LOCUS       XM_047434540            2142 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SPG7 matrix AAA peptidase subunit,
            paraplegin (SPG7), transcript variant X6, mRNA.
ACCESSION   XM_047434540
VERSION     XM_047434540.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000016.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
     gene            1..2142
                     /gene="SPG7"
                     /gene_synonym="CAR; CMAR; PGN; SPG5C"
                     /note="SPG7 matrix AAA peptidase subunit, paraplegin;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 41 ESTs, 588 long SRA reads, 1
                     Protein, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 77 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:6687"
                     /db_xref="HGNC:HGNC:11237"
                     /db_xref="MIM:602783"
     CDS             394..1467
                     /gene="SPG7"
                     /gene_synonym="CAR; CMAR; PGN; SPG5C"
                     /codon_start=1
                     /product="mitochondrial inner membrane m-AAA protease
                     component paraplegin isoform X6"
                     /protein_id="XP_047290496.1"
                     /db_xref="GeneID:6687"
                     /db_xref="HGNC:HGNC:11237"
                     /db_xref="MIM:602783"
                     /translation="MTQRMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTL
                     QERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSV
                     HTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSITP
                     RTNAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTSGAQDDLRKVTR
                     IAYSMVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRHT
                     EKVLQDNLDKLQALANALLEKEVINYEDIEALIGPPPHGPKKMIAPQRWIDAQREKQD
                     LGEEETEETQQPPLGGEEPTWPK"
ORIGIN      
        1 tgttctacgc agaaatagaa gagctgaaac tggtgtatcc ttatcacggc gttctacaca
       61 gcgactagaa gagctgaaac tggtgtatcc ttatcacggt gttgtacgca gaaatagaag
      121 agctgaaact ggtgtatcct tatcacggtg ttgtacgcag aaatagaaga gctgaaactg
      181 gtgtatcctt atcacggtgt tctacgcaga aatagaagag ctgaaactgg tgtatcctta
      241 tcacggtgtt ctacgcagaa atagaagagc tgaaactggt gtatccttat cacggtgttc
      301 tacgcagcaa tagaagagct gaaactggtg tatccttatc atggtgttct atgcagcagt
      361 agaaggaaac tttcttcctg cagcaacaag gaaatgacgc aaagaatggg taccacagac
      421 catgtcatcg tcctggcgtc cacgaaccga gctgacattt tggacggtgc tctgatgagg
      481 ccaggccgac tggaccggca cgtcttcatt gatctcccca cgctgcagga gaggcgggag
      541 atttttgagc agcacctgaa gagcctgaag ctgacccagt ccagcacctt ttactcccag
      601 cgtctggcag agctgacacc aggattcagt ggggctgaca tcgccaacat ctgcaatgag
      661 gctgcgctgc acgcggcgcg ggagggacac acttccgtgc acactctcaa cttcgagtac
      721 gccgtggagc gcgtcctcgc agggactgcc aaaaagagca agatcctgtc caaggaagaa
      781 cagaaagtgg ttgcgtttca tgagtcgggc cacgccttgg tgggctggat gctggagcac
      841 acggaggccg tgatgaaggt ctccataacc cctcggacaa acgccgccct gggctttgct
      901 cagatgctcc ccagagacca gcacctcttc accaaggagc agctgtttga gcggatgtgc
      961 atggccctgg gaggacgggc ctcggaagca ctgtccttca acgaggtcac ttctggggca
     1021 caggacgacc tgaggaaggt cacccgcatc gcctactcca tggtgaagca gtttgggatg
     1081 gcacctggca tcgggcccat ctccttccct gaggcgcagg agggcctcat gggcatcggg
     1141 cggcgcccct tcagccaagg cctgcagcag atgatggacc atgaagcaag actgctggtg
     1201 gccaaggcct acagacacac cgagaaggtg ctgcaggaca acctggacaa gttgcaggcg
     1261 ctggcaaacg cccttctgga aaaggaagtg ataaactatg aggacattga ggctctcatt
     1321 ggcccgccgc cccatgggcc gaagaaaatg atcgcaccgc agaggtggat cgacgcccag
     1381 agggagaaac aggacttggg cgaggaggag accgaagaga cccagcagcc tccacttgga
     1441 ggcgaagagc cgacttggcc caagtagttg ggaggtgttg gctgcacgtg cgggtggtcc
     1501 gggaagtgag ggctcactca gccaccctga gttgcttttc agctgaggtt tgcacttcct
     1561 ctcgcggccc tcagtagtcc ctgcacagtg acttctgaga tctgttgatt gatgaccctt
     1621 ttcatgattt taagtttctc tgcagaaact actgacggag tcctgtgttt gtgagtcgtt
     1681 tcccctatgg ggaaggttat cagtgcttcc cgagtgagca tggaacactt cgagttccca
     1741 gggttataga cagtcgttcc cagtgtggct gaggccaccc agaggcagca gagcattcag
     1801 actccaaaca gacccctgtt catgccgacg cttgcacgac cgccccagtt cctgtggctc
     1861 cctcggaatg ctaaggggat cggacatgaa aggaccctgt gagccgattg tcctatctcc
     1921 agcggccctg tcatccagct cactcatcaa tggggccagt caggcccagg cactgggctc
     1981 cggaggactc accactgccc cctgctgcca tgtggactgg tgcaagttga ggacttcttg
     2041 ctggtctagt cacgcatgca gtgttgggga tgccttggtt tttactgctc tgagaattgt
     2101 tgagatactt tactaataaa ctgtgtagtt ggaaaatcta ca
//
