgtttgaga cagaggatgg ttctaaagat gagtggaggg gaatggtctt
      721 agcacgtgca cctgtcatga acacatggtt ttacattacc tatgagaaag accctgtctt
      781 gtacatgtac caactcttag atgattacaa agaaggcgac cttcgcatta tgcctgattc
      841 caatgattca cctccagcag aaagggaacc aggagaagtt gtggacagcc tggtaggcaa
      901 acaagtggaa tatgccaaag aagatggctc gaaaaggact ggcatggtca ttcatcaagt
      961 agaagccaag ccctccgtct atttcatcaa gtttgatgat gatttccata tttatgtcta
     1021 cgatttggtg aaaacatcct agatgtcatc acaaactctg ccaaatttgt ggaactatga
     1081 aatgtattat ttgtagacat aaagacttga ttgctttcca gtttaatgaa agcttaaatg
     1141 tccctgcgaa cccacaatct ctgccagcag aactggtttt gttctgaata gtacagattg
     1201 atgtgaacac aaagcatttt gtgtaaggag aacccctttc ttttaaaaga agtctgtcta
     1261 tttcgagggg agttacaggc aagtttggta aaagttaagc tagtatcata gtcatttaaa
     1321 attgtaatag atcttaacca ttttccccct caccctaact ctcttattct gccgccacaa
     1381 tgcaagcata gtttgatgtt ttcgttattg ccttttttga gatgtatgta tctgtatcta
     1441 cctatatcta tatgtgtgta tacatatata atatatacac acagatacaa gtgtacacac
     1501 acacaccaca caccacacac accccactgg cagtctttgt ggattaggat gggggtgaca
     1561 taattttctt gagtttaaca ggagtgcttt acccaagtca gtcatggata tgatatcact
     1621 gctctttatt taaaagtaaa ctttgggcac aggaaccata tgggaacatt cagcttgttt
     1681 aaaaaaaaaa aatcagaagt tcagagcacc ttttcaatct ggagccctta aaccataagt
     1741 ccaaatatga attatttgtg aacagttaat gacccatatt agaattttac aatctggtga
     1801 acaatctggg taaaaggcta cctttaattc taagcttcat ttttttttgg gggggggtta
     1861 cattttaatc ataaattctt ttttgcaaag cccaggttct tgttccacac agtgtaatgt
     1921 aggtgtattt tggacagcac atatggtcca ttgtgtacaa gtcagtaatc tggatttcag
     1981 tacatggatt taaaaggcaa caatccatca ctggtttgtg tgtttttggt taagtttctg
     2041 gaagaataca atgcttttat attggaagta taagttttga gtggcattgt tgccttctaa
     2101 caagctctct gggactttta aagttttatt actattattg ctaatgtatg attatggtca
     2161 gagactttca acccacccct tcctgcctac ccctggcttt tcctcacaaa gaatgtctag
     2221 acaaacagca gcttagtctc ctgacacctc ttgtggggtg catgttcctg ctccaggtat
     2281 gctgttcatg tggattcatt ccattcagtg gccccttggg gtttgcatgc cagtgaagcg
     2341 ttaccataga agagccagcc gtttgtgttc gcttggtagg tgtaagtaat agcagccctt
     2401 agccacggag tctttatgtg gtttattcct gcaaggttgt tttaaactga aatagaactg
     2461 ctagtgtgat tggttgatca gcaaaacagc tgctctcatt ttgttttgga ggaaccctgg
     2521 tggtttgaca gccaggagaa aggccatatg tgaaaccagt ctcttgtgga gattggaaat
     2581 cctccctgat atttgggcag agcctaaacg tgcatgcttg tcactcaaac accagaagtt
     2641 tgaatcagag gtctgagtga cctcttttgt ggctgttctt gatggtttcc aggcctcgtt
     2701 atgcatggtt tgcttgatgc ccattttttg tgccttgtgc tgttggatgg taacgaccac
     2761 tcaccatgta aacacagtac ctcagttttc tgtccacagc tgcagtcgct ctgtccctcg
     2821 tgcttcactg tgggcagcca gggacaagct tctgaaagca gtgtgatacc caagtcatag
     2881 gtgcttctcg tatgtgaaca ggtgtcattc tacagatctg ttatgtgttt tcctgttgac
     2941 tcttaagagt ccctgcatgt aaatctcaaa gctgagcctg gctcccagag tccagactga
     3001 cattacagcg caagagtttg caagtgtgtc cagcatgcac caactgtgca gaacttggct
     3061 cggtaacttt gcgtggaaaa ataaagtaca ttttgaagta tcttgagggt tgggtcaatt
     3121 gagacatttc tagcattact taatgacttg cattgtggtt tttctgcaag caactttaat
     3181 gacttttttt ataccacatg gtctcccagt ttctagatga atgcaacatg atgatggtga
     3241 tgatgacgat gagtttaatc attgttcatt tattgccttt agggctgagg gaaagggaag
     3301 gtttgttttt ttttctcccc attttccccc attctgtctt tcttttggtg acttacacca
     3361 catgtaatga cgctatgact aattctgctc ccaagccctt gtatcttggg cttcatttta
     3421 ggctcatgtg tcagatctgc atgcattgct tgcatttttc tggtatctga atgttggttc
     3481 cttgttccag gaattcaaca ttaatttcca aaagtatcat gggacttgtg acaatacaag
     3541 acatgaatct atgtataaaa tttatcggcc tttctcattt acctgctcta gtattattgt
     3601 attgtgtgtg cgtgcgtgtg tgatgtcagg ctgccacgta aaacttcaga gaaaaatctt
     3661 aaaagcagac catccttttt tgcatgctct attctaagta gaatgttcaa tgtaactgac
     3721 taaaattgca tgttaaagat atttaggttt ttttgttttc tttattttta tttgttttca
     3781 gtttcctgta tatttgctta ctgtgccgtt ttagtggttt taggataaaa atgcactggt
     3841 gaagcaaatg tagtgccaac agaaggtgat tttccagttg taaatgtcat gcagcatttg
     3901 aagggactgt gttttcttaa aaaaaaatca cagttacttc taaaccagat ttcatttctt
     3961 ttattgtttt atgtgccaaa ccacgaagtg cattgggctt caatctctga acactgtaga
     4021 cccattagaa gactgttccg attgttacaa attgtagtgc ctgaaaacac tcttaagctg
     4081 attgtcttaa caaaatgaaa gttctccaaa gacaaaacag aacaattatt ataacaaaat
     4141 aattatggtt gaaatgtctg tggttccttg gaaatgctgc gctctttgtg tttttccatc
     4201 attagtgcag ttggaatgaa tgtgtatagg tcagaggtct tcgtgttcac attttaaaat
     4261 taggtaaatg acctcatctt tcaagcttga attcattttt aattttaatt ttattttata
     4321 caatgtgtag acagttccct gttctctgca tttagaagta tacacaatat aaatctgtta
     4381 attctgtaag taatttttat aattatgatg taactctatc ttatccttaa aacatttaaa
     4441 ataaaccctt tatgtgcaa
//
