LOCUS       NM_152323               1217 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens Spi-C transcription factor (SPIC), mRNA.
ACCESSION   NM_152323
VERSION     NM_152323.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Go,E.M., Oh,J.H., Park,J.H., Lee,S.Y. and Lee,N.K.
  TITLE     Spi-C positively regulates RANKL-mediated osteoclast
            differentiation and function
  JOURNAL   Exp Mol Med 52 (4), 691-701 (2020)
   PUBMED   32341419
  REMARK    GeneRIF: Spi-C positively regulates RANKL-mediated osteoclast
            differentiation and function.
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Carlsson,R., Thorell,K., Liberg,D. and Leanderson,T.
  TITLE     SPI-C and STAT6 can cooperate to stimulate IgE germline
            transcription
  JOURNAL   Biochem Biophys Res Commun 344 (4), 1155-1160 (2006)
   PUBMED   16647686
  REMARK    GeneRIF: A protein interaction between SPI-C and STAT6 is the basis
            for a novel mechanism for regulation of IL4 induced gene
            expression.
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Carlsson,R., Hjalmarsson,A., Liberg,D., Persson,C. and
            Leanderson,T.
  TITLE     Genomic structure of mouse SPI-C and genomic structure and
            expression pattern of human SPI-C
  JOURNAL   Gene 299 (1-2), 271-278 (2002)
   PUBMED   12459275
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090671.5, AF518404.1 and
            BC032317.1.
            
            On May 17, 2019 this sequence version replaced NM_152323.2.
            
            Summary: The protein encoded by this gene regulates the development
            of red pulp macrophages, which are necessary for iron homeostasis
            and the recycling of red blood cells. [provided by RefSeq, Aug
            2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF518404.1, BI770622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000551346.2/ ENSP00000448580.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC090671.5         176555-176639       c
            86-936              AF518404.1         1-851
            937-1217            BC032317.1         719-999
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..1217
                     /gene="SPIC"
                     /gene_synonym="SPI-C"
                     /note="Spi-C transcription factor"
                     /db_xref="GeneID:121599"
                     /db_xref="HGNC:HGNC:29549"
                     /db_xref="MIM:612568"
     exon            1..167
                     /gene="SPIC"
                     /gene_synonym="SPI-C"
                     /inference="alignment:Splign:2.1.0"
     exon            168..247
                     /gene="SPIC"
                     /gene_synonym="SPI-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..991
                     /gene="SPIC"
                     /gene_synonym="SPI-C"
                     /note="Spi-C transcription factor (Spi-1/PU.1 related)"
                     /codon_start=1
                     /product="transcription factor Spi-C"
                     /protein_id="NP_689536.1"
                     /db_xref="CCDS:CCDS9082.1"
                     /db_xref="GeneID:121599"
                     /db_xref="HGNC:HGNC:29549"
                     /db_xref="MIM:612568"
                     /translation="MTCVEQDKLGQAFEDAFEVLRQHSTGDLQYSPDYRNYLALINHR
                     PHVKGNSSCYGVLPTEEPVYNWRTVINSAADFYFEGNIHQSLQNITENQLVQPTLLQQ
                     KGGKGRKKLRLFEYLHESLYNPEMASCIQWVDKTKGIFQFVSKNKEKLAELWGKRKGN
                     RKTMTYQKMARALRNYGRSGEITKIRRKLTYQFSEAILQRLSPSYFLGKEIFYSQCVQ
                     PDQEYLSLNNWNANYNYTYANYHELNHHDC"
     exon            248..341
                     /gene="SPIC"
                     /gene_synonym="SPI-C"
                     /inference="alignment:Splign:2.1.0"
     exon            342..454
                     /gene="SPIC"
                     /gene_synonym="SPI-C"
                     /inference="alignment:Splign:2.1.0"
     exon            455..563
                     /gene="SPIC"
                     /gene_synonym="SPI-C"
                     /inference="alignment:Splign:2.1.0"
     exon            564..1217
                     /gene="SPIC"
                     /gene_synonym="SPI-C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatggttatg tcttaacaat tctaattttt aaaaaaaata ttactatttt ttttcatcag
       61 agccattgca ctggaaaata attttttatt ttcatgatag cctaccgttg aatttaccgt
      121 tctgatatta atgaaacatc tctataaagg gttgaagtgt cttcccggat tgtcaactta
      181 ttttatttta ttttcttcaa gcaacaattg ctaaggaaca gaattgtcaa tttattaatg
      241 aaatatgacg tgtgttgaac aagacaagct gggtcaagca tttgaagatg cttttgaggt
      301 tctgaggcaa cattcaactg gagatcttca gtactcgcca gattacagaa attacctggc
      361 tttaatcaac catcgtcctc atgtcaaagg aaattccagc tgctatggag tgttgcctac
      421 agaggagcct gtctataatt ggagaacggt aattaacagt gctgcggact tctattttga
      481 aggaaatatt catcaatctc tgcagaacat aactgaaaac cagctggtac aacccactct
      541 tctccagcaa aaggggggaa aaggcaggaa gaagctccga ctgtttgaat accttcacga
      601 atccctgtat aatccggaga tggcatcttg tattcagtgg gtagataaaa ccaaaggcat
      661 ctttcagttt gtatcaaaaa acaaagaaaa acttgccgag ctttggggga aaagaaaagg
      721 caacaggaag accatgactt accagaaaat ggccagggca ctcagaaatt acggaagaag
      781 tggggaaatt accaaaatcc ggaggaagct gacttaccag ttcagtgagg ccattctcca
      841 aagactctct ccatcctatt tcctggggaa agagatcttc tattcacagt gtgttcaacc
      901 tgatcaagaa tatctcagtt taaataactg gaatgcaaat tataattata catatgccaa
      961 ttaccatgag ctaaatcacc atgattgcta aatatacttt catatttcat ggtttactgg
     1021 catcggaaat ctctacaagt tttaatgatt tctccctccc tctctttttt tcctcctctg
     1081 aagaaattta ggatttttct cttaaagcaa atactaaaga ggaaaaaaaa ttaactttat
     1141 tgttgctttt atcaaagagt atgtaatcta tactaacttg ttgggaaatt ctgccaatga
     1201 acaacttttt tataata
//
