LOCUS       NM_144718               5417 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens spindle and centriole associated protein 1 (SPICE1),
            transcript variant 1, mRNA.
ACCESSION   NM_144718
VERSION     NM_144718.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5417)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5417)
  AUTHORS   Deretic,J., Kerr,A. and Welburn,J.P.I.
  TITLE     A rapid computational approach identifies SPICE1 as an Aurora
            kinase substrate
  JOURNAL   Mol Biol Cell 30 (3), 312-323 (2019)
   PUBMED   30485161
  REMARK    GeneRIF: temporal and spatial Aurora kinase-mediated regulation of
            SPICE1 is important for correct chromosome segregation.
REFERENCE   3  (bases 1 to 5417)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   4  (bases 1 to 5417)
  AUTHORS   Comartin,D., Gupta,G.D., Fussner,E., Coyaud,E., Hasegan,M.,
            Archinti,M., Cheung,S.W., Pinchev,D., Lawo,S., Raught,B.,
            Bazett-Jones,D.P., Luders,J. and Pelletier,L.
  TITLE     CEP120 and SPICE1 cooperate with CPAP in centriole elongation
  JOURNAL   Curr Biol 23 (14), 1360-1366 (2013)
   PUBMED   23810536
  REMARK    GeneRIF: CEP120 associates with SPICE1 and CPAP, and depletion of
            any of these proteins results in short procentrioles. Furthermore,
            CEP120 or CPAP overexpression results in excessive centriole
            elongation, a process dependent on CEP120, SPICE1, and CPAP.
REFERENCE   5  (bases 1 to 5417)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   6  (bases 1 to 5417)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 5417)
  AUTHORS   Archinti,M., Lacasa,C., Teixido-Travesa,N. and Luders,J.
  TITLE     SPICE--a previously uncharacterized protein required for centriole
            duplication and mitotic chromosome congression
  JOURNAL   J Cell Sci 123 (Pt 18), 3039-3046 (2010)
   PUBMED   20736305
  REMARK    GeneRIF: SPICE is required for centriole duplication and mitotic
            chromosome congression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP278430.1, AY099107.1, AC112128.4 and U79249.1.
            
            On May 17, 2019 this sequence version replaced NM_144718.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832148.1, SRR1803614.116530.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295872.8/ ENSP00000295872.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BP278430.1         32-81
            51-3499             AY099107.1         2-3450
            3500-3977           AC112128.4         157259-157736
            3978-5417           U79249.1           1-1440
FEATURES             Location/Qualifiers
     source          1..5417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..5417
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /note="spindle and centriole associated protein 1"
                     /db_xref="GeneID:152185"
                     /db_xref="HGNC:HGNC:25083"
                     /db_xref="MIM:613447"
     exon            1..260
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..2828
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /note="coiled-coil domain-containing protein 52"
                     /codon_start=1
                     /product="spindle and centriole-associated protein 1"
                     /protein_id="NP_653319.1"
                     /db_xref="CCDS:CCDS2973.1"
                     /db_xref="GeneID:152185"
                     /db_xref="HGNC:HGNC:25083"
                     /db_xref="MIM:613447"
                     /translation="MSFVRVNRCGPRVGVRKTPKVKKKKTSVKQEWDNTVTDLTVHRA
                     TPEDLVRRHEIHKSKNRALVHWELQEKALKRKWRKQKPETLNLEKRRLSIMKEILSDQ
                     YQMQDVLEKSDHLIAAAKELFPRRRTGFPNVTVAPDSSQGPIVVNQDPITQSIFNESV
                     IEPQALNDVDGEEEGTVNSQSGESENENELDNSLNSQSNTNTDRFLQQLTEENFELIS
                     KLWTDIQQKIATQSQITPPGTPSSALSSGEQRAALNATNAVKRLQTRLQPEESTETLD
                     SSYVVGHVLNSRKQKQLLNKVKRKPNLHALSKPKKNISSGSTTSADLPNRTNSNLDVL
                     KHMIHEVEHEMEEYERWTGREVKGLQSSQGLTGFTLSLVSSLCRLVRYLKESEIQLRK
                     EVETRQQLEQVLGDHRELIDALTAEILRLREENAATQARLQQYMVTTDEQLISLTHAI
                     KNCPVINNRQEIQASESGATGRRVMDSPERPVVNANVSVPLMFREEVAEFPQEELPVK
                     LSQVPDPPDNMNLAKNFPAHIFEPAVLLTPPRQKSNLKFSPLQDVLRRTVQTRPAPRL
                     PPTVEIIEKEQNWEEKTLPIDTDIQNSSEENRLFTQRWRVSHMGEDLENKTQAPFVNL
                     SQPLCNSHSNTQQSRSPTFSEELPVLGDGQQLRTNESLIQRKDIMTRIADLTLQNSAI
                     KAHMNNIIEPRGEQGDGLRELNKQESASDMTSTFPVAQSLTPGSMEERIAELNRQSME
                     ARGKLLQLIEQQKLVGLNLSPPMSPVQLPLRAWTEGAKRTIEVSIPGAEAPESSKCST
                     VSPVSGINTRRSSGATGNSCSPLNATSGSGRFTPLNPRAKIEKQNEEGWFALSTHVS"
     exon            261..359
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            360..407
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            408..551
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            552..645
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            646..752
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            753..871
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1011
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1149
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1415
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1547
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1695
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1917
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2402
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2583
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2686
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2774
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..5417
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3337..3342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /note="hexamer: AATATA"
     polyA_site      3357
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /note="major polyA site"
     regulatory      3475..3480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /note="hexamer: AATAAA"
     polyA_site      3499
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /note="major polyA site"
     regulatory      5392..5397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
                     /note="hexamer: AATAAA"
     polyA_site      5417
                     /gene="SPICE1"
                     /gene_synonym="CCDC52; SPICE"
ORIGIN      
        1 aacctgtggc gcgctccgcg gttccggcgc ctgaagtttt agctgcggtg gcggcggcag
       61 tcgggaccga ctgcaaggca ggttgagatg atggatctga ggcttgcagc tcgcagtccc
      121 aacgagcctt agggaccagg gctaccaaaa gggtggggag aacggtggtg gcatctgtct
      181 gttgcctggg atccaggcgc ccggttgggg aatccttact tcaggaagcg cagccgcggc
      241 tctgtgtttt gagagtgcaa atgtcatttg tcagagtgaa ccgctgtggt ccccgagttg
      301 gtgtaagaaa gacaccgaaa gtaaagaaga agaaaacttc agtgaaacaa gaatgggata
      361 ataccgtgac tgatctaacc gttcatcggg caactcccga agatctggta cgccgtcatg
      421 aaatacacaa atcgaagaat agagcattag tacactggga actccaagaa aaagctttga
      481 agagaaaatg gaggaagcag aaaccagaaa ctttaaatct tgagaaaaga agattgtcta
      541 tcatgaagga gattctttct gatcaatacc agatgcaaga tgtgttggag aaatctgatc
      601 atctaatagc tgcagcaaaa gagctgtttc ctcgtaggcg cacagggttt ccaaatgtaa
      661 cagtggctcc tgattcctct cagggtccca ttgtggtaaa tcaagaccct atcacccaat
      721 ctatctttaa tgagtctgtc atagaacctc aggctcttaa tgatgtagat ggtgaagaag
      781 aaggaactgt taatagccag tcaggagaaa gtgagaatga gaatgagttg gataactctc
      841 taaactctca gtctaacacg aatacagaca ggtttctcca acaactaaca gaagagaatt
      901 ttgagttaat tagtaagttg tggactgaca ttcagcagaa aatagcaacc cagtcacaaa
      961 taactcctcc aggaacgcca tcatctgctc tttcatcagg ggagcaaaga gctgctctga
     1021 atgctaccaa tgctgtcaag agactccaaa ccaggcttca gcctgaagaa tctactgaga
     1081 ctctagactc aagctacgtt gtgggacacg tgctgaactc aaggaagcaa aaacagctgt
     1141 taaataaagt gaaaaggaaa ccgaatttgc atgctctttc caagccgaag aaaaacatat
     1201 catcaggtag cacaacctct gcagacttac caaataggac taattccaac ctggatgtcc
     1261 tcaaacacat gatacatgaa gtggaacatg aaatggaaga atatgagcgg tggacaggtc
     1321 gcgaggtcaa gggtctgcag agcagtcagg gtcttacagg cttcactttg tcgctggtga
     1381 gctccctctg tcgcctggtt cggtacctta aagagagtga gatccagcta cgtaaagaag
     1441 tagagacaag gcaacaactg gaacaagtat taggtgatca tcgagagctc attgatgctc
     1501 tgacagctga aattcttcgt cttagagaag aaaacgctgc tacacaggca agacttcagc
     1561 agtacatggt cacaacagat gagcaactga tatcactcac acatgctatt aagaactgtc
     1621 ctgtgataaa taacagacaa gaaattcagg catcagaaag cggagccaca ggtagaagag
     1681 ttatggacag tccagagcgt ccagttgtaa atgccaatgt ctcagtgcca ttgatgttca
     1741 gagaggaagt ggctgaattc ccacaggaag agttgcccgt taaactgtct caggtgccag
     1801 accctccaga taacatgaat ctggccaaga attttccagc acatattttt gagccagctg
     1861 tgttgttaac accacccagg cagaagagca acttaaaatt ctctcctctt caggacgtat
     1921 tgagaaggac tgttcaaact cgtcctgctc cacgacttcc tccaactgtg gaaataattg
     1981 agaaggaaca aaattgggaa gagaagacct tacctattga tacagacatt cagaattcaa
     2041 gtgaagagaa tcgtctcttc actcagagat ggagagtctc tcacatggga gaagatttgg
     2101 agaacaaaac tcaggctcct tttgttaacc tctcacagcc cctctgcaat tcccattcca
     2161 acactcaaca gtcaagaagc cccacattct cagaagagct cccagtactg ggagatgggc
     2221 agcagctgag aacaaatgag tcattaatac aaagaaagga cataatgaca cgaattgctg
     2281 atttgacatt gcagaattca gctatcaagg cacatatgaa taatattatt gagcccagag
     2341 gagagcaagg ggatggactc cgggagttga acaaacaaga aagtgcaagt gacatgactt
     2401 ctacttttcc agtagcacag tctctaacac caggtagtat ggaggaacgg attgcagaat
     2461 tgaatcgaca aagtatggag gctcgtggaa aactactgca gttgatagag cagcagaaac
     2521 ttgttggttt gaatctttct ccaccaatgt cacctgttca gttacctctc agagcatgga
     2581 ctgaaggagc aaagaggaca attgaggtat ctattccagg agcagaagcc ccagaaagct
     2641 caaaatgtag tactgtctct cccgtcagcg ggataaatac aagaagatct tccggggcta
     2701 ctggtaattc ttgttctcca ctaaatgcca cctcaggaag tgggagattc acacctctta
     2761 atccaagagc aaagattgag aaacagaatg aagaaggctg gtttgctctt tctacccatg
     2821 tatcataagt gaagtcaagt ctcactgagt ttgttcttaa taatttatta cttccctttc
     2881 cctgctctga cttttaagtt tttatatcct tctttcagat aaaacctaca aagatcctgt
     2941 gaattagtac taatgaaaca gagaaataaa gcaattattt tttgactttc tcaaataagt
     3001 tttcaacaac caactgacct acagctccct gtgaatgaaa ctttgactgt agagaagtta
     3061 aagttttgta ttttaatact ttcttaagta ttttaagggt tttttttatt aatacatttt
     3121 tacctttatc tttattcagg gttttttgag gtttagtata tcttagttga tccatttatt
     3181 tatttatttt cctgaagaac taatttgctt tgcatgtaac ttacaataaa attcctctgt
     3241 gtgattagag tctggctttc aggaatatgt aacacccact tttctttctt ttttcttggg
     3301 aagtcattgc tgttcatcac tttttccatc aagtgaaata tacagcctta aaaacaatag
     3361 gcctgggagt gtttgtttat atttgcttaa gcaggtaaga gtggttgcat ttattataaa
     3421 atcttatgta gtttttaaat gtgaaaatgt catcaataat ggtaatgcaa atcaaataaa
     3481 tatgattcta gagctcaaat gcctaaatgt ggtaacattg atttaatggt atatttaatg
     3541 cttcaaacaa ttaaatagaa aaagttgcta ttaattttcc cagccctgaa tttaagcaga
     3601 tctttcaggg tagatttctc tttttttttt ttttttgaga cagagtcttg ctttattgcc
     3661 caggctggag tgcagttgta taatctggtt cactgccacc tcagtctcct gggttcaagc
     3721 aatcctctta cctcagcctc ctgagtagct aggattatag gttcatgcca ccacgcccag
     3781 ctaatttgtg tattttcagt agagacgggg tttcaccatg ttggccaggc tgatctcgaa
     3841 ctcctgacct caaatgatcc acctgccttg gtttcccaaa gtgccgggat tacaggtgtg
     3901 agccactgca cccggctcag gatagatttt tcagggtacc cttttggttc tgagatgttt
     3961 atttctattt taaacttgtt ttttgaatga tctctgctcc ctggctctat gataggaatt
     4021 ctcaacctga gtgaacaatt caaactgaga ttacttgtgt ttagactcat atattttgat
     4081 aacatatgac ttctccagta tgccccagaa agctgctaat aacttgctca acctgaaatt
     4141 tacagttttc caaattacag gttggcagag atactggatt gataacaaca tccacagtta
     4201 tcatataatc attcttatgc tgtaaacaaa attattttgg ttagcagaat ttaataatta
     4261 actgttaact acatactagg caatattgta gccactttat gtgcttcatg acaccttatg
     4321 ggataggtac tattatcctc attttgcaga tgaggaaact gaggtacaag gaggtatttt
     4381 ctcaaggtca cacaactagg gagtggtggc attagaatgg gaacataggc agtctttctc
     4441 caaagcctat gctgtgctgc ctcttgttgg agagtaaacc tgttttacag tgtgtgtagt
     4501 atggaagcag cataataata agaatagctg ttccttattg agccattact gtggcagaca
     4561 ccgtactata agctgtggta tcaccattat ctcatttgaa tctcatagta gacctatcag
     4621 ttagaggtat gtaaatgctt cctcctctcc cagcaccttt acagatgagg atgctgagcc
     4681 ctagaggtga agaaagttgt ctaatgacag agtgcttgta agaggtaaag ccaagacttg
     4741 aagctctttc ttgcagttac tggatttctc ctaatttacg ggaactaata cagtacagta
     4801 gctaaggatg caagtactga aaccagaaat cttgcctcaa atgccatttc tgccacttga
     4861 gctgtgtact ttggacaaat taatctaatc tttcccattt gaaagtcaga cataatgtct
     4921 tccctagagg cttgtgagga ttaagtgagg caagtgtatg taaatgggct gagatcagag
     4981 cttggctcac aacactcagt aatgatcact gccaattttt tttggtatat aaataaataa
     5041 atacactatt tcccccatgt ttccaatttt taagacattg tatagtgaat ttattgtatc
     5101 tttctcagat taacaattgc acacagtgct tgaaatttag aggtatttca cctgaaaaga
     5161 tgtctagaga ttgaaagaaa acatgctggg catatgattt gaaaatataa ataacatgct
     5221 atttaaaaat aagtttaccc tatgttttct atcttttctg gcacctagat ataccattta
     5281 ataagtaata gcaaggataa tcattttttt aagccctgga aaatcttgat taaagaggac
     5341 atttcagtat tgcaaataaa tgcatggtat ttgtgtaaca ttgtggaaac taataaacac
     5401 aaattgtatt atagcaa
//
